JP2013533879A5 - - Google Patents
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- JP2013533879A5 JP2013533879A5 JP2013518581A JP2013518581A JP2013533879A5 JP 2013533879 A5 JP2013533879 A5 JP 2013533879A5 JP 2013518581 A JP2013518581 A JP 2013518581A JP 2013518581 A JP2013518581 A JP 2013518581A JP 2013533879 A5 JP2013533879 A5 JP 2013533879A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- substituted
- unsubstituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35956910P | 2010-06-29 | 2010-06-29 | |
| US61/359,569 | 2010-06-29 | ||
| PCT/US2011/042215 WO2012003189A1 (en) | 2010-06-29 | 2011-06-28 | Compositions and methods for modulating the wnt signaling pathway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533879A JP2013533879A (ja) | 2013-08-29 |
| JP2013533879A5 true JP2013533879A5 (https=) | 2014-07-03 |
| JP5778270B2 JP5778270B2 (ja) | 2015-09-16 |
Family
ID=44514972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518581A Expired - Fee Related JP5778270B2 (ja) | 2010-06-29 | 2011-06-28 | Wntシグナル伝達経路調節のための組成物および方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9181235B2 (https=) |
| EP (1) | EP2588453B1 (https=) |
| JP (1) | JP5778270B2 (https=) |
| KR (1) | KR20130131290A (https=) |
| CN (1) | CN102958917B (https=) |
| AR (1) | AR082029A1 (https=) |
| AU (1) | AU2011271479B2 (https=) |
| BR (1) | BR112012033350A2 (https=) |
| CA (1) | CA2803879A1 (https=) |
| CL (1) | CL2012003604A1 (https=) |
| CO (1) | CO6650353A2 (https=) |
| CU (1) | CU20120174A7 (https=) |
| DO (1) | DOP2012000329A (https=) |
| EA (1) | EA201390032A1 (https=) |
| EC (1) | ECSP13012410A (https=) |
| ES (1) | ES2536216T3 (https=) |
| MA (1) | MA34388B1 (https=) |
| MX (1) | MX2012015092A (https=) |
| NI (1) | NI201200190A (https=) |
| PE (1) | PE20130311A1 (https=) |
| PH (1) | PH12012502571A1 (https=) |
| SG (1) | SG186473A1 (https=) |
| TN (1) | TN2012000575A1 (https=) |
| TW (1) | TW201206921A (https=) |
| UY (1) | UY33469A (https=) |
| WO (1) | WO2012003189A1 (https=) |
| ZA (1) | ZA201300319B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| RU2486859C1 (ru) * | 2012-02-02 | 2013-07-10 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский институт глазных болезней имени Гельмгольца" Министерства здравоохранения и социального развития Российской Федерации | Способ оценки эффективности комбинированного органосохраняющего лечения первичной начальной ретинобластомы у детей |
| EP2861590B1 (en) * | 2012-06-15 | 2017-10-25 | Curegenix Inc. | Compound as wnt signaling inhibitor, composition, and use thereof |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
| AP2016009099A0 (en) * | 2013-11-01 | 2016-03-31 | Novartis Ag | Aminoheteroaryl benzamides as kinase inhibitors |
| KR102525131B1 (ko) * | 2014-10-08 | 2023-04-24 | 레드엑스 파마 피엘씨 | Wnt 신호 경로의 억제제로서의 N-피리디닐 아세트아미드 유도체 |
| PT3204381T (pt) * | 2014-10-08 | 2022-07-18 | Redx Pharma Plc | Derivados de n-piridinil acetamida como inibidores da via de sinalização wnt |
| CN104557862B (zh) * | 2014-12-15 | 2017-05-17 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
| JP6889116B2 (ja) | 2015-02-03 | 2021-06-18 | カドモン ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 安定トリエンチン製剤 |
| US20180092866A1 (en) * | 2015-04-15 | 2018-04-05 | University Of Utah Research Foundation | Substituted n-([1,1'-biphenyl]-3-yl)-[1,1'-biphenyl]-3-carboxamide analogs as inhibitors for beta-catenin/b-cell lymphoma 9 interactions |
| AU2016267142B2 (en) * | 2015-05-26 | 2020-12-24 | Curegenix Corporation | Tumor biomarkers and use thereof |
| CN107759584B (zh) * | 2016-08-16 | 2021-06-01 | 苏州云轩医药科技有限公司 | 一种具有Wnt信号通路抑制活性的氨基五元杂环化合物及其应用 |
| CN107056754B (zh) * | 2015-12-07 | 2020-12-04 | 苏州信诺维医药科技有限公司 | 内嵌脲类结构的wnt通路抑制剂 |
| EP3388428B1 (en) * | 2015-12-07 | 2021-08-04 | Suzhou Sinovent Pharmaceuticals Company | Five-membered heterocyclic amides wnt pathway inhibitor |
| WO2017165839A1 (en) | 2016-03-25 | 2017-09-28 | University Of Utah Research Foundation | Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/b-cell lymphoma 9 inhibitors |
| WO2018045182A1 (en) * | 2016-09-01 | 2018-03-08 | The Board Of Regents Of Hte University Of Texas System | Disubstituted and trisubtituted 1,2,3-triazoles as wnt inhibitors |
