|
US4324893A
(en)
|
1979-04-18 |
1982-04-13 |
American Home Products Corporation |
4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
|
|
JP2544939B2
(ja)
|
1987-09-01 |
1996-10-16 |
大塚製薬株式会社 |
ベンゾヘテロ環誘導体
|
|
UY27304A1
(es)
|
2001-05-24 |
2002-12-31 |
Avanir Pharmaceuticals |
Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
|
|
BR0312204A
(pt)
|
2002-06-27 |
2005-04-26 |
Schering Ag |
Antagonista de receptor ccr5 de quinolina substituìda
|
|
GB0230018D0
(en)
|
2002-12-23 |
2003-01-29 |
Syngenta Ltd |
Fungicides
|
|
TW200418829A
(en)
|
2003-02-14 |
2004-10-01 |
Avanir Pharmaceutics |
Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
|
|
WO2004087880A2
(en)
|
2003-03-26 |
2004-10-14 |
Bayer Pharmaceuticals Corporation |
Compounds and their use to treat diabetes and related disorders
|
|
GB0316915D0
(en)
|
2003-07-18 |
2003-08-20 |
Glaxo Group Ltd |
Compounds
|
|
EP1660087A2
(en)
|
2003-07-22 |
2006-05-31 |
Janssen Pharmaceutica N.V. |
Quinolinone derivatives as inhibitors of c-fms kinase
|
|
CN1839133A
(zh)
|
2003-08-22 |
2006-09-27 |
阿文尼尔药品公司 |
作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用
|
|
US7381401B2
(en)
|
2004-01-08 |
2008-06-03 |
The University Of Chicago |
T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ｏｘ４０ｌ抗體
|
|
PT2343320T
(pt)
|
2005-03-25 |
2018-01-23 |
Gitr Inc |
Anticorpos anti-gitr e as suas utilizações
|
|
PL1879573T3
(pl)
|
2005-05-10 |
2013-05-31 |
Incyte Holdings Corp |
Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
US8450351B2
(en)
|
2005-12-20 |
2013-05-28 |
Incyte Corporation |
N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
|
|
GB0605689D0
(en)
|
2006-03-21 |
2006-05-03 |
Novartis Ag |
Organic compounds
|
|
JP5422204B2
(ja)
|
2006-03-30 |
2014-02-19 |
国立大学法人 千葉大学 |
ＤＧＫα阻害剤を含有する抗癌剤
|
|
JP2007308402A
(ja)
|
2006-05-17 |
2007-11-29 |
Sumitomo Chemical Co Ltd |
シンナモイル化合物及びその用途
|
|
JP2007308441A
(ja)
|
2006-05-22 |
2007-11-29 |
Sumitomo Chemical Co Ltd |
含複素環化合物及びその用途
|
|
WO2008036642A2
(en)
|
2006-09-19 |
2008-03-27 |
Incyte Corporation |
N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
|
|
CL2007002650A1
(es)
|
2006-09-19 |
2008-02-08 |
Incyte Corp |
Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
|
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
US8591886B2
(en)
|
2007-07-12 |
2013-11-26 |
Gitr, Inc. |
Combination therapies employing GITR binding molecules
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
US10047066B2
(en)
|
2007-11-30 |
2018-08-14 |
Newlink Genetics Corporation |
IDO inhibitors
|
|
WO2009156652A1
(fr)
|
2008-05-29 |
2009-12-30 |
Saint-Gobain Centre De Recherches Et D'etudes Europeen |
Structure en nid d'abeille a base de titanate d'aluminium
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
WO2010042489A2
(en)
|
2008-10-06 |
2010-04-15 |
Emory University |
Aminoquinoline derived heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
US20110319416A1
(en)
|
2009-01-28 |
2011-12-29 |
Emory University |
Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions
|
|
KR101790802B1
(ko)
|
2009-09-03 |
2017-10-27 |
머크 샤프 앤드 돔 코포레이션 |
항-ｇｉｔｒ 항체
|
|
EP2493862B1
(en)
|
2009-10-28 |
2016-10-05 |
Newlink Genetics Corporation |
Imidazole derivatives as ido inhibitors
|
|
ES2722300T3
(es)
|
2009-12-10 |
2019-08-09 |
Hoffmann La Roche |
Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
|
|
EP2542256B1
(en)
|
2010-03-04 |
2019-05-22 |
MacroGenics, Inc. |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
US9169323B2
(en)
|
2010-03-05 |
2015-10-27 |
Hoffmann-La Roche Inc. |
Antibodies against human CSF-1R
|
|
JP5989547B2
(ja)
|
2010-03-05 |
2016-09-07 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
ヒトｃｓｆ−１ｒに対する抗体及びその使用
|
|
HRP20190047T1
(hr)
|
2010-05-04 |
2019-02-22 |
Five Prime Therapeutics, Inc. |
Protutijela koja se vežu na csf1r
|
|
US9050334B2
(en)
|
2010-07-16 |
2015-06-09 |
Innov88 Llc |
MIF inhibitors and their uses
|
|
MX337040B
(es)
|
2010-09-09 |
2016-02-09 |
Pfizer |
Moleculas de union a 4-1bb.
