JP2024056817A5 - - Google Patents
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- JP2024056817A5 JP2024056817A5 JP2024018149A JP2024018149A JP2024056817A5 JP 2024056817 A5 JP2024056817 A5 JP 2024056817A5 JP 2024018149 A JP2024018149 A JP 2024018149A JP 2024018149 A JP2024018149 A JP 2024018149A JP 2024056817 A5 JP2024056817 A5 JP 2024056817A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- variable region
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 168
- 239000000427 antigen Substances 0.000 claims 27
- 102000036639 antigens Human genes 0.000 claims 27
- 108091007433 antigens Proteins 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 27
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 2
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163197259P | 2021-06-04 | 2021-06-04 | |
| US63/197,259 | 2021-06-04 | ||
| US202263325828P | 2022-03-31 | 2022-03-31 | |
| US63/325,828 | 2022-03-31 | ||
| US202263339326P | 2022-05-06 | 2022-05-06 | |
| US63/339,326 | 2022-05-06 | ||
| PCT/IB2022/055170 WO2022254379A1 (en) | 2021-06-04 | 2022-06-02 | Anti-sirp-alpha antibodies |
| JP2022576817A JP7436711B2 (ja) | 2021-06-04 | 2022-06-02 | 抗ｓｉｒｐ－アルファ抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022576817A Division JP7436711B2 (ja) | 2021-06-04 | 2022-06-02 | 抗ｓｉｒｐ－アルファ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024056817A JP2024056817A (ja) | 2024-04-23 |
| JP2024056817A5 true JP2024056817A5 (https=) | 2024-05-21 |
Family
ID=82156310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022576817A Active JP7436711B2 (ja) | 2021-06-04 | 2022-06-02 | 抗ｓｉｒｐ－アルファ抗体 |
| JP2024018149A Pending JP2024056817A (ja) | 2021-06-04 | 2024-02-08 | 抗ｓｉｒｐ－アルファ抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022576817A Active JP7436711B2 (ja) | 2021-06-04 | 2022-06-02 | 抗ｓｉｒｐ－アルファ抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11572412B2 (https=) |
| EP (1) | EP4347653A1 (https=) |
| JP (2) | JP7436711B2 (https=) |
| KR (1) | KR20240027677A (https=) |
| AU (1) | AU2022284373A1 (https=) |
| BR (1) | BR112023025194A2 (https=) |
| CA (1) | CA3218692A1 (https=) |
| CL (2) | CL2023003554A1 (https=) |
| CO (1) | CO2023017156A2 (https=) |
| CR (1) | CR20230573A (https=) |
| DO (1) | DOP2023000259A (https=) |
| EC (1) | ECSP23088844A (https=) |
| IL (1) | IL308741A (https=) |
| JO (1) | JOP20230311A1 (https=) |
| MX (1) | MX2023014389A (https=) |
| PH (1) | PH12023553159A1 (https=) |
| SA (1) | SA523451800B1 (https=) |
| TW (1) | TW202317620A (https=) |
| WO (1) | WO2022254379A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102702926B1 (ko) * | 2017-04-13 | 2024-09-06 | 사이로파 비.브이. | 항-sirp 알파 항체 |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| TW202317620A (zh) | 2021-06-04 | 2023-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗ＳＩＲＰα抗體 |
| EP4619435A1 (en) | 2022-11-16 | 2025-09-24 | Boehringer Ingelheim International GmbH | Predictive efficacy biomarkers for anti-sirpa antibodies |
| WO2024200820A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Method of synthesis of targeted lipid nanoparticle and uses thereof |
| EP4687991A1 (en) | 2023-03-30 | 2026-02-11 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
