CN116209442A - 吡啶并[4,3-b]吲哚衍生物及其作为药物的用途 - Google Patents

吡啶并[4,3-b]吲哚衍生物及其作为药物的用途 Download PDF

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Publication number
CN116209442A
CN116209442A CN202180065543.XA CN202180065543A CN116209442A CN 116209442 A CN116209442 A CN 116209442A CN 202180065543 A CN202180065543 A CN 202180065543A CN 116209442 A CN116209442 A CN 116209442A
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compound according
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disease
compound
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CN202180065543.XA
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English (en)
Chinese (zh)
Inventor
L·法德
J·伯奇
M·圣-翁奇
S·多里奇
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Vantex Treatment Usa
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Vantex Treatment Usa
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Publication of CN116209442A publication Critical patent/CN116209442A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202180065543.XA 2020-09-24 2021-09-23 吡啶并[4,3-b]吲哚衍生物及其作为药物的用途 Pending CN116209442A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063082695P 2020-09-24 2020-09-24
US63/082,695 2020-09-24
PCT/US2021/051670 WO2022066851A1 (en) 2020-09-24 2021-09-23 PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

Publications (1)

Publication Number Publication Date
CN116209442A true CN116209442A (zh) 2023-06-02

Family

ID=80846865

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180065543.XA Pending CN116209442A (zh) 2020-09-24 2021-09-23 吡啶并[4,3-b]吲哚衍生物及其作为药物的用途

Country Status (7)

Country Link
US (1) US20240018138A1 (https=)
EP (1) EP4216940A4 (https=)
JP (1) JP2023543254A (https=)
CN (1) CN116209442A (https=)
AU (1) AU2021349249A1 (https=)
CA (1) CA3196153A1 (https=)
WO (1) WO2022066851A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025040087A1 (zh) * 2023-08-21 2025-02-27 上海交通大学 一类螺环四氢-γ-咔啉衍生物的制备方法以及应用
WO2025218659A1 (en) * 2024-04-16 2025-10-23 Insilico Medicine Ip Limited Novel compounds as cyclic gmp-amp synthase inhibitor and uses thereof
WO2026026969A1 (zh) * 2024-08-01 2026-02-05 杭州英创医药科技有限公司 作为cGAS抑制剂的化合物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022137085A1 (en) 2020-12-22 2022-06-30 Novartis Ag Indole derivatives useful in treating conditions associated with cgas
EP4496796A1 (en) * 2022-03-22 2025-01-29 Ventus Therapeutics U.S., Inc. Hexahydropyrido[4,3-b]indolyl ketone derivatives useful as cgas modulators
AU2023409125A1 (en) * 2022-12-21 2025-06-26 Eli Lilly And Company Azepino[4,5-b]indolone cgas inhibitors
AU2024326748A1 (en) 2023-08-18 2026-04-02 Katholieke Universiteit Leuven 1,3-dihydro-2h-pyrrolo[3,4-c]quinoline derivatives as cgas inhibitors for the treatment of inflammatory and/or autoimmune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019153002A1 (en) * 2018-02-05 2019-08-08 Lama Lodoe 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases
CN111511729A (zh) * 2017-12-19 2020-08-07 默克专利股份公司 Tlr7/8拮抗剂及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2424366B1 (en) * 2009-04-29 2016-02-17 Medivation Technologies, Inc. Pyrido [4, 3-b]indoles and methods of use
EP3472162B1 (en) * 2016-06-16 2021-11-17 F. Hoffmann-La Roche AG Heteroaryl estrogen receptor modulators and uses thereof
CA3125625A1 (en) * 2019-01-04 2020-07-09 Bellbrook Labs, Llc Inhibitors of cgas activity as therapeutic agents
US12522603B2 (en) * 2019-03-13 2026-01-13 The Rockefeller University Inhibitors of gas for treating autoinflammatory diseases and cancer metastasis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111511729A (zh) * 2017-12-19 2020-08-07 默克专利股份公司 Tlr7/8拮抗剂及其用途
WO2019153002A1 (en) * 2018-02-05 2019-08-08 Lama Lodoe 2,3,4,5-tetrahydro-1h-pyrido[4, 3-b]indole inhibitors of cgas for treating autoinflammatory diseases

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025040087A1 (zh) * 2023-08-21 2025-02-27 上海交通大学 一类螺环四氢-γ-咔啉衍生物的制备方法以及应用
WO2025218659A1 (en) * 2024-04-16 2025-10-23 Insilico Medicine Ip Limited Novel compounds as cyclic gmp-amp synthase inhibitor and uses thereof
WO2026026969A1 (zh) * 2024-08-01 2026-02-05 杭州英创医药科技有限公司 作为cGAS抑制剂的化合物

Also Published As

Publication number Publication date
AU2021349249A1 (en) 2023-04-13
JP2023543254A (ja) 2023-10-13
EP4216940A1 (en) 2023-08-02
CA3196153A1 (en) 2022-03-31
EP4216940A4 (en) 2025-01-01
WO2022066851A1 (en) 2022-03-31
US20240018138A1 (en) 2024-01-18

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