JP2023530271A5 - - Google Patents

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Publication number
JP2023530271A5
JP2023530271A5 JP2022575989A JP2022575989A JP2023530271A5 JP 2023530271 A5 JP2023530271 A5 JP 2023530271A5 JP 2022575989 A JP2022575989 A JP 2022575989A JP 2022575989 A JP2022575989 A JP 2022575989A JP 2023530271 A5 JP2023530271 A5 JP 2023530271A5
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Japan
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JP2022575989A
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English (en)
Japanese (ja)
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JP2023530271A (ja
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Priority claimed from PCT/US2021/036954 external-priority patent/WO2021252859A1/en
Publication of JP2023530271A publication Critical patent/JP2023530271A/ja
Publication of JP2023530271A5 publication Critical patent/JP2023530271A5/ja
Pending legal-status Critical Current

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JP2022575989A 2020-06-12 2021-06-11 Apol1の阻害剤及びこれを使用する方法 Pending JP2023530271A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063038275P 2020-06-12 2020-06-12
US63/038,275 2020-06-12
US202063040183P 2020-06-17 2020-06-17
US63/040,183 2020-06-17
PCT/US2021/036954 WO2021252859A1 (en) 2020-06-12 2021-06-11 Inhibitors of apol1 and use of the same

Publications (2)

Publication Number Publication Date
JP2023530271A JP2023530271A (ja) 2023-07-14
JP2023530271A5 true JP2023530271A5 (https=) 2024-06-06

Family

ID=76731125

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022575989A Pending JP2023530271A (ja) 2020-06-12 2021-06-11 Apol1の阻害剤及びこれを使用する方法

Country Status (7)

Country Link
US (1) US12281102B2 (https=)
EP (1) EP4165022A1 (https=)
JP (1) JP2023530271A (https=)
CN (1) CN116157393A (https=)
AU (1) AU2021286728A1 (https=)
CA (1) CA3185604A1 (https=)
WO (1) WO2021252859A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
WO2021154997A1 (en) 2020-01-29 2021-08-05 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
IL296035A (en) 2020-03-06 2022-10-01 Vertex Pharma Methods of treating apol-1 dependent focal segmental glomerulosclerosis
CN115867543A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CA3185604A1 (en) 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
MX2024008868A (es) * 2022-01-18 2024-09-23 Maze Therapeutics Inc Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso.

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WO2021154997A1 (en) 2020-01-29 2021-08-05 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
US20210246121A1 (en) 2020-02-04 2021-08-12 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and methods of using same
IL296035A (en) 2020-03-06 2022-10-01 Vertex Pharma Methods of treating apol-1 dependent focal segmental glomerulosclerosis
JP2023524563A (ja) 2020-05-07 2023-06-12 ラムバム メド-テック リミテッド Apol1-関連疾患の治療に使用するための組成物
CA3185604A1 (en) 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
CN115867543A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CN115867532A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1的抑制剂及其用途
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
US20230119114A1 (en) 2021-08-26 2023-04-20 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitors and methods of using same
EP4440697A1 (en) 2021-11-30 2024-10-09 Vertex Pharmaceuticals Incorporated Spirocyclic inhibitors of apol1 and methods of using same
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
CN119212986A (zh) 2022-02-08 2024-12-27 弗特克斯药品有限公司 作为apol1的抑制剂的螺哌啶衍生物及其使用方法
CA3251050A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES USED AS APOL1 INHIBITORS AND THEIR METHODS OF USE
AU2023219516A1 (en) 2022-02-08 2024-08-22 Vertex Pharmaceuticals Incorporated 2-methyl-4-phenylpiperidin-4-ol derivatives as inhibitors of apol1 and methods of using same
EP4476228A1 (en) 2022-02-08 2024-12-18 Vertex Pharmaceuticals Incorporated 4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] derivatives as inhibitors of apol1 and methods of using same

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