| WO2025072871A2 (en) * | 2023-09-28 | 2025-04-03 | Memorial Sloan-Kettering Cancer Center | ANTI-SIRPα ANTIBODY COMPOSITIONS AND USES THEREOF |
| WO2025074337A1 (en) | 2023-10-06 | 2025-04-10 | Boehringer Ingelheim International Gmbh | Use of anti-sirp-alpha antibodies to treat a liver disease or disorder |
| WO2025074328A1 (en) | 2023-10-06 | 2025-04-10 | Boehringer Ingelheim International Gmbh | Use of anti-sirp-alpha antibodies to treat cancer |
| JP2025154039A (ja) | 2024-03-29 | 2025-10-10 | 日揮触媒化成株式会社 | 流動接触分解触媒及びその製造方法 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US6037454A (en) | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| US8613922B2 (en) | 2003-04-24 | 2013-12-24 | The University Of North Carolina At Chapel Hill | Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP) |
| US20100215640A1 (en) | 2003-04-24 | 2010-08-26 | The University Of North Carolina At Chapel Hill | Method for inhibiting cellular activation by insulin-like growth factor-1 |
| HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| JP2011500569A (ja) | 2007-10-12 | 2011-01-06 | マサチューセッツ インスティテュート オブ テクノロジー | ワクチンナノテクノロジー |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| HRP20150553T1 (hr) | 2009-05-15 | 2015-08-28 | University Health Network | Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju |
| GB201015765D0 (en) | 2010-09-21 | 2010-10-27 | Immatics Biotechnologies Gmbh | Use of myeloid cell biomarkers for the diagnosis of cancer |
| CN103620032B (zh) | 2010-12-31 | 2016-02-24 | 生物蛋白有限公司 | 抗体的快速人源化 |
| WO2012149416A2 (en) | 2011-04-28 | 2012-11-01 | University Of Southern California | Human myeloid derived suppressor cell cancer markers |
| WO2013056352A1 (en) | 2011-10-19 | 2013-04-25 | University Health Network | Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers |
| KR101764096B1 (ko) | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| CN106456749B (zh) | 2014-03-11 | 2021-03-30 | 小利兰·斯坦福大学托管委员会 | 抗SIRPα抗体和双特异性巨噬细胞增强型抗体 |
| CN105085679B (zh) | 2014-04-25 | 2019-01-11 | 上海津曼特生物科技有限公司 | 全人源抗rankl抗体 |
| BR112018070823A2 (pt) | 2016-04-14 | 2019-02-05 | Ose Immunotherapeutics | anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno, composição farmacêutica, produto de combinação, molécula de ácido nucleico isolada, vetor, célula hospedeira isolada, polipeptídeo, métodos para fabricar um anticorpo, in vitro ou ex vivo para determinar células positivas para sirpa, de diagnóstico e para prever a resposta de um sujeito, e, uso de um anticorpo anti-sirpa ou um fragmento de ligação a antígeno do mesmo ou um mimético de ligação a anticorpo e in vitro ou ex vivo de pelo menos um anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno. |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| AU2017371070B2 (en) | 2016-12-09 | 2025-01-02 | Alector Llc | Anti-SIRP-alpha antibodies and methods of use thereof |
| WO2018160739A1 (en) | 2017-02-28 | 2018-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Antifibrotic activity of cd47 blockade |
| KR102702926B1 (ko) | 2017-04-13 | 2024-09-06 | 사이로파 비.브이. | 항-sirp 알파 항체 |
| CN118271443A (zh) * | 2017-05-16 | 2024-07-02 | 拜奥迪斯私人有限公司 | 抗SIRPα抗体 |
