JP2024119791A5 - - Google Patents
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- JP2024119791A5 JP2024119791A5 JP2024070972A JP2024070972A JP2024119791A5 JP 2024119791 A5 JP2024119791 A5 JP 2024119791A5 JP 2024070972 A JP2024070972 A JP 2024070972A JP 2024070972 A JP2024070972 A JP 2024070972A JP 2024119791 A5 JP2024119791 A5 JP 2024119791A5
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- Prior art keywords
- amino acid
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- acid sequence
- hvr
- antibody
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- 150000001413 amino acids Chemical group 0.000 claims 149
- 239000000556 agonist Substances 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 5
- 108090000695 Cytokines Proteins 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
- 101000795107 Homo sapiens Triggering receptor expressed on myeloid cells 1 Proteins 0.000 claims 4
- 102100029681 Triggering receptor expressed on myeloid cells 1 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000004936 stimulating effect Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 229960004641 rituximab Drugs 0.000 claims 3
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 2
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 2
- 108090001007 Interleukin-8 Proteins 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229960002450 ofatumumab Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims 1
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims 1
- 108010021472 Fc gamma receptor IIB Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101001010591 Homo sapiens Interleukin-20 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 102100026720 Interferon beta Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000177 Interleukin-11 Proteins 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102100030692 Interleukin-20 Human genes 0.000 claims 1
- 108010065637 Interleukin-23 Proteins 0.000 claims 1
- 108010067003 Interleukin-33 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 1
- 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108090000630 Oncostatin M Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 238000002679 ablation Methods 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940120638 avastin Drugs 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 108091006374 cAMP receptor proteins Proteins 0.000 claims 1
- 238000000315 cryotherapy Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000011393 cytotoxic chemotherapy Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940080856 gleevec Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229940022353 herceptin Drugs 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 229960002411 imatinib Drugs 0.000 claims 1
- 108091008042 inhibitory receptors Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000007674 radiofrequency ablation Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662304018P | 2016-03-04 | 2016-03-04 | |
| US62/304,018 | 2016-03-04 | ||
| PCT/US2017/020745 WO2017152102A2 (en) | 2016-03-04 | 2017-03-03 | Anti-trem1 antibodies and methods of use thereof |
| JP2018546004A JP7023853B2 (ja) | 2016-03-04 | 2017-03-03 | 抗ｔｒｅｍ１抗体及びその使用方法 |
| JP2022018475A JP7480197B2 (ja) | 2016-03-04 | 2022-02-09 | 抗ｔｒｅｍ１抗体及びその使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022018475A Division JP7480197B2 (ja) | 2016-03-04 | 2022-02-09 | 抗ｔｒｅｍ１抗体及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024119791A JP2024119791A (ja) | 2024-09-03 |
| JP2024119791A5 true JP2024119791A5 (https=) | 2025-01-20 |
Family
ID=58348000
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546004A Active JP7023853B2 (ja) | 2016-03-04 | 2017-03-03 | 抗ｔｒｅｍ１抗体及びその使用方法 |
| JP2022018475A Active JP7480197B2 (ja) | 2016-03-04 | 2022-02-09 | 抗ｔｒｅｍ１抗体及びその使用方法 |
| JP2024070972A Withdrawn JP2024119791A (ja) | 2016-03-04 | 2024-04-24 | 抗ｔｒｅｍ１抗体及びその使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546004A Active JP7023853B2 (ja) | 2016-03-04 | 2017-03-03 | 抗ｔｒｅｍ１抗体及びその使用方法 |
| JP2022018475A Active JP7480197B2 (ja) | 2016-03-04 | 2022-02-09 | 抗ｔｒｅｍ１抗体及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US11472877B2 (https=) |
