JP2024509695A - 多重特異性結合タンパク質分解プラットフォームおよび使用方法 - Google Patents

多重特異性結合タンパク質分解プラットフォームおよび使用方法 Download PDF

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JP2024509695A
JP2024509695A JP2023547039A JP2023547039A JP2024509695A JP 2024509695 A JP2024509695 A JP 2024509695A JP 2023547039 A JP2023547039 A JP 2023547039A JP 2023547039 A JP2023547039 A JP 2023547039A JP 2024509695 A JP2024509695 A JP 2024509695A
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rnf43
znrf3
binding protein
multispecific binding
antibody
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JP2024509695A5 (https=
Inventor
ニコラス ジョン アガード，
スーザ エ メロ， フェリペ デ
チン リー，
ハディル モハメッド ゲハド モハメッド フアード エルサイード マレイ，
ウェン－ティン ケー． ツァイ，
ソヴァージュ， フレデリク ジョセフ ドゥ
チェヤン ホー，
イー セイル キー，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2023547039A 2021-02-03 2022-02-02 多重特異性結合タンパク質分解プラットフォームおよび使用方法 Pending JP2024509695A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163145336P 2021-02-03 2021-02-03
US63/145,336 2021-02-03
US202163217470P 2021-07-01 2021-07-01
US63/217,470 2021-07-01
US202163274288P 2021-11-01 2021-11-01
US63/274,288 2021-11-01
PCT/US2022/014938 WO2022169872A1 (en) 2021-02-03 2022-02-02 Multispecific binding protein degrader platform and methods of use

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JP2024509695A true JP2024509695A (ja) 2024-03-05
JP2024509695A5 JP2024509695A5 (https=) 2025-02-06

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US (1) US20240101708A1 (https=)
EP (1) EP4288458A1 (https=)
JP (1) JP2024509695A (https=)
WO (1) WO2022169872A1 (https=)

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WO2022169872A1 (en) 2022-08-11
US20240101708A1 (en) 2024-03-28

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