JP2024505027A5 - - Google Patents

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Publication number
JP2024505027A5
JP2024505027A5 JP2023545204A JP2023545204A JP2024505027A5 JP 2024505027 A5 JP2024505027 A5 JP 2024505027A5 JP 2023545204 A JP2023545204 A JP 2023545204A JP 2023545204 A JP2023545204 A JP 2023545204A JP 2024505027 A5 JP2024505027 A5 JP 2024505027A5
Authority
JP
Japan
Prior art keywords
seq
sequence
sequence described
enhancer
expression construct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023545204A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024505027A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/014956 external-priority patent/WO2022169884A2/en
Publication of JP2024505027A publication Critical patent/JP2024505027A/ja
Publication of JP2024505027A5 publication Critical patent/JP2024505027A5/ja
Pending legal-status Critical Current

Links

JP2023545204A 2021-02-02 2022-02-02 Gaba作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物 Pending JP2024505027A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163144743P 2021-02-02 2021-02-02
US63/144,743 2021-02-02
PCT/US2022/014956 WO2022169884A2 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

Publications (2)

Publication Number Publication Date
JP2024505027A JP2024505027A (ja) 2024-02-02
JP2024505027A5 true JP2024505027A5 (enExample) 2025-02-10

Family

ID=82742483

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023545204A Pending JP2024505027A (ja) 2021-02-02 2022-02-02 Gaba作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物

Country Status (6)

Country Link
US (1) US20240117377A1 (enExample)
EP (1) EP4288064A4 (enExample)
JP (1) JP2024505027A (enExample)
AU (1) AU2022217778A1 (enExample)
CA (1) CA3207224A1 (enExample)
WO (1) WO2022169884A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025019685A2 (en) * 2023-07-18 2025-01-23 Allen Institute Antisense oligonucleotides and artificial expression constructs for expressing rna in inhibitory neurons
EP4780964A1 (en) * 2023-09-18 2026-07-29 Allen Institute Artificial expression constructs for modulating gene expression in neurons and astrocytes for the assessment and/or treatment of slc6a1-related disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118814A2 (en) * 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
EP1859060A2 (en) * 2005-02-28 2007-11-28 Integragen Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof
EP3702460A1 (en) * 2010-11-12 2020-09-02 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
CR20160519A (es) * 2014-05-13 2017-01-27 The Trustees Of The Univ Of Pennysylvania Composiciones que comprenden avv que expresa constructos de anticuerpos duales y sus usos
KR102616820B1 (ko) * 2017-03-17 2023-12-21 애드베룸 바이오테크놀로지스, 인코포레이티드 향상된 유전자 발현을 위한 조성물 및 방법
EP3781174A4 (en) * 2018-04-09 2022-01-26 Allen Institute RESCUE OF VOLTAGE CONTROLLED SODIUM CHANNEL FUNCTION IN INHIBITORY NEURONS
US12467064B2 (en) * 2018-10-08 2025-11-11 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
WO2021092518A1 (en) * 2019-11-08 2021-05-14 The Board Of Regents Of The University Of Texas Transgene cassettes, aav vectors and aav viral vectors for the expression of human codon-optimized slc6a1
US12655444B2 (en) * 2020-03-27 2026-06-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells

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