JP2024109660A5 - - Google Patents
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- JP2024109660A5 JP2024109660A5 JP2024076686A JP2024076686A JP2024109660A5 JP 2024109660 A5 JP2024109660 A5 JP 2024109660A5 JP 2024076686 A JP2024076686 A JP 2024076686A JP 2024076686 A JP2024076686 A JP 2024076686A JP 2024109660 A5 JP2024109660 A5 JP 2024109660A5
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- nucleic acid
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025170065A JP2026012727A (ja) | 2019-02-02 | 2025-10-08 | 遺伝子編集における非意図的な変異の阻害 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019074577 | 2019-02-02 | ||
| CNPCT/CN2019/074577 | 2019-02-02 | ||
| PCT/CN2020/074218 WO2020156575A1 (en) | 2019-02-02 | 2020-02-03 | Inhibition of unintended mutations in gene editing |
| JP2021544682A JP7518549B2 (ja) | 2019-02-02 | 2020-02-03 | 遺伝子編集における非意図的な変異の阻害 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544682A Division JP7518549B2 (ja) | 2019-02-02 | 2020-02-03 | 遺伝子編集における非意図的な変異の阻害 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025170065A Division JP2026012727A (ja) | 2019-02-02 | 2025-10-08 | 遺伝子編集における非意図的な変異の阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024109660A JP2024109660A (ja) | 2024-08-14 |
| JP2024109660A5 true JP2024109660A5 (https=) | 2024-09-12 |
| JP7761294B2 JP7761294B2 (ja) | 2025-10-28 |
Family
ID=71841894
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544682A Active JP7518549B2 (ja) | 2019-02-02 | 2020-02-03 | 遺伝子編集における非意図的な変異の阻害 |
| JP2024076686A Active JP7761294B2 (ja) | 2019-02-02 | 2024-05-09 | 遺伝子編集における非意図的な変異の阻害 |
| JP2025170065A Pending JP2026012727A (ja) | 2019-02-02 | 2025-10-08 | 遺伝子編集における非意図的な変異の阻害 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544682A Active JP7518549B2 (ja) | 2019-02-02 | 2020-02-03 | 遺伝子編集における非意図的な変異の阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025170065A Pending JP2026012727A (ja) | 2019-02-02 | 2025-10-08 | 遺伝子編集における非意図的な変異の阻害 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11384353B2 (https=) |
| EP (1) | EP3918083A4 (https=) |
| JP (3) | JP7518549B2 (https=) |
| KR (1) | KR20210126042A (https=) |
| CN (4) | CN116656676A (https=) |
| AU (3) | AU2020214090B2 (https=) |
| BR (1) | BR112021015092A2 (https=) |
| CA (1) | CA3128283A1 (https=) |
| IL (1) | IL285194A (https=) |
| SG (1) | SG11202108303SA (https=) |
| WO (1) | WO2020156575A1 (https=) |
| ZA (2) | ZA202105895B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117120621A (zh) * | 2020-11-12 | 2023-11-24 | 上海科技大学 | 提高效率和准确性的基因组编辑 |
| CN112575014B (zh) * | 2020-12-11 | 2022-04-01 | 安徽省农业科学院水稻研究所 | 一种碱基编辑器SpCas9-LjCDAL1及其构建和应用 |
| CN115161316B (zh) * | 2021-04-02 | 2025-12-23 | 上海科技大学 | 一种引导编辑工具、融合rna及其用途 |
| WO2022206986A1 (en) * | 2021-04-02 | 2022-10-06 | Shanghaitech University | Gene therapy for treating beta-hemoglobinopathies |
| EP4330389A4 (en) * | 2021-04-30 | 2025-04-30 | Alnylam Pharmaceuticals, Inc. | RISC REORIENTATION FOR RNA EDITING |
| US12123006B2 (en) * | 2021-05-18 | 2024-10-22 | Shanghaitech University | Base editing tool and use thereof |
| WO2023283092A1 (en) * | 2021-07-06 | 2023-01-12 | Prime Medicine, Inc. | Compositions and methods for efficient genome editing |
