|
US4166452A
(en)
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6019790A
(ja)
|
1983-07-14 |
1985-01-31 |
Yakult Honsha Co Ltd |
新規なカンプトテシン誘導体
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
JPS63501765A
(ja)
|
1985-11-01 |
1988-07-21 |
インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド |
抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5049668A
(en)
|
1989-09-15 |
1991-09-17 |
Research Triangle Institute |
10,11-methylenedioxy-20(RS)-camptothecin analogs
|
|
US5004758A
(en)
|
1987-12-01 |
1991-04-02 |
Smithkline Beecham Corporation |
Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
|
|
JPH0615547B2
(ja)
|
1988-01-20 |
1994-03-02 |
株式会社ヤクルト本社 |
新規なカンプトテシン誘導体
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
WO1991004260A2
(en)
|
1989-09-15 |
1991-04-04 |
Research Triangle Institute |
10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
SG46445A1
(en)
|
1990-01-26 |
1998-02-20 |
Immunomedics Inc |
Vaccines against cancer and infectious diseases
|
|
JP2684104B2
(ja)
|
1990-02-09 |
1997-12-03 |
株式会社ヤクルト本社 |
新規なカンプトテシン誘導体
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
EP0585287B1
(en)
|
1990-07-10 |
1999-10-13 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
SK283693B6
(sk)
|
1990-09-28 |
2003-12-02 |
Smithkline Beecham Corporation |
Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli
|
|
US5162532A
(en)
|
1990-12-20 |
1992-11-10 |
North Carolina State University |
Intermediates and method of making camptothecin and camptothecin analogs
|
|
US5658920A
(en)
|
1991-01-16 |
1997-08-19 |
Daiichi Pharmaceutical Co., Ltd. |
Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
AU665025B2
(en)
|
1991-09-23 |
1995-12-14 |
Cambridge Antibody Technology Limited |
Production of chimeric antibodies - a combinatorial approach
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
AU2394392A
(en)
|
1991-12-10 |
1993-07-19 |
Smithkline Beecham Corporation |
Treatment of colorectal cancer
|
|
DE69333823T2
(de)
|
1992-03-24 |
2006-05-04 |
Cambridge Antibody Technology Ltd., Melbourn |
Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
|
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
EP0731842A1
(en)
|
1993-12-03 |
1996-09-18 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
CA2192725C
(en)
|
1995-12-28 |
2004-04-20 |
Kenji Tsujihara |
Camptothecin derivatives
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
ES2276708T3
(es)
|
1999-11-24 |
2007-07-01 |
Immunogen, Inc. |
Agentes citotoxicos que comprenden taxanos y su uso terapeutico.
|
|
ES2639222T5
(es)
|
2000-10-06 |
2023-11-24 |
Kyowa Kirin Co Ltd |
Células que producen unas composiciones de anticuerpo
|
|
US6855720B2
(en)
|
2001-03-01 |
2005-02-15 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
US6403604B1
(en)
|
2001-03-01 |
2002-06-11 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US6756397B2
(en)
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
CN100522955C
(zh)
|
2002-08-02 |
2009-08-05 |
伊缪诺金公司 |
含有新型强效紫杉烷的细胞毒性剂及其治疗用途
|
|
JP2006500364A
(ja)
|
2002-08-16 |
2006-01-05 |
イムノージェン インコーポレーテッド |
高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
CN100406460C
(zh)
|
2003-11-10 |
2008-07-30 |
中国科学院上海药物研究所 |
喜树碱的新衍生物、制备方法和用途
|
|
KR20120064120A
(ko)
|
2004-06-01 |
2012-06-18 |
제넨테크, 인크. |
항체 약물 접합체 및 방법
|
|
CN100354279C
(zh)
|
2004-06-04 |
2007-12-12 |
中国科学院上海药物研究所 |
喜树碱的新型结构衍生物、制备方法和用途
|
|
EP1817341A2
(en)
|
2004-11-29 |
2007-08-15 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
WO2007095389A2
(en)
|
2006-02-17 |
2007-08-23 |
Novacea, Inc. |
Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
|
|
KR20200058590A
(ko)
|
2008-04-30 |
2020-05-27 |
이뮤노젠 아이엔씨 |
가교제 및 그 용도
|
|
EP2276506A4
(en)
|
2008-04-30 |
2014-05-07 |
Immunogen Inc |
EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
|
|
WO2011150386A1
(en)
|
2010-05-28 |
2011-12-01 |
Qualcomm Incorporated |
Dataset creation for tracking targets with dynamically changing portions
|
|
ES2371171B1
(es)
|
2010-06-08 |
2012-11-16 |
Consejo Superior De Investigaciones Científicas (Csic) |
Derivados de camptotecina como agentes antitumorales.
|
|
ES2373172B1
(es)
|
2010-07-16 |
2012-12-10 |
Consejo Superior De Investigaciones Científicas (Csic) |
Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales.
|
|
CN102477042A
(zh)
|
2010-11-26 |
2012-05-30 |
复旦大学 |
10-羟基喜树碱衍生物及其制备方法和用途
|
|
US9511150B2
(en)
*
|
2011-07-19 |
2016-12-06 |
CellMosaic, Inc. |
Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof
|
|
DK2907824T3
(en)
|
2012-10-11 |
2018-07-23 |
Daiichi Sankyo Co Ltd |
ANTIBODY-drug conjugate
|
|
CN103289461B
(zh)
|
2013-07-01 |
2016-05-04 |
厦门大学 |
喜树碱及其衍生物作为防污剂的应用
|
|
KR102399277B1
(ko)
|
2014-04-10 |
2022-05-18 |
다이이찌 산쿄 가부시키가이샤 |
항her3 항체-약물 콘주게이트
|
|
JP6612738B2
(ja)
*
|
2014-04-10 |
2019-11-27 |
第一三共株式会社 |
抗her2抗体−薬物コンジュゲート
|
|
AU2016214964A1
(en)
|
2015-02-06 |
2017-09-07 |
University Of Technology Sydney |
Devices, frameworks and methodologies configured to enable automated monitoring and analysis of dwell time
|
|
SG10201912173RA
(en)
*
|
2016-10-07 |
2020-02-27 |
Daiichi Sankyo Co Ltd |
Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate
|
|
CN109106951A
(zh)
|
2017-08-18 |
2019-01-01 |
四川百利药业有限责任公司 |
一种喜树碱-抗体偶联物
|
|
US20210163964A1
(en)
|
2018-04-06 |
2021-06-03 |
University Of Florida Research Foundation, Incorporated |
Engineered streptomyces albus strains
|
|
CA3094313A1
(en)
|
2018-04-06 |
2019-10-10 |
Seattle Genetics, Inc. |
Camptothecin peptide conjugates
|
|
TWI851577B
(zh)
|
2018-06-07 |
2024-08-11 |
美商思進公司 |
喜樹鹼結合物
|
|
CN109467563B
(zh)
|
2018-06-08 |
2021-08-03 |
浙江大学 |
一种喜树碱衍生物及其在制备抗炎症药物中的应用
|
|
JP7561141B2
(ja)
*
|
2019-04-26 |
2024-10-03 |
イミュノジェン・インコーポレーテッド |
カンプトテシン誘導体
|
|
MX2022010457A
(es)
|
2020-02-25 |
2022-11-16 |
Mediboston Ltd |
Derivados de camptotecina y conjugados de esta.
|
|
IL299001A
(en)
*
|
2020-06-19 |
2023-02-01 |
Hangzhou Dac Biotech Co Ltd |
Pairings of a cell-binding molecule with camptocin analogs
|