JP2668762B2 - 寒冷沈降物を用いて製造した改良組織接着剤 - Google Patents
寒冷沈降物を用いて製造した改良組織接着剤Info
- Publication number
- JP2668762B2 JP2668762B2 JP28112592A JP28112592A JP2668762B2 JP 2668762 B2 JP2668762 B2 JP 2668762B2 JP 28112592 A JP28112592 A JP 28112592A JP 28112592 A JP28112592 A JP 28112592A JP 2668762 B2 JP2668762 B2 JP 2668762B2
- Authority
- JP
- Japan
- Prior art keywords
- component
- cryoprecipitate
- thrombin
- glue
- aprotinin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003106 tissue adhesive Substances 0.000 title claims abstract description 35
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 21
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 20
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 20
- 108010039627 Aprotinin Proteins 0.000 claims abstract description 16
- 229960004405 aprotinin Drugs 0.000 claims abstract description 14
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims abstract description 14
- 108091005804 Peptidases Proteins 0.000 claims abstract description 11
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 9
- 239000001110 calcium chloride Substances 0.000 description 7
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 239000004472 Lysine Substances 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 108010094028 Prothrombin Proteins 0.000 description 2
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- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 description 2
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- 230000001070 adhesive effect Effects 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
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- 239000003868 thrombin inhibitor Substances 0.000 description 2
- 229940108519 trasylol Drugs 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
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- 208000035049 Blood-Borne Infections Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
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- DEOKFPFLXFNAON-UHFFFAOYSA-N N-α-Benzoyl-DL-arginine 4-nitroanilide hydrochloride Chemical compound Cl.C=1C=C([N+]([O-])=O)C=CC=1NC(=O)C(CCCN=C(N)N)NC(=O)C1=CC=CC=C1 DEOKFPFLXFNAON-UHFFFAOYSA-N 0.000 description 1
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- 229910001424 calcium ion Inorganic materials 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical class NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Packages (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE91/01850 | 1991-09-27 | ||
| PCT/EP1991/001850 WO1993005822A1 (en) | 1991-09-27 | 1991-09-27 | Tissue glue prepared by using cryoprecipitate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05194263A JPH05194263A (ja) | 1993-08-03 |
| JP2668762B2 true JP2668762B2 (ja) | 1997-10-27 |
Family
ID=8165612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28112592A Expired - Lifetime JP2668762B2 (ja) | 1991-09-27 | 1992-09-28 | 寒冷沈降物を用いて製造した改良組織接着剤 |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JP2668762B2 (cs) |
| AT (1) | ATE200631T1 (cs) |
| AU (1) | AU648198B2 (cs) |
| BR (1) | BR9203763A (cs) |
| CA (1) | CA2079077C (cs) |
| CZ (1) | CZ280540B6 (cs) |
| DE (1) | DE69231791T2 (cs) |
| ES (1) | ES2155437T3 (cs) |
| FI (1) | FI924306L (cs) |
| HU (2) | HUT67051A (cs) |
| IL (1) | IL103118A (cs) |
| NO (1) | NO316155B1 (cs) |
| SK (1) | SK294292A3 (cs) |
| WO (1) | WO1993005822A1 (cs) |
| ZA (1) | ZA927360B (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE180492T1 (de) * | 1991-09-05 | 1999-06-15 | Baxter Int | Topischer fibrinogenkomplex |
| ITMI20021917A1 (it) * | 2002-09-10 | 2004-03-11 | New Dawn Consultores E Servicos L Da | Attivatore per la formazione di gel piastrinico, gel di plasma povero di piastrine o gel di plasma ricco di piastrine. |
| EP2011524A1 (en) | 2007-07-02 | 2009-01-07 | Omrix Biopharmaceuticals Ltd. | Fibrin glue with a visualization agent |
| EP2034010A1 (en) | 2007-08-30 | 2009-03-11 | Omrix Biopharmaceuticals Ltd. | Compositions suitable for repair and/or treatment of injured spinal tissue |
| EP2331158B1 (en) | 2008-09-22 | 2013-09-11 | Omrix Biopharmaceuticals Ltd. | Implantable device comprising a substrate pre-coated with stabilized fibrin |
