JP2023504568A5 - - Google Patents
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- Publication number
- JP2023504568A5 JP2023504568A5 JP2022534346A JP2022534346A JP2023504568A5 JP 2023504568 A5 JP2023504568 A5 JP 2023504568A5 JP 2022534346 A JP2022534346 A JP 2022534346A JP 2022534346 A JP2022534346 A JP 2022534346A JP 2023504568 A5 JP2023504568 A5 JP 2023504568A5
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962943779P | 2019-12-04 | 2019-12-04 | |
| US201962943797P | 2019-12-04 | 2019-12-04 | |
| US62/943,779 | 2019-12-04 | ||
| US62/943,797 | 2019-12-04 | ||
| US202062972194P | 2020-02-10 | 2020-02-10 | |
| US62/972,194 | 2020-02-10 | ||
| US202063022248P | 2020-05-08 | 2020-05-08 | |
| US63/022,248 | 2020-05-08 | ||
| US202063087582P | 2020-10-05 | 2020-10-05 | |
| US63/087,582 | 2020-10-05 | ||
| PCT/US2020/063494 WO2021113777A2 (en) | 2019-12-04 | 2020-12-04 | Circular rna compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504568A JP2023504568A (ja) | 2023-02-03 |
| JPWO2021113777A5 JPWO2021113777A5 (https=) | 2023-12-13 |
| JP2023504568A5 true JP2023504568A5 (https=) | 2023-12-13 |
Family
ID=76222668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022534346A Pending JP2023504568A (ja) | 2019-12-04 | 2020-12-04 | 環状ｒｎａ組成物及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US11679120B2 (https=) |
| EP (2) | EP4289951A3 (https=) |
| JP (1) | JP2023504568A (https=) |
| CN (2) | CN115052635B (https=) |
| AU (1) | AU2020397956A1 (https=) |
| CA (1) | CA3160739A1 (https=) |
| ES (1) | ES2961245T3 (https=) |
| MX (1) | MX2022006854A (https=) |
| WO (1) | WO2021113777A2 (https=) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3100276A1 (en) | 2018-06-06 | 2019-12-12 | Massachusetts Institute Of Technology | Circular rna for translation in eukaryotic cells |
| WO2020237227A1 (en) | 2019-05-22 | 2020-11-26 | Massachusetts Institute Of Technology | Circular rna compositions and methods |
| AU2020397956A1 (en) | 2019-12-04 | 2022-07-07 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| WO2021236952A1 (en) * | 2020-05-20 | 2021-11-25 | Flagship Pioneering, Inc. | Compositions and methods for producing human polyclonal antibodies |
| MX2023002439A (es) | 2020-09-03 | 2023-05-09 | Flagship Pioneering Innovations Vi Llc | Composiciones immunogénicas y usos de las mismas. |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| CN115997018A (zh) | 2021-03-10 | 2023-04-21 | 尔知渃米斯股份有限公司 | 自身环化rna构建体 |
| JP2024512669A (ja) | 2021-03-31 | 2024-03-19 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | タノトランスミッションポリペプチド及び癌の処置におけるそれらの使用 |
| EP4359521A4 (en) * | 2021-06-25 | 2025-12-17 | Univ Leland Stanford Junior | COMPOSITIONS AND METHOD FOR IMPROVED PROTEIN TRANSLATION FROM RECOMBINANT CIRCULAR RNAS |
| IL309767A (en) * | 2021-07-13 | 2024-02-01 | Generation Bio Co | Single chain variable fragment (scfv) modified lipid nanoparticle compositions and uses thereof |
| CN114591952B (zh) * | 2021-08-13 | 2024-06-25 | 苏州科锐迈德生物医药科技有限公司 | 一种组织特异性表达的环状rna分子及其应用 |
| WO2023039594A1 (en) | 2021-09-13 | 2023-03-16 | Ganna Bio, Inc. | Glycan conjugate compositions and methods |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| CN118317944A (zh) | 2021-09-14 | 2024-07-09 | 雷纳嘉德医疗管理公司 | 非环状脂质及其使用方法 |
| ES2994006T3 (en) | 2021-09-17 | 2025-01-16 | Flagship Pioneering Innovations Vi Llc | Compositions and methods for producing circular polyribonucleotides |
| CA3233336A1 (en) * | 2021-09-26 | 2023-03-30 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Circular rna and preparation method thereof |
| JP2024538144A (ja) | 2021-10-18 | 2024-10-18 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ポリリボヌクレオチドを精製するための組成物及び方法 |
| MX2024006440A (es) | 2021-11-24 | 2024-08-19 | Flagship Pioneering Innovations Vi Llc | Composiciones inmunogenicas y sus usos. |
