JP2024518425A5 - - Google Patents
Info
- Publication number
- JP2024518425A5 JP2024518425A5 JP2023568474A JP2023568474A JP2024518425A5 JP 2024518425 A5 JP2024518425 A5 JP 2024518425A5 JP 2023568474 A JP2023568474 A JP 2023568474A JP 2023568474 A JP2023568474 A JP 2023568474A JP 2024518425 A5 JP2024518425 A5 JP 2024518425A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- het
- group
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021092257 | 2021-05-08 | ||
| CNPCT/CN2021/092257 | 2021-05-08 | ||
| PCT/CN2022/091066 WO2022237627A1 (en) | 2021-05-08 | 2022-05-06 | Substituted spiro derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024518425A JP2024518425A (ja) | 2024-05-01 |
| JP2024518425A5 true JP2024518425A5 (https=) | 2025-05-14 |
Family
ID=76159226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023568474A Pending JP2024518425A (ja) | 2021-05-08 | 2022-05-06 | 置換スピロ誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240417405A1 (https=) |
| EP (1) | EP4334320A1 (https=) |
| JP (1) | JP2024518425A (https=) |
| KR (1) | KR20240005747A (https=) |
| CN (1) | CN117730081A (https=) |
| AU (1) | AU2022275192A1 (https=) |
| BR (1) | BR112023021040A2 (https=) |
| CA (1) | CA3214746A1 (https=) |
| MX (1) | MX2023013176A (https=) |
| WO (1) | WO2022237627A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202525813A (zh) | 2019-12-19 | 2025-07-01 | 比利時商健生藥品公司 | 經取代之直鏈螺環接衍生物 |
| CA3215379A1 (en) * | 2021-05-08 | 2022-11-17 | Olivier Alexis Georges Querolle | Substituted spiro derivatives |
| CN120529900A (zh) | 2022-11-24 | 2025-08-22 | 奥莱松基因组股份有限公司 | 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102984941B (zh) | 2009-09-04 | 2016-08-17 | 密执安大学评议会 | 用于治疗白血病的组合物和方法 |
| WO2014164543A1 (en) | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof |
| USRE49687E1 (en) | 2014-09-09 | 2023-10-10 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| AU2016378579A1 (en) | 2015-12-22 | 2018-06-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-MLL interaction |
| PH12018501955B1 (en) | 2016-03-16 | 2024-01-24 | Kura Oncology Inc | Bridged bicyclic inhibitors of menin-mll and methods of use |
| PL3429591T3 (pl) | 2016-03-16 | 2023-07-17 | Kura Oncology, Inc. | Podstawione pochodne tieno[2,3-d]pirymidyny jako inhibitory meniny-mll i metody ich zastosowania |
| EA036637B1 (ru) | 2016-03-31 | 2020-12-02 | Такеда Фармасьютикал Компани Лимитед | Гетероциклические спиросоединения, ингибирующие моноацилглицерин-липазу |
| JP6991585B2 (ja) | 2016-05-02 | 2022-01-12 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | メニン阻害剤としてのピペリジン |
| WO2017207387A1 (en) * | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction |
| WO2017214367A1 (en) * | 2016-06-10 | 2017-12-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
| WO2018024602A1 (en) | 2016-08-04 | 2018-02-08 | Bayer Aktiengesellschaft | 2,7-diazaspiro[4.4]nonanes |
| CA3033239A1 (en) | 2016-09-14 | 2018-03-22 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-mll interaction |
| CA3033020A1 (en) | 2016-09-14 | 2018-03-22 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-mll interaction |
| AU2017326006B2 (en) | 2016-09-16 | 2021-10-28 | Vitae Pharmaceuticals, LLC. | Inhibitors of the menin-MLL interaction |
| WO2018109088A1 (en) | 2016-12-15 | 2018-06-21 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-mll interaction |
| WO2018175746A1 (en) | 2017-03-24 | 2018-09-27 | Kura Oncology, Inc. | Methods for treating hematological malignancies and ewing's sarcoma |
| WO2018226976A1 (en) | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
| EP3684361A4 (en) | 2017-09-20 | 2021-09-08 | Kura Oncology, Inc. | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHOD OF USING |
| JP7307729B2 (ja) * | 2017-12-20 | 2023-07-12 | ヤンセン ファーマシューティカ エヌ．ベー． | メニン－ｍｌｌ相互作用のエキソ－アザスピロ阻害剤 |
| KR102779601B1 (ko) | 2018-08-27 | 2025-03-12 | 스미토모 파마 가부시키가이샤 | 광학 활성인 아자비시클로환 유도체 |
| JP2022503792A (ja) | 2018-09-26 | 2022-01-12 | クラ オンコロジー，インク． | メニン阻害剤を用いた血液悪性腫瘍の処置 |
| TW202525813A (zh) | 2019-12-19 | 2025-07-01 | 比利時商健生藥品公司 | 經取代之直鏈螺環接衍生物 |
| CN111297863B (zh) | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| CA3215379A1 (en) * | 2021-05-08 | 2022-11-17 | Olivier Alexis Georges Querolle | Substituted spiro derivatives |
-
2022
- 2022-05-06 US US18/559,689 patent/US20240417405A1/en active Pending
- 2022-05-06 MX MX2023013176A patent/MX2023013176A/es unknown
- 2022-05-06 EP EP22725156.8A patent/EP4334320A1/en active Pending
- 2022-05-06 BR BR112023021040A patent/BR112023021040A2/pt not_active Application Discontinuation
- 2022-05-06 WO PCT/CN2022/091066 patent/WO2022237627A1/en not_active Ceased
- 2022-05-06 JP JP2023568474A patent/JP2024518425A/ja active Pending
- 2022-05-06 CA CA3214746A patent/CA3214746A1/en active Pending
- 2022-05-06 AU AU2022275192A patent/AU2022275192A1/en not_active Abandoned
- 2022-05-06 KR KR1020237038540A patent/KR20240005747A/ko active Pending
- 2022-05-06 CN CN202280033505.0A patent/CN117730081A/zh active Pending
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