JP2892699B2 - 新規な抗生物質メルサシジンおよびその製法 - Google Patents

新規な抗生物質メルサシジンおよびその製法

Info

Publication number
JP2892699B2
JP2892699B2 JP1210228A JP21022889A JP2892699B2 JP 2892699 B2 JP2892699 B2 JP 2892699B2 JP 1210228 A JP1210228 A JP 1210228A JP 21022889 A JP21022889 A JP 21022889A JP 2892699 B2 JP2892699 B2 JP 2892699B2
Authority
JP
Japan
Prior art keywords
mersacidin
culture
carried out
compound
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1210228A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02142800A (ja
Inventor
スクマル・チヤタジー
スガタ・チヤタジー
ビマル・ナレツシユ・ガングリ
デイ―パク・クマル・チヤタジー
ラジエンドラ・クマル・ハリプラサド・ジヤニ
リヒアルト・ヘルムート・ルツプ
ハンス‐ヴオルフラム・フエールハーバー
ヘルベルト・コグラー
ゲールハルト・ザイベルト
フオルカー・テーツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPH02142800A publication Critical patent/JPH02142800A/ja
Application granted granted Critical
Publication of JP2892699B2 publication Critical patent/JP2892699B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
JP1210228A 1988-08-17 1989-08-16 新規な抗生物質メルサシジンおよびその製法 Expired - Lifetime JP2892699B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3827868.5 1988-08-17
DE3827868A DE3827868A1 (de) 1988-08-17 1988-08-17 Ein neues antibiotikum, mersacidin, ein verfahren zu seiner herstellung und seine verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
JPH02142800A JPH02142800A (ja) 1990-05-31
JP2892699B2 true JP2892699B2 (ja) 1999-05-17

Family

ID=6361001

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1210228A Expired - Lifetime JP2892699B2 (ja) 1988-08-17 1989-08-16 新規な抗生物質メルサシジンおよびその製法

Country Status (20)

Country Link
US (1) US5112806A (enFirst)
EP (1) EP0362520B1 (enFirst)
JP (1) JP2892699B2 (enFirst)
KR (1) KR0139628B1 (enFirst)
AT (1) ATE113296T1 (enFirst)
AU (1) AU613228B2 (enFirst)
CA (1) CA1338171C (enFirst)
DE (2) DE3827868A1 (enFirst)
DK (1) DK175121B1 (enFirst)
ES (1) ES2064398T3 (enFirst)
FI (1) FI94648C (enFirst)
HU (1) HU203906B (enFirst)
IE (1) IE64706B1 (enFirst)
IL (1) IL91317A0 (enFirst)
IN (1) IN167138B (enFirst)
NO (1) NO174517B (enFirst)
NZ (1) NZ230303A (enFirst)
PH (1) PH27179A (enFirst)
PT (1) PT91468B (enFirst)
ZA (1) ZA896245B (enFirst)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0700998B1 (en) * 1994-09-12 2003-11-26 Aventis Pharma Deutschland GmbH Recombinant mersacidin and a method for production
US5910479A (en) * 1996-10-18 1999-06-08 Ambi Inc. Method for the treatment of Streptococcus pneumoniae infection
US6861236B2 (en) * 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
GB0406870D0 (en) 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
JP2009509519A (ja) * 2005-09-27 2009-03-12 ノヴァクタ バイオシステムズ リミティッド ランチビオティックメルサシジンの変種およびそれらの使用
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714030D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
ES2520165T3 (es) * 2009-01-14 2014-11-11 Novacta Biosystems Limited Derivados de desoxiactagardina
CN102388060B (zh) 2009-02-04 2014-09-10 诺瓦克塔生物系统有限公司 阿肽加定衍生物
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
KR102582570B1 (ko) * 2021-03-19 2023-09-22 한국생명공학연구원 유박테리움 칼란데리, 이의 배양액 또는 이의 배양액 추출물을 유효성분으로 포함하는 암 예방 또는 치료용 조성물
EP4404946A4 (en) * 2021-09-22 2026-01-07 Biomedit Inc METHOD FOR INHIBITING DISEASES SURRIDATED BY RESPIRATORY VIRUSES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
JPS61134398A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 新生理活性物質プリパスタチン及びその製造法

Also Published As

Publication number Publication date
FI893842A7 (fi) 1990-02-18
DK175121B1 (da) 2004-06-07
ES2064398T3 (es) 1995-02-01
ZA896245B (en) 1990-04-25
EP0362520A3 (de) 1991-10-23
CA1338171C (en) 1996-03-19
KR0139628B1 (ko) 1998-07-01
HU203906B (en) 1991-10-28
FI893842A0 (fi) 1989-08-15
AU613228B2 (en) 1991-07-25
NZ230303A (en) 1992-06-25
ATE113296T1 (de) 1994-11-15
FI94648C (fi) 1995-10-10
DE3827868A1 (de) 1990-02-22
IE64706B1 (en) 1995-08-23
EP0362520A2 (de) 1990-04-11
PT91468B (pt) 1995-05-04
EP0362520B1 (de) 1994-10-26
US5112806A (en) 1992-05-12
NO174517B (no) 1994-02-07
PH27179A (en) 1993-04-02
AU3996689A (en) 1990-02-22
NO174517C (enFirst) 1994-05-18
DE58908558D1 (de) 1994-12-01
DK403789D0 (da) 1989-08-16
IL91317A0 (en) 1990-03-19
IN167138B (enFirst) 1990-09-01
IE892638L (en) 1990-02-17
KR900003206A (ko) 1990-03-26
PT91468A (pt) 1990-03-08
NO893288L (no) 1990-02-19
JPH02142800A (ja) 1990-05-31
FI94648B (fi) 1995-06-30
DK403789A (da) 1990-02-18
HUT55054A (en) 1991-04-29
NO893288D0 (no) 1989-08-16

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