| EP4436984A1 (en) | 2021-11-24 | 2024-10-02 | Flagship Pioneering Innovations VI, LLC | Coronavirus immunogen compositions and their uses |
| AU2022397292A1 (en) | 2021-11-24 | 2024-05-30 | Flagship Pioneering Innovations Vi, Llc | Varicella-zoster virus immunogen compositions and their uses |
| JP2024546855A (ja) | 2021-12-17 | 2024-12-26 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 変性条件下での環状ｒｎａの濃縮方法 |
| KR20240117149A (ko) | 2021-12-22 | 2024-07-31 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법 |
| MX2024007870A (es) | 2021-12-23 | 2024-08-15 | Flagship Pioneering Innovations Vi Llc | Polirribonucleotidos circulares que codifican polipeptidos antifusogenicos. |
| WO2023122752A1 (en) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| EP4486728A4 (en) * | 2022-03-02 | 2026-02-25 | Barcode Nanotech Ltd | IONIZABLE LIPIDS AND COMPOSITIONS CONTAINING THEM |
| CN114507691A (zh) * | 2022-03-02 | 2022-05-17 | 深圳市瑞吉生物科技有限公司 | 一种用于制备环状rna的载体及其应用 |
| EP4499607A1 (en) | 2022-03-25 | 2025-02-05 | Sail Biomedicines, Inc. | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
| CN119013404A (zh) * | 2022-04-06 | 2024-11-22 | 新加坡科技研究局 | 用于产生环状rna的载体 |
| CA3255619A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | CYCLIC LIPIDS AND LIPID NANOPARTICLES (LPNs) FOR THE SUPPLY OF NUCLEIC ACIDS OR PEPTIDES INTENDED FOR USE IN VACCINATION AGAINST INFECTIOUS AGENTS |
| JP2025511756A (ja) | 2022-04-08 | 2025-04-16 | フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー | ワクチン及び関連する方法 |
| US12297285B2 (en) * | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| CN115786374B (zh) * | 2022-07-06 | 2023-10-13 | 广州吉赛生物科技股份有限公司 | 一种利用鱼腥藻内含子自剪切核酶精准制备环状rna的方法 |
| JP2025525778A (ja) | 2022-08-01 | 2025-08-07 | フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー | 免疫調節タンパク質及び関連方法 |
| AU2023334610A1 (en) | 2022-08-31 | 2025-03-13 | Sail Biomedicines, Inc. | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
| US12247202B2 (en) * | 2022-09-10 | 2025-03-11 | Exclcirc (Suzhou) Biomedical Co., Ltd. | Circular RNAS and preparation methods thereof |
| EP4584252A1 (en) * | 2022-09-11 | 2025-07-16 | Barcode Nanotech Ltd. | Ionizable lipids and compositions comprising same |
| EP4596605A4 (en) * | 2022-09-30 | 2026-01-14 | Xiamen Sinopeg Biotech Co Ltd | PEGYLATED LIPID CONTAINING A LYSIN NUCLEUS |
| WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| EP4605009A2 (en) | 2022-10-21 | 2025-08-27 | GanNA Bio, Inc. | Glycan conjugate compositions and methods |
| AU2023372397A1 (en) | 2022-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| CN115927592B (zh) * | 2022-11-07 | 2024-06-28 | 中南大学湘雅医院 | Csde1基因为靶点在制备用于治疗非酒精性脂肪肝的药物中的应用 |
| CN120390656A (zh) | 2022-11-08 | 2025-07-29 | 欧纳医疗公司 | 环状rna组合物 |
| EP4615465A1 (en) | 2022-11-08 | 2025-09-17 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for producing circular polyribonucleotides |
| WO2024124164A2 (en) * | 2022-12-09 | 2024-06-13 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of immunostimulatory cytokines to chimeric antigen receptor immune cells |
| AU2023398825A1 (en) | 2022-12-15 | 2025-06-26 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2024151583A2 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
| US20240238473A1 (en) | 2023-01-09 | 2024-07-18 | Beth Israel Deaconess Medical Center, Inc. | Recombinant nucleic acid molecules and their use in wound healing |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| US20240252520A1 (en) | 2023-01-09 | 2024-08-01 | Beth Israel Deaconess Medical Center, Inc. | Therapeutic agents and their use for treating chronic wounds |
| WO2024167885A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
