JP2025102784A5 - - Google Patents
Info
- Publication number
- JP2025102784A5 JP2025102784A5 JP2025034660A JP2025034660A JP2025102784A5 JP 2025102784 A5 JP2025102784 A5 JP 2025102784A5 JP 2025034660 A JP2025034660 A JP 2025034660A JP 2025034660 A JP2025034660 A JP 2025034660A JP 2025102784 A5 JP2025102784 A5 JP 2025102784A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cas9 polypeptide
- terminal fragment
- cas9
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799702P | 2019-01-31 | 2019-01-31 | |
| US62/799,702 | 2019-01-31 | ||
| JP2021544294A JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| PCT/US2020/016285 WO2020160514A1 (en) | 2019-01-31 | 2020-01-31 | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Division JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025102784A JP2025102784A (ja) | 2025-07-08 |
| JP2025102784A5 true JP2025102784A5 (enExample) | 2025-10-31 |
Family
ID=71842366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| JP2025034660A Pending JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220098572A1 (enExample) |
| EP (1) | EP3918078A4 (enExample) |
| JP (2) | JP7646552B2 (enExample) |
| KR (1) | KR20210121113A (enExample) |
| CN (1) | CN114040977B (enExample) |
| AU (1) | AU2020215730A1 (enExample) |
| CA (1) | CA3127493A1 (enExample) |
| WO (1) | WO2020160514A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180250424A1 (en) | 2014-10-10 | 2018-09-06 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| CA3100019A1 (en) | 2018-05-11 | 2019-11-14 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| BR112022017715A2 (pt) | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| US20230159913A1 (en) | 2020-04-28 | 2023-05-25 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| EP4209589A4 (en) * | 2020-09-04 | 2024-09-25 | National University Corporation Kobe University | Miniaturized cytidine deaminase-containing complex for modifying double-stranded dna |
| CN116601293A (zh) * | 2020-12-07 | 2023-08-15 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| CN112195164B (zh) * | 2020-12-07 | 2021-04-23 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| KR20240004276A (ko) * | 2021-03-26 | 2024-01-11 | 빔 테라퓨틱스, 인크. | 아데노신 데아미나아제 변이체 및 이의 용도 |
| EP4367227A4 (en) * | 2021-07-06 | 2025-04-30 | Prime Medicine, Inc. | Compositions and methods for efficient genome editing |
| MX2024002927A (es) | 2021-09-08 | 2024-05-29 | Flagship Pioneering Innovations Vi Llc | Metodos y composiciones para modular un genoma. |
| WO2023225451A1 (en) * | 2022-05-14 | 2023-11-23 | The Regents Of The University Of California | Genome editing systems for multiplexing point mutation introduction in living cells |
| WO2025119306A1 (zh) * | 2023-12-06 | 2025-06-12 | 北京齐禾生科生物科技有限公司 | 优化工程化t细胞的碱基编辑系统及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015089486A2 (en) * | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| US20150166984A1 (en) * | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| DK3234200T3 (da) * | 2014-12-20 | 2021-08-23 | Arc Bio Llc | Fremgangsmåde til målrettet depletering af nukleinsyrer ved anvendelse af CRISPR/CAS-systemproteiner |
| WO2016123243A1 (en) * | 2015-01-28 | 2016-08-04 | The Regents Of The University Of California | Methods and compositions for labeling a single-stranded target nucleic acid |
| US10392607B2 (en) * | 2015-06-03 | 2019-08-27 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
| RU2752834C2 (ru) * | 2015-06-18 | 2021-08-09 | Те Брод Инститьют, Инк. | Мутации фермента crispr, уменьшающие нецелевые эффекты |
| US11008555B2 (en) * | 2015-09-17 | 2021-05-18 | The Regents Of The University Of California | Variant Cas9 polypeptides comprising internal insertions |
| US12043852B2 (en) * | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| CA3032699A1 (en) * | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| US11840694B2 (en) * | 2016-10-17 | 2023-12-12 | Nanyang Technological University | Truncated CRISPR-Cas proteins for DNA targeting |
| WO2018119359A1 (en) * | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3601562A1 (en) * | 2017-03-23 | 2020-02-05 | President and Fellows of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018213726A1 (en) * | 2017-05-18 | 2018-11-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| CA3064601A1 (en) * | 2017-06-26 | 2019-01-03 | The Broad Institute, Inc. | Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing |
-
2020
- 2020-01-31 CA CA3127493A patent/CA3127493A1/en active Pending
- 2020-01-31 US US17/427,410 patent/US20220098572A1/en active Pending
- 2020-01-31 KR KR1020217026724A patent/KR20210121113A/ko active Pending
- 2020-01-31 CN CN202080026678.0A patent/CN114040977B/zh active Active
- 2020-01-31 WO PCT/US2020/016285 patent/WO2020160514A1/en not_active Ceased
- 2020-01-31 JP JP2021544294A patent/JP7646552B2/ja active Active
- 2020-01-31 AU AU2020215730A patent/AU2020215730A1/en active Pending
- 2020-01-31 EP EP20748889.1A patent/EP3918078A4/en active Pending
-
2025
- 2025-03-05 JP JP2025034660A patent/JP2025102784A/ja active Pending
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