JP2729333B2 - 血管拡張療法が必要とされる症状を治療するための医薬組成物 - Google Patents
血管拡張療法が必要とされる症状を治療するための医薬組成物Info
- Publication number
- JP2729333B2 JP2729333B2 JP6503397A JP50339794A JP2729333B2 JP 2729333 B2 JP2729333 B2 JP 2729333B2 JP 6503397 A JP6503397 A JP 6503397A JP 50339794 A JP50339794 A JP 50339794A JP 2729333 B2 JP2729333 B2 JP 2729333B2
- Authority
- JP
- Japan
- Prior art keywords
- nitrite
- pharmaceutical composition
- methyl
- dinitrite
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US908,224 | 1978-05-22 | ||
| US07/908,224 US5278192A (en) | 1992-07-02 | 1992-07-02 | Method of vasodilator therapy for treating a patient with a condition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06510800A JPH06510800A (ja) | 1994-12-01 |
| JP2729333B2 true JP2729333B2 (ja) | 1998-03-18 |
Family
ID=25425396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6503397A Expired - Fee Related JP2729333B2 (ja) | 1992-07-02 | 1993-06-30 | 血管拡張療法が必要とされる症状を治療するための医薬組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5278192A (Direct) |
| EP (1) | EP0604642A1 (Direct) |
| JP (1) | JP2729333B2 (Direct) |
| KR (1) | KR0170789B1 (Direct) |
| CN (1) | CN1086997A (Direct) |
| AU (1) | AU667948B2 (Direct) |
| CA (1) | CA2116785C (Direct) |
| CZ (1) | CZ39894A3 (Direct) |
| HU (1) | HUT70501A (Direct) |
| IL (1) | IL106217A (Direct) |
| MX (1) | MX9303982A (Direct) |
| NO (1) | NO305886B1 (Direct) |
| NZ (1) | NZ254490A (Direct) |
| OA (1) | OA09890A (Direct) |
| PL (1) | PL302613A1 (Direct) |
| SK (1) | SK23594A3 (Direct) |
| TW (1) | TW261530B (Direct) |
| WO (1) | WO1994001103A1 (Direct) |
| ZA (1) | ZA934771B (Direct) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646181A (en) * | 1992-07-02 | 1997-07-08 | Research Foundation Of State University Of New York | Method and compositions for treating impotence |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| US5973011A (en) * | 1994-03-30 | 1999-10-26 | Isis Pharma Gmbh | Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction |
| US5681278A (en) * | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
| US5594032A (en) * | 1994-11-10 | 1997-01-14 | Gonzalez-Cadavid; Nestor F. | Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA |
| US5665077A (en) * | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
| US5645839A (en) * | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US5658936A (en) * | 1995-09-18 | 1997-08-19 | Brigham & Women's Hospital, Inc. | Enhancement of erectile function with renin-angiotensin system inhibitors |
| US5897880A (en) | 1995-09-29 | 1999-04-27 | Lam Pharmaceuticals, Llc. | Topical drug preparations |
| US6036977A (en) * | 1995-09-29 | 2000-03-14 | L.A.M. Pharmaceutical Corp. | Drug preparations for treating sexual dysfunction |
| US6251436B1 (en) | 1995-09-29 | 2001-06-26 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
| US6387407B1 (en) | 1995-09-29 | 2002-05-14 | L.A.M. Pharmaceutical Corporation | Topical drug preparations |
| US6258032B1 (en) * | 1997-01-29 | 2001-07-10 | William M. Hammesfahr | Method of diagnosis and treatment and related compositions and apparatus |
| WO1997027745A1 (en) * | 1996-01-31 | 1997-08-07 | Technology Licensing Co. L.L.C. | Method of diagnosis and treatment and related compositions and apparatus |
| GB9608408D0 (en) | 1996-04-23 | 1996-06-26 | Adams Michael A | Treatment of erectile dysfunction |
| US5797887A (en) * | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
| US6191156B1 (en) | 1997-04-11 | 2001-02-20 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating bladder dysfunction |
| US5958884A (en) * | 1997-04-11 | 1999-09-28 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating erectile dysfunction |
| ZA989356B (en) * | 1997-10-16 | 1998-11-16 | Isis Pharma Gmbh | Pharmaceutical preparations |
| US6056966A (en) * | 1998-05-18 | 2000-05-02 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for treating impotence |
| US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| US7045152B2 (en) * | 1999-09-08 | 2006-05-16 | Duke University | Treating pulmonary disorders with gaseous agent causing repletion of GSNO |
| JP2004501143A (ja) | 2000-06-22 | 2004-01-15 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化タキサン、組成物および使用方法 |
