JP2025023938A5 - - Google Patents

Download PDF

Info

Publication number
JP2025023938A5
JP2025023938A5 JP2024185776A JP2024185776A JP2025023938A5 JP 2025023938 A5 JP2025023938 A5 JP 2025023938A5 JP 2024185776 A JP2024185776 A JP 2024185776A JP 2024185776 A JP2024185776 A JP 2024185776A JP 2025023938 A5 JP2025023938 A5 JP 2025023938A5
Authority
JP
Japan
Prior art keywords
methods
new products
manufacturing methods
manufacturing
methods substantially
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024185776A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025023938A (ja
Filing date
Publication date
Priority claimed from GBGB1900529.7A external-priority patent/GB201900529D0/en
Application filed filed Critical
Publication of JP2025023938A publication Critical patent/JP2025023938A/ja
Publication of JP2025023938A5 publication Critical patent/JP2025023938A5/ja
Pending legal-status Critical Current

Links

JP2024185776A 2019-01-15 2024-10-22 Cd38に特異的な二環式ペプチドリガンド Pending JP2025023938A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1900529.7 2019-01-15
GBGB1900529.7A GB201900529D0 (en) 2019-01-15 2019-01-15 Bicyclic peptide ligands specific for CD38
JP2021540842A JP7645801B2 (ja) 2019-01-15 2020-01-15 Cd38に特異的な二環式ペプチドリガンド
PCT/GB2020/050073 WO2020148529A1 (en) 2019-01-15 2020-01-15 Bicyclic peptide ligands specific for cd38

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021540842A Division JP7645801B2 (ja) 2019-01-15 2020-01-15 Cd38に特異的な二環式ペプチドリガンド

Publications (2)

Publication Number Publication Date
JP2025023938A JP2025023938A (ja) 2025-02-19
JP2025023938A5 true JP2025023938A5 (enExample) 2025-03-03

Family

ID=65528180

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021540842A Active JP7645801B2 (ja) 2019-01-15 2020-01-15 Cd38に特異的な二環式ペプチドリガンド
JP2024185776A Pending JP2025023938A (ja) 2019-01-15 2024-10-22 Cd38に特異的な二環式ペプチドリガンド

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021540842A Active JP7645801B2 (ja) 2019-01-15 2020-01-15 Cd38に特異的な二環式ペプチドリガンド

Country Status (6)

Country Link
US (1) US12516084B2 (enExample)
EP (1) EP3911365A1 (enExample)
JP (2) JP7645801B2 (enExample)
CN (1) CN113543813B (enExample)
GB (1) GB201900529D0 (enExample)
WO (1) WO2020148529A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS61853B1 (sr) 2014-10-29 2021-06-30 Bicyclerd Ltd Biciklični peptidni ligandi specifični za mt1-mmp
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Cd137に対して特異的な二環式ペプチドリガンド
KR20200128518A (ko) 2018-02-23 2020-11-13 바이사이클티엑스 리미티드 다량체성 비사이클릭 펩타이드 리간드
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
CN113474045A (zh) 2018-12-21 2021-10-01 拜斯科技术开发有限公司 Pd-l1特异性的双环肽配体
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI862640B (zh) 2019-07-30 2024-11-21 英商拜西可泰克斯有限公司 異質雙環肽複合物
KR20230074119A (ko) 2020-08-03 2023-05-26 바이사이클티엑스 리미티드 펩타이드 기반 링커

