JP2025013879A5 - - Google Patents
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- Publication number
- JP2025013879A5 JP2025013879A5 JP2024182444A JP2024182444A JP2025013879A5 JP 2025013879 A5 JP2025013879 A5 JP 2025013879A5 JP 2024182444 A JP2024182444 A JP 2024182444A JP 2024182444 A JP2024182444 A JP 2024182444A JP 2025013879 A5 JP2025013879 A5 JP 2025013879A5
- Authority
- JP
- Japan
- Prior art keywords
- foxp3
- locus
- nucleotide sequence
- homology
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims 10
- 125000006850 spacer group Chemical group 0.000 claims 6
- 101710163270 Nuclease Proteins 0.000 claims 5
- 210000004698 lymphocyte Anatomy 0.000 claims 4
- 108020005004 Guide RNA Proteins 0.000 claims 3
- 101001000998 Homo sapiens Protein phosphatase 1 regulatory subunit 12C Proteins 0.000 claims 3
- 102100035620 Protein phosphatase 1 regulatory subunit 12C Human genes 0.000 claims 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 2
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 2
- 108010042407 Endonucleases Proteins 0.000 claims 2
- 102000004533 Endonucleases Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims 1
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 102000053917 human FOXP3 Human genes 0.000 claims 1
- 230000000527 lymphocytic effect Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663561P | 2018-04-27 | 2018-04-27 | |
| US62/663,561 | 2018-04-27 | ||
| US201862773414P | 2018-11-30 | 2018-11-30 | |
| US62/773,414 | 2018-11-30 | ||
| JP2020560338A JP7575949B2 (ja) | 2018-04-27 | 2019-04-25 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
| PCT/US2019/029159 WO2019210078A1 (en) | 2018-04-27 | 2019-04-25 | Expression of human foxp3 in gene edited t cells |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560338A Division JP7575949B2 (ja) | 2018-04-27 | 2019-04-25 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025013879A JP2025013879A (ja) | 2025-01-28 |
| JP2025013879A5 true JP2025013879A5 (enExample) | 2025-04-10 |
Family
ID=68295504
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560338A Active JP7575949B2 (ja) | 2018-04-27 | 2019-04-25 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
| JP2024182444A Pending JP2025013879A (ja) | 2018-04-27 | 2024-10-18 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560338A Active JP7575949B2 (ja) | 2018-04-27 | 2019-04-25 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210253652A1 (enExample) |
| EP (1) | EP3784689A4 (enExample) |
| JP (2) | JP7575949B2 (enExample) |
| KR (1) | KR20210005146A (enExample) |
| CN (1) | CN112041334A (enExample) |
| AU (2) | AU2019257708B2 (enExample) |
| CA (1) | CA3091491A1 (enExample) |
| IL (1) | IL277036A (enExample) |
| SG (1) | SG11202007877SA (enExample) |
| WO (1) | WO2019210078A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016427822B2 (en) * | 2016-10-31 | 2025-01-23 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Method for treating autoimmune disease using CD4 T-cells with engineered stabilization of expression of endogennous FOXP3 gene |
| CN112218882A (zh) | 2018-04-27 | 2021-01-12 | 西雅图儿童医院（Dba西雅图儿童研究所） | Foxp3在经编辑的cd34+细胞中的表达 |
| EP3921427A1 (en) * | 2019-02-05 | 2021-12-15 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Recombinant vectors suitable for the treatment of ipex syndrome |
| CA3141159A1 (en) * | 2019-05-21 | 2020-11-26 | Sangamo Therapeutics, Inc. | Controlled transgene expression in regulatory t cells |
