JP2024505027A - Ｇａｂａ作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物 - Google Patents

Ｇａｂａ作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物 Download PDF

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JP2024505027A
JP2024505027A JP2023545204A JP2023545204A JP2024505027A JP 2024505027 A JP2024505027 A JP 2024505027A JP 2023545204 A JP2023545204 A JP 2023545204A JP 2023545204 A JP2023545204 A JP 2023545204A JP 2024505027 A JP2024505027 A JP 2024505027A
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seq
ehgt
expression construct
enhancer
artificial expression
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JP2024505027A5 (enExample
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ゴア，ブライアン
セバスティアン レイン，エドワード
ピー． レヴィ，ボアズ
メイチェン，デジャ
マーティネス，レフュジオ
ケー． ミック，ジョン
ティン，ジョナサン
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アレン インスティテュート
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JP2023545204A 2021-02-02 2022-02-02 Ｇａｂａ作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物 Pending JP2024505027A (ja)

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US202163144743P 2021-02-02 2021-02-02
US63/144,743 2021-02-02
PCT/US2022/014956 WO2022169884A2 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

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JP2024505027A5 JP2024505027A5 (enExample) 2025-02-10

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US (1) US20240117377A1 (enExample)
EP (1) EP4288064A4 (enExample)
JP (1) JP2024505027A (enExample)
AU (1) AU2022217778A1 (enExample)
CA (1) CA3207224A1 (enExample)
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WO2025019685A2 (en) * 2023-07-18 2025-01-23 Allen Institute Antisense oligonucleotides and artificial expression constructs for expressing rna in inhibitory neurons
EP4780964A1 (en) * 2023-09-18 2026-07-29 Allen Institute Artificial expression constructs for modulating gene expression in neurons and astrocytes for the assessment and/or treatment of slc6a1-related disorders

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
WO2019199867A1 (en) * 2018-04-09 2019-10-17 Allen Institute Rescuing voltage-gated sodium channel function in inhibitory neurons
WO2020076614A1 (en) * 2018-10-08 2020-04-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
WO2021195591A2 (en) * 2020-03-27 2021-09-30 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells

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WO2005118814A2 (en) * 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
EP1859060A2 (en) * 2005-02-28 2007-11-28 Integragen Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof
EP3702460A1 (en) * 2010-11-12 2020-09-02 The General Hospital Corporation Polycomb-associated non-coding rnas
CR20160519A (es) * 2014-05-13 2017-01-27 The Trustees Of The Univ Of Pennysylvania Composiciones que comprenden avv que expresa constructos de anticuerpos duales y sus usos
KR102616820B1 (ko) * 2017-03-17 2023-12-21 애드베룸 바이오테크놀로지스, 인코포레이티드 향상된 유전자 발현을 위한 조성물 및 방법
WO2021092518A1 (en) * 2019-11-08 2021-05-14 The Board Of Regents Of The University Of Texas Transgene cassettes, aav vectors and aav viral vectors for the expression of human codon-optimized slc6a1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
WO2019199867A1 (en) * 2018-04-09 2019-10-17 Allen Institute Rescuing voltage-gated sodium channel function in inhibitory neurons
WO2020076614A1 (en) * 2018-10-08 2020-04-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
WO2021195591A2 (en) * 2020-03-27 2021-09-30 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells

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CA3207224A1 (en) 2022-08-11
WO2022169884A2 (en) 2022-08-11
AU2022217778A9 (en) 2023-09-28
US20240117377A1 (en) 2024-04-11
AU2022217778A1 (en) 2023-08-31
WO2022169884A3 (en) 2022-09-15
EP4288064A2 (en) 2023-12-13
EP4288064A4 (en) 2025-01-15

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