JP2023543254A - ピリド［４，３－ｂ］インドール誘導体およびその医薬としての使用 - Google Patents

ピリド［４，３－ｂ］インドール誘導体およびその医薬としての使用 Download PDF

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Publication number
JP2023543254A
JP2023543254A JP2023519165A JP2023519165A JP2023543254A JP 2023543254 A JP2023543254 A JP 2023543254A JP 2023519165 A JP2023519165 A JP 2023519165A JP 2023519165 A JP2023519165 A JP 2023519165A JP 2023543254 A JP2023543254 A JP 2023543254A
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substituted
compound according
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disease
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JP2023519165A
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Japanese (ja)
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JP2023543254A5 (https=
Inventor
フェーダー，リー
バーチ，ジェイソン
サン－オンジュ，ミゲル
ドリッチ，ステファン
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Ventus Therapeutics US Inc
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Ventus Therapeutics US Inc
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Publication of JP2023543254A publication Critical patent/JP2023543254A/ja
Publication of JP2023543254A5 publication Critical patent/JP2023543254A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023519165A 2020-09-24 2021-09-23 ピリド［４，３－ｂ］インドール誘導体およびその医薬としての使用 Pending JP2023543254A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063082695P 2020-09-24 2020-09-24
US63/082,695 2020-09-24
PCT/US2021/051670 WO2022066851A1 (en) 2020-09-24 2021-09-23 PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

Publications (2)

Publication Number Publication Date
JP2023543254A true JP2023543254A (ja) 2023-10-13
JP2023543254A5 JP2023543254A5 (https=) 2024-10-01

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ID=80846865

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023519165A Pending JP2023543254A (ja) 2020-09-24 2021-09-23 ピリド［４，３－ｂ］インドール誘導体およびその医薬としての使用

Country Status (7)

Country Link
US (1) US20240018138A1 (https=)
EP (1) EP4216940A4 (https=)
JP (1) JP2023543254A (https=)
CN (1) CN116209442A (https=)
AU (1) AU2021349249A1 (https=)
CA (1) CA3196153A1 (https=)
WO (1) WO2022066851A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022137085A1 (en) 2020-12-22 2022-06-30 Novartis Ag Indole derivatives useful in treating conditions associated with cgas
EP4496796A1 (en) * 2022-03-22 2025-01-29 Ventus Therapeutics U.S., Inc. Hexahydropyrido[4,3-b]indolyl ketone derivatives useful as cgas modulators
AU2023409125A1 (en) * 2022-12-21 2025-06-26 Eli Lilly And Company Azepino[4,5-b]indolone cgas inhibitors
AU2024326748A1 (en) 2023-08-18 2026-04-02 Katholieke Universiteit Leuven 1,3-dihydro-2h-pyrrolo[3,4-c]quinoline derivatives as cgas inhibitors for the treatment of inflammatory and/or autoimmune diseases
CN119490508A (zh) * 2023-08-21 2025-02-21 上海交通大学 一类螺环四氢-γ-咔啉衍生物的制备方法以及应用
WO2025218659A1 (en) * 2024-04-16 2025-10-23 Insilico Medicine Ip Limited Novel compounds as cyclic gmp-amp synthase inhibitor and uses thereof
WO2026026969A1 (zh) * 2024-08-01 2026-02-05 杭州英创医药科技有限公司 作为cGAS抑制剂的化合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012525431A (ja) * 2009-04-29 2012-10-22 メディベイション テクノロジーズ， インコーポレイテッド ピリド［４，３−ｂ］インドールおよびその使用方法
WO2019153002A1 (en) * 2018-02-05 2019-08-08 Lama Lodoe 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases
JP2019521982A (ja) * 2016-06-16 2019-08-08 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ヘテロアリールエストロゲン受容体モジュレーター及びその使用
WO2020142729A1 (en) * 2019-01-04 2020-07-09 BellBrook Labs Inhibitors of cgas activity as therapeutic agents
WO2020186027A1 (en) * 2019-03-13 2020-09-17 Daisuke Tomita Inhibitors of cgas for treating autoinflammatory diseases and cancer metastasis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111511729A (zh) * 2017-12-19 2020-08-07 默克专利股份公司 Tlr7/8拮抗剂及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012525431A (ja) * 2009-04-29 2012-10-22 メディベイション テクノロジーズ， インコーポレイテッド ピリド［４，３−ｂ］インドールおよびその使用方法
JP2019521982A (ja) * 2016-06-16 2019-08-08 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ヘテロアリールエストロゲン受容体モジュレーター及びその使用
WO2019153002A1 (en) * 2018-02-05 2019-08-08 Lama Lodoe 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases
WO2020142729A1 (en) * 2019-01-04 2020-07-09 BellBrook Labs Inhibitors of cgas activity as therapeutic agents
WO2020186027A1 (en) * 2019-03-13 2020-09-17 Daisuke Tomita Inhibitors of cgas for treating autoinflammatory diseases and cancer metastasis

Also Published As

Publication number Publication date
AU2021349249A1 (en) 2023-04-13
EP4216940A1 (en) 2023-08-02
CA3196153A1 (en) 2022-03-31
EP4216940A4 (en) 2025-01-01
WO2022066851A1 (en) 2022-03-31
CN116209442A (zh) 2023-06-02
US20240018138A1 (en) 2024-01-18

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