CA2079077A1 - Tissue glue prepared by using cryoprecipitate - Google Patents

Tissue glue prepared by using cryoprecipitate

Info

Publication number
CA2079077A1
CA2079077A1 CA2079077A CA2079077A CA2079077A1 CA 2079077 A1 CA2079077 A1 CA 2079077A1 CA 2079077 A CA2079077 A CA 2079077A CA 2079077 A CA2079077 A CA 2079077A CA 2079077 A1 CA2079077 A1 CA 2079077A1
Authority
CA
Canada
Prior art keywords
component
tissue glue
cryoprecipitate
glue prepared
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2079077A
Other languages
French (fr)
Other versions
CA2079077C (en
Inventor
Uri Martinowitz
Frederic Bal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals SA
Original Assignee
Uri Martinowitz
Frederic Bal
Octapharma Ag
Opperbas Holding B.V.
Omrix Biopharmaceuticals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8165612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2079077(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Uri Martinowitz, Frederic Bal, Octapharma Ag, Opperbas Holding B.V., Omrix Biopharmaceuticals S.A. filed Critical Uri Martinowitz
Publication of CA2079077A1 publication Critical patent/CA2079077A1/en
Application granted granted Critical
Publication of CA2079077C publication Critical patent/CA2079077C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pyrane Compounds (AREA)
  • Packages (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Vehicle Body Suspensions (AREA)

Abstract

A tissue glue is described comprising a component A which comprises a cryoprecipitate of whole blood and a component B comprising a proteolytic enzyme being capable of cleaving specifically fibrinogen present in component A, and causing the formation of a fibrine polymer, in a preferred embodiment component A of the tissue glue comprises 3,000 to 5,000 KIU/ml of aprotinin. In another preferred embodiment component B of the tissue glue is a protease derived from the venom of the South American pit viper. This protease is known under the name batroxobin.
CA002079077A 1991-09-27 1992-09-24 Tissue glue prepared by using cryoprecipitate Expired - Fee Related CA2079077C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP91/01850 1991-09-27
PCT/EP1991/001850 WO1993005822A1 (en) 1991-09-27 1991-09-27 Tissue glue prepared by using cryoprecipitate

Publications (2)

Publication Number Publication Date
CA2079077A1 true CA2079077A1 (en) 1993-03-28
CA2079077C CA2079077C (en) 1999-11-30

Family

ID=8165612

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002079077A Expired - Fee Related CA2079077C (en) 1991-09-27 1992-09-24 Tissue glue prepared by using cryoprecipitate

Country Status (15)

Country Link
JP (1) JP2668762B2 (en)
AT (1) ATE200631T1 (en)
AU (1) AU648198B2 (en)
BR (1) BR9203763A (en)
CA (1) CA2079077C (en)
CZ (1) CZ280540B6 (en)
DE (1) DE69231791T2 (en)
ES (1) ES2155437T3 (en)
FI (1) FI924306A (en)
HU (2) HUT67051A (en)
IL (1) IL103118A (en)
NO (1) NO316155B1 (en)
SK (1) SK294292A3 (en)
WO (1) WO1993005822A1 (en)
ZA (1) ZA927360B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005067A1 (en) * 1991-09-05 1993-03-18 Baxter International, Inc. Topical fibrinogen complex
ITMI20021917A1 (en) * 2002-09-10 2004-03-11 New Dawn Consultores E Servicos L Da ACTIVATOR FOR THE FORMATION OF PLASTIC GEL, PLASMA GEL POOR OF PLATES OR PLASMA GEL RICH IN PLATES.
EP2011524A1 (en) 2007-07-02 2009-01-07 Omrix Biopharmaceuticals Ltd. Fibrin glue with a visualization agent
EP2034010A1 (en) 2007-08-30 2009-03-11 Omrix Biopharmaceuticals Ltd. Compositions suitable for repair and/or treatment of injured spinal tissue
ES2438491T3 (en) 2008-09-22 2014-01-17 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
KR101786786B1 (en) 2010-01-28 2017-10-18 옴릭스 바이오파머슈티컬스 리미티드 Method for improved fibrin sealing
IL213864A0 (en) 2011-06-30 2011-08-31 Omrix Biopharmaceuticals Ltd Method for removing a lytic enzyme from a heterogeneous mixture
US10130346B2 (en) 2012-07-24 2018-11-20 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a bodily organ
EP2941196A1 (en) 2012-12-30 2015-11-11 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a portion of a bodily organ
USD754325S1 (en) 2013-06-06 2016-04-19 Omrix Biopharmaceuticals Ltd. Device of a curable fluid composition to a bodily organ
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One component fibrin glue comprising a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One component fibrin glue comprising zymogens
IL231230A0 (en) 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen formulation
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for preparing and administering one-component fibrin sealant
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
EP3258945B1 (en) 2015-02-16 2020-10-07 Nayacure Therapeutics Ltd. Modified blood clots
IL247821A0 (en) 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Sealant formulations and uses thereof
IL249725A0 (en) 2016-12-22 2017-03-30 Omrix Biopharmaceuticals Ltd Hemostatic composition comprising an anion exchanger and a calcium salt
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and compositions for preventing tissue adhesion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT359652B (en) * 1979-02-15 1980-11-25 Immuno Ag METHOD FOR PRODUCING A TISSUE ADHESIVE
ATE20824T1 (en) * 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg ENRICHED PLASMA DERIVES TO SUPPORT WOUND CLOSURE AND HEALING.
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
DE3622642A1 (en) * 1986-07-05 1988-01-14 Behringwerke Ag ONE-COMPONENT TISSUE ADHESIVE AND METHOD FOR THE PRODUCTION THEREOF
EP0341007B1 (en) * 1988-05-02 1994-09-14 Project Hear Surgical adhesive material
FR2650508A1 (en) * 1989-08-01 1991-02-08 Fondation Nale Transfusion San PASTEURIZED ADHESIVE FOR JOINING HUMAN OR ANIMAL TISSUES

Also Published As

Publication number Publication date
SK294292A3 (en) 1994-06-08
JPH05194263A (en) 1993-08-03
AU2528892A (en) 1993-04-01
CZ294292A3 (en) 1994-02-16
WO1993005822A1 (en) 1993-04-01
CZ280540B6 (en) 1996-02-14
NO316155B1 (en) 2003-12-22
DE69231791T2 (en) 2001-11-22
HU9203070D0 (en) 1992-12-28
ZA927360B (en) 1993-05-03
CA2079077C (en) 1999-11-30
ES2155437T3 (en) 2001-05-16
NO923737L (en) 1993-03-29
JP2668762B2 (en) 1997-10-27
IL103118A (en) 1996-11-14
BR9203763A (en) 1993-04-20
ATE200631T1 (en) 2001-05-15
AU648198B2 (en) 1994-04-14
FI924306A0 (en) 1992-09-25
IL103118A0 (en) 1993-02-21
DE69231791D1 (en) 2001-05-23
HUT67051A (en) 1995-01-30
FI924306A (en) 1993-03-28
HU211631A9 (en) 1995-12-28
NO923737D0 (en) 1992-09-25

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