JP2950616B2 - トリテルペン誘導体 - Google Patents

トリテルペン誘導体

Info

Publication number
JP2950616B2
JP2950616B2 JP4501761A JP50176192A JP2950616B2 JP 2950616 B2 JP2950616 B2 JP 2950616B2 JP 4501761 A JP4501761 A JP 4501761A JP 50176192 A JP50176192 A JP 50176192A JP 2950616 B2 JP2950616 B2 JP 2950616B2
Authority
JP
Japan
Prior art keywords
compound
hydrogen
formula
endothelin
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP4501761A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1992012991A1 (ja
Inventor
正文 藤本
謙介 櫻井
伸一 三原
美春 中村
敏郎 鴻池
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP4501761A priority Critical patent/JP2950616B2/ja
Publication of JPWO1992012991A1 publication Critical patent/JPWO1992012991A1/ja
Application granted granted Critical
Publication of JP2950616B2 publication Critical patent/JP2950616B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
JP4501761A 1991-01-29 1991-12-13 トリテルペン誘導体 Expired - Fee Related JP2950616B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4501761A JP2950616B2 (ja) 1991-01-29 1991-12-13 トリテルペン誘導体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2937291 1991-01-29
JP3-29372 1991-01-29
PCT/JP1991/001707 WO1992012991A1 (fr) 1991-01-29 1991-12-13 Derive de triterpene
JP4501761A JP2950616B2 (ja) 1991-01-29 1991-12-13 トリテルペン誘導体

Publications (2)

Publication Number Publication Date
JPWO1992012991A1 JPWO1992012991A1 (ja) 1993-01-14
JP2950616B2 true JP2950616B2 (ja) 1999-09-20

Family

ID=12274319

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4501761A Expired - Fee Related JP2950616B2 (ja) 1991-01-29 1991-12-13 トリテルペン誘導体

Country Status (8)

Country Link
US (1) US5248807A (https=)
EP (1) EP0526642B1 (https=)
JP (1) JP2950616B2 (https=)
AT (1) ATE164588T1 (https=)
DE (1) DE69129193T2 (https=)
DK (1) DK0526642T3 (https=)
ES (1) ES2115665T3 (https=)
WO (1) WO1992012991A1 (https=)

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US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
WO1993023404A1 (en) * 1992-05-19 1993-11-25 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
US5352800A (en) * 1993-03-11 1994-10-04 Merck & Co., Inc. Process for the production of a novel endothelin antagonist
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5401745A (en) * 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
CA2121724A1 (en) 1993-04-21 1994-10-22 Toshifumi Watanabe Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
DK0628569T3 (da) * 1993-06-11 1996-09-30 Shionogi & Co Triterpenderivater og endothelinreceptorantagonister indeholdende samme
JP3373591B2 (ja) 1993-06-11 2003-02-04 塩野義製薬株式会社 硫酸化トリテルペン誘導体およびそれを含有するエンドセリンレセプター拮抗剤
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
CN1034334C (zh) * 1993-08-14 1997-03-26 贵州省中医研究所 齐酞酸钠及其药物组合物
US5492917A (en) * 1993-09-29 1996-02-20 Merck & Co., Inc. Endothelin antagonists incorporating a cyclobutane
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
DK0838223T3 (da) * 1995-06-02 2003-11-17 Shionogi & Co Hjerneødeminhibitor
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
AP9901643A0 (en) 1997-04-28 1999-10-02 Texas Biotechnology Corp Sulfonamides for treatment of endothelin-mediated disorders.
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
HUP0203935A3 (en) 1999-12-31 2006-02-28 Encysive Pharmaceuticals Inc H Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use
KR100900177B1 (ko) * 2002-03-22 2009-06-02 시오노기세이야쿠가부시키가이샤 트리테르펜 유도체의 제조 방법
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
US8017793B2 (en) 2004-05-14 2011-09-13 Shionogi & Co., Ltd. Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst
AU2005319179B2 (en) * 2004-12-21 2011-10-13 Dow Global Technologies Llc Polypropylene-based adhesive compositions
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US7795306B2 (en) * 2006-03-03 2010-09-14 Inderjit Kumar Dev Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
MX2008011842A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Procedimientos y composiciones para el tratamiento de insuficiencia cardiaca diastolica.
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases
PL2252283T3 (pl) 2008-01-11 2019-09-30 Reata Pharmaceuticals, Inc. Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
CN103342729B (zh) * 2013-03-26 2016-09-14 中国科学院上海药物研究所 咖啡酰基取代的五环三萜类衍生物及其用途
KR102486434B1 (ko) 2016-11-08 2023-01-09 리아타 파마슈티컬즈 홀딩스, 엘엘씨 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법
MX2020006995A (es) 2018-01-04 2020-09-09 Amryt Res Limited Extractos de corteza de abedul que contienen betulina y su formulacion.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
JPS63222119A (ja) * 1987-03-10 1988-09-16 Rooman Kogyo:Kk 肝臓疾患用剤
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
WO1992012991A1 (fr) 1992-08-06
EP0526642A1 (en) 1993-02-10
EP0526642A4 (https=) 1994-02-09
EP0526642B1 (en) 1998-04-01
ATE164588T1 (de) 1998-04-15
ES2115665T3 (es) 1998-07-01
DE69129193T2 (de) 1998-07-30
DK0526642T3 (da) 1998-10-19
US5248807A (en) 1993-09-28
DE69129193D1 (en) 1998-05-07

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