| EP (1) | EP3423493A2 (https=) |
| JP (3) | JP7023853B2 (https=) |
| WO (1) | WO2017152102A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
| MA40861A (fr) * | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| WO2019032624A1 (en) * | 2017-08-08 | 2019-02-14 | Pionyr Immunotherapeutics, Inc. | COMPOSITIONS AND METHODS FOR DEACTIVATING TREM1-EXPRESSING MESHLOID CELLS |
| US11975024B2 (en) | 2017-12-19 | 2024-05-07 | Musc Foundation For Research Development | T regulatory (Treg) cell transplantation in osteogenesis imperfecta (OI) |
| EP3732201A4 (en) | 2017-12-19 | 2022-04-20 | Surrozen Operating, Inc. | WNT SURROGATES AND THEIR USES |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| CN111655729B (zh) * | 2017-12-19 | 2023-10-20 | 瑟罗泽恩奥普瑞汀公司 | 抗卷曲蛋白抗体和使用方法 |
| JP7490565B2 (ja) * | 2017-12-29 | 2024-05-27 | アレクトル エルエルシー | 抗ｔｍｅｍ１０６ｂ抗体及びその使用方法 |
| MX394121B (es) | 2018-03-14 | 2025-03-24 | Surface Oncology Inc | Anticuerpos que se unen a cd39 y sus usos |
| EP3774902A1 (en) | 2018-04-02 | 2021-02-17 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| WO2020060781A1 (en) | 2018-09-17 | 2020-03-26 | Abcuro, Inc. | Anti-klrg1 antibodies |
| US12534532B2 (en) * | 2018-10-26 | 2026-01-27 | Crage Medical Co., Limited | CLL1-targeting antibody and application thereof |
| JP7492522B2 (ja) * | 2019-02-06 | 2024-05-29 | パイオニア イミュノセラピューティクス インコーポレイテッド | 抗ｔｒｅｍ１抗体及び関連方法 |
| US10836828B2 (en) | 2019-02-06 | 2020-11-17 | Pionyr Immunotherapeutics, Inc. | Anti-TREM1 antibodies and related methods |
| CN110170053A (zh) * | 2019-05-30 | 2019-08-27 | 澳门科技大学 | 组合物、其在制备肿瘤免疫治疗药物中的应用及药物组合物 |
| CN114144435B (zh) * | 2019-07-15 | 2024-06-25 | 百时美施贵宝公司 | 针对人trem-1的抗体及其用途 |
| JP7796005B2 (ja) | 2019-07-15 | 2026-01-08 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｔｒｅｍ－１抗体およびその使用 |
| US20220372160A1 (en) | 2019-09-16 | 2022-11-24 | Surface Oncology, Inc. | Anti-CD39 Antibody Compositions and Methods |
| MX2022016548A (es) * | 2020-06-26 | 2023-03-14 | Amgen Inc | Muteínas de il-10 y proteínas de fusión de las mismas. |
| JP2023550596A (ja) * | 2020-11-02 | 2023-12-04 | ユーシービー バイオファルマ エスアールエル | 運動ニューロン神経変性障害の治療のための抗ｔｒｅｍ１中和抗体の使用 |
| EP4334355A1 (en) * | 2021-05-03 | 2024-03-13 | UCB Biopharma SRL | Antibodies |
| KR20240026959A (ko) * | 2021-06-02 | 2024-02-29 | 이노트렘 | 항-ｔｒｅｍ-1 항체 |
| EP4359441A1 (en) * | 2021-06-25 | 2024-05-01 | Amgen Inc. | Treatment of cardiovascular disease with trem-1 antigen binding proteins |
| EP4562056A1 (en) | 2023-04-21 | 2025-06-04 | Celsius Therapeutics, Inc. | Anti-trem1 antibody agents, compositions, and uses thereof |
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| SMT201700488T1 (it) * | 2012-02-15 | 2017-11-15 | Novo Nordisk As | Anticorpi che legano e bloccano il recettore d'innesco espresso sulle cellule mieloidi-1 (trem-1) |
| US9550830B2 (en) * | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| DK2892920T3 (da) | 2012-09-07 | 2020-06-08 | Inst Nat Sante Rech Med | Hæmmende peptider afledt af udløsningsreceptor udtrykt på myeloide celler-1 (trem-1) trem-lignende transskript 1 (tlt-1) og anvendelser deraf |
| LT2953969T (lt) * | 2013-02-08 | 2019-12-10 | Novartis Ag | Anti-il-17a antikūnai ir jų panaudojimas autoimuninių ir uždegiminių ligų gydymui |
| EP3172232B1 (en) | 2014-07-17 | 2023-12-27 | Novo Nordisk A/S | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity. |
| KR102733407B1 (ko) * | 2017-08-03 | 2024-11-21 | 알렉터 엘엘씨 | 항-cd33 항체 및 이의 이용 방법 |
-
2017
- 2017-03-03 WO PCT/US2017/020745 patent/WO2017152102A2/en not_active Ceased
- 2017-03-03 US US16/078,965 patent/US11472877B2/en active Active
- 2017-03-03 JP JP2018546004A patent/JP7023853B2/ja active Active
- 2017-03-03 EP EP17711511.0A patent/EP3423493A2/en active Pending
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2022
- 2022-02-09 JP JP2022018475A patent/JP7480197B2/ja active Active
- 2022-09-13 US US17/931,757 patent/US12110327B2/en active Active
-
2024
- 2024-04-24 JP JP2024070972A patent/JP2024119791A/ja not_active Withdrawn
- 2024-09-04 US US18/824,619 patent/US20250092131A1/en active Pending
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