JP7518549B2 - 遺伝子編集における非意図的な変異の阻害 - Google Patents

遺伝子編集における非意図的な変異の阻害 Download PDF

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JP7518549B2
JP7518549B2 JP2021544682A JP2021544682A JP7518549B2 JP 7518549 B2 JP7518549 B2 JP 7518549B2 JP 2021544682 A JP2021544682 A JP 2021544682A JP 2021544682 A JP2021544682 A JP 2021544682A JP 7518549 B2 JP7518549 B2 JP 7518549B2
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protease
editing
fragment
base
fusion protein
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JP2022526695A (ja
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ジア チェン
ベイ ヤン
リー ヤン
シンシュー ファン
リジェ ワン
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ShanghaiTech University
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
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    • C07K2319/50—Fusion polypeptide containing protease site
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21111—Aqualysin 1 (3.4.21.111)
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    • C12Y304/22—Cysteine endopeptidases (3.4.22)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005—Cytidine deaminase (3.5.4.5)

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JP2021544682A 2019-02-02 2020-02-03 遺伝子編集における非意図的な変異の阻害 Active JP7518549B2 (ja)

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JP2024076686A JP7761294B2 (ja) 2019-02-02 2024-05-09 遺伝子編集における非意図的な変異の阻害
JP2025170065A JP2026012727A (ja) 2019-02-02 2025-10-08 遺伝子編集における非意図的な変異の阻害

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CN2019074577 2019-02-02
CNPCT/CN2019/074577 2019-02-02
PCT/CN2020/074218 WO2020156575A1 (en) 2019-02-02 2020-02-03 Inhibition of unintended mutations in gene editing

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US (3) US11384353B2 (https=)
EP (1) EP3918083A4 (https=)
JP (3) JP7518549B2 (https=)
KR (1) KR20210126042A (https=)
CN (4) CN116656676A (https=)
AU (3) AU2020214090B2 (https=)
BR (1) BR112021015092A2 (https=)
CA (1) CA3128283A1 (https=)
IL (1) IL285194A (https=)
SG (1) SG11202108303SA (https=)
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