|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
GB9510716D0
(en)
*
|
1995-05-26 |
1995-07-19 |
Pharmacia Spa |
Substituted camptothecin derivatives and process for their preparation
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US20070258987A1
(en)
|
2000-11-28 |
2007-11-08 |
Seattle Genetics, Inc. |
Recombinant Anti-Cd30 Antibodies and Uses Thereof
|
|
CN100406460C
(zh)
|
2003-11-10 |
2008-07-30 |
中国科学院上海药物研究所 |
喜树碱的新衍生物、制备方法和用途
|
|
AR048098A1
(es)
|
2004-03-15 |
2006-03-29 |
Wyeth Corp |
Conjugados de caliqueamicina
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
CN1587265A
(zh)
|
2004-07-08 |
2005-03-02 |
浙江大学 |
10－烷氧基喜树碱衍生物及其制备方法与应用
|
|
JP2008521828A
(ja)
|
2004-11-29 |
2008-06-26 |
シアトル ジェネティックス， インコーポレイテッド |
操作された抗体およびイムノコンジュゲート
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
RU2448979C2
(ru)
|
2006-12-14 |
2012-04-27 |
Ридженерон Фармасьютикалз, Инк. |
Антитела человека к дельта-подобному лиганду-4 человека
|
|
WO2008122039A2
(en)
|
2007-04-02 |
2008-10-09 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Selenocysteine mediated hybrid antibody molecules
|
|
EP2167963B1
(en)
|
2007-05-23 |
2019-04-17 |
Ventana Medical Systems, Inc. |
Polymeric carriers for immunohistochemistry and in situ hybridization
|
|
SG189817A1
(en)
|
2008-04-30 |
2013-05-31 |
Immunogen Inc |
Potent conjugates and hydrophilic linkers
|
|
AU2009275358C1
(en)
|
2008-07-21 |
2015-09-24 |
Polytherics Limited |
Novel reagents and method for conjugating biological molecules
|
|
KR101000067B1
(ko)
|
2008-12-30 |
2010-12-10 |
엘지전자 주식회사 |
고효율 태양전지용 레이저 소성장치 및 고효율 태양전지 제조방법
|
|
JO3182B1
(ar)
|
2009-07-29 |
2018-03-08 |
Regeneron Pharma |
مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
|
|
AU2010283632B2
(en)
|
2009-08-10 |
2016-08-25 |
Ucl Business Plc |
Reversible covalent linkage of functional molecules
|
|
SI2528625T1
(sl)
|
2010-04-15 |
2013-11-29 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
US20130244905A1
(en)
|
2010-07-06 |
2013-09-19 |
Ed Grabczyk |
Reporter for RNA Polymerase II Termination
|
|
SMT201700023T1
(it)
|
2010-08-02 |
2017-03-08 |
Regeneron Pharma |
Topi che producono proteine leganti vl
|
|
CN110078789A
(zh)
|
2011-05-27 |
2019-08-02 |
Ambrx 公司 |
含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
BR112014009070B1
(pt)
|
2011-10-14 |
2021-11-23 |
Medimmune Limited |
Método de síntese e intermediários úteis na preparação de pirrolobenzo-diazepinas
|
|
EP2751111B1
(en)
|
2011-10-14 |
2017-04-26 |
MedImmune Limited |
Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
|
|
CN103997893B
(zh)
|
2011-10-14 |
2019-04-12 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
RU2014124984A
(ru)
|
2011-12-05 |
2016-01-27 |
Идженика Биотерапьютикс, Инк. |
Конъюгаты антитело-лекарственное средство и родственные соединения, композиции и способы
|
|
CN105142672B
(zh)
|
2012-10-23 |
2019-04-05 |
西纳福克斯股份有限公司 |
经修饰的抗体、抗体-缀合物及其制备方法
|
|
KR102445502B1
(ko)
*
|
2014-04-10 |
2022-09-21 |
다이이찌 산쿄 가부시키가이샤 |
항her3 항체-약물 콘주게이트
|
|
US9951141B2
(en)
|
2014-06-02 |
2018-04-24 |
Regeneron Pharmaceuticals, Inc. |
Antibody-drug conjugates, their preparation and their therapeutic use
|
|
BR112018014759B1
(pt)
|
2016-01-25 |
2024-02-27 |
Regeneron Pharmaceuticals, Inc |
Compostos derivados de maitasinoide e seus conjugados, composição compreendendo os mesmos, seus métodos de fabricação e uso
|
|
EP3419670A2
(en)
|
2016-02-26 |
2019-01-02 |
Regeneron Pharmaceuticals, Inc. |
Optimized transglutaminase site-specific antibody conjugation
|
|
WO2018026742A1
(en)
*
|
2016-08-01 |
2018-02-08 |
Askgene Pharma Inc. |
Novel antibody-albumin-drug conjugates (aadc) and methods for using them
|
|
ES3046537T3
(en)
|
2016-11-08 |
2025-12-02 |
Regeneron Pharma |
Steroids and protein-conjugates thereof
|
|
JP7381478B2
(ja)
*
|
2017-10-23 |
2023-11-15 |
マブリンク ビオシオンス |
単一分子量ポリサルコシンを含むリガンド－薬物－複合体
|
|
KR102871690B1
(ko)
|
2018-04-30 |
2025-10-16 |
리제너론 파마슈티칼스 인코포레이티드 |
Her2 및/또는 aplp2에 결합하는 항체 및 이중특이적 항원-결합 분자 및 접합체 그리고 이들의 용도
|
|
CN118955710A
(zh)
*
|
2018-05-09 |
2024-11-15 |
里珍纳龙药品有限公司 |
抗msr1抗体及其使用方法
|
|
SG11202010496WA
(en)
*
|
2018-05-18 |
2020-12-30 |
Daiichi Sankyo Co Ltd |
Anti-muc1 antibody-drug conjugate
|
|
BR112021013464A2
(pt)
|
2019-01-08 |
2021-09-21 |
Regeneron Pharmaceuticals, Inc. |
Ligantes sem traço e conjugados de proteína dos mesmos
|
|
EP3976112A1
(en)
*
|
2019-06-03 |
2022-04-06 |
Synaffix B.V. |
Acetal-based cleavable linkers
|
|
KR20220148200A
(ko)
*
|
2020-02-28 |
2022-11-04 |
리제너론 파마슈티칼스 인코포레이티드 |
Her2에 결합하는 이중특이적 항원 결합 분자 및 이의 사용 방법
|
|
CN116390771A
(zh)
*
|
2020-07-13 |
2023-07-04 |
瑞泽恩制药公司 |
与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途
|
|
AU2021335257A1
(en)
*
|
2020-09-04 |
2023-03-09 |
Merck Patent Gmbh |
Anti-CEACAM5 antibodies and conjugates and uses thereof
|
|
BR112023019495A2
(pt)
*
|
2021-03-30 |
2023-11-07 |
Centre Nat Rech Scient |
Ligante de autorreação induzida por enzima tendo propriedades fisicoquímicas e farmacológicas melhoradas
|
|
GEAP202416409A
(en)
*
|
2021-05-07 |
2024-02-26 |
Alx Oncology Inc |
Exatecan derivatives and antibody-drug conjugates thereof
|
|
JP2024521629A
(ja)
*
|
2021-06-02 |
2024-06-04 |
シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド |
抗体薬物コンジュゲート、及びその調製方法及びその使用
|
|
JP2025525296A
(ja)
*
|
2022-06-27 |
2025-08-05 |
トライオール インコーポレイテッド |
自壊性基を含む化合物及びそれを含むリガンド－薬物コンジュゲート
|