JP2024056895A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024056895A5 JP2024056895A5 JP2024020937A JP2024020937A JP2024056895A5 JP 2024056895 A5 JP2024056895 A5 JP 2024056895A5 JP 2024020937 A JP2024020937 A JP 2024020937A JP 2024020937 A JP2024020937 A JP 2024020937A JP 2024056895 A5 JP2024056895 A5 JP 2024056895A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant expression
- expression system
- amino acid
- ktag
- spytag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662376855P | 2016-08-18 | 2016-08-18 | |
| US62/376,855 | 2016-08-18 | ||
| US201662415858P | 2016-11-01 | 2016-11-01 | |
| US62/415,858 | 2016-11-01 | ||
| US201762481589P | 2017-04-04 | 2017-04-04 | |
| US62/481,589 | 2017-04-04 | ||
| PCT/US2017/047687 WO2018035503A1 (en) | 2016-08-18 | 2017-08-18 | Crispr-cas genome engineering via a modular aav delivery system |
| JP2019530374A JP2019524162A (ja) | 2016-08-18 | 2017-08-18 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ−Ｃａｓゲノム編集 |
| JP2022142859A JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ－Ｃａｓゲノム編集 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022142859A Division JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ－Ｃａｓゲノム編集 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024056895A JP2024056895A (ja) | 2024-04-23 |
| JP2024056895A5 true JP2024056895A5 (https=) | 2024-09-13 |
Family
ID=61197157
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530374A Pending JP2019524162A (ja) | 2016-08-18 | 2017-08-18 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ−Ｃａｓゲノム編集 |
| JP2022142859A Pending JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ－Ｃａｓゲノム編集 |
| JP2024020937A Pending JP2024056895A (ja) | 2016-08-18 | 2024-02-15 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ－Ｃａｓゲノム編集 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530374A Pending JP2019524162A (ja) | 2016-08-18 | 2017-08-18 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ−Ｃａｓゲノム編集 |
| JP2022142859A Pending JP2022184901A (ja) | 2016-08-18 | 2022-09-08 | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ－Ｃａｓゲノム編集 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20200340012A1 (https=) |
| EP (1) | EP3500667A4 (https=) |
| JP (3) | JP2019524162A (https=) |
| KR (1) | KR20190065251A (https=) |
| CN (1) | CN109996880A (https=) |
| AU (1) | AU2017313917B2 (https=) |
| CA (1) | CA3034089A1 (https=) |
| IL (2) | IL315358A (https=) |
| WO (1) | WO2018035503A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| JP7305534B2 (ja) * | 2016-07-06 | 2023-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛関連障害を処置するための物質及び方法 |
| AU2017292173B2 (en) | 2016-07-06 | 2022-01-13 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗－ilt4抗體及抗原結合片段 |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| PL3645553T3 (pl) | 2017-06-27 | 2023-07-17 | Regeneron Pharmaceuticals, Inc. | Zrekombinowane cząstki wirusowe o zmodyfikowanym tropizmie i ich zastosowania do celowanego wprowadzania materiału genetycznego do komórek ludzkich |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN109929839B (zh) * | 2017-12-18 | 2021-02-12 | 华东师范大学 | 拆分型单碱基基因编辑系统及其应用 |
| US12421525B2 (en) | 2018-02-28 | 2025-09-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Conjugates comprising AAVs and CAS9 polypeptides |
| AU2019237514A1 (en) | 2018-03-23 | 2020-10-08 | University Of Massachusetts | Gene therapeutics for treating bone disorders |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| MX2020013930A (es) * | 2018-06-22 | 2021-03-09 | Hoffmann La Roche | Oligonucleotidos para modular la expresion del canal de sodio dependiente de voltaje alfa subunidad 9 (scn9a). |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CN112585266A (zh) * | 2018-08-07 | 2021-03-30 | 摩大力斯医疗株式会社 | 新型转录激活物 |
