JP2023515672A5 - - Google Patents

Info

Publication number
JP2023515672A5
JP2023515672A5 JP2022552551A JP2022552551A JP2023515672A5 JP 2023515672 A5 JP2023515672 A5 JP 2023515672A5 JP 2022552551 A JP2022552551 A JP 2022552551A JP 2022552551 A JP2022552551 A JP 2022552551A JP 2023515672 A5 JP2023515672 A5 JP 2023515672A5
Authority
JP
Japan
Prior art keywords
microrna
mir
binding site
vector
microrna binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022552551A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023515672A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/020032 external-priority patent/WO2021178246A1/en
Publication of JP2023515672A publication Critical patent/JP2023515672A/ja
Publication of JP2023515672A5 publication Critical patent/JP2023515672A5/ja
Priority to JP2026007624A priority Critical patent/JP2026076236A/ja
Pending legal-status Critical Current

Links

JP2022552551A 2020-03-02 2021-02-26 心筋細胞発現マイクロrnaによる遺伝子ベクター制御 Pending JP2023515672A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026007624A JP2026076236A (ja) 2020-03-02 2026-01-20 心筋細胞発現マイクロrnaによる遺伝子ベクター制御

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062984183P 2020-03-02 2020-03-02
US62/984,183 2020-03-02
PCT/US2021/020032 WO2021178246A1 (en) 2020-03-02 2021-02-26 Gene vector control by cardiomyocyte-expressed micrornas

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026007624A Division JP2026076236A (ja) 2020-03-02 2026-01-20 心筋細胞発現マイクロrnaによる遺伝子ベクター制御

Publications (2)

Publication Number Publication Date
JP2023515672A JP2023515672A (ja) 2023-04-13
JP2023515672A5 true JP2023515672A5 (enExample) 2024-03-05

Family

ID=75143738

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022552551A Pending JP2023515672A (ja) 2020-03-02 2021-02-26 心筋細胞発現マイクロrnaによる遺伝子ベクター制御
JP2026007624A Pending JP2026076236A (ja) 2020-03-02 2026-01-20 心筋細胞発現マイクロrnaによる遺伝子ベクター制御

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2026007624A Pending JP2026076236A (ja) 2020-03-02 2026-01-20 心筋細胞発現マイクロrnaによる遺伝子ベクター制御

Country Status (10)

Country Link
US (1) US20230103731A1 (enExample)
EP (1) EP4114421A1 (enExample)
JP (2) JP2023515672A (enExample)
KR (1) KR20220149590A (enExample)
CN (1) CN115552022A (enExample)
AU (1) AU2021230476A1 (enExample)
BR (1) BR112022017551A2 (enExample)
CA (1) CA3173567A1 (enExample)
IL (1) IL295989A (enExample)
WO (1) WO2021178246A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020047467A2 (en) 2018-08-30 2020-03-05 Tenaya Therapeutics, Inc. Cardiac cell reprogramming with myocardin and ascl1
WO2025178388A1 (ko) * 2024-02-20 2025-08-28 가천대학교 산학협력단 통증 치료용 의약 조성물
WO2025219365A1 (en) * 2024-04-15 2025-10-23 BioNTech SE Repression of cargo expression
CN120754123A (zh) * 2025-08-15 2025-10-10 吉林大学第一医院 LncRNA XIST在制备预防血管紧张素II引起心肌损伤药物中的应用