| WO2023088440A1 (en) * | 2021-11-18 | 2023-05-25 | Correctsequence Therapeutics | Regeneration of surface antigen-negative cells |
| EP4477759A4 (en) * | 2022-02-08 | 2025-12-31 | Toolgen Inc | A method for predicting off-target outcomes that can occur in a genome editing process using a primary editing system. |
| CN119013310A (zh) * | 2022-02-17 | 2024-11-22 | 正序(上海)生物科技有限公司 | 具有改善的编辑精确度的突变的胞嘧啶脱氨酶 |
| GB2634837A (en) | 2022-06-07 | 2025-04-23 | Scribe Therapeutics Inc | Compositions and methods for the targeting of PCSK9 |
| WO2024012435A1 (en) | 2022-07-11 | 2024-01-18 | CorrectSequence Therapeutics Co., Ltd | Gene editing systems and methods for treating hereditary angioedema |
| CA3265664A1 (en) | 2022-08-25 | 2024-02-29 | Life Edit Therapeutics, Inc. | CHEMICAL MODIFICATION OF GUIDE RNA WITH A LOCKED NUCLEIC ACID FOR RNA-GUIDED NUCLEASE-MEDIATED GENE EDITING |
| WO2024088401A1 (en) * | 2022-10-28 | 2024-05-02 | CorrectSequence Therapeutics Co., Ltd | Gene editing systems and methods for reducing immunogenicity and graft versus host response |
| KR20250126155A (ko) | 2022-11-04 | 2025-08-22 | 라이프 에디트 테라퓨틱스, 인크. | 내부 삽입 부위를 갖는 진화된 아데닌 데아미나제 및 rna-가이드 뉴클레아제 융합 단백질 및 사용 방법 |
| WO2024109745A1 (en) * | 2022-11-21 | 2024-05-30 | CorrectSequence Therapeutics Co., Ltd | Gene editing systems and methods for treating hbv infection |
| WO2024112957A1 (en) * | 2022-11-23 | 2024-05-30 | Amber Bio Inc. | Gene-modifying endonucleases |
| EP4634383A1 (en) | 2022-12-16 | 2025-10-22 | Life Edit Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| WO2024127370A1 (en) | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target trac gene and methods of use |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| CN116286740A (zh) * | 2023-02-24 | 2023-06-23 | 四川大学华西医院 | 碱基编辑器和引导编辑器及构建与应用 |
| WO2025022367A2 (en) | 2023-07-27 | 2025-01-30 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| WO2025061147A1 (en) * | 2023-09-21 | 2025-03-27 | Shanghaitech University | Rna editing systems of high efficiency and specificity |
| AU2024357861A1 (en) | 2023-10-12 | 2026-04-23 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025083619A1 (en) | 2023-10-18 | 2025-04-24 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and acive fragments and variants thereof and methods of use |
| CN117092084B (zh) * | 2023-10-20 | 2024-01-12 | 浙江迪福润丝生物科技有限公司 | Wnv蛋白酶抑制剂的筛选方法和抑制效果评价方法 |
| WO2025140399A1 (en) * | 2023-12-26 | 2025-07-03 | Correctsequence Therapeutics (Shanghai) Co., Ltd | Gene editing systems and methods for treating cardiovascular disease |
| WO2025174908A1 (en) | 2024-02-12 | 2025-08-21 | Life Edit Therapeutics, Inc. | Novel rna-guided nucleases and proteins for polymerase editing |
| WO2025185623A1 (en) * | 2024-03-04 | 2025-09-12 | Shanghaitech University | Virus-like particles for gene editing |
| WO2026003754A1 (en) | 2024-06-25 | 2026-01-02 | Life Edit Therapeutics, Inc. | Novel reverse transcriptases and uses thereof |
| CN118995709A (zh) * | 2024-08-23 | 2024-11-22 | 东北农业大学 | 一种提高基因编辑效率的重组型pegRNA及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6445314A (en) | 1987-04-16 | 1989-02-17 | Res Corp Technologies Inc | Antitumoral |
