JP2025102784A5 - - Google Patents
Info
- Publication number
- JP2025102784A5 JP2025102784A5 JP2025034660A JP2025034660A JP2025102784A5 JP 2025102784 A5 JP2025102784 A5 JP 2025102784A5 JP 2025034660 A JP2025034660 A JP 2025034660A JP 2025034660 A JP2025034660 A JP 2025034660A JP 2025102784 A5 JP2025102784 A5 JP 2025102784A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cas9 polypeptide
- terminal fragment
- cas9
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799702P | 2019-01-31 | 2019-01-31 | |
| US62/799,702 | 2019-01-31 | ||
| JP2021544294A JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| PCT/US2020/016285 WO2020160514A1 (en) | 2019-01-31 | 2020-01-31 | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Division JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025102784A JP2025102784A (ja) | 2025-07-08 |
| JP2025102784A5 true JP2025102784A5 (enExample) | 2025-10-31 |
Family
ID=71842366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| JP2025034660A Pending JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220098572A1 (enExample) |
| EP (1) | EP3918078A4 (enExample) |
| JP (2) | JP7646552B2 (enExample) |
| KR (1) | KR20210121113A (enExample) |
| CN (1) | CN114040977B (enExample) |
| AU (1) | AU2020215730A1 (enExample) |
| CA (1) | CA3127493A1 (enExample) |
| WO (1) | WO2020160514A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| KR102852347B1 (ko) | 2018-05-11 | 2025-09-01 | 빔 테라퓨틱스, 인크. | 프로그래밍가능한 염기 편집기 시스템을 이용하여 병원성 아미노산을 치환하는 방법 |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| US20230159913A1 (en) | 2020-04-28 | 2023-05-25 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| US20230323335A1 (en) * | 2020-09-04 | 2023-10-12 | National University Corporation Kobe University | Miniaturized cytidine deaminase-containing complex for modifying double-stranded dna |
| CN116601293A (zh) * | 2020-12-07 | 2023-08-15 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| CN113308451B (zh) * | 2020-12-07 | 2023-07-25 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| JP2024511163A (ja) * | 2021-03-26 | 2024-03-12 | ビーム セラピューティクス インク． | アデノシンデアミナーゼバリアント及びその使用 |
| CA3224970A1 (en) * | 2021-07-06 | 2023-01-12 | Holly A. REES | Compositions and methods for efficient genome editing |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| US20250361530A1 (en) * | 2022-05-14 | 2025-11-27 | The Regents Of The University Of California | Genome editing systems for multiplexing point mutation introduction in living cells |
| WO2025119307A1 (zh) * | 2023-12-06 | 2025-06-12 | 北京齐禾生科生物科技有限公司 | 优化的qbe碱基编辑系统及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11053481B2 (en) * | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| WO2015089486A2 (en) * | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| CN107406875B (zh) * | 2014-12-20 | 2021-12-07 | 阿克生物公司 | 使用CRISPR/Cas系统蛋白靶向消减、富集、和分割核酸的组合物及方法 |
| WO2016123243A1 (en) * | 2015-01-28 | 2016-08-04 | The Regents Of The University Of California | Methods and compositions for labeling a single-stranded target nucleic acid |
| EP3303634B1 (en) * | 2015-06-03 | 2023-08-30 | The Regents of The University of California | Cas9 variants and methods of use thereof |
| MX392008B (es) * | 2015-06-18 | 2025-03-21 | Broad Inst Inc | Mutaciones de la enzima crispr que reducen los efectos fuera del blanco |
| EP3350203A4 (en) * | 2015-09-17 | 2019-06-26 | The Regents of The University of California | POLYPEPTIDES OF CAS9 VARIANT WITH INTERNAL INSERTIONS |
| IL294014B2 (en) * | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| WO2018027078A1 (en) * | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| SG10201913505WA (en) * | 2016-10-17 | 2020-02-27 | Univ Nanyang Tech | Truncated crispr-cas proteins for dna targeting |
| US10745677B2 (en) * | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| GB2575930A (en) * | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| US12297436B2 (en) * | 2017-05-18 | 2025-05-13 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| KR102761791B1 (ko) * | 2017-06-26 | 2025-02-05 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법 |
-
2020
- 2020-01-31 CN CN202080026678.0A patent/CN114040977B/zh active Active
- 2020-01-31 JP JP2021544294A patent/JP7646552B2/ja active Active
- 2020-01-31 US US17/427,410 patent/US20220098572A1/en active Pending
- 2020-01-31 WO PCT/US2020/016285 patent/WO2020160514A1/en not_active Ceased
- 2020-01-31 EP EP20748889.1A patent/EP3918078A4/en active Pending
- 2020-01-31 CA CA3127493A patent/CA3127493A1/en active Pending
- 2020-01-31 AU AU2020215730A patent/AU2020215730A1/en active Pending
- 2020-01-31 KR KR1020217026724A patent/KR20210121113A/ko active Pending
-
2025
- 2025-03-05 JP JP2025034660A patent/JP2025102784A/ja active Pending
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