CA2079077A1 - Tissue glue prepared by using cryoprecipitate - Google Patents
Tissue glue prepared by using cryoprecipitateInfo
- Publication number
- CA2079077A1 CA2079077A1 CA2079077A CA2079077A CA2079077A1 CA 2079077 A1 CA2079077 A1 CA 2079077A1 CA 2079077 A CA2079077 A CA 2079077A CA 2079077 A CA2079077 A CA 2079077A CA 2079077 A1 CA2079077 A1 CA 2079077A1
- Authority
- CA
- Canada
- Prior art keywords
- component
- cryoprecipitate
- tissue glue
- glue prepared
- fibrine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003106 tissue adhesive Substances 0.000 title abstract 3
- 102000008946 Fibrinogen Human genes 0.000 abstract 2
- 108010049003 Fibrinogen Proteins 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 229940012952 fibrinogen Drugs 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical group C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 239000003998 snake venom Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Packages (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Pyrane Compounds (AREA)
Abstract
A tissue glue is described comprising a component A which comprises a cryoprecipitate of whole blood and high an amount of a protease inhibitor corresponding to 3,000 to 5,000 KIU/ml units of aprotinin, and a component B comprising a proteolytic enzyme being capable of cleaving specifically fibrinogen present in component A and causing the formation of a fibrine polymer.
In another embodiment an improved tissue glue is described comprising a component A which comprises a cryoprecipitate of whole blood, and a component B comprising a proteolytic enzyme obtainable from snake venom which enzyme is capable of cleaving specifically fibrinogen present in component A and causing the formation of a fibrine polymer.
In another embodiment an improved tissue glue is described comprising a component A which comprises a cryoprecipitate of whole blood, and a component B comprising a proteolytic enzyme obtainable from snake venom which enzyme is capable of cleaving specifically fibrinogen present in component A and causing the formation of a fibrine polymer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP91/01850 | 1991-09-27 | ||
| PCT/EP1991/001850 WO1993005822A1 (en) | 1991-09-27 | 1991-09-27 | Tissue glue prepared by using cryoprecipitate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2079077A1 true CA2079077A1 (en) | 1993-03-28 |
| CA2079077C CA2079077C (en) | 1999-11-30 |
Family
ID=8165612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002079077A Expired - Fee Related CA2079077C (en) | 1991-09-27 | 1992-09-24 | Tissue glue prepared by using cryoprecipitate |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JP2668762B2 (en) |
| AT (1) | ATE200631T1 (en) |
| AU (1) | AU648198B2 (en) |
| BR (1) | BR9203763A (en) |
| CA (1) | CA2079077C (en) |
| CZ (1) | CZ280540B6 (en) |
| DE (1) | DE69231791T2 (en) |
| ES (1) | ES2155437T3 (en) |
| FI (1) | FI924306L (en) |
| HU (2) | HUT67051A (en) |
| IL (1) | IL103118A (en) |
| NO (1) | NO316155B1 (en) |
| SK (1) | SK294292A3 (en) |
| WO (1) | WO1993005822A1 (en) |
| ZA (1) | ZA927360B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE180492T1 (en) * | 1991-09-05 | 1999-06-15 | Baxter Int | TOPICAL FIBRINOGEN COMPLEX |
| ITMI20021917A1 (en) * | 2002-09-10 | 2004-03-11 | New Dawn Consultores E Servicos L Da | ACTIVATOR FOR THE FORMATION OF PLASTIC GEL, PLASMA GEL POOR OF PLATES OR PLASMA GEL RICH IN PLATES. |
| EP2011524A1 (en) | 2007-07-02 | 2009-01-07 | Omrix Biopharmaceuticals Ltd. | Fibrin glue with a visualization agent |
| EP2034010A1 (en) | 2007-08-30 | 2009-03-11 | Omrix Biopharmaceuticals Ltd. | Compositions suitable for repair and/or treatment of injured spinal tissue |
| EP2331158B1 (en) | 2008-09-22 | 2013-09-11 | Omrix Biopharmaceuticals Ltd. | Implantable device comprising a substrate pre-coated with stabilized fibrin |
| CA2787883C (en) | 2010-01-28 | 2019-02-19 | Erez Ilan | Method for improved fibrin sealing |
| IL213864A0 (en) | 2011-06-30 | 2011-08-31 | Omrix Biopharmaceuticals Ltd | Method for removing a lytic enzyme from a heterogeneous mixture |
| US10130346B2 (en) | 2012-07-24 | 2018-11-20 | Omrix Biopharmaceuticals Ltd. | Device and method for the application of a curable fluid composition to a bodily organ |
