JP2024056895A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024056895A5 JP2024056895A5 JP2024020937A JP2024020937A JP2024056895A5 JP 2024056895 A5 JP2024056895 A5 JP 2024056895A5 JP 2024020937 A JP2024020937 A JP 2024020937A JP 2024020937 A JP2024020937 A JP 2024020937A JP 2024056895 A5 JP2024056895 A5 JP 2024056895A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant expression
- expression system
- amino acid
- ktag
- spytag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662376855P | 2016-08-18 | 2016-08-18 | |
| US62/376,855 | 2016-08-18 | ||
| US201662415858P | 2016-11-01 | 2016-11-01 | |
| US62/415,858 | 2016-11-01 | ||
| US201762481589P | 2017-04-04 | 2017-04-04 | |
| US62/481,589 | 2017-04-04 | ||
| PCT/US2017/047687 WO2018035503A1 (en) | 2016-08-18 | 2017-08-18 | Crispr-cas genome engineering via a modular aav delivery system |
| JP2019530374A JP2019524162A (ja) | 2016-08-18 | 2017-08-18 | モジュラーAAV送達システムによるCRISPR−Casゲノム編集 |
| JP2022142859A JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーAAV送達システムによるCRISPR-Casゲノム編集 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022142859A Division JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーAAV送達システムによるCRISPR-Casゲノム編集 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024056895A JP2024056895A (ja) | 2024-04-23 |
| JP2024056895A5 true JP2024056895A5 (https=) | 2024-09-13 |
Family
ID=61197157
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530374A Pending JP2019524162A (ja) | 2016-08-18 | 2017-08-18 | モジュラーAAV送達システムによるCRISPR−Casゲノム編集 |
| JP2022142859A Pending JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーAAV送達システムによるCRISPR-Casゲノム編集 |
| JP2024020937A Pending JP2024056895A (ja) | 2016-08-18 | 2024-02-15 | モジュラーAAV送達システムによるCRISPR-Casゲノム編集 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530374A Pending JP2019524162A (ja) | 2016-08-18 | 2017-08-18 | モジュラーAAV送達システムによるCRISPR−Casゲノム編集 |
| JP2022142859A Pending JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーAAV送達システムによるCRISPR-Casゲノム編集 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20200340012A1 (https=) |
| EP (1) | EP3500667A4 (https=) |
| JP (3) | JP2019524162A (https=) |
| KR (1) | KR20190065251A (https=) |
| CN (1) | CN109996880A (https=) |
| AU (1) | AU2017313917B2 (https=) |
| CA (1) | CA3034089A1 (https=) |
| IL (2) | IL315358A (https=) |
| WO (1) | WO2018035503A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN109843914B (zh) | 2016-07-06 | 2024-03-15 | 沃泰克斯药物股份有限公司 | 用于治疗疼痛相关病症的材料和方法 |
| JP7305534B2 (ja) * | 2016-07-06 | 2023-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛関連障害を処置するための物質及び方法 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) * | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗-ilt4抗體及抗原結合片段 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| LT3645553T (lt) * | 2017-06-27 | 2023-04-25 | Regeneron Pharmaceuticals, Inc. | Modifikuoto tropizmo rekombinantinės viruso dalelės ir jų panaudojimas genetinės medžiagos tiksliniam įvedimui į žmogaus ląsteles |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN109929839B (zh) * | 2017-12-18 | 2021-02-12 | 华东师范大学 | 拆分型单碱基基因编辑系统及其应用 |
| AU2019227910B2 (en) * | 2018-02-28 | 2025-07-17 | The Regents Of The University Of California | A modular system for gene and protein delivery based on AAV |
| EP4169576A1 (en) * | 2018-03-23 | 2023-04-26 | University of Massachusetts | Gene therapeutics for treating bone disorders |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3810776A1 (en) * | 2018-06-22 | 2021-04-28 | F. Hoffmann-La Roche AG | Oligonucleotides for modulating scn9a expression |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| AU2019317066A1 (en) * | 2018-08-07 | 2021-02-18 | Modalis Therapeutics Corporation | Novel transcription activator |