| WO2020033083A1 (en) * | 2018-08-10 | 2020-02-13 | Cornell University | Optimized base editors enable efficient editing in cells, organoids and mice |
| US12486519B2 (en) | 2018-08-18 | 2025-12-02 | President And Fellows Of Harvard College | In situ gene editing |
| KR20210055733A (ko) * | 2018-09-07 | 2021-05-17 | 빔 테라퓨틱스, 인크. | 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US20220202957A1 (en) * | 2019-04-09 | 2022-06-30 | The Regents Of The University Of California | Long-lasting analgesia via targeted in vivo epigenetic repression |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP3736330A1 (en) * | 2019-05-08 | 2020-11-11 | European Molecular Biology Laboratory | Modified adeno-associated virus (aav) particles for gene therapy |
| CA3149259A1 (en) * | 2019-10-02 | 2021-04-08 | Christian Kupatt | Treatment of diseases caused by frame shift mutations |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN114929869A (zh) | 2019-11-08 | 2022-08-19 | 科亚韦治疗公司 | 修饰的腺相关病毒载体及将其递送至中枢神经系统 |
| CN110760544A (zh) * | 2019-11-12 | 2020-02-07 | 保定诺未科技有限公司 | 拆分型SpCas9慢病毒载体及其在干细胞基因编辑中的应用 |
| WO2021209574A1 (en) * | 2020-04-15 | 2021-10-21 | Fondazione Telethon | Constructs comprising inteins |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| CN111500635B (zh) * | 2020-07-02 | 2020-10-09 | 北京大学第三医院（北京大学第三临床医学院） | 一种包含携带核酸分子的载体的试剂盒 |
| CN116802279A (zh) | 2020-11-06 | 2023-09-22 | 科亚韦治疗公司 | 内酰胺修饰的腺相关病毒载体 |
| CA3201533A1 (en) | 2020-11-11 | 2022-05-19 | European Molecular Biology Laboratory | Modified viral particles for gene therapy |
| JP2024505570A (ja) * | 2021-02-01 | 2024-02-06 | ナヴェガ セラピューティクス， インコーポレイテッド | 神経学的疾患及び疼痛を治療するためのエピジェネティック遺伝子調節 |
| CN114107347B (zh) * | 2021-11-24 | 2022-10-28 | 中国人民解放军空军军医大学 | 一种基于具有按需抗炎功能、装载炎症响应型mRNA的工程化外泌体及其构建方法和应用 |
| WO2024129990A2 (en) * | 2022-12-14 | 2024-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically modified aavs |
| CN116530470B (zh) * | 2022-12-26 | 2025-09-23 | 华中科技大学同济医学院附属同济医院 | 一种自身免疫性肝炎小鼠模型的创建方法及应用 |
| CN116676334B (zh) * | 2023-02-08 | 2025-05-27 | 深圳大学 | 抑郁症动物模型的构建方法 |
| AU2024258906A1 (en) * | 2023-04-17 | 2025-11-06 | Sangamo Therapeutics, Inc. | Zinc finger protein transcription factors for repressing nav1.7 expression |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US5811407A (en) | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
| US6982082B1 (en) | 1997-08-27 | 2006-01-03 | President And Fellows Of Harvard College | Gene therapy by cell specific targeting |
| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| ES2340230T3 (es) | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
| NZ522840A (en) | 2000-06-01 | 2004-12-24 | Univ North Carolina | A parvovirus vector that carries a duplexed genome resulting in co-packaging of strands of plus and minus polarity tethered together |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| US6531235B2 (en) | 2001-06-06 | 2003-03-11 | Max-Planck-Institute für Mikrostrukturphysik | Non-c-axis oriented bismuth-layered perovskite ferroelectric structure epitaxially grown on buffered silicon |
| NZ532635A (en) | 2001-11-13 | 2007-05-31 | Univ Pennsylvania | A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method |
| EP1453543B1 (en) | 2001-11-21 | 2017-08-30 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
| DK2359869T3 (en) | 2001-12-17 | 2019-04-15 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof |
| US20050106558A1 (en) * | 2001-12-21 | 2005-05-19 | Luca Perabo | Library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism |
| US7071172B2 (en) | 2002-04-30 | 2006-07-04 | The University Of North Carolina At Chapel Hill | Secretion signal vectors |