| DE60136366D1 (de) * | 2000-08-11 | 2008-12-11 | David R Whitlock | Ammoniak-oxidierende bakterien enthaltende zusammensetzungen zur steigerung der stickoxidproduktion, stickoxid-vorläufer und verfahren zu deren verwendung |
| US20020172712A1 (en) * | 2001-03-19 | 2002-11-21 | Alan Drizen | Antiemetic, anti-motion sustained release drug delivery system |
| WO2002083074A2 (en) * | 2001-04-13 | 2002-10-24 | Children's Hospital Medical Center | Methods for the treatment of hepatic disorders |
| US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
| US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
| US20030138494A1 (en) * | 2001-05-15 | 2003-07-24 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
| US6676855B2 (en) * | 2001-08-02 | 2004-01-13 | Duke University | Use of a blood-flow decrease preventing agent in conjunction with insufflating gas |
| US20040225275A1 (en) * | 2001-08-02 | 2004-11-11 | Reynolds James Dixon | Fetal physiology during maternal surgery or diagnosis |
| EP1472021A4 (en) * | 2002-01-11 | 2008-04-16 | David R Whitlock | AMMONIA OXIDIZING BACTERIUM COMPOSITIONS AND METHODS OF USE |
| WO2003075832A2 (en) | 2002-03-06 | 2003-09-18 | Duke University | Methods and composition based on discovery of metabolism of nitroclycerin |
| US7776925B2 (en) * | 2002-03-06 | 2010-08-17 | Duke University | Reversing, postponing or preventing the occurrence of GTN tolerance and/or generation of reactive oxygen species from mitochondria |
| US20060263419A1 (en) * | 2002-03-12 | 2006-11-23 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
| US8822473B2 (en) * | 2002-05-21 | 2014-09-02 | Gilead Sciences, Inc. | Method of treating diabetes |
| ES2523873T3 (es) | 2002-05-21 | 2014-12-02 | Gilead Sciences, Inc. | Administración de un inhibidor parcial de la oxidación de ácidos grasos, tal como ranolazina, para el tratamiento de la diabetes |
| US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| WO2005063221A1 (en) * | 2003-12-19 | 2005-07-14 | Duke University | Measuring vasodilating activity of blood samples to track disease course |
| WO2006110601A2 (en) * | 2005-04-07 | 2006-10-19 | Nitromed, Inc. | The genetic risk assessment in heart failure: impact of the genetic variation of nos3 |
| EP1890693A4 (en) * | 2005-06-13 | 2009-09-30 | Yeda Res & Dev | USE OF ALLYLMERCAPTOCAPTOPRIL FOR TREATING OR PREVENTING OBESITY AND DISEASES ASSOCIATED WITH OBESITY |
| US20090054381A1 (en) * | 2005-10-04 | 2009-02-26 | Nitromed, Inc. | Methods for treating respiratory disorders |
| ATE534618T1 (de) * | 2006-03-14 | 2011-12-15 | Lars E Gustafsson | Neues verfahren zur herstellung therapeutischer verbindungen und zusammensetzungen, dadurch hergestellte verbindungen und zusammensetzungen und deren verwendung |
| US7625852B2 (en) * | 2006-06-07 | 2009-12-01 | Henry Hadry | Nail polish remover |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| JP5795165B2 (ja) | 2007-11-15 | 2015-10-14 | ルイジアナ ステイト ユニヴァーシティー | 慢性虚血における亜硝酸塩の使用 |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| WO2010147742A2 (en) | 2009-06-18 | 2010-12-23 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| US10463689B2 (en) | 2009-10-14 | 2019-11-05 | Board Of Supervisors Of Louisiana State University | Pharmaceutical formulations of nitrite and uses thereof |
| WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
| US20110144067A1 (en) * | 2009-12-07 | 2011-06-16 | Toscano John P | N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives |
| JP5832447B2 (ja) * | 2009-12-07 | 2015-12-16 | ザ ジョンズ ホプキンス ユニバーシティ | ビスアシル化ヒドロキシルアミン誘導体 |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| EP2731658B1 (en) | 2011-07-12 | 2020-04-01 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into trans-dermal catheter |
| EP2887927B1 (en) * | 2012-08-23 | 2018-03-28 | Cardiolynx AG | Extended release compositions of an amino-c2-c6-alkyl nitrate |
| CA2899602C (en) | 2013-02-20 | 2024-01-30 | Theravasc Inc. | Pharmaceutical uses of inorganic nitrites |
| US20170037363A1 (en) | 2014-04-15 | 2017-02-09 | Aobiome Llc | Ammonia-oxidizing nitrosomonas eutropha strain d23 |
| US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