| US20210355475A1 (en) * | 2018-08-10 | 2021-11-18 | Cornell University | Optimized base editors enable efficient editing in cells, organoids and mice |
| KR20210058816A (ko) | 2018-08-18 | 2021-05-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 원 위치에 유전자 편집 |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US20220202957A1 (en) * | 2019-04-09 | 2022-06-30 | The Regents Of The University Of California | Long-lasting analgesia via targeted in vivo epigenetic repression |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP3736330A1 (en) * | 2019-05-08 | 2020-11-11 | European Molecular Biology Laboratory | Modified adeno-associated virus (aav) particles for gene therapy |
| WO2021064162A1 (en) * | 2019-10-02 | 2021-04-08 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Treatment of diseases caused by frame shift mutations |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| KR20220094216A (ko) | 2019-11-08 | 2022-07-05 | 코브 테라퓨틱스 | 변형된 아데노-관련 바이러스 벡터 및 이의 중추신경계로의 전달 |
| CN110760544A (zh) * | 2019-11-12 | 2020-02-07 | 保定诺未科技有限公司 | 拆分型SpCas9慢病毒载体及其在干细胞基因编辑中的应用 |
| WO2021209574A1 (en) * | 2020-04-15 | 2021-10-21 | Fondazione Telethon | Constructs comprising inteins |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN111500635B (zh) * | 2020-07-02 | 2020-10-09 | 北京大学第三医院(北京大学第三临床医学院) | 一种包含携带核酸分子的载体的试剂盒 |
| CN116802279A (zh) | 2020-11-06 | 2023-09-22 | 科亚韦治疗公司 | 内酰胺修饰的腺相关病毒载体 |
| AU2021378075B2 (en) | 2020-11-11 | 2025-03-27 | Borea Therapeutics S.R.L. | Modified viral particles for gene therapy |
| JP2024505570A (ja) * | 2021-02-01 | 2024-02-06 | ナヴェガ セラピューティクス, インコーポレイテッド | 神経学的疾患及び疼痛を治療するためのエピジェネティック遺伝子調節 |
| CN114107347B (zh) * | 2021-11-24 | 2022-10-28 | 中国人民解放军空军军医大学 | 一种基于具有按需抗炎功能、装载炎症响应型mRNA的工程化外泌体及其构建方法和应用 |
| WO2024129990A2 (en) * | 2022-12-14 | 2024-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically modified aavs |
| CN116530470B (zh) * | 2022-12-26 | 2025-09-23 | 华中科技大学同济医学院附属同济医院 | 一种自身免疫性肝炎小鼠模型的创建方法及应用 |
| CN116676334B (zh) * | 2023-02-08 | 2025-05-27 | 深圳大学 | 抑郁症动物模型的构建方法 |
| CN121175075A (zh) * | 2023-04-17 | 2025-12-19 | 桑加莫治疗公司 | 用于阻遏nav1.7表达的锌指蛋白转录因子 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US5811407A (en) | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
| US6982082B1 (en) | 1997-08-27 | 2006-01-03 | President And Fellows Of Harvard College | Gene therapy by cell specific targeting |
| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| ATE318923T1 (de) | 2000-06-01 | 2006-03-15 | Univ North Carolina | Doppelsträngige parvovirus-vektoren |
| US6531235B2 (en) | 2001-06-06 | 2003-03-11 | Max-Planck-Institute für Mikrostrukturphysik | Non-c-axis oriented bismuth-layered perovskite ferroelectric structure epitaxially grown on buffered silicon |
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| AU2002365366B2 (en) | 2001-11-21 | 2007-05-10 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| EP1456383B1 (en) * | 2001-12-21 | 2014-03-12 | Medigene AG | A library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism |
| AU2003223766A1 (en) | 2002-04-30 | 2003-11-17 | University Of North Carolina At Chapel Hill | Secretion signal vectors |
| US7301898B1 (en) | 2002-07-29 | 2007-11-27 | Brocade Communications Systems, Inc. | Credit sharing for fibre channel links with multiple virtual channels |