| IL322468A (en) | 2023-02-13 | 2025-09-01 | Flagship Pioneering Innovations Vii Llc | Ionizable lipids containing degradable crosslinkers and lipid carriers for therapeutic compositions |
| CN116411023B (zh) * | 2023-02-24 | 2025-08-12 | 北京大学人民医院 | 一种新型环状rna成环序列构建car-t细胞及在治疗小细胞肺癌中的应用 |
| WO2024192420A1 (en) | 2023-03-15 | 2024-09-19 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising polyribonucleotides and uses thereof |
| EP4680276A1 (en) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Immunogenic compositions and uses thereof |
| WO2024216128A1 (en) | 2023-04-12 | 2024-10-17 | Flagship Pioneering Innovations Vi, Llc | Trems for use in correction of missense mutations |
| WO2024216191A1 (en) | 2023-04-12 | 2024-10-17 | Flagship Pioneering Innovations Vi, Llc | Modified trems, compositions, and related methods thereof |
| EP4698150A1 (en) | 2023-04-19 | 2026-02-25 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024220746A2 (en) | 2023-04-21 | 2024-10-24 | Flagship Pioneering Innovations Vii, Llc | Rnai agents targeting fatty acid synthase and related methods |
| WO2024233308A2 (en) | 2023-05-05 | 2024-11-14 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| EP4464713A1 (en) | 2023-05-18 | 2024-11-20 | Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii | Circular rna analogs, preparation and application thereof |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2024258829A1 (en) | 2023-06-12 | 2024-12-19 | Flagship Pioneering Innovations Vii, Llc | Sars-cov-2 vaccine compositions and related methods |
| WO2025006684A1 (en) | 2023-06-28 | 2025-01-02 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
| WO2025007148A1 (en) | 2023-06-30 | 2025-01-02 | Orna Therapeutics, Inc. | Polymer lipid nanoparticle compositions for delivering circular polynucleotides |
| CN119265241A (zh) | 2023-06-30 | 2025-01-07 | 深圳菁童生命科学有限公司 | 一种无相分离转录因子介导启始阶段重编程使细胞年轻化的方法 |
| WO2025011502A1 (zh) * | 2023-07-07 | 2025-01-16 | 仁景(苏州)生物科技有限公司 | 制备环状rna方法及用于所述方法的核酸序列 |
| AU2024299627A1 (en) | 2023-07-25 | 2026-01-22 | Flagship Pioneering Innovations Vii, Llc | Cas endonucleases and related methods |
| WO2025042786A1 (en) | 2023-08-18 | 2025-02-27 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| WO2025049690A1 (en) | 2023-08-29 | 2025-03-06 | Orna Therapeutics, Inc. | Circular polyethylene glycol lipids |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025054236A2 (en) | 2023-09-06 | 2025-03-13 | Flagship Pioneering Innovations Vii, Llc | Sars-cov-2 vaccine compositions and related methods |
| AU2024344058A1 (en) | 2023-09-18 | 2026-04-02 | Flagship Pioneering Innovations Vii, Llc | Ionizable lipidoid compositions and therapeutic uses thereof |
| WO2025072331A1 (en) | 2023-09-26 | 2025-04-03 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| WO2025096807A2 (en) | 2023-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vii, Llc | Novel therapeutic dna forms |
| WO2025101501A1 (en) | 2023-11-07 | 2025-05-15 | Orna Therapeutics, Inc. | Circular rna compositions |
| WO2025106670A1 (en) | 2023-11-14 | 2025-05-22 | Flagship Pioneering Innovations Vii, Llc | Ionizable lipidoid compositions and therapeutic uses thereof |
| US20250161347A1 (en) | 2023-11-22 | 2025-05-22 | Flagship Pioneering Innovations Vii, Llc | Methods and compositions for treating non-alcoholic fatty liver disease |
| WO2025117877A2 (en) | 2023-12-01 | 2025-06-05 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| WO2025117969A1 (en) | 2023-12-01 | 2025-06-05 | Orna Therapeutics, Inc. | Process for manufacturing lipid nanoparticles |
| WO2025120230A1 (en) | 2023-12-07 | 2025-06-12 | T-Curx Gmbh | Method of producing leukocytes expressing artificial antigen receptors |
| WO2025124548A1 (zh) * | 2023-12-13 | 2025-06-19 | 上海瑞宏迪医药有限公司 | 一种咪唑类脂质及其应用 |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| TW202545974A (zh) | 2024-01-26 | 2025-12-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 免疫受體抑制蛋白及相關方法 |
