CA3127493A1 - Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors - Google Patents
Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors Download PDFInfo
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- CA3127493A1 CA3127493A1 CA3127493A CA3127493A CA3127493A1 CA 3127493 A1 CA3127493 A1 CA 3127493A1 CA 3127493 A CA3127493 A CA 3127493A CA 3127493 A CA3127493 A CA 3127493A CA 3127493 A1 CA3127493 A1 CA 3127493A1
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- deaminase
- fusion protein
- amino acid
- cas9
- terminal fragment
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| PCT/US2020/016285 WO2020160514A1 (en) | 2019-01-31 | 2020-01-31 | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
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| KR102852347B1 (ko) | 2018-05-11 | 2025-09-01 | 빔 테라퓨틱스, 인크. | 프로그래밍가능한 염기 편집기 시스템을 이용하여 병원성 아미노산을 치환하는 방법 |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| US20230159913A1 (en) | 2020-04-28 | 2023-05-25 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| US20230323335A1 (en) * | 2020-09-04 | 2023-10-12 | National University Corporation Kobe University | Miniaturized cytidine deaminase-containing complex for modifying double-stranded dna |
| CN116601293A (zh) * | 2020-12-07 | 2023-08-15 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
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| US10745677B2 (en) * | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| GB2575930A (en) * | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| US12297436B2 (en) * | 2017-05-18 | 2025-05-13 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| KR102761791B1 (ko) * | 2017-06-26 | 2025-02-05 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법 |
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2020
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- 2020-01-31 JP JP2021544294A patent/JP7646552B2/ja active Active
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- 2020-01-31 WO PCT/US2020/016285 patent/WO2020160514A1/en not_active Ceased
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|---|---|
| JP2022519507A (ja) | 2022-03-24 |
| EP3918078A1 (en) | 2021-12-08 |
| WO2020160514A1 (en) | 2020-08-06 |
| JP2025102784A (ja) | 2025-07-08 |
| AU2020215730A1 (en) | 2021-07-29 |
| JP7646552B2 (ja) | 2025-03-17 |
| US20220098572A1 (en) | 2022-03-31 |
| CN114040977A (zh) | 2022-02-11 |
| EP3918078A4 (en) | 2022-12-14 |
| CN114040977B (zh) | 2024-09-03 |
| KR20210121113A (ko) | 2021-10-07 |
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