| EP2345731B1 (en) | 2003-09-30 | 2015-10-21 | The Trustees of the University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| JP5136766B2 (ja) | 2004-12-15 | 2013-02-06 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | キメラベクター |
| ES2525067T3 (es) | 2005-04-07 | 2014-12-17 | The Trustees Of The University Of Pennsylvania | Método de incremento de la función de un vector de AAV |
| US7867484B2 (en) | 2006-01-27 | 2011-01-11 | University Of North Carolina At Chapel Hill | Heparin and heparan sulfate binding chimeric vectors |
| EP2012822B1 (en) | 2006-04-28 | 2010-01-20 | The Trustees of the University of Pennsylvania | Modified adenovirus hexon protein and uses thereof |
| EP2018421B1 (en) | 2006-04-28 | 2012-12-19 | The Trustees of the University of Pennsylvania | Scalable production method for aav |
| US9725485B2 (en) * | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
| CN101883858B (zh) | 2007-11-28 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用 |
| AU2008331905B2 (en) | 2007-11-28 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Simian subfamily B adenovirus SAdV-28 and uses thereof |
| WO2009137006A2 (en) | 2008-04-30 | 2009-11-12 | The University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
| WO2010051367A1 (en) | 2008-10-31 | 2010-05-06 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses sadv-43, -45,-48,-49, and -50 and uses thereof |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| CA2762203A1 (en) | 2009-05-29 | 2010-12-02 | Soumitra Roy | Simian adenovirus 41 and uses thereof |
| JP5618557B2 (ja) | 2010-01-29 | 2014-11-05 | 富士フイルム株式会社 | 感活性光線性または感放射線性樹脂組成物、及び該組成物を用いたパターン形成方法 |
| US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| AU2011332025B2 (en) | 2010-11-23 | 2015-06-25 | The Trustees Of The University Of Pennsylvania | Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof |
| WO2012109570A1 (en) | 2011-02-10 | 2012-08-16 | The University Of North Carolina At Chapel Hill | Viral vectors with modified transduction profiles and methods of making and using the same |
| SG11201407343XA (en) | 2012-05-18 | 2014-12-30 | Univ Pennsylvania | Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof |
| CA2886161A1 (en) | 2012-09-29 | 2014-04-03 | The Trustees Of The University Of Pennsylvania | Veterinary composition and methods for non-surgical neutering and castration |
| EP3031921B1 (en) * | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| US20140271550A1 (en) | 2013-03-14 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses |
| AU2014235096B2 (en) | 2013-03-15 | 2020-03-19 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating MPSI |
| WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
| CN115120746A (zh) | 2013-05-15 | 2022-09-30 | 明尼苏达大学董事会 | 腺相关病毒介导的基因向中枢神经系统转移 |
| EP3492597A3 (en) * | 2013-05-21 | 2019-08-28 | University of Florida Research Foundation, Inc. | Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer |
| EP3003391B1 (en) * | 2013-05-31 | 2021-09-22 | The Regents of The University of California | Adeno-associated virus variants and methods of use thereof |
| WO2014197748A2 (en) * | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| WO2015040075A1 (en) * | 2013-09-18 | 2015-03-26 | Genome Research Limited | Genomic screening methods using rna-guided endonucleases |
| WO2015048577A2 (en) * | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| CN104592364B (zh) * | 2013-10-30 | 2018-05-01 | 北京大学 | 定点突变和定点修饰的腺相关病毒、其制备方法及应用 |
| EP3470089A1 (en) * | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| EP3115457B1 (en) * | 2014-03-05 | 2019-10-02 | National University Corporation Kobe University | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| SMT202000531T1 (it) | 2014-03-09 | 2020-11-10 | Univ Pennsylvania | Composizioni utili in trattamento di deficit di ornitina transcarbamilasi(otc) |