| CA2787883C (en) | 2010-01-28 | 2019-02-19 | Erez Ilan | Method for improved fibrin sealing |
| IL213864A0 (en) | 2011-06-30 | 2011-08-31 | Omrix Biopharmaceuticals Ltd | Method for removing a lytic enzyme from a heterogeneous mixture |
| US10130346B2 (en) | 2012-07-24 | 2018-11-20 | Omrix Biopharmaceuticals Ltd. | Device and method for the application of a curable fluid composition to a bodily organ |
| JP6246833B2 (ja) | 2012-12-30 | 2017-12-13 | オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． | 身体器官の一部に硬化性流体組成物を塗布するための装置及び方法 |
| USD754325S1 (en) | 2013-06-06 | 2016-04-19 | Omrix Biopharmaceuticals Ltd. | Device of a curable fluid composition to a bodily organ |
| IL230151A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing a polymerization inhibitor |
| IL230150A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing zymogens |
| IL231230A0 (en) | 2014-02-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Fibrinogen preparation |
| IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for the preparation and administration of one-component fibrin glue |
| IL234246A0 (en) | 2014-08-21 | 2014-11-30 | Omrix Biopharmaceuticals Ltd | Stabilized thrombin |
| US10905716B2 (en) | 2015-02-16 | 2021-02-02 | Nayacure Therapeutics Ltd. | Modified blood clots |
| IL247821A0 (en) | 2016-09-14 | 2017-01-31 | Omrix Biopharmaceuticals Ltd | Adhesive preparations and their use |
| IL249725A0 (en) | 2016-12-22 | 2017-03-30 | Omrix Biopharmaceuticals Ltd | A hemostatic preparation containing an anion exchanger and a calcium salt |
| IL263679A (en) * | 2018-12-12 | 2019-03-31 | Omrix Biopharmaceuticals Ltd | Kits, methods, and compositions for preventing tissue adhesion |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| ATE20824T1 (de) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| US4627879A (en) * | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
| DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
| DE68918155T2 (de) * | 1988-05-02 | 1995-03-02 | Matrix Pharma | Chirurgisches Klebstoffmaterial. |
| FR2650508A1 (fr) * | 1989-08-01 | 1991-02-08 | Fondation Nale Transfusion San | Colle pasteurisee pour reunir des tissus humain ou animal |
-
1991
- 1991-09-27 SK SK2942-92A patent/SK294292A3/sk unknown
- 1991-09-27 CZ CS922942A patent/CZ280540B6/cs unknown
- 1991-09-27 WO PCT/EP1991/001850 patent/WO1993005822A1/en active Application Filing
-
1992
- 1992-09-02 AT AT92114942T patent/ATE200631T1/de active
- 1992-09-02 DE DE69231791T patent/DE69231791T2/de not_active Expired - Lifetime
- 1992-09-02 ES ES92114942T patent/ES2155437T3/es not_active Expired - Lifetime
- 1992-09-09 IL IL10311892A patent/IL103118A/en not_active IP Right Cessation
- 1992-09-22 AU AU25288/92A patent/AU648198B2/en not_active Expired
- 1992-09-24 CA CA002079077A patent/CA2079077C/en not_active Expired - Fee Related
- 1992-09-25 HU HU9203070A patent/HUT67051A/hu unknown
- 1992-09-25 ZA ZA927360A patent/ZA927360B/xx unknown
- 1992-09-25 FI FI924306A patent/FI924306L/fi unknown
- 1992-09-25 BR BR929203763A patent/BR9203763A/pt not_active Application Discontinuation
- 1992-09-25 NO NO19923737A patent/NO316155B1/no not_active IP Right Cessation
- 1992-09-28 JP JP28112592A patent/JP2668762B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-30 HU HU95P/P00739P patent/HU211631A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO923737D0 (no) | 1992-09-25 |
| WO1993005822A1 (en) | 1993-04-01 |
| NO923737L (no) | 1993-03-29 |
| IL103118A0 (en) | 1993-02-21 |
| CA2079077C (en) | 1999-11-30 |
| ATE200631T1 (de) | 2001-05-15 |
| DE69231791T2 (de) | 2001-11-22 |
| FI924306A7 (fi) | 1993-03-28 |
| NO316155B1 (no) | 2003-12-22 |
| JPH05194263A (ja) | 1993-08-03 |
| BR9203763A (pt) | 1993-04-20 |
| AU2528892A (en) | 1993-04-01 |
| CZ294292A3 (en) | 1994-02-16 |
| AU648198B2 (en) | 1994-04-14 |
| FI924306L (fi) | 1993-03-28 |
| ZA927360B (en) | 1993-05-03 |
| CZ280540B6 (cs) | 1996-02-14 |
| HU211631A9 (en) | 1995-12-28 |
| HU9203070D0 (en) | 1992-12-28 |
| SK294292A3 (en) | 1994-06-08 |
| DE69231791D1 (de) | 2001-05-23 |
| HUT67051A (en) | 1995-01-30 |
| CA2079077A1 (en) | 1993-03-28 |
| ES2155437T3 (es) | 2001-05-16 |
| FI924306A0 (fi) | 1992-09-25 |
| IL103118A (en) | 1996-11-14 |
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