| WO2025166238A1 (en) | 2024-01-31 | 2025-08-07 | Orna Therapeutics, Inc. | Fast-shedding polyethylene glycol lipids |
| WO2025194019A1 (en) | 2024-03-14 | 2025-09-18 | Flagship Pioneering Innovations Vii, Llc | Methods for treating liver fibrosis and non-alcoholic fatty liver disease |
| WO2025217275A2 (en) | 2024-04-10 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Immune cell targeted compositions and related methods |
| WO2025240680A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245188A2 (en) | 2024-05-21 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Methods of treating liver steatosis and non-alcoholic fatty liver disease |
| WO2025245111A1 (en) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor targeting proteins and related methods |
| WO2025250751A1 (en) | 2024-05-31 | 2025-12-04 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| US20260000702A1 (en) | 2024-06-26 | 2026-01-01 | Flagship Pioneering Innovations Vii, Llc | Therapeutic circular dna forms |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026006593A1 (en) | 2024-06-28 | 2026-01-02 | Orna Therapeutics, Inc. | Synthetic internal ribosome entry sites |
| WO2026055342A1 (en) | 2024-09-04 | 2026-03-12 | Arsenal Biosciences, Inc. | Synthetic pathway activators |
| WO2026055543A1 (en) | 2024-09-06 | 2026-03-12 | Flagship Pioneering Innovations Vii, Llc | Modified dna compositions and related methods |
| WO2026055547A1 (en) | 2024-09-06 | 2026-03-12 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| WO2026064313A1 (en) | 2024-09-17 | 2026-03-26 | Flagship Pioneering Innovations Vii, Llc | Rna compositions and related methods |
| WO2026072709A1 (en) | 2024-09-25 | 2026-04-02 | Orna Therapeutics, Inc. | Chimeric antigen receptors targeting bcma |
| CN121737128A (zh) * | 2026-03-02 | 2026-03-27 | 合肥综合性国家科学中心大健康研究院 | 一种提高环状rna稳定性的序列优化方法及应用和产品 |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2948884A1 (de) | 1979-12-05 | 1981-06-11 | Basf Ag, 6700 Ludwigshafen | 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren |
| US4661450A (en) | 1983-05-03 | 1987-04-28 | Molecular Genetics Research And Development Limited Partnership | Molecular cloning of RNA using RNA ligase and synthetic oligonucleotides |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| FR2645866B1 (fr) | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| JPH07502898A (ja) | 1992-01-13 | 1995-03-30 | デューク・ユニバーシティー | 酵素ｒｎａ分子 |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5283241A (en) | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| DK148292D0 (da) | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Forbindelser |
| US5591737A (en) | 1992-12-17 | 1997-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US6096880A (en) | 1993-04-15 | 2000-08-01 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| US5434261A (en) | 1993-07-26 | 1995-07-18 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| HUT75224A (en) | 1993-10-19 | 1997-04-28 | Merck & Co Inc | Combination of bisphosphonates and growth hormone secretagogues |
| AU686780B2 (en) | 1994-03-11 | 1998-02-12 | Merck & Co., Inc. | Composition for the treatment of lung disease |
| CA2144940A1 (en) | 1994-03-18 | 1995-09-19 | Chikara Murakata | Therapeutic agent for thrombocytopenia and indolocarbazole derivatives |
| US5656606A (en) | 1995-02-17 | 1997-08-12 | Merck & Co., Inc. | Camphor compounds promote release of growth hormone |
| US5747485A (en) | 1995-04-13 | 1998-05-05 | Merck & Co., Inc. | Substituted azetidiones as anti-inflammatory and antidegenerative agents |
| US5766903A (en) | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| GB2308064A (en) | 1995-10-31 | 1997-06-18 | Merck & Co Inc | Treatment of congestive heart failure with a growth hormone secretagogue |