| WO2015164723A1 (en) | 2014-04-25 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| LT3137497T (lt) * | 2014-05-02 | 2021-07-26 | Genzyme Corporation | Aav vektoriai, skirti tinklainės ir cns genų terapijai |
| ES2833230T3 (es) | 2014-05-13 | 2021-06-14 | Univ Pennsylvania | Composiciones que comprenden AVV que expresan construcciones y usos de doble anticuerpo del mismo |
| EP2982758A1 (en) * | 2014-08-04 | 2016-02-10 | Centre Hospitalier Universitaire Vaudois (CHUV) | Genome editing for the treatment of huntington's disease |
| EP3212165B1 (en) * | 2014-10-30 | 2024-02-28 | President and Fellows of Harvard College | Delivery of negatively charged proteins using cationic lipids |
| PT3216867T (pt) * | 2014-11-04 | 2020-07-16 | Univ Kobe Nat Univ Corp | Método para modificar a sequência de genoma para introduzir mutação específica a sequência de adn alvo por reação de remoção de bases, e complexo molecular nele utilizado |
| WO2016112242A1 (en) * | 2015-01-08 | 2016-07-14 | President And Fellows Of Harvard College | Split cas9 proteins |
| WO2016112921A1 (en) * | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| CN106011104B (zh) * | 2015-05-21 | 2019-09-27 | 清华大学 | 利用拆分Cas系统进行基因编辑和表达调控方法 |
| WO2016205749A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US10954513B2 (en) * | 2015-06-18 | 2021-03-23 | University Of Utah Research Foundation | RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain |
| CN116814590A (zh) | 2015-10-22 | 2023-09-29 | 布罗德研究所有限公司 | Vi-b型crispr酶和系统 |
| WO2017075335A1 (en) * | 2015-10-28 | 2017-05-04 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
| CN109843914B (zh) * | 2016-07-06 | 2024-03-15 | 沃泰克斯药物股份有限公司 | 用于治疗疼痛相关病症的材料和方法 |
-
2017
- 2017-08-18 IL IL315358A patent/IL315358A/en unknown
- 2017-08-18 CA CA3034089A patent/CA3034089A1/en active Pending
- 2017-08-18 KR KR1020197007526A patent/KR20190065251A/ko not_active Ceased
- 2017-08-18 JP JP2019530374A patent/JP2019524162A/ja active Pending
- 2017-08-18 IL IL264872A patent/IL264872B2/en unknown
- 2017-08-18 AU AU2017313917A patent/AU2017313917B2/en active Active
- 2017-08-18 CN CN201780064482.9A patent/CN109996880A/zh active Pending
- 2017-08-18 US US16/325,679 patent/US20200340012A1/en active Pending
- 2017-08-18 WO PCT/US2017/047687 patent/WO2018035503A1/en not_active Ceased
- 2017-08-18 EP EP17842247.3A patent/EP3500667A4/en active Pending
-
2022
- 2022-09-08 JP JP2022142859A patent/JP2022184901A/ja active Pending
-
2024
- 2024-02-15 JP JP2024020937A patent/JP2024056895A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024056895A5 (https=) | ||
| JP2022190081A5 (https=) | ||
| JP2022549140A5 (https=) | ||
| JP2021118724A5 (https=) | ||
| JP2021523702A5 (https=) | ||
| JP2022068181A5 (https=) | ||
| JP2021106619A5 (https=) | ||
| IL292264B1 (en) | Aav transfer cassette | |
| JP2022508182A5 (https=) | ||
| JP2022551744A5 (https=) | ||
| EP2660325A3 (en) | AAV vectors and corresponding nucleotide sequences and methods | |
| JP2022516004A5 (https=) | ||
| JP2018510648A5 (https=) | ||
| JP2022520803A5 (https=) | ||
| JP2020519284A5 (https=) | ||
| JP2021514659A5 (https=) | ||
| JP2017509632A5 (https=) | ||
| JP2023515692A5 (https=) | ||
| HRP20192141T1 (hr) | Genska terapija za retinitis pigmentosa | |
| JP2022542828A5 (https=) | ||
| JP2022525302A5 (https=) | ||
| JP2022524434A5 (https=) | ||
| IL273394B1 (en) | Variant rnai | |
| JP2022505106A5 (https=) | ||
| JP2024512483A5 (https=) |