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2642514A (en) 1946-08-10 1953-06-16 American Cyanamid Co Ion exchange process with magnetic ion exchange resins
GB1239978A (en) 1968-07-15 1971-07-21 Permutt Company Ltd Ion-exchange processes
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US20020164788A1 (en) 1994-12-02 2002-11-07 The Wellcome Foundation Limited Humanized antibodies to CD38
WO1997008320A1 (en) 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Protein/(poly)peptide libraries
EP0941120A4 (en) 1996-11-05 2004-08-18 Bristol Myers Squibb Co BRANCHED PEPTIDLINKERS
US6326144B1 (en) 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
JP4630459B2 (ja) 1998-09-24 2011-02-09 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 水溶性発光量子ドットおよびその生体分子コンジュゲート
US6927203B1 (en) 1999-08-17 2005-08-09 Purdue Research Foundation Treatment of metastatic disease
AU2003217606C1 (en) 2002-02-21 2008-07-17 Institute Of Virology Soluble Form of Carbonic Anhydrase IX (s-CA IX), Assays to Detect s-CA IX, CA IXs Coexpression with HER-2/neu/c-erbB-2 and CA IX-Specific Monoclonal Antibodies to Non-Immunodominant Epitopes
AU2003286411A1 (en) 2002-12-12 2004-06-30 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
NZ548990A (en) 2004-02-06 2009-06-26 Morphosys Ag Anti-CD38 human antibodies and uses therefor
CA2505655C (en) 2004-04-28 2013-07-09 Warren Chan Stable, water-soluble quantum dot, method of preparation and conjugates thereof
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
PL1866328T3 (pl) 2005-03-22 2011-05-31 Rohto Pharma Peptydy zwiększające wytwarzanie kolagenu lub kwasu hialuronowego
AU2006287416A1 (en) 2005-09-07 2007-03-15 Medimmune, Llc Toxin conjugated Eph receptor antibodies
WO2007093836A1 (en) 2006-02-13 2007-08-23 Cellectis Meganuclease variants cleaving a dna target sequence from a xp gene and uses thereof
WO2008033561A2 (en) 2006-09-15 2008-03-20 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins
CN101232326B (zh) 2007-01-22 2012-01-11 中兴通讯股份有限公司 用于无源光网络系统的动态带宽分配装置及其实现方法
WO2008134761A2 (en) 2007-04-30 2008-11-06 Intezyne Technologies, Inc. Modification of biological targeting groups for the treatment of cancer
CN101918844A (zh) 2007-06-18 2010-12-15 米迪缪尼有限公司 表达epha2和erbb2的细胞的协同治疗
WO2009097397A2 (en) 2008-01-30 2009-08-06 Dyax Corp. Metalloproteinase binding proteins
CN101497878B (zh) 2008-01-30 2012-11-07 房学迅 特异性高效亲和膜ⅰ型基质金属蛋白酶(mt1-mmp)的多肽、蛋白及其应用
DK2257624T5 (da) * 2008-02-05 2012-09-10 Medical Res Council Fremgangsmåder og sammensætninger
DK2257309T3 (da) 2008-02-27 2020-01-20 Yeda Res And Development Company Ltd Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner
US8293714B2 (en) 2008-05-05 2012-10-23 Covx Technology Ireland, Ltd. Anti-angiogenic compounds
FR2932189A1 (fr) 2008-06-10 2009-12-11 Commissariat Energie Atomique Biopuces pour la detection de l'activite enzymatique d'une enzyme protease
GB0913775D0 (en) 2009-08-06 2009-09-16 Medical Res Council Multispecific peptides
US20120183847A1 (en) 2009-05-19 2012-07-19 Aic Blab Composite current collector and methods therefor
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
AU2010321738B2 (en) 2009-11-23 2016-07-14 Palatin Technologies, Inc. Melanocortin-1 receptor-specific cyclic peptides
US9073974B2 (en) 2009-12-21 2015-07-07 The Regents Of The University Of California RGD-containing cyclic peptides
EP2343081A1 (en) 2009-12-31 2011-07-13 Rijksuniversiteit Groningen Interferon analogs
WO2012057624A1 (en) 2010-10-25 2012-05-03 Pepscan Systems B.V. Novel bicyclic peptide mimetics
US20130072598A1 (en) 2011-03-18 2013-03-21 Board Of Regents Of The University Of Nebraska Thermoplastics from Distillers Dried Grains and Feathers
