JP2023513752A - 外部から導入された細胞シグナル伝達調節因子を過剰発現する免疫細胞及びその使用 - Google Patents

外部から導入された細胞シグナル伝達調節因子を過剰発現する免疫細胞及びその使用 Download PDF

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JP2023513752A
JP2023513752A JP2022548955A JP2022548955A JP2023513752A JP 2023513752 A JP2023513752 A JP 2023513752A JP 2022548955 A JP2022548955 A JP 2022548955A JP 2022548955 A JP2022548955 A JP 2022548955A JP 2023513752 A JP2023513752 A JP 2023513752A
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cells
protein
domain
car
polynucleotide
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フン キム，
チョンジュ チョン，
ユ ワン，
ナムチュル ジュン，
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Beijing Yongtai Ruike Biotechnology Co Ltd
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4472742A1 (en) * 2022-02-03 2024-12-11 University College Cardiff Consultants Limited Novel t-cell receptor
CN114774364B (zh) * 2022-04-26 2024-04-26 深圳市体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其制备方法和应用
WO2024121426A1 (en) * 2022-12-09 2024-06-13 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Method for optimizing t cells for immuno-therapy
IL322949A (en) 2023-03-03 2025-10-01 Arsenal Biosciences Inc Systems targeting PSMA and CA9
CN116376844B (zh) * 2023-05-31 2023-08-11 四川大学华西医院 包含shp2 sh2结构域的靶向her2阳性肿瘤的car-t及制备方法和应用
CN116355859B (zh) * 2023-05-31 2023-08-11 四川大学华西医院 包含shp2 n-sh2结构域的靶向her2阳性肿瘤的car-t及制备方法和应用
CN116814664B (zh) * 2023-08-25 2023-12-12 中国医学科学院肿瘤医院 一种扩展肿瘤识别表位的cea嵌合抗原受体t细胞的制备与应用
WO2025111277A2 (en) * 2023-11-20 2025-05-30 Carisma Therapeutics Inc. Compositions and methods relating to redirected soluble modulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016056228A1 (ja) * 2014-10-09 2016-04-14 国立大学法人山口大学 Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞
WO2018237022A1 (en) * 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
CN109265565A (zh) * 2018-10-10 2019-01-25 苏州大学 一种携带分子开关的抗CD79b嵌合抗原受体及其修饰的免疫细胞和应用
JP2019535292A (ja) * 2016-11-28 2019-12-12 オートラス リミテッド シグナル伝達改変タンパク質

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098897A2 (en) 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
DK2956175T3 (da) * 2013-02-15 2017-11-27 Univ California Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf
CN109863242A (zh) * 2016-08-30 2019-06-07 纪念斯隆-凯特林癌症中心 用于治疗病毒感染和其它感染的免疫细胞组合物和使用方法
MA46862A (fr) * 2016-11-17 2019-09-25 Bluebird Bio Inc Convertisseur de signaux tgf béta
SG11201906552WA (en) * 2017-01-25 2019-08-27 Tessa Therapeutics Pte Ltd TGF-ß DECOY RECEPTOR
US20190381171A1 (en) * 2017-02-17 2019-12-19 Unum Therapeutics Inc. Co-use of anti-bcma antibody and antibody-coupled t cell receptor (actr) in cancer therapy and b cell disorders
KR102746901B1 (ko) * 2017-03-03 2024-12-26 옵시디안 테라퓨틱스, 인크. Cd19 조성물 및 면역요법을 위한 방법
CN110831619A (zh) * 2017-03-22 2020-02-21 诺华股份有限公司 具有增强功效的生物标志和car t细胞疗法
CN108218999B (zh) * 2018-01-02 2021-06-11 广东省人民医院(广东省医学科学院) 分泌il-7的嵌合抗原受体、病毒载体、表达细胞及制备方法与药物
WO2020123947A1 (en) * 2018-12-14 2020-06-18 Bluebird Bio, Inc. Dimerizing agent regulated immunoreceptor complexes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016056228A1 (ja) * 2014-10-09 2016-04-14 国立大学法人山口大学 Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞
JP2019535292A (ja) * 2016-11-28 2019-12-12 オートラス リミテッド シグナル伝達改変タンパク質
WO2018237022A1 (en) * 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
CN109265565A (zh) * 2018-10-10 2019-01-25 苏州大学 一种携带分子开关的抗CD79b嵌合抗原受体及其修饰的免疫细胞和应用

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