JP2023513354A - カルパイン-2阻害剤化合物および治療方法 - Google Patents
カルパイン-2阻害剤化合物および治療方法 Download PDFInfo
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- JP2023513354A JP2023513354A JP2022548842A JP2022548842A JP2023513354A JP 2023513354 A JP2023513354 A JP 2023513354A JP 2022548842 A JP2022548842 A JP 2022548842A JP 2022548842 A JP2022548842 A JP 2022548842A JP 2023513354 A JP2023513354 A JP 2023513354A
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025272786A JP2026053525A (ja) | 2020-02-12 | 2025-12-22 | カルパイン-2阻害剤化合物および治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062975644P | 2020-02-12 | 2020-02-12 | |
| US62/975,644 | 2020-02-12 | ||
| PCT/US2021/018042 WO2021163631A1 (en) | 2020-02-12 | 2021-02-12 | Calpain-2 inhibitor compounds and methods of treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025272786A Division JP2026053525A (ja) | 2020-02-12 | 2025-12-22 | カルパイン-2阻害剤化合物および治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023513354A true JP2023513354A (ja) | 2023-03-30 |
| JP2023513354A5 JP2023513354A5 (https=) | 2024-02-21 |
Family
ID=77291654
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022548842A Pending JP2023513354A (ja) | 2020-02-12 | 2021-02-12 | カルパイン-2阻害剤化合物および治療方法 |
| JP2025272786A Pending JP2026053525A (ja) | 2020-02-12 | 2025-12-22 | カルパイン-2阻害剤化合物および治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025272786A Pending JP2026053525A (ja) | 2020-02-12 | 2025-12-22 | カルパイン-2阻害剤化合物および治療方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US12606520B2 (https=) |
| JP (2) | JP2023513354A (https=) |
| WO (1) | WO2021163631A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025255171A1 (en) * | 2024-06-03 | 2025-12-11 | Western University Of Health Sciences | Treatment of neurodegenerative diseases and disorders |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017538681A (ja) * | 2014-11-11 | 2017-12-28 | ウェスタン ユニバーシティ オブ ヘルス サイエンス | アイソフォーム特異的カルパイン阻害剤、同定方法、およびその使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2252310A4 (en) | 2008-02-06 | 2011-09-07 | Georgia Tech Res Inst | HETEROCYCLIC PEPTIDE KETOAMIDE |
| US20210179543A1 (en) | 2018-08-13 | 2021-06-17 | Western University Of Health Sciences | Calpain-2 selective inhibitor compounds for treatment of glaucoma |
-
2021
- 2021-02-12 US US17/904,208 patent/US12606520B2/en active Active
- 2021-02-12 WO PCT/US2021/018042 patent/WO2021163631A1/en not_active Ceased
- 2021-02-12 JP JP2022548842A patent/JP2023513354A/ja active Pending
-
2025
- 2025-12-22 JP JP2025272786A patent/JP2026053525A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017538681A (ja) * | 2014-11-11 | 2017-12-28 | ウェスタン ユニバーシティ オブ ヘルス サイエンス | アイソフォーム特異的カルパイン阻害剤、同定方法、およびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US12606520B2 (en) | 2026-04-21 |
| WO2021163631A1 (en) | 2021-08-19 |
| JP2026053525A (ja) | 2026-03-25 |
| US20230091121A1 (en) | 2023-03-23 |
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