GB201117428D0 (en) 2011-10-07 2011-11-23 Bicycle Therapeutics Ltd Structured polypeptides with sarcosine linkers
US10800813B2 (en) 2011-10-07 2020-10-13 Bicyclerd Limited Modulation of structured polypeptide specificity
WO2014044873A1 (en) 2012-09-24 2014-03-27 Allozyne, Inc Amino acid derivatives
WO2014063012A1 (en) 2012-10-19 2014-04-24 The Board Of Trustees Of The Leland Stanford Junior University Conjugated knottin mini-proteins containing non-natural amino acids
EP2970487B1 (en) 2013-03-12 2020-03-11 Molecular Templates, Inc. Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
US20140274759A1 (en) * 2013-03-15 2014-09-18 Bicycle Therapeutics Limited Modification of polypeptides
EP2976362B1 (en) 2013-03-19 2019-10-23 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
GB201306623D0 (en) 2013-04-11 2013-05-29 Bicycle Therapeutics Ltd Modulation of structured polypeptide specificity
ES2705068T3 (es) 2013-05-23 2019-03-21 Ohio State Innovation Foundation Síntesis química y cribado de bibliotecas de péptidos bicíclicos
RU2715232C2 (ru) 2013-09-25 2020-02-26 Сайтомкс Терапьютикс, Инк. Субстраты матриксной металлопротеиназы и другие расщипляемые фрагменты и способы их использования
EP3062823B1 (en) 2013-10-28 2018-12-12 BicycleRD Limited Novel polypeptides
SI3102576T1 (sl) 2014-02-03 2019-08-30 Vitae Pharmaceuticals, Llc Inhibitorji dihidropirolopiridina ROR-gama
JP6875129B2 (ja) 2014-05-08 2021-05-19 ノボダイアックス, インコーポレイテッド 直接的な免疫組織化学アッセイ
RS59119B1 (sr) 2014-05-21 2019-09-30 Entrada Therapeutics Inc Peptidi koji prodiru u ćelije i postupci za njihovo pravljenje i upotrebu
GB201416960D0 (en) 2014-09-25 2014-11-12 Antikor Biopharma Ltd Biological materials and uses thereof
JP6917887B2 (ja) 2014-09-30 2021-08-11 ポリフォー・アクチェンゲゼルシャフトPolyphor Ag ベータ−ヘアピンペプチド模倣体
CA2963556C (en) 2014-10-24 2023-03-14 Research Corporation Technologies, Inc. Small antibody-like polypeptides that bind to epha2 receptor
RS61853B1 (sr) 2014-10-29 2021-06-30 Bicyclerd Ltd Biciklični peptidni ligandi specifični za mt1-mmp
JP2017537893A (ja) 2014-10-31 2017-12-21 アッヴィ・バイオセラピューティクス・インコーポレイテッド 抗cs1抗体および抗体薬結合体
ES2986970T3 (es) 2014-12-04 2024-11-13 Celgene Corp Conjugados de biomoléculas
IL237525A (en) 2015-03-03 2017-05-29 Shalom Eli Method for labeling a prostate-specific membrane antigen with a radioactive isotope
US10864101B2 (en) 2015-04-22 2020-12-15 Mitsui Chemicals, Inc. Garment provided with joint supporter section, and knee supporter
WO2016171242A1 (ja) 2015-04-24 2016-10-27 第一三共株式会社 Epha2の検出
JP2018521960A (ja) 2015-04-28 2018-08-09 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ(ウペエフエル)Ecole Polytechnique Federale de Lausanne (EPFL) 酵素で活性化された第XII因子(FXIIa)の新規阻害剤
WO2016179534A2 (en) 2015-05-06 2016-11-10 Janssen Biotech, Inc. Prostate specific membrane antigen binding fibronectin type iii domains
EP3115066A1 (en) 2015-07-07 2017-01-11 Technische Universität München Novel psma-specific binding proteins
US9963495B2 (en) 2015-10-27 2018-05-08 The Board Of Trustees Of The Leland Stanford Junior University Polypeptides targeting vascular endothelial growth factor receptor and prostate specific membrane antigen
EP3181146A1 (en) 2015-12-16 2017-06-21 Ruprecht-Karls-Universität Heidelberg Cyclic ntcp-targeting peptides and their uses as entry inhibitors
GB201600903D0 (en) * 2016-01-18 2016-03-02 Bicycle Therapeutics Ltd Peptide derivaties
GB201600911D0 (en) 2016-01-18 2016-03-02 Bicycle Therapeutics Ltd Stabilized peptide derivatives
US10765625B2 (en) 2016-03-15 2020-09-08 The Board Of Trustees Of The Leland Stanford Junior University Knottin-drug conjugates and methods of using the same