| WO2015168677A1 (en) | 2014-05-02 | 2015-11-05 | Excelsior Medical Corporation | Strip package for antiseptic cap |
| EP3294404B1 (en) | 2015-05-08 | 2025-06-11 | ICU Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
| WO2018071717A1 (en) | 2016-10-14 | 2018-04-19 | Icu Medical, Inc. | Sanitizing caps for medical connectors |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| CA3118905A1 (en) | 2018-11-21 | 2020-05-28 | Icu Medical, Inc. | Antimicrobial device comprising a cap with ring and insert |
| GB2579240B (en) | 2018-11-27 | 2020-12-16 | Attgeno Ab | New processes, compositions and medical uses |
| GB202007929D0 (en) * | 2020-05-27 | 2020-07-08 | Attgeno Ab | New medical uses |
| WO2022072663A1 (en) * | 2020-10-01 | 2022-04-07 | Emergent Product Development Gaithersburg Inc. | Stabilized alkyl nitrite compositions |
| CA3204371A1 (en) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3106511A (en) * | 1961-12-14 | 1963-10-08 | Revlon | Amyl nitrite inhalant composition |
| CA1163195A (en) * | 1980-06-26 | 1984-03-06 | Alec D. Keith | Polymeric diffusion matrix containing a vasodilator |
| US4450175A (en) * | 1982-09-23 | 1984-05-22 | Warshaw Thelma G | Method and compositions for treating acne |
| DE3305690A1 (de) * | 1983-02-18 | 1984-08-30 | Heinrich Mack Nachf., 7918 Illertissen | Glycerinmononitrate zur behandlung der angina pectoris |
| US4751087A (en) * | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
| US4681584A (en) * | 1985-05-03 | 1987-07-21 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
| US4615699A (en) * | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
| JPH06696B2 (ja) * | 1987-01-27 | 1994-01-05 | 積水化学工業株式会社 | テ−プ製剤 |
| JPH06697B2 (ja) * | 1987-01-27 | 1994-01-05 | 積水化学工業株式会社 | テ−プ製剤 |
| US4956181A (en) * | 1987-05-08 | 1990-09-11 | Eastman Kodak | Nitrate therapy for angina pectoris |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
-
1992
- 1992-07-02 US US07/908,224 patent/US5278192A/en not_active Expired - Fee Related
-
1993
- 1993-06-30 AU AU46587/93A patent/AU667948B2/en not_active Ceased
- 1993-06-30 PL PL93302613A patent/PL302613A1/xx unknown
- 1993-06-30 US US08/199,280 patent/US5489610A/en not_active Expired - Fee Related
- 1993-06-30 NZ NZ254490A patent/NZ254490A/xx unknown
- 1993-06-30 SK SK235-94A patent/SK23594A3/sk unknown
- 1993-06-30 JP JP6503397A patent/JP2729333B2/ja not_active Expired - Fee Related
- 1993-06-30 HU HU9400627A patent/HUT70501A/hu unknown
- 1993-06-30 EP EP93916879A patent/EP0604642A1/en not_active Withdrawn
- 1993-06-30 KR KR1019940700689A patent/KR0170789B1/ko not_active Expired - Fee Related
- 1993-06-30 CZ CZ94398A patent/CZ39894A3/cs unknown
- 1993-06-30 WO PCT/US1993/006235 patent/WO1994001103A1/en not_active Ceased
- 1993-06-30 CA CA002116785A patent/CA2116785C/en not_active Expired - Fee Related
- 1993-07-01 MX MX9303982A patent/MX9303982A/es not_active IP Right Cessation
- 1993-07-02 CN CN93116247A patent/CN1086997A/zh active Pending
- 1993-07-02 IL IL106217A patent/IL106217A/en not_active IP Right Cessation
- 1993-07-02 ZA ZA934771A patent/ZA934771B/xx unknown
- 1993-08-20 TW TW082106738A patent/TW261530B/zh active
-
1994
- 1994-02-28 OA OA60477A patent/OA09890A/en unknown
- 1994-02-28 NO NO940691A patent/NO305886B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT70501A (en) | 1995-10-30 |
| JPH06510800A (ja) | 1994-12-01 |
| MX9303982A (es) | 1994-02-28 |
| US5489610A (en) | 1996-02-06 |
| EP0604642A1 (en) | 1994-07-06 |
| CZ39894A3 (en) | 1994-11-16 |
| IL106217A0 (en) | 1993-11-15 |
| NO940691L (no) | 1994-03-18 |
| NZ254490A (en) | 1997-08-22 |
| HU9400627D0 (en) | 1994-06-28 |
| NO305886B1 (no) | 1999-08-16 |
| AU4658793A (en) | 1994-01-31 |
| OA09890A (en) | 1994-09-15 |
| TW261530B (Direct) | 1995-11-01 |
| WO1994001103A1 (en) | 1994-01-20 |
| CA2116785C (en) | 1998-04-07 |
| CA2116785A1 (en) | 1994-01-20 |
| ZA934771B (en) | 1994-01-20 |
| KR0170789B1 (ko) | 1999-02-01 |
| AU667948B2 (en) | 1996-04-18 |
| NO940691D0 (no) | 1994-02-28 |
| CN1086997A (zh) | 1994-05-25 |
| IL106217A (en) | 1998-04-05 |
| PL302613A1 (en) | 1994-09-05 |
| US5278192A (en) | 1994-01-11 |
| SK23594A3 (en) | 1994-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |