JP2023528292A5 - - Google Patents
Info
- Publication number
- JP2023528292A5 JP2023528292A5 JP2022571242A JP2022571242A JP2023528292A5 JP 2023528292 A5 JP2023528292 A5 JP 2023528292A5 JP 2022571242 A JP2022571242 A JP 2022571242A JP 2022571242 A JP2022571242 A JP 2022571242A JP 2023528292 A5 JP2023528292 A5 JP 2023528292A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- chloro
- trifluoromethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20175820.8A EP3912625A1 (en) | 2020-05-20 | 2020-05-20 | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
| EP20175820.8 | 2020-05-20 | ||
| PCT/EP2021/063463 WO2021234084A1 (en) | 2020-05-20 | 2021-05-20 | Maxi-k potassium channel openers for the treatment of fragile x associated disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023528292A JP2023528292A (ja) | 2023-07-04 |
| JP2023528292A5 true JP2023528292A5 (https=) | 2024-05-28 |
Family
ID=70802691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022571242A Pending JP2023528292A (ja) | 2020-05-20 | 2021-05-20 | 脆弱Ｘ関連障害の処置のためのｍａｘｉ－Ｋカリウムチャネルオープナー |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20240351994A1 (https=) |
| EP (2) | EP3912625A1 (https=) |
| JP (1) | JP2023528292A (https=) |
| KR (1) | KR20230016194A (https=) |
| CN (1) | CN115666554A (https=) |
| AU (1) | AU2021274879A1 (https=) |
| BR (1) | BR112022023318A2 (https=) |
| CA (1) | CA3177423A1 (https=) |
| DK (1) | DK4153170T3 (https=) |
| FI (1) | FI4153170T3 (https=) |
| IL (1) | IL297493A (https=) |
| MX (1) | MX2022014461A (https=) |
| PH (1) | PH12022553155A1 (https=) |
| PL (1) | PL4153170T3 (https=) |
| PT (1) | PT4153170T (https=) |
| WO (1) | WO2021234084A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250170120A1 (en) * | 2022-01-31 | 2025-05-29 | The Board Of Regents Of The University Of Texas System | Allosteric sting modulators and methods of use |
| WO2025233532A1 (en) | 2024-05-10 | 2025-11-13 | Les Laboratoires Servier | Maxi-k potassium channel openers and therapeutic applications thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565483A (en) | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| JP2000191661A (ja) * | 1998-12-25 | 2000-07-11 | Mitsubishi-Tokyo Pharmaceuticals Inc | 環状アミド化合物 |
| FR2807038B1 (fr) | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
| MXPA03000032A (es) | 2000-06-29 | 2003-08-19 | Neurosearch As | Uso de derivados de oxindol 3-sustituidos como moduladores de los canales de potasio kcnq. |
| US6348486B1 (en) | 2000-10-17 | 2002-02-19 | American Home Products Corporation | Methods for modulating bladder function |
| EP1363624A2 (en) | 2001-02-20 | 2003-11-26 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators of kcnq potassium channels |
| FR2827604B1 (fr) * | 2001-07-17 | 2003-09-19 | Sanofi Synthelabo | Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
| GEP20074230B (en) | 2002-03-20 | 2007-11-12 | Bristol Myers Squibb Co | Phosphate prodrugs of fluorooxindoles |
| JP4989976B2 (ja) * | 2004-02-13 | 2012-08-01 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 翻訳開始阻害剤としての３−３−二置換オキシインドール |
| US20070299102A1 (en) * | 2004-04-08 | 2007-12-27 | Topo Target A/S | Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer |
| US7576082B2 (en) * | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
| JP2010525024A (ja) * | 2007-04-24 | 2010-07-22 | トポターゲット・アクティーゼルスカブ | 置換３−（４−ヒドロキシフェニル）−インドリン−２−オン化合物 |
| FR2920023B1 (fr) * | 2007-08-16 | 2013-02-08 | Sanofi Aventis | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique |
| US8703775B2 (en) * | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
| JO3032B1 (ar) * | 2008-10-17 | 2016-09-05 | Xenon Pharmaceuticals Inc | مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية. |
