JP2024531944A5 - - Google Patents
Info
- Publication number
- JP2024531944A5 JP2024531944A5 JP2024508097A JP2024508097A JP2024531944A5 JP 2024531944 A5 JP2024531944 A5 JP 2024531944A5 JP 2024508097 A JP2024508097 A JP 2024508097A JP 2024508097 A JP2024508097 A JP 2024508097A JP 2024531944 A5 JP2024531944 A5 JP 2024531944A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- hcdr2
- hcdr1
- hcdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110909032.3 | 2021-08-09 | ||
| CN202110909032 | 2021-08-09 | ||
| PCT/CN2022/110314 WO2023016348A1 (en) | 2021-08-09 | 2022-08-04 | Cldn18.2-targeting antibody, bispecific antibody and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024531944A JP2024531944A (ja) | 2024-09-03 |
| JP2024531944A5 true JP2024531944A5 (https=) | 2025-08-04 |
Family
ID=82942472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024508097A Pending JP2024531944A (ja) | 2021-08-09 | 2022-08-04 | Ｃｌｄｎ１８．２標的化抗体、二重特異性抗体、及びそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12428479B2 (https=) |
| EP (1) | EP4384547A1 (https=) |
| JP (1) | JP2024531944A (https=) |
| KR (1) | KR20240044467A (https=) |
| CN (1) | CN118019763A (https=) |
| AR (1) | AR126739A1 (https=) |
| AU (1) | AU2022326063A1 (https=) |
| CA (1) | CA3228137A1 (https=) |
| CL (1) | CL2024000374A1 (https=) |
| CO (1) | CO2024002857A2 (https=) |
| CR (1) | CR20240124A (https=) |
| EC (1) | ECSP24018785A (https=) |
| IL (1) | IL310578A (https=) |
| MX (1) | MX2024001761A (https=) |
| TW (1) | TW202334215A (https=) |
| WO (1) | WO2023016348A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115667316A (zh) * | 2020-06-30 | 2023-01-31 | 和铂医药(上海)有限责任公司 | Fab-HCAb结构的结合蛋白 |
| CN119569886A (zh) * | 2023-09-06 | 2025-03-07 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
| CN120829517A (zh) * | 2024-04-22 | 2025-10-24 | 鲁南新时代生物技术有限公司 | 抗cldn18.2/cd3双特异性抗体及用途 |
| WO2026076388A1 (en) * | 2024-10-03 | 2026-04-09 | The Broad Institute, Inc. | Vhh polypeptides that bind to claudin-18, compositions and methods of use thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| KR20030032922A (ko) | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| WO2005118788A2 (en) | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| JP6499079B2 (ja) * | 2012-11-13 | 2019-04-10 | バイオエヌテック アーゲーＢｉｏＮＴｅｃｈ ＡＧ | クローディンを発現するガン疾患を処置するための剤 |
| WO2014146672A1 (en) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2016180468A1 (en) | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Claudin-18.2-specific immunoreceptors and t cell epitopes |
| PE20180484A1 (es) | 2015-10-02 | 2018-03-07 | Hoffmann La Roche | Moleculas biespecificas de union a antigeno activadoras de celulas t |
| PE20241349A1 (es) | 2016-09-14 | 2024-07-03 | Teneobio Inc | Anticuerpos de union a cd3 |
| EP3567053A4 (en) | 2016-12-28 | 2020-08-12 | Osaka University | ANTI-CLAUDINE-2 MONOCLONAL ANTIBODY |
| JP2021508479A (ja) * | 2017-12-27 | 2021-03-11 | テネオバイオ， インコーポレイテッド | ヘテロ二量体特異的抗体上のｃｄ３デルタ及びｃｄ３イプシロン |
| US12054543B2 (en) | 2018-07-25 | 2024-08-06 | Accurus Biosciences, Inc. | CLDN 18.2-specific monoclonal antibodies and methods of use thereof |
| WO2020025792A1 (en) | 2018-08-03 | 2020-02-06 | Amgen Research (Munich) Gmbh | Antibody constructs for cldn18.2 and cd3 |
| WO2020205331A1 (en) | 2019-03-29 | 2020-10-08 | Phanes Therapeutics, Inc. | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof |
| CN114206935B (zh) * | 2019-05-24 | 2024-01-12 | 三优生物医药(上海)有限公司 | 新型cldn18.2结合分子 |
| WO2021009692A1 (en) * | 2019-07-15 | 2021-01-21 | Medimmune Limited | Tripartite systems for protein dimerization and methods of use |
| KR102777693B1 (ko) * | 2019-07-17 | 2025-03-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Claudin18 항체 및 암 치료 방법 |
| CA3165585A1 (en) * | 2019-12-27 | 2021-07-01 | Nanjing Legend Biotech Co., Ltd. | Claudin18.2 binding moieties and uses thereof |
| TW202330622A (zh) * | 2020-04-29 | 2023-08-01 | 美商泰尼歐生物公司 | 具有經修飾重鏈恆定區之多特異性重鏈抗體 |
| US20240109963A1 (en) * | 2020-11-16 | 2024-04-04 | Ab Therapeutics, Inc. | Multispecific antibodies and uses thereof |
| CN112480248B (zh) * | 2020-11-24 | 2023-05-05 | 三优生物医药(上海)有限公司 | 与cld18a2特异性结合的分子 |
-
2022
- 2022-08-04 IL IL310578A patent/IL310578A/en unknown
- 2022-08-04 AU AU2022326063A patent/AU2022326063A1/en active Pending
- 2022-08-04 JP JP2024508097A patent/JP2024531944A/ja active Pending
- 2022-08-04 EP EP22757202.1A patent/EP4384547A1/en active Pending
- 2022-08-04 WO PCT/CN2022/110314 patent/WO2023016348A1/en not_active Ceased
- 2022-08-04 KR KR1020247007499A patent/KR20240044467A/ko active Pending
- 2022-08-04 MX MX2024001761A patent/MX2024001761A/es unknown
- 2022-08-04 CN CN202280054294.9A patent/CN118019763A/zh active Pending
- 2022-08-04 CR CR20240124A patent/CR20240124A/es unknown
- 2022-08-04 CA CA3228137A patent/CA3228137A1/en active Pending
- 2022-08-08 AR ARP220102131A patent/AR126739A1/es unknown
- 2022-08-08 TW TW111129765A patent/TW202334215A/zh unknown
- 2022-08-08 US US17/818,072 patent/US12428479B2/en active Active
-
2024
- 2024-02-07 CL CL2024000374A patent/CL2024000374A1/es unknown
- 2024-03-07 EC ECSENADI202418785A patent/ECSP24018785A/es unknown
- 2024-03-08 CO CONC2024/0002857A patent/CO2024002857A2/es unknown
-
2025
- 2025-07-18 US US19/273,244 patent/US20250340631A1/en active Pending
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