KR20180121905A (ko) 2016-03-16 2018-11-09 메리맥 파마슈티컬즈, 인크. 에프린 수용체 a2(epha2)의 나노리포솜 표적화 및 관련된 진단
KR102775461B1 (ko) 2016-04-01 2025-02-28 어비디티 바이오사이언시스 인크. 핵산-폴리펩타이드 조성물 및 이의 용도
US10836796B2 (en) 2016-04-20 2020-11-17 Hangzhou Dac Biotech Co., Ltd. Derivatives of amanita toxins and their conjugation to a cell binding molecule
RU2018139339A (ru) 2016-04-22 2020-05-22 Эллигейтор Биосайенс Аб Новые биспецифические полипептиды против cd137
GB201607827D0 (en) 2016-05-04 2016-06-15 Bicycle Therapeutics Ltd Bicyclic peptide-toxin conjugates specific for MT1-MMP
SG11201810591VA (en) 2016-05-27 2018-12-28 Abbvie Biotherapeutics Inc Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen
WO2018096365A1 (en) 2016-11-27 2018-05-31 Bicyclerd Limited Methods for treating cancer
US11730819B2 (en) 2016-12-23 2023-08-22 Bicycletx Limited Peptide derivatives having novel linkage structures
CN110506049B (zh) 2016-12-23 2024-08-16 拜斯科技术开发有限公司 用于结合mt1-mmp的肽配体
WO2018127699A1 (en) 2017-01-06 2018-07-12 Bicyclerd Limited Compounds for treating cancer
SG11201907753TA (en) 2017-02-24 2019-09-27 Macrogenics Inc Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
GB201706477D0 (en) 2017-04-24 2017-06-07 Bicycle Therapeutics Ltd Modification of polypeptides
EP3615550A1 (en) 2017-04-27 2020-03-04 BicycleTx Limited Bicyclic peptide ligands and uses thereof
WO2018222987A1 (en) 2017-06-01 2018-12-06 Tarveda Therapeutics, Inc. Targeted constructs
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Cd137に対して特異的な二環式ペプチドリガンド
US20200291096A1 (en) 2017-08-14 2020-09-17 Bicyclerd Limited Bicyclic peptide ligand sting conjugates and uses thereof
US20200283482A1 (en) 2017-08-14 2020-09-10 Bicyclerd Limited Bicyclic peptide ligand prr-a conjugates and uses thereof
WO2019084060A1 (en) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
JP7426931B2 (ja) 2017-11-07 2024-02-02 レゲネロン ファーマシューティカルス,インコーポレーテッド 抗体薬物コンジュゲートのための親水性リンカー
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
WO2019136442A1 (en) 2018-01-08 2019-07-11 Kleo Pharmaceuticals, Inc. Cd16a binding agents and uses thereof
KR20200128518A (ko) 2018-02-23 2020-11-13 바이사이클티엑스 리미티드 다량체성 비사이클릭 펩타이드 리간드
KR20200139236A (ko) 2018-04-04 2020-12-11 바이사이클티엑스 리미티드 헤테로탠덤 비사이클릭 펩티드 복합체
EP3797120A1 (en) 2018-05-21 2021-03-31 Compass Therapeutics LLC Compositions and methods for enhancing the killing of target cells by nk cells
GB201810327D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to IL-17
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
GB201810329D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to integrin avB3
GB201810325D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to PSMA
GB201810320D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to CD38
CN112955459A (zh) 2018-10-23 2021-06-11 拜斯科技术开发有限公司 双环肽配体和其用途
SG11202104356VA (en) 2018-10-30 2021-05-28 Bicyclerd Ltd Bt1718 for use in treating cancer
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
US20220024982A1 (en) 2018-12-13 2022-01-27 Bicycletx Limited Bicyclic peptide ligands specific for mt1-mmp
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
CA3120800A1 (en) 2018-12-17 2020-06-25 Revitope Limited Twin immune cell engager
CN113474045A (zh) 2018-12-21 2021-10-01 拜斯科技术开发有限公司 Pd-l1特异性的双环肽配体
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US10882987B2 (en) 2019-01-09 2021-01-05 Nova Chemicals (International) S.A. Ethylene interpolymer products having intermediate branching
GB201900526D0 (en) 2019-01-15 2019-03-06 Bicyclerd Ltd Bicyclic peptide ligands specific for caix