| EP2540295A1 (en) | 2011-06-27 | 2013-01-02 | Centre national de la recherche scientifique | Compositions for the treatment of Fragile X syndrome |
| JP6370368B2 (ja) | 2013-03-27 | 2018-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｒｄ４阻害剤としてのインドリノン類似体 |
| US20180318285A1 (en) * | 2015-03-10 | 2018-11-08 | President And Fellows Of Harvard College | Methods for treatment of autism spectrum disorders |
| EP3601235B1 (en) * | 2017-03-30 | 2026-03-04 | XWPharma Ltd. | Bicyclic heteroaryl derivatives, preparation and therapeutic uses thereof |
| WO2020183307A1 (en) * | 2019-03-08 | 2020-09-17 | The University Of Buea | Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones and their analogues and derivatives and methods of treating cancer and other diseases |
-
2020
- 2020-05-20 EP EP20175820.8A patent/EP3912625A1/en not_active Withdrawn
-
2021
- 2021-05-20 WO PCT/EP2021/063463 patent/WO2021234084A1/en not_active Ceased
- 2021-05-20 CA CA3177423A patent/CA3177423A1/en active Pending
- 2021-05-20 IL IL297493A patent/IL297493A/en unknown
- 2021-05-20 MX MX2022014461A patent/MX2022014461A/es unknown
- 2021-05-20 PT PT217271477T patent/PT4153170T/pt unknown
- 2021-05-20 KR KR1020227044772A patent/KR20230016194A/ko active Pending
- 2021-05-20 BR BR112022023318A patent/BR112022023318A2/pt unknown
- 2021-05-20 US US17/999,400 patent/US20240351994A1/en active Pending
- 2021-05-20 EP EP21727147.7A patent/EP4153170B1/en active Active
- 2021-05-20 PL PL21727147.7T patent/PL4153170T3/pl unknown
- 2021-05-20 CN CN202180035813.2A patent/CN115666554A/zh active Pending
- 2021-05-20 AU AU2021274879A patent/AU2021274879A1/en active Pending
- 2021-05-20 PH PH1/2022/553155A patent/PH12022553155A1/en unknown
- 2021-05-20 JP JP2022571242A patent/JP2023528292A/ja active Pending
- 2021-05-20 FI FIEP21727147.7T patent/FI4153170T3/fi active
- 2021-05-20 DK DK21727147.7T patent/DK4153170T3/da active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2720237C2 (ru) | Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет | |
| US10231967B2 (en) | Compounds and their use as BACE inhibitors | |
| TWI535442B (zh) | A nitrogen-containing heterocyclic compound having an action of inhibiting the production of canine erythritine | |
| CN113214287B (zh) | Hpk1抑制剂及其使用方法 | |
| TW202200552A (zh) | 作為用於免疫活化之DGKζ抑制劑之經取代胺基噻唑 | |
| CN105189506A (zh) | 用于治疗寄生虫疾病的化合物和组合物 | |
| EA032621B1 (ru) | Индазолкарбоксамиды, способы их получения, содержащие их фармацевтические препараты и их применение для изготовления лекарственных средств | |
| US20160045505A1 (en) | Compounds and compositions for the treatment of parasitic diseases | |
| EA023420B1 (ru) | Замещенные имидазопиридазины | |
| JP7269928B2 (ja) | インドールアミン ２，３－ジオキシゲナーゼ（ｉｄｏ）阻害剤としての新規の置換ビアリール化合物 | |
| JP2025517733A (ja) | ヘテロアレーン、それを含む医薬組成物、及びその使用方法 | |
| WO2014151630A2 (en) | Compounds and compositions for the treatment of parasitic diseases | |
| JP2016514711A (ja) | ヤヌスキナーゼ阻害剤としての非環式シアノエチルピラゾロピリドン | |
| JP2023528292A5 (https=) | ||
| EA030823B1 (ru) | СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТОЗОЙНОЙ ПРОТЕОСОМЫ ДЛЯ ЛЕЧЕНИЯ ПАРАЗИТАРНОГО ЗАБОЛЕВАНИЯ, ТАКОГО КАК ЛЕЙШМАНИОЗ | |
| AU2023357827A1 (en) | Cyclopentane compound | |
| US20240076291A1 (en) | Modified isoindolinones as glucosylceramide synthase inhibitors | |
| KR20260041885A (ko) | 표적화된 단백질 분해를 위한 치환된 피페리딘디온 | |
| US20260124201A1 (en) | Cyclopentane compound | |
| JP2025158955A (ja) | シクロペンタン化合物を含む医薬組成物 | |
| US20240287022A1 (en) | Il4i1 inhibitors and methods of use | |
| EA053099B1 (ru) | Циклопентановое соединение | |
| HK40057478B (zh) | Hpk1抑制剂及其使用方法 | |
| EA047452B1 (ru) | Биарильные производные в качестве ингибиторов белок-белкового взаимодействия yap/taz-tead |