| US5700549A (en) | 1996-06-24 | 1997-12-23 | International Business Machines Corporation | Structure to reduce stress in multilayer ceramic substrates |
| GB2324726A (en) | 1997-05-01 | 1998-11-04 | Merck & Co Inc | Combination Therapy for the Treatment of Osteoporosis |
| EP0897908A1 (de) | 1997-08-19 | 1999-02-24 | Roche Diagnostics GmbH | 3-Aryl-Succinamido-Hydroxamsäuren, Prozesse zu ihrer Herstellung und diese Substanzen enthaltende Medikamente |
| IL135578A0 (en) | 1997-10-29 | 2001-05-20 | Genzyme Corp | Compositions and methods for treating lysosomal storage disease |
| US6211174B1 (en) | 1997-10-31 | 2001-04-03 | Merck & Co., Inc. | Naphtho-fused lactams promote release of growth hormone |
| US5948902A (en) | 1997-11-20 | 1999-09-07 | South Alabama Medical Science Foundation | Antisense oligonucleotides to human serine/threonine protein phosphatase genes |
| WO1999035281A1 (en) | 1998-01-09 | 1999-07-15 | University Of Utah Research Foundation | Method for in vitro amplification of circular dna |
| US6210931B1 (en) | 1998-11-30 | 2001-04-03 | The United States Of America As Represented By The Secretary Of Agriculture | Ribozyme-mediated synthesis of circular RNA |
| CA2400634A1 (en) | 2000-02-17 | 2001-08-23 | Chester Li | Genetic modification of the lung as a portal for gene delivery |
| BRPI0109522B8 (pt) | 2000-03-28 | 2017-04-11 | Farm Bioindustries Pty Ltd | construto genético linear e métodos para gerar planta transgênica ou progênie da mesma resistente a vírus ssdna e planta ou parte da mesma geneticamente modificada |
| EP1355159A1 (de) | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen von Fragmenten der Carbamoylphosphat Synthetase 1 (CPS 1) für die Diagnose von Entzündungserkrankungen und Sepsis |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| CN1882548A (zh) | 2003-10-24 | 2006-12-20 | 奥斯佩克斯制药公司 | 2,6－二异丙基苯酚的pH敏感性前药 |
| WO2005079803A1 (en) | 2004-02-13 | 2005-09-01 | Pfizer Products, Inc. | Compounds for treatment of cardiovascular diseases |
| US7799565B2 (en) | 2004-06-07 | 2010-09-21 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering RNA |
| US8361794B2 (en) | 2004-06-29 | 2013-01-29 | Immunocore Limited | Cells expressing a modified T cell receptor |
| US7786153B2 (en) | 2005-03-02 | 2010-08-31 | Abbott Laboratories Inc. | Compounds that are useful for improving pharmacokinetics |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| US9006487B2 (en) | 2005-06-15 | 2015-04-14 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| WO2007044627A2 (en) | 2005-10-06 | 2007-04-19 | Sloan Kettering Institute For Cancer Research | Compositions and methods for delivery of interfering rna |
| CN101016264A (zh) | 2007-01-22 | 2007-08-15 | 西安新安医药科技有限公司 | 用于治疗的硝基咪唑衍生物、制备方法及用途 |
| JP5296328B2 (ja) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | １本鎖環状ｒｎａおよびその製造方法 |
| US8283344B2 (en) | 2007-09-10 | 2012-10-09 | Merck & Co., Inc. | Method of treating inherited severe neutropenia |
| PT2242773T (pt) | 2008-02-11 | 2017-09-15 | Cure Tech Ltd | Anticorpos monoclonais para o tratamento de tumores |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| CN102203132A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂的组合物和使用方法 |
| WO2010098788A2 (en) | 2008-08-25 | 2010-09-02 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| JP5147612B2 (ja) | 2008-09-11 | 2013-02-20 | 本田技研工業株式会社 | 自動二輪車のレギュレータ冷却構造 |
| CN104119242B (zh) | 2008-10-09 | 2017-07-07 | 泰米拉制药公司 | 改善的氨基脂质和递送核酸的方法 |
| ES2646630T3 (es) | 2008-11-07 | 2017-12-14 | Massachusetts Institute Of Technology | Lipidoides aminoalcohólicos y usos de los mismos |
| WO2010084371A1 (en) | 2009-01-26 | 2010-07-29 | Mitoprod | Novel circular interfering rna molecules |