GB201900525D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for caix
GB201900527D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for integrin avb3
GB201900528D0 (en) 2019-01-15 2019-03-06 Bicyclerd Ltd Bicyclic peptide ligands specific for integrin AVB3
GB201900530D0 (en) 2019-01-15 2019-03-06 Bicyclerd Ltd Bicyclic peptide ligands specific for CD38
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
WO2020165600A1 (en) 2019-02-14 2020-08-20 Bicycletx Limited Bicyclic peptide ligand sting conjugates and uses thereof
US20220135614A1 (en) 2019-03-04 2022-05-05 Bicyclerd Limited Synthesis of bicycle toxin conjugates, and intermediates thereof
AU2020253990A1 (en) 2019-04-02 2021-10-28 Bicycletx Limited Bicycle toxin conjugates and uses thereof
WO2020225577A1 (en) 2019-05-09 2020-11-12 Bicycletx Limited Bicyclic peptide ligands specific for ox40
TWI869398B (zh) 2019-05-10 2025-01-11 英商拜西克爾德有限公司 治療癌症之方法
TWI862640B (zh) 2019-07-30 2024-11-21 英商拜西可泰克斯有限公司 異質雙環肽複合物
WO2021028686A1 (en) 2019-08-13 2021-02-18 Bicycletx Limited Modified multimeric bicyclic peptide ligands
GB201912320D0 (en) 2019-08-28 2019-10-09 Bicycletx Ltd PBP Binding Bicyclic Peptide Ligands
PT4464721T (pt) 2019-10-03 2025-06-24 Bicycletx Ltd Complexos peptídicos bicíclicos heterotandem
GB201914872D0 (en) 2019-10-15 2019-11-27 Bicycletx Ltd Bicyclic peptide ligand drug conjugates
US20220387611A1 (en) 2019-10-16 2022-12-08 Bicyclerd Limited Methods for treating cancer
CA3158741A1 (en) 2019-11-27 2021-06-03 Gavin Bennett Bicyclic peptide ligands specific for epha2 and uses thereof
IT202000001231A1 (it) 2020-01-22 2021-07-22 Celery S R L Nuovi ceppi di batteri lattici, composizione alimentare che li comprende, preparazione di tale composizione
GB202002706D0 (en) 2020-02-26 2020-04-08 Bicycletx Ltd Pbp3 binding bicyclic peptide ligands
GB202002705D0 (en) 2020-02-26 2020-04-08 Bicycletx Ltd Anti-infective bicyclic peptide conjugates
KR20230037502A (ko) 2020-05-20 2023-03-16 바이사이클티엑스 리미티드 넥틴-4에 특이적인 바이사이클릭 펩티드 리간드 및 이의 용도
IL298868A (en) 2020-06-12 2023-02-01 Bicycletx Ltd Treatment of diseases characterized by overexpression of hepatocyte receptor A2 that produces erythropoietin (EPHA2)
KR20230074119A (ko) 2020-08-03 2023-05-26 바이사이클티엑스 리미티드 펩타이드 기반 링커
EP4196792A1 (en) 2020-08-17 2023-06-21 BicycleTX Limited Bicycle conjugates specific for nectin-4 and uses thereof
ES2992468T3 (es) 2021-01-08 2024-12-12 Bicycletx Ltd Ligandos peptídicos bicíclicos específicos para linfocitos NK
CN117157305A (zh) 2021-01-08 2023-12-01 拜斯科技术开发有限公司 抗感染的双环肽配体
CA3206529A1 (en) 2021-01-08 2022-07-14 Bicycletx Limited Heterotandem bicyclic peptide complexes
US20250186539A2 (en) 2021-01-11 2025-06-12 Bicycletx Limited Methods for treating cancer
AU2022340959A1 (en) 2021-09-03 2024-03-07 Bicycletx Limited Synthesis of bicycle toxin conjugates, and intermediates thereof
KR20240100420A (ko) 2021-11-16 2024-07-01 바이사이클티엑스 리미티드 암을 치료하기 위한 방법

Similar Documents

Publication Publication Date Title
JP2024156852A5 (enExample)
JP2024133471A5 (enExample)
JP2026012786A5 (enExample)
JP2024063016A5 (enExample)
JP2023113641A5 (enExample)
JP2025023938A5 (enExample)
JP2024037765A5 (enExample)
JP2023113681A5 (enExample)
JP2025106258A5 (enExample)
JP2023153863A5 (enExample)
JP2023164986A5 (enExample)
JP2024156705A5 (enExample)
JP2023134519A5 (enExample)
JP2025118771A5 (enExample)
JP2025038009A5 (enExample)
JP2024088648A5 (enExample)
JP2023103231A5 (enExample)
JP2025143267A5 (enExample)
JP2024160274A5 (enExample)
JP2023139025A5 (enExample)
JP2025124655A5 (enExample)
JP2025041678A5 (enExample)
JP2024038101A5 (enExample)
JP2023100679A5 (enExample)
JP2025163046A5 (enExample)