JP2024051082A5 - - Google Patents
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- Publication number
- JP2024051082A5 JP2024051082A5 JP2024027527A JP2024027527A JP2024051082A5 JP 2024051082 A5 JP2024051082 A5 JP 2024051082A5 JP 2024027527 A JP2024027527 A JP 2024027527A JP 2024027527 A JP2024027527 A JP 2024027527A JP 2024051082 A5 JP2024051082 A5 JP 2024051082A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- region
- capsid polypeptide
- aav2 capsid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671949P | 2018-05-15 | 2018-05-15 | |
| US62/671,949 | 2018-05-15 | ||
| PCT/US2019/031307 WO2019221992A1 (en) | 2018-05-15 | 2019-05-08 | Viral vectors exhibiting improved gene delivery properties |
| JP2020564154A JP2021522840A (ja) | 2018-05-15 | 2019-05-08 | 改善された遺伝子送達特性を示すウイルスベクター |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564154A Division JP2021522840A (ja) | 2018-05-15 | 2019-05-08 | 改善された遺伝子送達特性を示すウイルスベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024051082A JP2024051082A (ja) | 2024-04-10 |
| JP2024051082A5 true JP2024051082A5 (https=) | 2024-04-19 |
| JP7741575B2 JP7741575B2 (ja) | 2025-09-18 |
Family
ID=68540740
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564154A Withdrawn JP2021522840A (ja) | 2018-05-15 | 2019-05-08 | 改善された遺伝子送達特性を示すウイルスベクター |
| JP2024027527A Active JP7741575B2 (ja) | 2018-05-15 | 2024-02-27 | 改善された遺伝子送達特性を示すウイルスベクター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564154A Withdrawn JP2021522840A (ja) | 2018-05-15 | 2019-05-08 | 改善された遺伝子送達特性を示すウイルスベクター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12338267B2 (https=) |
| EP (1) | EP3813845A4 (https=) |
| JP (2) | JP2021522840A (https=) |
| AU (1) | AU2019270900B2 (https=) |
| CA (1) | CA3100066A1 (https=) |
| WO (1) | WO2019221992A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3461836A1 (en) | 2017-09-28 | 2019-04-03 | Universität zu Köln | Mutated adeno-associated viral capsid proteins for chemical coupling of ligands, nanoparticles or drugs via thioether binding and production method thereof |
| EP4069856A1 (en) * | 2019-12-04 | 2022-10-12 | Sangamo Therapeutics, Inc. | Novel compositions and methods for producing recombinant aav |
| EP4097121A1 (en) * | 2020-01-29 | 2022-12-07 | Genzyme Corporation | Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof |
| CN111349148A (zh) * | 2020-03-13 | 2020-06-30 | 辉大(上海)生物科技有限公司 | 一种腺相关病毒载体及其用途 |
| KR20230005941A (ko) * | 2020-05-01 | 2023-01-10 | 트러스티스 오브 보스톤 칼리지 | 향상된 유전자 요법을 위한 아데노-관련 바이러스(aav)의 제어된 변형 |
| CA3222914A1 (en) * | 2021-06-23 | 2022-12-29 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
| WO2023283962A1 (en) * | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| KR20240095539A (ko) | 2021-10-08 | 2024-06-25 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 변이체 및 이의 사용 방법 |
| EP4508065A2 (en) * | 2022-04-15 | 2025-02-19 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
| EP4508228A2 (en) * | 2022-04-15 | 2025-02-19 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
| WO2026084101A1 (ko) * | 2024-10-18 | 2026-04-23 | 주식회사 아바타테라퓨틱스 | 아데노연관바이러스 변이체 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
| CA2373110A1 (en) | 2000-03-14 | 2001-09-20 | Neurologix, Inc. | Production of chimeric capsid vectors |
| WO2002053703A2 (en) | 2001-01-05 | 2002-07-11 | Children's Hospital, Inc. | Aav2 vectors and methods |
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| EP1486567A1 (en) | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| EP2345731B1 (en) | 2003-09-30 | 2015-10-21 | The Trustees of the University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| US9725485B2 (en) * | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
| ES2714007T3 (es) | 2007-04-09 | 2019-05-24 | Univ Florida | Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso |
| WO2009108274A2 (en) * | 2008-02-26 | 2009-09-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for adeno-associated virus (aav) with hi loop mutations |
| WO2013170078A1 (en) | 2012-05-09 | 2013-11-14 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
| LT3137497T (lt) | 2014-05-02 | 2021-07-26 | Genzyme Corporation | Aav vektoriai, skirti tinklainės ir cns genų terapijai |
| JP7406783B2 (ja) * | 2015-12-14 | 2023-12-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | パルボウイルスベクターの高められた送達のための改変キャプシドタンパク質 |
| WO2017147477A1 (en) * | 2016-02-26 | 2017-08-31 | University Of Florida Research Foundation, Inc. | Aav heparin mutants that display significantly improved eye and brain transduction |
-
2019
- 2019-05-08 EP EP19804601.3A patent/EP3813845A4/en active Pending
- 2019-05-08 CA CA3100066A patent/CA3100066A1/en active Pending
- 2019-05-08 JP JP2020564154A patent/JP2021522840A/ja not_active Withdrawn
- 2019-05-08 US US17/055,318 patent/US12338267B2/en active Active
- 2019-05-08 AU AU2019270900A patent/AU2019270900B2/en active Active
- 2019-05-08 WO PCT/US2019/031307 patent/WO2019221992A1/en not_active Ceased
-
2024
- 2024-02-27 JP JP2024027527A patent/JP7741575B2/ja active Active
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