JP2024526217A - アッセイシグナル増幅のための方法、組成物及びキット - Google Patents
アッセイシグナル増幅のための方法、組成物及びキット Download PDFInfo
- Publication number
- JP2024526217A JP2024526217A JP2023579630A JP2023579630A JP2024526217A JP 2024526217 A JP2024526217 A JP 2024526217A JP 2023579630 A JP2023579630 A JP 2023579630A JP 2023579630 A JP2023579630 A JP 2023579630A JP 2024526217 A JP2024526217 A JP 2024526217A
- Authority
- JP
- Japan
- Prior art keywords
- reagent
- detectable label
- detectable
- binding
- signal amplification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163215660P | 2021-06-28 | 2021-06-28 | |
| US63/215,660 | 2021-06-28 | ||
| PCT/US2022/035068 WO2023278293A1 (en) | 2021-06-28 | 2022-06-27 | Methods, compositions, and kits for assay signal amplification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024526217A true JP2024526217A (ja) | 2024-07-17 |
| JPWO2023278293A5 JPWO2023278293A5 (enExample) | 2025-07-07 |
Family
ID=82703171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023579630A Pending JP2024526217A (ja) | 2021-06-28 | 2022-06-27 | アッセイシグナル増幅のための方法、組成物及びキット |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230020070A1 (enExample) |
| EP (1) | EP4363857A1 (enExample) |
| JP (1) | JP2024526217A (enExample) |
| KR (1) | KR20240051109A (enExample) |
| CN (1) | CN117999482A (enExample) |
| AU (1) | AU2022304570A1 (enExample) |
| CA (1) | CA3225576A1 (enExample) |
| IL (1) | IL309517A (enExample) |
| TW (1) | TW202317992A (enExample) |
| WO (1) | WO2023278293A1 (enExample) |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4442204A (en) | 1981-04-10 | 1984-04-10 | Miles Laboratories, Inc. | Homogeneous specific binding assay device and preformed complex method |
| US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US6316607B1 (en) | 1986-04-30 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent assays |
| US5591581A (en) | 1986-04-30 | 1997-01-07 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods for their use |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US5786141A (en) | 1994-08-26 | 1998-07-28 | Bard; Allen J. | Electrogenerated chemiluminescence labels for analysis and/or referencing |
| US5679519A (en) * | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
| US6136268A (en) | 1999-08-17 | 2000-10-24 | Orion Diagnostica | Method for luminescence measurements |
| US6808939B2 (en) | 2001-06-29 | 2004-10-26 | Igen International, Inc. | ECL labels having improved non-specific binding properties, methods of using and kits containing the same |
| DK2461156T3 (da) | 2001-06-29 | 2020-08-03 | Meso Scale Technologies Llc | Indretning til luminescenstestmålinger |
| EP1436620B1 (en) * | 2001-09-10 | 2014-04-23 | Meso Scale Technologies, LLC | Methods and apparatus for conducting multiple measurements on a sample |
| CA2772050C (en) | 2002-12-26 | 2016-09-06 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
| US7981362B2 (en) | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
| EP1766400B1 (en) | 2004-06-03 | 2009-04-15 | Meso Scale Technologies, LLC | Methods for conducting whole blood assays |
| AU2006330913B2 (en) | 2005-12-21 | 2011-10-27 | Meso Scale Technologies, Llc | Assay modules having assay reagents and methods of making and using same |
| JP5955218B2 (ja) | 2009-07-27 | 2016-07-20 | メソ スケール テクノロジーズ エルエルシー | アッセイ情報管理方法及びデバイス |
| CA2782694C (en) | 2009-12-07 | 2018-03-27 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
| WO2012015809A2 (en) | 2010-07-27 | 2012-02-02 | Xinri Cong | Consumable data management |
| WO2014008381A2 (en) | 2012-07-05 | 2014-01-09 | Meso Scale Technologies, Llc. | Assay cartridge valve system |
| JP6087293B2 (ja) | 2011-01-06 | 2017-03-01 | メソ スケール テクノロジーズ エルエルシー | アッセイカートリッジ及びその使用方法 |
| ES2622998T3 (es) | 2012-08-02 | 2017-07-10 | F. Hoffmann-La Roche Ag | Nuevos complejos basados en iridio para EQL |
| WO2014107576A2 (en) | 2013-01-04 | 2014-07-10 | Meso Scale Technologies, Llc | Assay apparatuses, methods and reagents |
| KR102275006B1 (ko) | 2013-03-11 | 2021-07-09 | 메소 스케일 테크놀러지즈, 엘엘시 | 다중화 어세이를 수행하기 위한 개선된 방법 |
| US10114015B2 (en) * | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| US9618510B2 (en) * | 2013-03-13 | 2017-04-11 | Meso Scale Technologies, Llc. | Assay methods |
| AU2015259048B2 (en) * | 2014-05-15 | 2021-09-09 | Meso Scale Technologies, Llc. | Improved assay methods |
| CA3129007A1 (en) | 2015-04-06 | 2016-10-13 | Eli N. Glezer | High throughput system for performing assays using electrochemiluminescence including a consumable shaking apparatus |
| CA2992983C (en) | 2015-07-23 | 2022-10-25 | Meso Scale Technologies, Llc. | Integrated consumable data management system & platform |
| CA3031446A1 (en) | 2016-07-22 | 2018-01-25 | Meso Scale Technologies, Llc. | Integrated consumable data management system & platform |
| AU2019418498A1 (en) | 2019-01-03 | 2021-07-15 | Meso Scale Technologies, Llc | Compositions and methods for carrying out assay measurements |
-
2022
- 2022-06-27 AU AU2022304570A patent/AU2022304570A1/en active Pending
- 2022-06-27 EP EP22747837.7A patent/EP4363857A1/en active Pending
- 2022-06-27 IL IL309517A patent/IL309517A/en unknown
- 2022-06-27 CA CA3225576A patent/CA3225576A1/en active Pending
- 2022-06-27 KR KR1020247002999A patent/KR20240051109A/ko active Pending
- 2022-06-27 US US17/849,917 patent/US20230020070A1/en active Pending
- 2022-06-27 JP JP2023579630A patent/JP2024526217A/ja active Pending
- 2022-06-27 WO PCT/US2022/035068 patent/WO2023278293A1/en not_active Ceased
- 2022-06-27 CN CN202280051025.7A patent/CN117999482A/zh active Pending
- 2022-06-28 TW TW111124084A patent/TW202317992A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4363857A1 (en) | 2024-05-08 |
| IL309517A (en) | 2024-02-01 |
| US20230020070A1 (en) | 2023-01-19 |
| AU2022304570A1 (en) | 2024-01-18 |
| WO2023278293A1 (en) | 2023-01-05 |
| TW202317992A (zh) | 2023-05-01 |
| CN117999482A (zh) | 2024-05-07 |
| KR20240051109A (ko) | 2024-04-19 |
| CA3225576A1 (en) | 2023-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250627 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250627 |