|
|
WO2012142498A2
(en)
|
2011-04-13 |
2012-10-18 |
Innovimmune Biotherapeutics, Inc. |
Mif inhibitors and their uses
|
|
NO2694640T3
(https=)
|
2011-04-15 |
2018-03-17 |
|
|
|
JP6072771B2
(ja)
|
2011-04-20 |
2017-02-01 |
メディミューン，エルエルシー |
Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子
|
|
KR101764096B1
(ko)
|
2011-11-28 |
2017-08-02 |
메르크 파텐트 게엠베하 |
항-ｐｄ-ｌ1 항체 및 그의 용도
|
|
RU2658603C2
(ru)
|
2011-12-15 |
2018-06-21 |
Ф.Хоффманн-Ля Рош Аг |
Антитела против человеческого csf-1r и их применения
|
|
KR20140127855A
(ko)
|
2012-02-06 |
2014-11-04 |
제넨테크, 인크. |
Csf1r 억제제를 사용하는 조성물 및 방법
|
|
AR089939A1
(es)
|
2012-02-09 |
2014-10-01 |
Glenmark Pharmaceuticals Sa |
COMPUESTOS BICICLICOS COMO INHIBIDORES DE mPGES-1
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
RU2670743C9
(ru)
|
2012-05-11 |
2018-12-19 |
Файв Прайм Терапьютикс, Инк. |
Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
|
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
|
CN107759690A
(zh)
|
2012-08-31 |
2018-03-06 |
戊瑞治疗有限公司 |
用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
|
|
WO2014039513A2
(en)
|
2012-09-04 |
2014-03-13 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
|
|
MA41168A
(fr)
|
2014-12-17 |
2017-10-24 |
Acraf |
Nouveaux composés antibactériens
|
|
ES2898765T3
(es)
|
2015-04-10 |
2022-03-08 |
Araxes Pharma Llc |
Compuestos de quinazolina sustituidos y métodos de uso de los mismos
|
|
PT3889145T
(pt)
|
2015-12-17 |
2024-04-02 |
Merck Patent Gmbh |
8-ciano-5-piperidino-quinolinas como antagonistas de tlr7/8 e suas utilizações para tratamento de distúrbios imunitários
|
|
US10946020B2
(en)
|
2016-04-06 |
2021-03-16 |
University Of Virginia Patent Foundation |
Compositions and methods for treating cancer
|
|
CN110366550A
(zh)
|
2016-12-22 |
2019-10-22 |
美国安进公司 |
作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
|
|
GB201700814D0
(en)
|
2017-01-17 |
2017-03-01 |
Liverpool School Tropical Medicine |
Compounds
|
|
AU2018273356B2
(en)
|
2017-05-22 |
2021-09-16 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
US12187687B2
(en)
|
2017-06-26 |
2025-01-07 |
University Of Virginia Patent Foundation |
Compositions and uses thereof
|
|
AU2018340475B2
(en)
|
2017-09-28 |
2023-01-19 |
Transthera Sciences (Nanjing), Inc. |
PDE9 inhibitor and use thereof
|
|
CA3098574A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
CN112585139B
(zh)
*
|
2018-06-27 |
2023-12-01 |
百时美施贵宝公司 |
用作t细胞激活剂的萘啶酮化合物
|
|
KR102767739B1
(ko)
|
2018-06-27 |
2025-02-12 |
브리스톨-마이어스 스큅 컴퍼니 |
T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물
|
|
WO2020071550A1
(ja)
|
2018-10-04 |
2020-04-09 |
京都薬品工業株式会社 |
Ｃｄｋ８阻害剤およびその用途
|
|
AR119821A1
(es)
|
2019-08-28 |
2022-01-12 |
Bristol Myers Squibb Co |
Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
|
|
US20230064809A1
(en)
|
2019-11-28 |
2023-03-02 |
Bayer Aktiengesellschaft |
Substituted aminoquinolones as dgkalpha inhibitors for immune activation
|
|
US20230062100A1
(en)
|
2019-11-28 |
2023-03-02 |
Bayer Aktiengesellschaft |
Substituted aminoquinolones as dgkalpha inhibitors for immune activation
|
|
CR20220236A
(es)
|
2019-11-28 |
2022-10-03 |
Bayer Pharma AG |
Aminoquinolonas sustituidas como inhibidores de dgk alfa para la activación inmune
|