JP2023509766A5 - - Google Patents

Info

Publication number
JP2023509766A5
JP2023509766A5 JP2022541951A JP2022541951A JP2023509766A5 JP 2023509766 A5 JP2023509766 A5 JP 2023509766A5 JP 2022541951 A JP2022541951 A JP 2022541951A JP 2022541951 A JP2022541951 A JP 2022541951A JP 2023509766 A5 JP2023509766 A5 JP 2023509766A5
Authority
JP
Japan
Prior art keywords
cells
expression construct
immune
composition according
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022541951A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023509766A (ja
JP7690211B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/012510 external-priority patent/WO2021142127A1/en
Publication of JP2023509766A publication Critical patent/JP2023509766A/ja
Publication of JP2023509766A5 publication Critical patent/JP2023509766A5/ja
Application granted granted Critical
Publication of JP7690211B2 publication Critical patent/JP7690211B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022541951A 2020-01-08 2021-01-07 Cd70陽性腫瘍を標的化するようにナチュラルキラー細胞を操作する方法 Active JP7690211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062958563P 2020-01-08 2020-01-08
US62/958,563 2020-01-08
PCT/US2021/012510 WO2021142127A1 (en) 2020-01-08 2021-01-07 A method of engineering natural killer cells to target cd70-positive tumors

Publications (3)

Publication Number Publication Date
JP2023509766A JP2023509766A (ja) 2023-03-09
JP2023509766A5 true JP2023509766A5 (https=) 2023-12-27
JP7690211B2 JP7690211B2 (ja) 2025-06-10

Family

ID=76788268

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022541951A Active JP7690211B2 (ja) 2020-01-08 2021-01-07 Cd70陽性腫瘍を標的化するようにナチュラルキラー細胞を操作する方法

Country Status (11)

Country Link
US (1) US20230060351A1 (https=)
EP (1) EP4087618A4 (https=)
JP (1) JP7690211B2 (https=)
KR (1) KR20220125805A (https=)
CN (1) CN115243728A (https=)
AU (1) AU2021205249A1 (https=)
BR (1) BR112022013445A2 (https=)
CA (1) CA3166832A1 (https=)
MX (1) MX2022008485A (https=)
TW (1) TW202135840A (https=)
WO (1) WO2021142127A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024539129A (ja) * 2021-10-21 2024-10-28 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増強された代謝適合性を有する治療用免疫細胞の製造方法およびその組成物
WO2023100153A1 (en) * 2021-12-03 2023-06-08 Crispr Therapeutics Ag Use of anti-cd70 antibodies for identifying subjects susceptible for treatment with nk cell-based anti-cd70 therapy
KR20250004736A (ko) * 2022-04-07 2025-01-08 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 조작된 자연 살해 세포의 활성화 및 증대 및 항체와의 조합을 위한 방법
WO2024251290A1 (en) * 2023-06-09 2024-12-12 Suzhou Cure Genetics Biosciences Co., Limited Engineered immune cells and uses thereof
CN116769722B (zh) * 2023-07-04 2024-07-16 杭州荣谷生物科技有限公司 功能增强型car-nk细胞、其制备方法及其在免疫疗法中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2686347B1 (en) 2011-03-16 2018-05-02 argenx BVBA Antibodies to cd70
GB201206559D0 (en) * 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
EP3230310B1 (en) 2014-12-08 2019-06-12 The U.S.A. as represented by the Secretary, Department of Health and Human Services Anti-cd70 chimeric antigen receptors
AU2017237543B2 (en) * 2016-03-23 2020-02-06 Institut Pasteur Korea Antibody that binds to envelope glycoprotein of severe fever with thrombocytopenia syndrome virus, and use for same
BR112019002035A2 (pt) * 2016-08-01 2019-05-14 Novartis Ag tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2
EP3612210A4 (en) 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS
CN112020518A (zh) 2018-02-01 2020-12-01 辉瑞公司 靶向cd70的嵌合抗原受体
KR20210005240A (ko) 2018-05-03 2021-01-13 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 면역 관문 차단과 함께 키메라 항원 수용체를 발현하도록 가공된 천연 킬러 세포
JP7599205B2 (ja) * 2018-06-01 2024-12-13 アンヘレス セラピューティクス インコーポレイテッド 細胞療法のための多様な抗原結合ドメイン、新規プラットフォームおよびその他の強化
CN109880802B (zh) 2018-11-30 2022-12-13 北京美康基免生物科技有限公司 一种基于cd19和cd70的双重嵌合抗原受体基因修饰的免疫细胞及其应用

Similar Documents

Publication Publication Date Title
JP2023509766A5 (https=)
US11679132B2 (en) Methods for enhancing efficacy of therapeutic immune cells
JP7264954B2 (ja) Her2を標的とするキメラ抗原受容体
JP7300763B2 (ja) Car発現ベクター及びcar発現t細胞
JP2022051744A (ja) Cs1標的化キメラ抗原受容体修飾t細胞
CN109385403B (zh) 靶向gpc3的car nk细胞
EP3995512A1 (en) Anti cd30 chimeric antigen receptor and its use
JP2022548902A5 (https=)
JP2024519515A5 (https=)
BR112016023500B1 (pt) Ácido nucleico que codifica um receptor quimérico, método para a preparação de uma célula hospedeira e usos do mesmo
JP2017512054A (ja) 三官能性t細胞−抗原カプラ及び方法並びにこれらの使用
CN109280086B (zh) 一种肿瘤微环境特异性活化的缺氧诱导型嵌合抗原受体
CN108276493A (zh) 一种新型嵌合抗原受体及其应用
JP6990244B2 (ja) ヒトcd123を標的とするキメラ受容体リガンド及びその応用
CN110564695A (zh) 靶向前列腺癌的增强型car-t细胞及其制备方法和药物
JP2024527559A5 (https=)
JP2024525609A5 (https=)
KR20210018838A (ko) 유전자 조작된 세포 및 응용
JP2023548467A5 (https=)
CN119546327A (zh) 多部分受体和信号传导复合物
KR20230066007A (ko) 신규한 보조자극 도메인을 포함하는 키메라 항원 수용체 및 이의 용도
CN111479918A (zh) 细胞
JP2024525492A5 (https=)
WO2021057906A1 (zh) 表达il-15的免疫效应细胞
Van Caeneghem et al. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities