|
US4166452A
(en)
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6019790A
(ja)
|
1983-07-14 |
1985-01-31 |
Yakult Honsha Co Ltd |
新規なカンプトテシン誘導体
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
DE3689123T2
(de)
|
1985-11-01 |
1994-03-03 |
Xoma Corp |
Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5049668A
(en)
|
1989-09-15 |
1991-09-17 |
Research Triangle Institute |
10,11-methylenedioxy-20(RS)-camptothecin analogs
|
|
US5004758A
(en)
|
1987-12-01 |
1991-04-02 |
Smithkline Beecham Corporation |
Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
|
|
JPH0615547B2
(ja)
|
1988-01-20 |
1994-03-02 |
株式会社ヤクルト本社 |
新規なカンプトテシン誘導体
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
WO1991004260A2
(en)
|
1989-09-15 |
1991-04-04 |
Research Triangle Institute |
10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP0438803B1
(en)
|
1990-01-26 |
1997-03-12 |
Immunomedics, Inc. |
Vaccines against cancer and infectious diseases
|
|
JP2684104B2
(ja)
|
1990-02-09 |
1997-12-03 |
株式会社ヤクルト本社 |
新規なカンプトテシン誘導体
|
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
FI931384A7
(fi)
|
1990-09-28 |
1993-03-26 |
Smithkline Beecham Corp |
Vesiliukoisia kamptotekiinianalogeja, prosesseja ja menetelmiä
|
|
US5162532A
(en)
|
1990-12-20 |
1992-11-10 |
North Carolina State University |
Intermediates and method of making camptothecin and camptothecin analogs
|
|
US5658920A
(en)
|
1991-01-16 |
1997-08-19 |
Daiichi Pharmaceutical Co., Ltd. |
Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
EP0661977A1
(en)
|
1991-12-10 |
1995-07-12 |
Smithkline Beecham Corporation |
Treatment of colorectal cancer
|
|
CA2131151A1
(en)
|
1992-03-24 |
1994-09-30 |
Kevin S. Johnson |
Methods for producing members of specific binding pairs
|
|
EP0563475B1
(en)
|
1992-03-25 |
2000-05-31 |
Immunogen Inc |
Cell binding agent conjugates of derivatives of CC-1065
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
WO1995015388A1
(en)
|
1993-12-03 |
1995-06-08 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
CA2192725C
(en)
|
1995-12-28 |
2004-04-20 |
Kenji Tsujihara |
Camptothecin derivatives
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
CA2388063C
(en)
|
1999-11-24 |
2010-06-08 |
Immunogen, Inc. |
Cytotoxic agents comprising taxanes and their therapeutic use
|
|
CA2953239A1
(en)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kirin Co., Ltd. |
Antibody composition-producing cell
|
|
US6855720B2
(en)
|
2001-03-01 |
2005-02-15 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
US6403604B1
(en)
|
2001-03-01 |
2002-06-11 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US6756397B2
(en)
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
BR0313197A
(pt)
|
2002-08-02 |
2005-08-09 |
Immunogen Inc |
Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico
|
|
DE60336149D1
(de)
|
2002-08-16 |
2011-04-07 |
Immunogen Inc |
Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
CN100406460C
(zh)
|
2003-11-10 |
2008-07-30 |
中国科学院上海药物研究所 |
喜树碱的新衍生物、制备方法和用途
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
CN100354279C
(zh)
|
2004-06-04 |
2007-12-12 |
中国科学院上海药物研究所 |
喜树碱的新型结构衍生物、制备方法和用途
|
|
JP2008521828A
(ja)
|
2004-11-29 |
2008-06-26 |
シアトル ジェネティックス, インコーポレイテッド |
操作された抗体およびイムノコンジュゲート
|
|
WO2007095389A2
(en)
|
2006-02-17 |
2007-08-23 |
Novacea, Inc. |
Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
|
|
NZ610239A
(en)
|
2008-04-30 |
2014-11-28 |
Immunogen Inc |
Cross-linkers and their uses
|
|
SG189817A1
(en)
|
2008-04-30 |
2013-05-31 |
Immunogen Inc |
Potent conjugates and hydrophilic linkers
|
|
JP2013535047A
(ja)
|
2010-05-28 |
2013-09-09 |
クゥアルコム・インコーポレイテッド |
動的に変化する部分を有するターゲットをトラッキングするためのデータセットの作成
|
|
ES2371171B1
(es)
|
2010-06-08 |
2012-11-16 |
Consejo Superior De Investigaciones Científicas (Csic) |
Derivados de camptotecina como agentes antitumorales.
