JP2024095678A5 - - Google Patents
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- Publication number
- JP2024095678A5 JP2024095678A5 JP2024040308A JP2024040308A JP2024095678A5 JP 2024095678 A5 JP2024095678 A5 JP 2024095678A5 JP 2024040308 A JP2024040308 A JP 2024040308A JP 2024040308 A JP2024040308 A JP 2024040308A JP 2024095678 A5 JP2024095678 A5 JP 2024095678A5
- Authority
- JP
- Japan
- Prior art keywords
- unit dose
- dose
- pirfenidone
- aqueous solution
- daily
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007864 aqueous solution Substances 0.000 claims 12
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 12
- 229960003073 pirfenidone Drugs 0.000 claims 12
- 230000008685 targeting Effects 0.000 claims 9
- 239000007788 liquid Substances 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000006199 nebulizer Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000003384 small molecules Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 239000007979 citrate buffer Substances 0.000 claims 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims 2
- 239000008363 phosphate buffer Substances 0.000 claims 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 102100031168 CCN family member 2 Human genes 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 1
- 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 claims 1
- 101000950669 Homo sapiens Mitogen-activated protein kinase 9 Proteins 0.000 claims 1
- 101001092910 Homo sapiens Serum amyloid P-component Proteins 0.000 claims 1
- -1 IW001 Proteins 0.000 claims 1
- 102100022337 Integrin alpha-V Human genes 0.000 claims 1
- 108010040765 Integrin alphaV Proteins 0.000 claims 1
- 108010005716 Interferon beta-1a Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 claims 1
- 102100037809 Mitogen-activated protein kinase 9 Human genes 0.000 claims 1
- 108010089484 PRM-151 Proteins 0.000 claims 1
- 102100036202 Serum amyloid P-component Human genes 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 229910001622 calcium bromide Inorganic materials 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 229960004461 interferon beta-1a Drugs 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 claims 1
- 229910001623 magnesium bromide Inorganic materials 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 1
- 229960004378 nintedanib Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 210000004879 pulmonary tissue Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675286P | 2012-07-24 | 2012-07-24 | |
| US61/675,286 | 2012-07-24 | ||
| US201361756983P | 2013-01-25 | 2013-01-25 | |
| US61/756,983 | 2013-01-25 | ||
| US201361824818P | 2013-05-17 | 2013-05-17 | |
| US61/824,818 | 2013-05-17 | ||
| JP2019224873A JP7120984B2 (ja) | 2012-07-24 | 2019-12-12 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2022024945A JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022024945A Division JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024095678A JP2024095678A (ja) | 2024-07-10 |
| JP2024095678A5 true JP2024095678A5 (https=) | 2025-01-31 |
Family
ID=49997965
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524425A Active JP6501264B2 (ja) | 2012-07-24 | 2013-07-24 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2018116525A Pending JP2018172402A (ja) | 2012-07-24 | 2018-06-19 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2019224873A Active JP7120984B2 (ja) | 2012-07-24 | 2019-12-12 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2022024945A Pending JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2024040308A Pending JP2024095678A (ja) | 2012-07-24 | 2024-03-14 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524425A Active JP6501264B2 (ja) | 2012-07-24 | 2013-07-24 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2018116525A Pending JP2018172402A (ja) | 2012-07-24 | 2018-06-19 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2019224873A Active JP7120984B2 (ja) | 2012-07-24 | 2019-12-12 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2022024945A Pending JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2877164B1 (https=) |
| JP (5) | JP6501264B2 (https=) |
| AU (5) | AU2013295800A1 (https=) |
| CA (1) | CA2880011C (https=) |
| ES (1) | ES2959198T3 (https=) |
| HU (1) | HUE063581T2 (https=) |
| NZ (1) | NZ705260A (https=) |
| WO (1) | WO2014018668A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6021117B2 (ja) | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク． | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| RU2726367C2 (ru) * | 2016-03-28 | 2020-07-13 | Пресидж Байосайенсиз, Инк. | Фармацевтические комбинации для лечения злокачественной опухоли |
| WO2018071435A1 (en) * | 2016-10-11 | 2018-04-19 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
| WO2018234527A1 (en) * | 2017-06-22 | 2018-12-27 | Softhale Nv | Aerosol delivery of pirfenidone |
| ES3032673T3 (en) * | 2017-06-22 | 2025-07-23 | Invox Belgium Nv | Aerosol delivery of pirfenidone |
| GB201807050D0 (en) * | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
| EP4424379A3 (en) | 2019-04-24 | 2024-10-30 | Convergene Llc | Small molecule bromodomain inhibitors and uses thereof |
| MY208300A (en) * | 2019-05-27 | 2025-04-30 | Dsm Ip Assets Bv | Selective hydrogenation of alkynes to alkenes in the presence of a phosphorus compound and an organic sulphur compound |
| JP7490813B2 (ja) * | 2020-04-22 | 2024-05-27 | ユンジン ファーム．カンパニー、リミテッド | 安全性と安定性が改善されたピルフェニドンを含む腸溶性製剤およびその製造方法 |
| AU2021396535A1 (en) * | 2020-12-07 | 2023-06-22 | Mannkind Corporation | Method and composition for treating pulmonary fibrosis |
| US12508228B2 (en) | 2022-03-30 | 2025-12-30 | The Chinese University Of Hong Kong | PFD loaded microspheres and method for preparing injectable composite microsphere hydrogel solution from same |
| CN115970069B (zh) * | 2022-12-13 | 2024-09-24 | 南通大学附属医院 | 载吡非尼酮纳米粒子复合涂层输尿管支架管的制备方法 |
| CN119548479A (zh) * | 2024-12-31 | 2025-03-04 | 延边大学 | 一种吸入用吡非尼酮溶液及其使用方法 |
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| JP6021117B2 (ja) * | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
-
2013
- 2013-07-24 JP JP2015524425A patent/JP6501264B2/ja active Active
- 2013-07-24 CA CA2880011A patent/CA2880011C/en active Active
- 2013-07-24 NZ NZ705260A patent/NZ705260A/en unknown
- 2013-07-24 AU AU2013295800A patent/AU2013295800A1/en not_active Abandoned
- 2013-07-24 ES ES13822166T patent/ES2959198T3/es active Active
- 2013-07-24 WO PCT/US2013/051880 patent/WO2014018668A2/en not_active Ceased
- 2013-07-24 EP EP13822166.8A patent/EP2877164B1/en active Active
- 2013-07-24 HU HUE13822166A patent/HUE063581T2/hu unknown
-
2018
- 2018-06-19 JP JP2018116525A patent/JP2018172402A/ja active Pending
- 2018-07-23 AU AU2018206852A patent/AU2018206852A1/en not_active Abandoned
-
2019
- 2019-12-12 JP JP2019224873A patent/JP7120984B2/ja active Active
-
2020
- 2020-03-03 AU AU2020201557A patent/AU2020201557B2/en active Active
-
2022
- 2022-02-21 JP JP2022024945A patent/JP2022078126A/ja active Pending
- 2022-11-16 AU AU2022271417A patent/AU2022271417A1/en not_active Abandoned
-
2024
- 2024-03-14 JP JP2024040308A patent/JP2024095678A/ja active Pending
- 2024-11-29 AU AU2024267029A patent/AU2024267029A1/en active Pending
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