| JP6246833B2 (en) | 2012-12-30 | 2017-12-13 | オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． | Apparatus and method for applying a curable fluid composition to a part of a body organ |
| USD754325S1 (en) | 2013-06-06 | 2016-04-19 | Omrix Biopharmaceuticals Ltd. | Device of a curable fluid composition to a bodily organ |
| IL230151A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One component fibrin glue comprising a polymerization inhibitor |
| IL230150A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One component fibrin glue comprising zymogens |
| IL231230A0 (en) | 2014-02-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Fibrinogen formulation |
| IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for preparing and administering one-component fibrin sealant |
| IL234246A0 (en) | 2014-08-21 | 2014-11-30 | Omrix Biopharmaceuticals Ltd | Stabilized thrombin |
| US10905716B2 (en) | 2015-02-16 | 2021-02-02 | Nayacure Therapeutics Ltd. | Modified blood clots |
| IL247821A0 (en) | 2016-09-14 | 2017-01-31 | Omrix Biopharmaceuticals Ltd | Sealant formulations and uses thereof |
| IL249725A0 (en) | 2016-12-22 | 2017-03-30 | Omrix Biopharmaceuticals Ltd | Hemostatic composition comprising an anion exchanger and a calcium salt |
| IL263679A (en) * | 2018-12-12 | 2019-03-31 | Omrix Biopharmaceuticals Ltd | Kits, methods, and ingredients for preventing tissue adhesion |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT359652B (en) * | 1979-02-15 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
| ATE20824T1 (en) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | ENRICHED PLASMA DERIVES TO SUPPORT WOUND CLOSURE AND HEALING. |
| US4627879A (en) * | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
| DE3622642A1 (en) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | ONE-COMPONENT TISSUE ADHESIVE AND METHOD FOR THE PRODUCTION THEREOF |
| DE68918155T2 (en) * | 1988-05-02 | 1995-03-02 | Matrix Pharma | Surgical adhesive material. |
| FR2650508A1 (en) * | 1989-08-01 | 1991-02-08 | Fondation Nale Transfusion San | PASTEURIZED ADHESIVE FOR JOINING HUMAN OR ANIMAL TISSUES |
-
1991
- 1991-09-27 SK SK2942-92A patent/SK294292A3/en unknown
- 1991-09-27 CZ CS922942A patent/CZ280540B6/en unknown
- 1991-09-27 WO PCT/EP1991/001850 patent/WO1993005822A1/en active Application Filing
-
1992
- 1992-09-02 AT AT92114942T patent/ATE200631T1/en active
- 1992-09-02 DE DE69231791T patent/DE69231791T2/en not_active Expired - Lifetime
- 1992-09-02 ES ES92114942T patent/ES2155437T3/en not_active Expired - Lifetime
- 1992-09-09 IL IL10311892A patent/IL103118A/en not_active IP Right Cessation
- 1992-09-22 AU AU25288/92A patent/AU648198B2/en not_active Expired
- 1992-09-24 CA CA002079077A patent/CA2079077C/en not_active Expired - Fee Related
- 1992-09-25 HU HU9203070A patent/HUT67051A/en unknown
- 1992-09-25 ZA ZA927360A patent/ZA927360B/en unknown
- 1992-09-25 FI FI924306A patent/FI924306L/en unknown
- 1992-09-25 BR BR929203763A patent/BR9203763A/en not_active Application Discontinuation
- 1992-09-25 NO NO19923737A patent/NO316155B1/en not_active IP Right Cessation
- 1992-09-28 JP JP28112592A patent/JP2668762B2/en not_active Expired - Lifetime
-
1995
- 1995-06-30 HU HU95P/P00739P patent/HU211631A9/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO923737D0 (en) | 1992-09-25 |
| WO1993005822A1 (en) | 1993-04-01 |
| NO923737L (en) | 1993-03-29 |
| IL103118A0 (en) | 1993-02-21 |
| CA2079077C (en) | 1999-11-30 |
| ATE200631T1 (en) | 2001-05-15 |
| DE69231791T2 (en) | 2001-11-22 |
| FI924306A7 (en) | 1993-03-28 |
| NO316155B1 (en) | 2003-12-22 |
| JPH05194263A (en) | 1993-08-03 |
| BR9203763A (en) | 1993-04-20 |
| AU2528892A (en) | 1993-04-01 |
| CZ294292A3 (en) | 1994-02-16 |
| AU648198B2 (en) | 1994-04-14 |
| FI924306L (en) | 1993-03-28 |
| ZA927360B (en) | 1993-05-03 |
| CZ280540B6 (en) | 1996-02-14 |
| HU211631A9 (en) | 1995-12-28 |
| HU9203070D0 (en) | 1992-12-28 |
| SK294292A3 (en) | 1994-06-08 |
| JP2668762B2 (en) | 1997-10-27 |
| DE69231791D1 (en) | 2001-05-23 |
| HUT67051A (en) | 1995-01-30 |
| ES2155437T3 (en) | 2001-05-16 |
| FI924306A0 (en) | 1992-09-25 |
| IL103118A (en) | 1996-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |