JP7023853B2 - 抗ｔｒｅｍ１抗体及びその使用方法 - Google Patents

抗ｔｒｅｍ１抗体及びその使用方法 Download PDF

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JP7023853B2
JP7023853B2 JP2018546004A JP2018546004A JP7023853B2 JP 7023853 B2 JP7023853 B2 JP 7023853B2 JP 2018546004 A JP2018546004 A JP 2018546004A JP 2018546004 A JP2018546004 A JP 2018546004A JP 7023853 B2 JP7023853 B2 JP 7023853B2
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trem1
antibody
seq
amino acid
acid sequence
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JP2019514347A5 (https=
JP2019514347A (ja
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アンドリュー ピンセティック，
アーノン ローゼンタール，
ヘレン ラム，
フランチェスカ アヴォガドリ－コナーズ，
スンジュ リー，
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アレクトル エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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JP2018546004A 2016-03-04 2017-03-03 抗ｔｒｅｍ１抗体及びその使用方法 Active JP7023853B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022018475A JP7480197B2 (ja) 2016-03-04 2022-02-09 抗ｔｒｅｍ１抗体及びその使用方法
JP2024070972A JP2024119791A (ja) 2016-03-04 2024-04-24 抗ｔｒｅｍ１抗体及びその使用方法

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US201662304018P 2016-03-04 2016-03-04
US62/304,018 2016-03-04
PCT/US2017/020745 WO2017152102A2 (en) 2016-03-04 2017-03-03 Anti-trem1 antibodies and methods of use thereof

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JP2019514347A JP2019514347A (ja) 2019-06-06
JP2019514347A5 JP2019514347A5 (https=) 2020-04-16
JP7023853B2 true JP7023853B2 (ja) 2022-02-22

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JP2022018475A Active JP7480197B2 (ja) 2016-03-04 2022-02-09 抗ｔｒｅｍ１抗体及びその使用方法
JP2024070972A Withdrawn JP2024119791A (ja) 2016-03-04 2024-04-24 抗ｔｒｅｍ１抗体及びその使用方法

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JP2024070972A Withdrawn JP2024119791A (ja) 2016-03-04 2024-04-24 抗ｔｒｅｍ１抗体及びその使用方法

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US (3) US11472877B2 (https=)
EP (1) EP3423493A2 (https=)
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WO (1) WO2017152102A2 (https=)

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JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
WO2019032624A1 (en) * 2017-08-08 2019-02-14 Pionyr Immunotherapeutics, Inc. COMPOSITIONS AND METHODS FOR DEACTIVATING TREM1-EXPRESSING MESHLOID CELLS
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CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CN117946267A (zh) * 2017-12-19 2024-04-30 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
JP7490565B2 (ja) * 2017-12-29 2024-05-27 アレクトル エルエルシー 抗ｔｍｅｍ１０６ｂ抗体及びその使用方法
KR20230020023A (ko) 2018-03-14 2023-02-09 서피스 온콜로지, 인크. Cd39에 결합하는 항체 및 이의 용도
WO2019195126A1 (en) 2018-04-02 2019-10-10 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
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JP2022505921A (ja) * 2018-10-26 2022-01-14 カファ セラピューティクス リミテッド Ｃｌｌ１を標的とする抗体およびその応用
US10836828B2 (en) 2019-02-06 2020-11-17 Pionyr Immunotherapeutics, Inc. Anti-TREM1 antibodies and related methods
KR20210126638A (ko) * 2019-02-06 2021-10-20 파이오니어 임뮤노테라퓨틱스, 인코퍼레이티드 항-trem1 항체 및 관련 방법
CN110170053A (zh) * 2019-05-30 2019-08-27 澳门科技大学 组合物、其在制备肿瘤免疫治疗药物中的应用及药物组合物
CN114174536B (zh) 2019-07-15 2026-03-27 百时美施贵宝公司 抗trem-1抗体及其用途
WO2021011681A1 (en) 2019-07-15 2021-01-21 Bristol-Myers Squibb Company Antibodies against human trem-1 and uses thereof
KR20220062500A (ko) 2019-09-16 2022-05-17 서피스 온콜로지, 인크. 항-cd39 항체 조성물 및 방법
PE20231082A1 (es) * 2020-06-26 2023-07-17 Amgen Inc Muteinas de il-10 y proteinas de fusion de las mismas referencia cruzada a solicitudes relacionadas
JP2023550596A (ja) * 2020-11-02 2023-12-04 ユーシービー バイオファルマ エスアールエル 運動ニューロン神経変性障害の治療のための抗ｔｒｅｍ１中和抗体の使用
IL308100A (en) 2021-05-03 2023-12-01 UCB Biopharma SRL Antibodies
CA3220167A1 (en) * 2021-06-02 2022-12-08 Marc Derive Anti-trem-1 antibodies
AU2022297535A1 (en) * 2021-06-25 2024-01-04 Amgen Inc. Treatment of cardiovascular disease with trem-1 antigen binding proteins
KR20260017009A (ko) 2023-04-21 2026-02-04 셀시우스 테라퓨틱스, 인코포레이티드 항-trem1 항체 제제, 조성물 및 이의 용도

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