CN109996880A - 基于模块化aav递送系统的crispr-cas基因组工程 - Google Patents

基于模块化aav递送系统的crispr-cas基因组工程 Download PDF

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Publication number
CN109996880A
CN109996880A CN201780064482.9A CN201780064482A CN109996880A CN 109996880 A CN109996880 A CN 109996880A CN 201780064482 A CN201780064482 A CN 201780064482A CN 109996880 A CN109996880 A CN 109996880A
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grna
aav
capsid
composition
cas9
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Chinese (zh)
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普拉尚特·马利
德拉瓦·卡特埃卡
阿纳·莫雷诺·科拉多
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University of California San Diego UCSD
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University of California San Diego UCSD
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CN201780064482.9A 2016-08-18 2017-08-18 基于模块化aav递送系统的crispr-cas基因组工程 Pending CN109996880A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662376855P 2016-08-18 2016-08-18
US62/376,855 2016-08-18
US201662415858P 2016-11-01 2016-11-01
US62/415,858 2016-11-01
US201762481589P 2017-04-04 2017-04-04
US62/481,589 2017-04-04
PCT/US2017/047687 WO2018035503A1 (en) 2016-08-18 2017-08-18 Crispr-cas genome engineering via a modular aav delivery system

Publications (1)

Publication Number Publication Date
CN109996880A true CN109996880A (zh) 2019-07-09

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CN201780064482.9A Pending CN109996880A (zh) 2016-08-18 2017-08-18 基于模块化aav递送系统的crispr-cas基因组工程

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Country Link
US (1) US20200340012A1 (https=)
EP (1) EP3500667A4 (https=)
JP (3) JP2019524162A (https=)
KR (1) KR20190065251A (https=)
CN (1) CN109996880A (https=)
AU (1) AU2017313917B2 (https=)
CA (1) CA3034089A1 (https=)
IL (2) IL315358A (https=)
WO (1) WO2018035503A1 (https=)

Cited By (2)

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CN110760544A (zh) * 2019-11-12 2020-02-07 保定诺未科技有限公司 拆分型SpCas9慢病毒载体及其在干细胞基因编辑中的应用
CN114107347A (zh) * 2021-11-24 2022-03-01 中国人民解放军空军军医大学 一种基于具有按需抗炎功能、装载炎症响应型mRNA的工程化外泌体及其构建方法和应用

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US10323236B2 (en) 2011-07-22 2019-06-18 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
CN109843914B (zh) 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
JP7305534B2 (ja) * 2016-07-06 2023-07-10 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛関連障害を処置するための物質及び方法
CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
WO2018031683A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
KR102622411B1 (ko) * 2016-10-14 2024-01-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵염기 에디터의 aav 전달
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
US12390514B2 (en) 2017-03-09 2025-08-19 President And Fellows Of Harvard College Cancer vaccine
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
KR20240116572A (ko) 2017-03-23 2024-07-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
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