CA3207224A1 - Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes - Google Patents

Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes Download PDF

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Publication number
CA3207224A1
CA3207224A1 CA3207224A CA3207224A CA3207224A1 CA 3207224 A1 CA3207224 A1 CA 3207224A1 CA 3207224 A CA3207224 A CA 3207224A CA 3207224 A CA3207224 A CA 3207224A CA 3207224 A1 CA3207224 A1 CA 3207224A1
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ehgt
core
seq
expression construct
enhancer
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English (en)
French (fr)
Inventor
Bryan GORE
Edward Sebastian LEIN
Boaz P. LEVI
Deja MACHEN
Refugio MARTINEZ
John K. Mich
Jonathan Ting
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Allen Institute
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Allen Institute
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CA3207224A 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes Pending CA3207224A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163144743P 2021-02-02 2021-02-02
US63/144,743 2021-02-02
PCT/US2022/014956 WO2022169884A2 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

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CA3207224A1 true CA3207224A1 (en) 2022-08-11

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CA3207224A Pending CA3207224A1 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

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US (1) US20240117377A1 (enExample)
EP (1) EP4288064A4 (enExample)
JP (1) JP2024505027A (enExample)
AU (1) AU2022217778A1 (enExample)
CA (1) CA3207224A1 (enExample)
WO (1) WO2022169884A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025019685A2 (en) * 2023-07-18 2025-01-23 Allen Institute Antisense oligonucleotides and artificial expression constructs for expressing rna in inhibitory neurons
EP4780964A1 (en) * 2023-09-18 2026-07-29 Allen Institute Artificial expression constructs for modulating gene expression in neurons and astrocytes for the assessment and/or treatment of slc6a1-related disorders

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* Cited by examiner, † Cited by third party
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WO2005118814A2 (en) * 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
EP1859060A2 (en) * 2005-02-28 2007-11-28 Integragen Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof
EP3702460A1 (en) * 2010-11-12 2020-09-02 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
CR20160519A (es) * 2014-05-13 2017-01-27 The Trustees Of The Univ Of Pennysylvania Composiciones que comprenden avv que expresa constructos de anticuerpos duales y sus usos
KR102616820B1 (ko) * 2017-03-17 2023-12-21 애드베룸 바이오테크놀로지스, 인코포레이티드 향상된 유전자 발현을 위한 조성물 및 방법
EP3781174A4 (en) * 2018-04-09 2022-01-26 Allen Institute RESCUE OF VOLTAGE CONTROLLED SODIUM CHANNEL FUNCTION IN INHIBITORY NEURONS
US12467064B2 (en) * 2018-10-08 2025-11-11 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
WO2021092518A1 (en) * 2019-11-08 2021-05-14 The Board Of Regents Of The University Of Texas Transgene cassettes, aav vectors and aav viral vectors for the expression of human codon-optimized slc6a1
US12655444B2 (en) * 2020-03-27 2026-06-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells

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WO2022169884A2 (en) 2022-08-11
AU2022217778A9 (en) 2023-09-28
US20240117377A1 (en) 2024-04-11
AU2022217778A1 (en) 2023-08-31
WO2022169884A3 (en) 2022-09-15
EP4288064A2 (en) 2023-12-13
JP2024505027A (ja) 2024-02-02
EP4288064A4 (en) 2025-01-15

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