|
|
ES2373172B1
(es)
|
2010-07-16 |
2012-12-10 |
Consejo Superior De Investigaciones Científicas (Csic) |
Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales.
|
|
CN102477042A
(zh)
|
2010-11-26 |
2012-05-30 |
复旦大学 |
10-羟基喜树碱衍生物及其制备方法和用途
|
|
US9511150B2
(en)
*
|
2011-07-19 |
2016-12-06 |
CellMosaic, Inc. |
Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof
|
|
ES2773710T3
(es)
|
2012-10-11 |
2020-07-14 |
Daiichi Sankyo Co Ltd |
Enlazadores para conjugados de anticuerpo - fármaco
|
|
CN103289461B
(zh)
|
2013-07-01 |
2016-05-04 |
厦门大学 |
喜树碱及其衍生物作为防污剂的应用
|
|
EP3130608B1
(en)
*
|
2014-04-10 |
2019-09-04 |
Daiichi Sankyo Co., Ltd. |
(anti-her2 antibody)-drug conjugate
|
|
KR102445502B1
(ko)
|
2014-04-10 |
2022-09-21 |
다이이찌 산쿄 가부시키가이샤 |
항her3 항체-약물 콘주게이트
|
|
EP3254267A4
(en)
|
2015-02-06 |
2018-10-24 |
University of Technology, Sydney |
Devices, frameworks and methodologies configured to enable automated monitoring and analysis of dwell time
|
|
KR20190066026A
(ko)
*
|
2016-10-07 |
2019-06-12 |
다이이찌 산쿄 가부시키가이샤 |
항 her2 항체-약물 콘주게이트 투여에 의한 내성암의 치료
|
|
WO2019034176A1
(zh)
|
2017-08-18 |
2019-02-21 |
四川百利药业有限责任公司 |
一种喜树碱-抗体偶联物
|
|
BR112020020466A2
(pt)
|
2018-04-06 |
2021-01-12 |
Seattle Genetics, Inc. |
Conjugados de peptídeo de camptotecina
|
|
WO2019195655A1
(en)
|
2018-04-06 |
2019-10-10 |
University Of Florida Research Foundation, Incorporated |
Engineered streptomyces albus strains
|
|
TWI851577B
(zh)
|
2018-06-07 |
2024-08-11 |
美商思進公司 |
喜樹鹼結合物
|
|
CN109467563B
(zh)
|
2018-06-08 |
2021-08-03 |
浙江大学 |
一种喜树碱衍生物及其在制备抗炎症药物中的应用
|
|
SG11202110922QA
(en)
*
|
2019-04-26 |
2021-10-28 |
Immunogen Inc |
Camptothecin derivatives
|
|
WO2021173773A1
(en)
|
2020-02-25 |
2021-09-02 |
Mediboston, Inc. |
Camptothecin derivatives and conjugates thereof
|
|
BR112022025583A2
(pt)
*
|
2020-06-19 |
2023-01-03 |
Hangzhou Dac Biotech Co Ltd |
Conjugado de molécula de ligação à superfície celular e análogo de camptotecina, composto conjugável, célula de tumor, composição farmacêutica, agente quimioterapêutico, e, agentes sinergísticos
|