| BR112020001653A2 (pt) | 2017-07-26 | 2020-07-21 | Forty Seven, Inc. | anticorpos anti-sirp-alfa e métodos relacionados |
| EP3694881A1 (en) | 2017-10-13 | 2020-08-19 | OSE Immunotherapeutics | Modified anti-sirpa antibodies and uses thereof |
| PE20201265A1 (es) | 2018-03-21 | 2020-11-19 | Alx Oncology Inc | Anticuerpos contra proteina alfa reguladora de senal y metodos de uso |
| JP7337099B2 (ja) | 2018-05-25 | 2023-09-01 | アレクトル エルエルシー | 抗ｓｉｒｐａ抗体およびその使用法 |
| SG11202012338QA (en) | 2018-07-10 | 2021-01-28 | Univ Kobe Nat Univ Corp | ANTI-SIRPa ANTIBODY |
| WO2020033646A1 (en) | 2018-08-08 | 2020-02-13 | Orionis Biosciences, Inc. | SIRP1α TARGETED CHIMERIC PROTEINS AND USES THEREOF |
| BR112021005585A2 (pt) | 2018-09-27 | 2021-06-29 | Celgene Corporation | proteínas de ligação a sirpa e métodos de uso das mesmas |
| JP2022507295A (ja) | 2018-11-14 | 2022-01-18 | アーチ オンコロジー，インコーポレイテッド | 治療用ＳＩＲＰα抗体 |
| JP7451520B2 (ja) | 2018-11-15 | 2024-03-18 | ビョンディス・ビー．ブイ． | ヒト化抗ＳＩＲＰα抗体 |
| WO2020180811A1 (en) | 2019-03-04 | 2020-09-10 | Qilu Puget Sound Biotherapeutics Corporation | Anti-sirp-alpha antibodies |
| AU2020286285A1 (en) | 2019-08-20 | 2021-03-11 | Elpiscience (Suzhou) Biopharma, Ltd. | Novel anti-SIRPa antibodies |
| CN111635458B (zh) | 2020-03-20 | 2026-02-17 | 健信生物科技(宁波)有限公司 | 靶向Sirpα的抗体或其抗原结合片段及其制备和应用 |
| CN112010979B (zh) | 2020-08-21 | 2022-05-10 | 博奥信生物技术（南京）有限公司 | 一种抗人SIRPα单克隆抗体及其用途 |
| CN111995682B (zh) | 2020-08-21 | 2022-05-10 | 博奥信生物技术（南京）有限公司 | 抗人SIRPα单克隆抗体及其用途 |
| CN112574310B (zh) | 2020-12-11 | 2023-05-05 | 浙江博锐生物制药有限公司 | 抗SIRPα抗体及其用途 |
| TW202317620A (zh) | 2021-06-04 | 2023-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗ＳＩＲＰα抗體 |
-
2022
- 2022-06-02 TW TW111120550A patent/TW202317620A/zh unknown
- 2022-06-02 BR BR112023025194A patent/BR112023025194A2/pt unknown
- 2022-06-02 EP EP22732651.9A patent/EP4347653A1/en active Pending
- 2022-06-02 WO PCT/IB2022/055170 patent/WO2022254379A1/en not_active Ceased
- 2022-06-02 JP JP2022576817A patent/JP7436711B2/ja active Active
- 2022-06-02 PH PH1/2023/553159A patent/PH12023553159A1/en unknown
- 2022-06-02 AU AU2022284373A patent/AU2022284373A1/en active Pending
- 2022-06-02 CA CA3218692A patent/CA3218692A1/en active Pending
- 2022-06-02 KR KR1020247000108A patent/KR20240027677A/ko active Pending
- 2022-06-02 IL IL308741A patent/IL308741A/en unknown
- 2022-06-02 MX MX2023014389A patent/MX2023014389A/es unknown
- 2022-06-02 US US17/831,245 patent/US11572412B2/en active Active
- 2022-11-14 US US18/055,352 patent/US12516127B2/en active Active
-
2023
- 2023-11-24 DO DO2023000259A patent/DOP2023000259A/es unknown
- 2023-11-24 EC ECSENADI202388844A patent/ECSP23088844A/es unknown
- 2023-11-29 JO JOJO/P/2023/0311A patent/JOP20230311A1/ar unknown
- 2023-11-29 CL CL2023003554A patent/CL2023003554A1/es unknown
- 2023-12-04 SA SA523451800A patent/SA523451800B1/ar unknown
- 2023-12-06 CR CR20230573A patent/CR20230573A/es unknown
- 2023-12-12 CO CONC2023/0017156A patent/CO2023017156A2/es unknown
-
2024
- 2024-02-08 JP JP2024018149A patent/JP2024056817A/ja active Pending
-
2025
- 2025-09-29 CL CL2025002941A patent/CL2025002941A1/es unknown
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