| US7301898B1 (en) | 2002-07-29 | 2007-11-27 | Brocade Communications Systems, Inc. | Credit sharing for fibre channel links with multiple virtual channels |
| CN1856576B (zh) | 2003-09-30 | 2011-05-04 | 宾夕法尼亚州立大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| EP1828390B1 (en) | 2004-12-15 | 2012-06-13 | The University Of North Carolina At Chapel Hill | Chimeric vectors |
| WO2006110689A2 (en) | 2005-04-07 | 2006-10-19 | The Trustees Of The University Of Pennsylvania | Method of increasing the function of an aav vector |
| US7867484B2 (en) | 2006-01-27 | 2011-01-11 | University Of North Carolina At Chapel Hill | Heparin and heparan sulfate binding chimeric vectors |
| EP2018421B1 (en) | 2006-04-28 | 2012-12-19 | The Trustees of the University of Pennsylvania | Scalable production method for aav |
| CN101437538A (zh) | 2006-04-28 | 2009-05-20 | 宾夕法尼亚州立大学托管会 | 修饰的腺病毒六邻体蛋白和其应用 |
| US9725485B2 (en) * | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
| CA2706257C (en) | 2007-11-28 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Simian subfamily b adenovirus sadv-28, -27, -29, -32, -33 and -35 and uses thereof |
| MX2010005858A (es) | 2007-11-28 | 2010-06-11 | Univ Pennsylvania | Adenovirus e simianos sadv-39, sadv-25.2, sadv-26, sadv-30, sadv-37 y sadv-38. |
| US8632764B2 (en) | 2008-04-30 | 2014-01-21 | University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
| US8940290B2 (en) | 2008-10-31 | 2015-01-27 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| CN102575232B (zh) | 2009-05-29 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿腺病毒41及其应用 |
| JP5618557B2 (ja) | 2010-01-29 | 2014-11-05 | 富士フイルム株式会社 | 感活性光線性または感放射線性樹脂組成物、及び該組成物を用いたパターン形成方法 |
| US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| WO2012071318A2 (en) | 2010-11-23 | 2012-05-31 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenoviruses a1321, a1325, a1295, a1309, a1316 and a1322 and uses thereof |
| WO2012109570A1 (en) | 2011-02-10 | 2012-08-16 | The University Of North Carolina At Chapel Hill | Viral vectors with modified transduction profiles and methods of making and using the same |
| WO2013173702A2 (en) | 2012-05-18 | 2013-11-21 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof |
| CA2886161A1 (en) | 2012-09-29 | 2014-04-03 | The Trustees Of The University Of Pennsylvania | Veterinary composition and methods for non-surgical neutering and castration |
| DK2931897T3 (en) * | 2012-12-12 | 2018-02-05 | Broad Inst Inc | CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS |
| US20140271550A1 (en) | 2013-03-14 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses |
| SI2984166T1 (sl) | 2013-03-15 | 2020-09-30 | The Trustees Of The University Of Pennsylvania | Sestavki za zdravljenje MPSI |
| US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
| CN105377039A (zh) | 2013-05-15 | 2016-03-02 | 明尼苏达大学董事会 | 腺相关病毒介导的基因向中枢神经系统转移 |
| KR102234672B1 (ko) * | 2013-05-21 | 2021-04-06 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 캡시드-변형된 raav3 벡터 조성물, 및 인간 간암의 유전자 요법에서의 용도 |
| US11136557B2 (en) * | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| EP3004370B1 (en) * | 2013-06-05 | 2024-08-21 | Duke University | Rna-guided gene editing and gene regulation |
| WO2016070129A1 (en) * | 2014-10-30 | 2016-05-06 | President And Fellows Of Harvard College | Delivery of negatively charged proteins using cationic lipids |
| WO2015040075A1 (en) * | 2013-09-18 | 2015-03-26 | Genome Research Limited | Genomic screening methods using rna-guided endonucleases |
| WO2015048577A2 (en) * | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| CN104592364B (zh) * | 2013-10-30 | 2018-05-01 | 北京大学 | 定点突变和定点修饰的腺相关病毒、其制备方法及应用 |
