JP2023529833A5 - - Google Patents

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Publication number
JP2023529833A5
JP2023529833A5 JP2022574447A JP2022574447A JP2023529833A5 JP 2023529833 A5 JP2023529833 A5 JP 2023529833A5 JP 2022574447 A JP2022574447 A JP 2022574447A JP 2022574447 A JP2022574447 A JP 2022574447A JP 2023529833 A5 JP2023529833 A5 JP 2023529833A5
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JP
Japan
Prior art keywords
sequence
sequence number
expression construct
artificial expression
composition according
Prior art date
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Application number
JP2022574447A
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English (en)
Japanese (ja)
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JP7767324B2 (ja
JP2023529833A (ja
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Priority claimed from PCT/US2021/036028 external-priority patent/WO2021248085A2/en
Publication of JP2023529833A publication Critical patent/JP2023529833A/ja
Publication of JP2023529833A5 publication Critical patent/JP2023529833A5/ja
Priority to JP2025181548A priority Critical patent/JP2026021417A/ja
Application granted granted Critical
Publication of JP7767324B2 publication Critical patent/JP7767324B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2022574447A 2020-06-04 2021-06-04 抑制性新皮質ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物 Active JP7767324B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025181548A JP2026021417A (ja) 2020-06-04 2025-10-28 抑制性新皮質ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063034794P 2020-06-04 2020-06-04
US63/034,794 2020-06-04
PCT/US2021/036028 WO2021248085A2 (en) 2020-06-04 2021-06-04 Artificial expression constructs for selectively modulating gene expression in inhibitory neocortical neurons

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025181548A Division JP2026021417A (ja) 2020-06-04 2025-10-28 抑制性新皮質ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物

Publications (3)

Publication Number Publication Date
JP2023529833A JP2023529833A (ja) 2023-07-12
JP2023529833A5 true JP2023529833A5 (enExample) 2024-04-23
JP7767324B2 JP7767324B2 (ja) 2025-11-11

Family

ID=78831739

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022574447A Active JP7767324B2 (ja) 2020-06-04 2021-06-04 抑制性新皮質ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物
JP2025181548A Pending JP2026021417A (ja) 2020-06-04 2025-10-28 抑制性新皮質ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025181548A Pending JP2026021417A (ja) 2020-06-04 2025-10-28 抑制性新皮質ニューロンにおいて遺伝子発現を選択的に調節する人工発現構築物

Country Status (6)

Country Link
US (1) US12692515B2 (enExample)
EP (1) EP4162041A4 (enExample)
JP (2) JP7767324B2 (enExample)
AU (1) AU2021284465A1 (enExample)
CA (1) CA3180017A1 (enExample)
WO (1) WO2021248085A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4507785A4 (en) * 2022-04-11 2026-06-03 Broad Inst Inc Activators for directed gene expression in neural cell populations, compositions and associated processes
US20260226502A1 (en) * 2023-02-02 2026-08-06 Allen Institute Artificial expression constructs for modulating gene expression in cells within the spinal cord

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US6001654A (en) 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
AU3642601A (en) 1999-11-05 2001-05-30 Avigen, Inc. Ecdysone-inducible adeno-associated virus expression vectors
US6395546B1 (en) 2000-02-01 2002-05-28 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
EP1430114B1 (en) 2001-09-14 2012-01-18 Stem Cell Therapeutics Inc. Prolactin induced increase in neural stem cell numbers and therapeutical use thereof
US20120308530A1 (en) 2011-06-03 2012-12-06 Beijing Allgens Medical Science & Technology Co., Ltd. Materials Composition and Methods to Control Neural Progenitor and Stem Cell Attachment, Proliferation and Guide Cell Differentiation
WO2014165753A1 (en) * 2013-04-05 2014-10-09 The Wistar Institute Of Anatomy And Biology Methods and compositions for diagnosis of glioblastoma or a subtype thereof
US20150376612A1 (en) * 2014-06-10 2015-12-31 The General Hospital Corporation CCCTC-Binding Factor (CTCF) RNA Interactome
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
KR20260004568A (ko) 2016-04-19 2026-01-08 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
AU2017302551B2 (en) 2016-07-26 2023-04-27 The General Hospital Corporation Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
EP3781174A4 (en) 2018-04-09 2022-01-26 Allen Institute RESCUE OF VOLTAGE CONTROLLED SODIUM CHANNEL FUNCTION IN INHIBITORY NEURONS
US12467064B2 (en) * 2018-10-08 2025-11-11 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
JP7590962B2 (ja) * 2018-11-05 2024-11-27 アレン インスティテュート 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物

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