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5591624A (en) 1988-03-21 1997-01-07 Chiron Viagene, Inc. Retroviral packaging cell lines
US7070994B2 (en) 1988-03-21 2006-07-04 Oxford Biomedica (Uk) Ltd. Packaging cells
JP3082204B2 (ja) 1988-09-01 2000-08-28 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5817491A (en) 1990-09-21 1998-10-06 The Regents Of The University Of California VSV G pseusdotyped retroviral vectors
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
WO1993003769A1 (en) 1991-08-20 1993-03-04 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Adenovirus mediated transfer of genes to the gastrointestinal tract
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
US5702932A (en) 1992-07-20 1997-12-30 University Of Florida Microinjection methods to transform arthropods with exogenous DNA
DE4228457A1 (de) 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
JPH08503855A (ja) 1992-12-03 1996-04-30 ジェンザイム・コーポレイション 嚢胞性線維症に対する遺伝子治療
US5834256A (en) 1993-06-11 1998-11-10 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
ATE304604T1 (de) 1993-06-24 2005-09-15 Frank L Graham Adenovirus vektoren für gentherapie
DE69434594T2 (de) 1993-10-25 2006-09-21 Canji, Inc., San Diego Rekombinante adenoviren-vektor und verfahren zur verwendung
US5656610A (en) 1994-06-21 1997-08-12 University Of Southern California Producing a protein in a mammal by injection of a DNA-sequence into the tongue
FR2722208B1 (fr) 1994-07-05 1996-10-04 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
FR2751345B1 (fr) 1996-07-16 1998-09-18 Univ Paris Curie Lignees d'encapsidation hautement productrices
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
CA2265460A1 (en) 1996-09-11 1998-03-19 The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services Aav4 vector and uses thereof
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
US6156303A (en) 1997-06-11 2000-12-05 University Of Washington Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
US5994624A (en) 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6984517B1 (en) 1998-05-28 2006-01-10 The United States Of America As Represented By The Department Of Health And Human Services AAV5 vector and uses thereof
US6759237B1 (en) 1998-11-05 2004-07-06 The Trustees Of The University Of Pennsylvania Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
US6995009B1 (en) 1999-06-01 2006-02-07 Chugai Seiyaku Kabushiki Kaisha Packaging cell
AU2001255575B2 (en) 2000-04-28 2006-08-31 The Trustees Of The University Of Pennsylvania Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
DE50109634D1 (de) 2000-08-31 2006-06-01 Edwin Lundgren Steuervorrichtung für einen lenkdrachen an einem boot
WO2002053703A2 (en) 2001-01-05 2002-07-11 Children's Hospital, Inc. Aav2 vectors and methods
SG10202108118RA (en) 2001-11-13 2021-08-30 Univ Pennsylvania A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
ES2975413T3 (es) 2001-12-17 2024-07-05 Univ Pennsylvania Secuencias de serotipo 8 de virus adenoasociado (AAV), vectores que las contienen y usos de las mismas
ES2526341T3 (es) 2001-12-17 2015-01-09 The Trustees Of The University Of Pennsylvania Secuencias de serotipo 9 de virus adeno-asociado (AAV), vectores que las contienen, y usos de las mismas
US7485291B2 (en) 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
PL2357189T3 (pl) 2003-06-19 2017-08-31 Genzyme Corporation Wiriony AAV o zmniejszonej immunoreaktywności i ich zastosowanie
US9441244B2 (en) 2003-06-30 2016-09-13 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
HUE054805T2 (hu) 2003-09-30 2021-09-28 Univ Pennsylvania Adeno-asszociált vírus (AAV) kládok, szekvenciák, az azokat tartalmazó vektorok és alkalmazásaik
EP2476756A1 (en) 2005-06-15 2012-07-18 Massachusetts Institute of Technology Amine-containing lipids and uses thereof
CN101448942B (zh) * 2005-12-12 2014-04-23 北卡罗来纳大学查珀尔希尔分校 调节肌细胞增殖和分化的microrna
BRPI0714794A2 (pt) * 2006-08-01 2013-05-21 Univ Texas identificaÇço de um micro-rna que ativa a expressço da cadeia pesada de beta-miosina
US20100303723A1 (en) 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
NZ583025A (en) * 2007-07-31 2012-06-29 Univ Texas Micro-rnas that control myosin expression and myofiber identity
CN102083980A (zh) * 2008-02-21 2011-06-01 得克萨斯系统大学董事会 调节平滑肌增殖和分化的微小rna及其用途
WO2009157201A1 (en) * 2008-06-26 2009-12-30 Osaka University Method and kit for preparing ips cells
US9333163B2 (en) 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains
MX2011004859A (es) 2008-11-07 2011-08-03 Massachusetts Inst Technology Lipidoides de aminoalcohol y usos de los mismos.
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US9238716B2 (en) 2011-03-28 2016-01-19 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
KR20150000461A (ko) 2011-10-27 2015-01-02 메사추세츠 인스티튜트 오브 테크놀로지 약물 캡슐화 마이크로스피어를 형성할 수 있는, n-말단 상에 관능화된 아미노산 유도체
WO2013078316A1 (en) 2011-11-23 2013-05-30 Nationwide Children's Hospital, Inc. Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
RU2020105656A (ru) * 2013-07-17 2021-01-27 Юниверсити Оф Питтсбург- Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Нетоксичные векторы на основе впг для применений в эффективной доставке генов и комплементирующие клетки для их продуцирования
US10538740B2 (en) * 2014-03-20 2020-01-21 Kyoto University Method for sorting cardiomyocytes
ES2860712T3 (es) 2015-03-24 2021-10-05 Univ California Variantes de virus adenoasociados y métodos de uso de las mismas
US20180072988A1 (en) * 2015-04-10 2018-03-15 Agency For Science, Technology And Research Generation of functional cells from stem cells
JP6853538B2 (ja) * 2016-03-15 2021-03-31 国立大学法人 筑波大学 線維芽細胞からの心臓前駆細胞と心筋細胞の直接製造方法