| EP4055039A1 (en) * | 2019-11-08 | 2022-09-14 | Sangamo Therapeutics, Inc. | Generation of engineered regulatory t cells |
| WO2021163642A2 (en) * | 2020-02-13 | 2021-08-19 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients |
| TW202227631A (zh) * | 2020-11-09 | 2022-07-16 | 英商圭爾醫療有限公司 | 冷凍保存經工程化之調節t細胞(tregs)之方法 |
| EP4355879A4 (en) * | 2021-06-14 | 2025-07-23 | Kamau Therapeutics Inc | METHODS FOR GENETIC MODIFICATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR ERYTHROCYTE-SPECIFIC EXPRESSION OF THERAPEUTIC PROTEINS |
| WO2023122099A2 (en) * | 2021-12-21 | 2023-06-29 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr-based gene editing to preserve splicing and expression of foxp3 isoforms 1 and 2 |
| CN115305237B (zh) * | 2022-07-08 | 2023-07-14 | 中南大学 | 一种优化的调节性t细胞的扩增及规模化生产的方法 |
| EP4634383A1 (en) * | 2022-12-16 | 2025-10-22 | Life Edit Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| WO2025006409A2 (en) * | 2023-06-24 | 2025-01-02 | Sonoma Biotherapeutics, Inc. | Compositions and methods for engineering cells |
| WO2025054503A1 (en) * | 2023-09-08 | 2025-03-13 | Sonoma Biotherapeutics, Inc. | Cells ectopically expressing foxp3 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110123502A1 (en) | 2007-02-21 | 2011-05-26 | Barry Simon C | Method for obtaining treg-cells |
| ES2883131T3 (es) * | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
| ES2880473T5 (es) * | 2015-01-30 | 2024-05-09 | Univ California | Suministro de proteínas en células hematopoyéticas primarias |
| HK1254190A1 (zh) * | 2015-05-08 | 2019-07-12 | President And Fellows Of Harvard College | 通用供体干细胞和相关方法 |
| CA3034094A1 (en) | 2016-08-16 | 2018-02-22 | Bluebird Bio, Inc. | Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use |
| WO2018073391A1 (en) * | 2016-10-19 | 2018-04-26 | Cellectis | Targeted gene insertion for improved immune cells therapy |
| WO2018081476A2 (en) * | 2016-10-27 | 2018-05-03 | Intima Bioscience, Inc. | Viral methods of t cell therapy |
| AU2016427822B2 (en) | 2016-10-31 | 2025-01-23 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Method for treating autoimmune disease using CD4 T-cells with engineered stabilization of expression of endogennous FOXP3 gene |
| CN109790518A (zh) * | 2017-05-08 | 2019-05-21 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| EP3672617A4 (en) * | 2017-08-22 | 2021-06-23 | The Regents of the University of California | LENTIVIRAL VECTORS EXPRESSING FOXP3 IN HEMATOPOIETIC STEM CELLS TO TREAT IMMUNITY DEFICIENCIES AND AUTOIMMUNE DISEASES |
| CN112218882A (zh) | 2018-04-27 | 2021-01-12 | 西雅图儿童医院（Dba西雅图儿童研究所） | Foxp3在经编辑的cd34+细胞中的表达 |
-
2019
- 2019-04-25 US US16/981,213 patent/US20210253652A1/en active Pending
- 2019-04-25 KR KR1020207033790A patent/KR20210005146A/ko active Pending
- 2019-04-25 WO PCT/US2019/029159 patent/WO2019210078A1/en not_active Ceased
- 2019-04-25 CN CN201980028523.8A patent/CN112041334A/zh active Pending
- 2019-04-25 CA CA3091491A patent/CA3091491A1/en active Pending
- 2019-04-25 EP EP19792759.3A patent/EP3784689A4/en active Pending
- 2019-04-25 AU AU2019257708A patent/AU2019257708B2/en active Active
- 2019-04-25 JP JP2020560338A patent/JP7575949B2/ja active Active
- 2019-04-25 SG SG11202007877SA patent/SG11202007877SA/en unknown
-
2020
- 2020-08-31 IL IL277036A patent/IL277036A/en unknown
-
2024
- 2024-10-18 JP JP2024182444A patent/JP2025013879A/ja active Pending
- 2024-11-22 AU AU2024266825A patent/AU2024266825A1/en active Pending
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