| EP3470089A1 (en) * | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| SG11201609211VA (en) * | 2014-03-05 | 2016-12-29 | Nat Univ Corp Univ Kobe | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| RS60902B1 (sr) | 2014-03-09 | 2020-11-30 | Univ Pennsylvania | Kompozicije korisne u lečenju nedostatka ornitinske transkarbamilaze (otc) |
| WO2015164723A1 (en) | 2014-04-25 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| IL248102B (en) * | 2014-05-02 | 2022-07-01 | Genzyme Corp | aav vectors for gene therapy of the central nervous system and retina |
| PE20170261A1 (es) | 2014-05-13 | 2017-04-12 | Univ Pennsylvania | Composiciones que comprenden virus adenoasociado (aav) que expresa constructos de anticuerpos duales y sus usos |
| EP2982758A1 (en) * | 2014-08-04 | 2016-02-10 | Centre Hospitalier Universitaire Vaudois (CHUV) | Genome editing for the treatment of huntington's disease |
| US10920215B2 (en) * | 2014-11-04 | 2021-02-16 | National University Corporation Kobe University | Method for modifying genome sequence to introduce specific mutation to targeted DNA sequence by base-removal reaction, and molecular complex used therein |
| WO2016112242A1 (en) * | 2015-01-08 | 2016-07-14 | President And Fellows Of Harvard College | Split cas9 proteins |
| WO2016112921A1 (en) * | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| CN106011104B (zh) * | 2015-05-21 | 2019-09-27 | 清华大学 | 利用拆分Cas系统进行基因编辑和表达调控方法 |
| US10954513B2 (en) * | 2015-06-18 | 2021-03-23 | University Of Utah Research Foundation | RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain |
| CA3012607A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzymes and systems |
| CN109153980B (zh) | 2015-10-22 | 2023-04-14 | 布罗德研究所有限公司 | Vi-b型crispr酶和系统 |
| US20180230489A1 (en) * | 2015-10-28 | 2018-08-16 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
| AU2017292173B2 (en) * | 2016-07-06 | 2022-01-13 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
-
2017
- 2017-08-18 WO PCT/US2017/047687 patent/WO2018035503A1/en not_active Ceased
- 2017-08-18 US US16/325,679 patent/US20200340012A1/en active Pending
- 2017-08-18 IL IL315358A patent/IL315358A/en unknown
- 2017-08-18 CA CA3034089A patent/CA3034089A1/en active Pending
- 2017-08-18 CN CN201780064482.9A patent/CN109996880A/zh active Pending
- 2017-08-18 IL IL264872A patent/IL264872B2/en unknown
- 2017-08-18 JP JP2019530374A patent/JP2019524162A/ja active Pending
- 2017-08-18 EP EP17842247.3A patent/EP3500667A4/en active Pending
- 2017-08-18 KR KR1020197007526A patent/KR20190065251A/ko not_active Ceased
- 2017-08-18 AU AU2017313917A patent/AU2017313917B2/en active Active
-
2022
- 2022-09-08 JP JP2022142859A patent/JP2022184901A/ja active Pending
-
2024
- 2024-02-15 JP JP2024020937A patent/JP2024056895A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024056895A5 (https=) | ||
| JP2022190081A5 (https=) | ||
| JP2021118724A5 (https=) | ||
| JP2021523702A5 (https=) | ||
| JP2022068181A5 (https=) | ||
| JP2021106619A5 (https=) | ||
| IL292264B1 (en) | Aav transfer cassette | |
| EP2660325A3 (en) | AAV vectors and corresponding nucleotide sequences and methods | |
| JP2018510648A5 (https=) | ||
| JP2020519284A5 (https=) | ||
| JPWO2020106916A5 (https=) | ||
| JP2021514659A5 (https=) | ||
| JP2017509632A5 (https=) | ||
| JPWO2021053222A5 (https=) | ||
| IL319564A (en) | BAG 3 methods and uses for treating cardiac amyloidosis | |
| JPWO2019213668A5 (https=) | ||
| JPWO2020168222A5 (https=) | ||
| JPWO2021011029A5 (https=) | ||
| JPWO2020186207A5 (https=) | ||
| JPWO2021178707A5 (https=) | ||
| JPWO2020186150A5 (https=) | ||
| JPWO2021076911A5 (https=) | ||
| JPWO2020081490A5 (https=) | ||
| JPWO2022195074A5 (https=) | ||
| JPWO2021221995A5 (https=) |