| US8288094B2 (en) | 2008-04-09 | 2012-10-16 | Institut Pasteur | APOBEC3 mediated DNA editing |
| AU2010215761B2 (en) * | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
| US20150165054A1 (en) * | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3080259B1 (en) * | 2013-12-12 | 2023-02-01 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| CN105886498A (zh) | 2015-05-13 | 2016-08-24 | 沈志荣 | CRISPR-Cas9特异性敲除人PCSK9基因的方法以及用于特异性靶向PCSK9基因的sgRNA |
| IL310721B2 (en) * | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3530737A4 (en) * | 2016-09-13 | 2020-04-29 | Toolgen Incorporated | METHOD FOR IDENTIFYING DNA BASE EDITING USING CYTOSINE DEAMINASE |
| US11192929B2 (en) * | 2016-12-08 | 2021-12-07 | Regents Of The University Of Minnesota | Site-specific DNA base editing using modified APOBEC enzymes |
| CN108342387B (zh) | 2017-01-24 | 2021-09-24 | 谭旭 | Pcsk9抑制剂类降血脂药的递送系统和生物制剂 |
| KR20240116572A (ko) * | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018208998A1 (en) * | 2017-05-10 | 2018-11-15 | The Regents Of The University Of California | Directed editing of cellular rna via nuclear delivery of crispr/cas9 |
| EP3630849A4 (en) * | 2017-05-25 | 2021-01-13 | The General Hospital Corporation | BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES |
| CN109136272A (zh) | 2017-06-15 | 2019-01-04 | 中山大学 | 用于特异性修复人hbb基因突变的碱基编辑系统、方法、试剂盒及其在人生殖系中的应用 |
| BR112019028146A2 (pt) * | 2017-07-31 | 2020-07-07 | Sigma-Aldrich Co. Llc | rna guia sintético para sistemas ativadores de crispr/cas |
| CN109021111B (zh) * | 2018-02-23 | 2021-12-07 | 上海科技大学 | 一种基因碱基编辑器 |
-
2020
- 2020-02-03 CN CN202211043562.5A patent/CN116656676A/zh active Pending
- 2020-02-03 SG SG11202108303SA patent/SG11202108303SA/en unknown
- 2020-02-03 JP JP2021544682A patent/JP7518549B2/ja active Active
- 2020-02-03 CN CN202211057011.4A patent/CN116355966A/zh active Pending
- 2020-02-03 CA CA3128283A patent/CA3128283A1/en active Pending
- 2020-02-03 US US17/427,040 patent/US11384353B2/en active Active
- 2020-02-03 AU AU2020214090A patent/AU2020214090B2/en active Active
- 2020-02-03 WO PCT/CN2020/074218 patent/WO2020156575A1/en not_active Ceased
- 2020-02-03 KR KR1020217028085A patent/KR20210126042A/ko active Pending
- 2020-02-03 EP EP20748289.4A patent/EP3918083A4/en active Pending
- 2020-02-03 BR BR112021015092A patent/BR112021015092A2/pt unknown
- 2020-02-03 CN CN202080026986.3A patent/CN113661248B/zh active Active
- 2020-02-03 CN CN202211042699.9A patent/CN116286802A/zh active Pending
-
2021
- 2021-07-28 IL IL285194A patent/IL285194A/en unknown
- 2021-08-17 ZA ZA2021/05895A patent/ZA202105895B/en unknown
-
2022
- 2022-07-11 US US17/862,354 patent/US11840685B2/en active Active
- 2022-11-16 ZA ZA2022/12490A patent/ZA202212490B/en unknown
- 2022-12-12 AU AU2022287550A patent/AU2022287550B2/en active Active
-
2023
- 2023-09-29 US US18/478,861 patent/US20240026342A1/en active Pending
-
2024
- 2024-05-09 JP JP2024076686A patent/JP7761294B2/ja active Active
-
2025
- 2025-10-08 JP JP2025170065A patent/JP2026012727A/ja active Pending
- 2025-10-24 AU AU2025256226A patent/AU2025256226A1/en active Pending
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