Similar Documents

Publication Publication Date Title
EP1390490B1 (en) Muscle-specific expression vectors
JP2009178593A (ja) 生体組織の細胞治療と電気治療の方法と装置
CN106978415B (zh) 转运rna片段及其应用
JP2023524291A5 (enExample)
JP2020534314A (ja) 不整脈源性右心室心筋症における電気的機能及び心臓機能並びに心構造を回復するための遺伝子療法戦略
Saitoh et al. Expression of myogenic factors in denervated chicken breast muscle: isolation of the chicken Myf5 gene
JP2019506895A (ja) 成人幹細胞から誘導されたペースメーカ細胞及びプルキンエ細胞
CN116218849B (zh) 针对utrophin激活治疗杜氏肌营养不良的sgRNA和应用
CN102127546B (zh) 一种骨骼肌特异性actin启动子及其应用
KR101760618B1 (ko) Sox 유전자가 이입된 비바이러스성 미니써클 벡터 및 이의 제조방법
CN107252491A (zh) 用于治疗心力衰竭的药物及其筛选方法和制备方法
JP2022525193A5 (enExample)
CN113559266A (zh) Ckip-1 3`UTR在预防和/或治疗心力衰竭疾病药物中的应用
JPWO2021020509A5 (enExample)
KR102236843B1 (ko) 새로운 재생 치료제로서의 camkk1
US20060128647A1 (en) Novel oligonucleotides and treating cardiac disorders by using the same
WO2021067613A1 (en) Compositions and methods for treating amyotrophic lateral sclerosis
CN110404053A (zh) 短肽mpm在制备用于治疗肌肉细胞分化相关疾病的药物中的应用
CN111840327B (zh) 治疗糖尿病足的间质干细胞制剂及其应用
US20250360171A1 (en) Chemogenetically gated ion channels and use thereof
CN113956345B (zh) Angpt4蛋白及其编码基因在调控心脏损伤后的修复与再生能力中的应用
US20240301355A1 (en) Methods of inducing cardiac cell proliferation and inducing heart regeneration
CN101502659A (zh) Krüppel样转录因子4的新用途
EP4547845A2 (en) Gene therapy of hippo signaling improves heart function in a clinically relevant model
Shah et al. Embryonic expression and evolution of duplicated E-protein genes in Xenopus laevis: parallels with ancestral E-protein genes