| EP3717465B1 (en) * | 2017-11-30 | 2026-01-21 | Step Pharma S.A.S. | Compounds |
| WO2019106156A1 (en) | 2017-11-30 | 2019-06-06 | Step Pharma S.A.S. | Compounds |
| WO2019124603A1 (ko) * | 2017-12-22 | 2019-06-27 | 경상대학교병원 | Iwr-1을 유효성분으로 함유하는 켈로이드 예방 또는 치료용 조성물 |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US12522587B2 (en) * | 2018-05-04 | 2026-01-13 | Remedy Plan, Inc. | Cancer treatments targeting cancer stem cells |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN111662228B (zh) * | 2019-03-07 | 2023-07-28 | 中国医学科学院药物研究所 | 吡啶酮酰联芳基胺类化合物及其用途 |
| IL288508B2 (en) | 2019-06-04 | 2026-02-01 | Step Pharma S A S | History of n-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl)tetrahydro-h2-pyran-4-carboxamide and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases |
| EP4438603A4 (en) | 2021-11-25 | 2025-06-11 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | CHIMERIC COMPOUND FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF |
| US20230399299A1 (en) * | 2022-06-14 | 2023-12-14 | Amygdala Neurosciences, Inc. | Aldh-2 inhibitor compounds and methods of use |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| EP1501514B1 (en) * | 2002-05-03 | 2012-12-19 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
| DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| US20080275062A1 (en) * | 2004-01-30 | 2008-11-06 | David Harold Drewry | Chemical Compounds |
| CA2637620A1 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| AU2007292242A1 (en) * | 2006-09-08 | 2008-03-13 | Genentech, Inc. | Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders |
| JP2011502148A (ja) | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのp2x3受容体アンタゴニスト |
| AU2008335709A1 (en) | 2007-12-13 | 2009-06-18 | Amgen Inc. | Gamma secretase modulators |
| ES2524883T3 (es) * | 2008-03-18 | 2014-12-15 | Merck Sharp & Dohme Corp. | 4-Hidroxipirimidina-5-carboxamidas sustituidas |
| JP2011521958A (ja) * | 2008-05-27 | 2011-07-28 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | Wntタンパク質シグナル伝達阻害剤 |
| US8384140B2 (en) | 2008-07-29 | 2013-02-26 | International Business Machines Corporation | Structure for dual contact trench capacitor and structure thereof |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
-
2011
- 2011-06-27 UY UY0001033469A patent/UY33469A/es not_active Application Discontinuation
- 2011-06-28 MX MX2012015092A patent/MX2012015092A/es not_active Application Discontinuation
- 2011-06-28 JP JP2013518581A patent/JP5778270B2/ja not_active Expired - Fee Related
- 2011-06-28 EA EA201390032A patent/EA201390032A1/ru unknown
- 2011-06-28 AU AU2011271479A patent/AU2011271479B2/en not_active Expired - Fee Related
- 2011-06-28 PH PH1/2012/502571A patent/PH12012502571A1/en unknown
- 2011-06-28 EP EP11733945.7A patent/EP2588453B1/en active Active
- 2011-06-28 BR BR112012033350A patent/BR112012033350A2/pt not_active IP Right Cessation
- 2011-06-28 SG SG2012095980A patent/SG186473A1/en unknown
- 2011-06-28 ES ES11733945.7T patent/ES2536216T3/es active Active
- 2011-06-28 US US13/701,982 patent/US9181235B2/en active Active
- 2011-06-28 PE PE2012002648A patent/PE20130311A1/es not_active Application Discontinuation
- 2011-06-28 KR KR1020137002280A patent/KR20130131290A/ko not_active Withdrawn
- 2011-06-28 MA MA35576A patent/MA34388B1/fr unknown
- 2011-06-28 CN CN201180032354.9A patent/CN102958917B/zh active Active
- 2011-06-28 CA CA2803879A patent/CA2803879A1/en not_active Abandoned
- 2011-06-28 WO PCT/US2011/042215 patent/WO2012003189A1/en not_active Ceased
- 2011-06-29 AR ARP110102283A patent/AR082029A1/es not_active Application Discontinuation
- 2011-06-29 TW TW100122939A patent/TW201206921A/zh unknown
-
2012
- 2012-12-05 TN TNP2012000575A patent/TN2012000575A1/en unknown
- 2012-12-20 NI NI201200190A patent/NI201200190A/es unknown
- 2012-12-20 CL CL2012003604A patent/CL2012003604A1/es unknown
- 2012-12-20 CU CU2012000174A patent/CU20120174A7/es unknown
- 2012-12-27 DO DO2012000329A patent/DOP2012000329A/es unknown
- 2012-12-27 CO CO12234891A patent/CO6650353A2/es unknown
-
2013
- 2013-01-14 ZA ZA2013/00319A patent/ZA201300319B/en unknown
- 2013-01-29 EC ECSP13012410 patent/ECSP13012410A/es unknown
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