| US20100305197A1 (en) * | 2009-02-05 | 2010-12-02 | Massachusetts Institute Of Technology | Conditionally Active Ribozymes And Uses Thereof |
| US20120202801A1 (en) | 2009-05-27 | 2012-08-09 | Liangxian Cao | Methods for treating breast cancer |
| US8697662B2 (en) | 2009-05-27 | 2014-04-15 | Ptc Therapeutics, Inc. | Methods for treating Kaposi sarcoma |
| WO2010138685A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
| MX373926B (es) | 2009-05-27 | 2020-07-10 | Ptc Therapeutics Inc | Metodos para tratar cancer y estados no neoplasicos. |
| US20120157402A1 (en) | 2009-05-27 | 2012-06-21 | Liangxian Cao | Methods for treating brain tumors |
| US20120157401A1 (en) | 2009-05-27 | 2012-06-21 | Ptc Therapeutics, Inc. | Methods for treating neurofibromatosis |
| JP5267874B2 (ja) | 2009-07-24 | 2013-08-21 | ソニー株式会社 | 信号処理装置、及び、信号処理方法 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| KR20110095439A (ko) | 2010-02-19 | 2011-08-25 | 건국대학교 산학협력단 | 암모니움 이미다졸륨 염 및 이를 함유하는 염료감응 태양전지용 전해질 조성물 |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| EP3354644A1 (en) | 2011-06-08 | 2018-08-01 | Translate Bio, Inc. | Cleavable lipids |
| GB2496898B (en) | 2011-11-25 | 2020-10-28 | Petroliam Nasional Berhad Petronas | Corrosion inhibition |
| JP6284181B2 (ja) | 2012-02-09 | 2018-02-28 | 国立研究開発法人理化学研究所 | 環状ｒｎａ及びタンパク質の製造方法 |
| EP3608308B1 (en) | 2013-03-08 | 2021-07-21 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| PL2968440T3 (pl) | 2013-03-15 | 2019-12-31 | Zymeworks Inc. | Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania |
| ES2746803T3 (es) | 2013-05-15 | 2020-03-06 | Robert Kruse | Traducción intracelular de ARN circular |
| EP3017013A4 (en) | 2013-05-28 | 2017-01-25 | Yanjie Xu | Refrigeration system with dual refrigerants and liquid working fluids |
| US8805972B1 (en) | 2013-06-26 | 2014-08-12 | Kaspersky Lab Zao | Multi-platform operational objective configurator for computing devices |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US9593077B2 (en) | 2013-11-18 | 2017-03-14 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| ES2895651T3 (es) * | 2013-12-19 | 2022-02-22 | Novartis Ag | Lípidos y composiciones lipídicas para la administración de agentes activos |
| SG10201912038TA (en) | 2014-04-23 | 2020-02-27 | Modernatx Inc | Nucleic acid vaccines |
| US10407683B2 (en) | 2014-07-16 | 2019-09-10 | Modernatx, Inc. | Circular polynucleotides |
| CA2955569C (en) | 2014-08-06 | 2023-02-14 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
| EP4219532A3 (en) | 2015-06-05 | 2023-08-16 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| WO2017009376A1 (en) | 2015-07-13 | 2017-01-19 | Curevac Ag | Method of producing rna from circular dna and corresponding template dna |
| WO2017027291A1 (en) | 2015-08-07 | 2017-02-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific car t-cells for solid tumor targeting |
| JP6685039B2 (ja) | 2015-08-26 | 2020-04-22 | 国立大学法人東北大学 | 化合物、イオン液体、白金族元素の抽出剤、白金族元素の抽出方法 |
| LU92830B1 (en) | 2015-09-15 | 2017-04-03 | Luxembourg Inst Of Health Lih | Biomarkers for heart failure |
| EP4286012A3 (en) | 2015-09-17 | 2024-05-29 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| CN105176981B (zh) | 2015-09-17 | 2017-03-15 | 广州永诺健康科技有限公司 | 用于环状rna表达的dna序列和表达载体及其应用 |
| EP3356556B1 (en) | 2015-09-29 | 2019-12-11 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | A method for diagnosing a disease by detection of circrna in bodily fluids |
| HK1258570A1 (zh) | 2015-09-30 | 2019-11-15 | Vertex Pharmaceuticals Inc. | 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法 |
| TW201729835A (zh) | 2015-10-22 | 2017-09-01 | 現代公司 | 呼吸道病毒疫苗 |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| US9834510B2 (en) | 2015-12-30 | 2017-12-05 | Arcturus Therapeutics, Inc. | Aromatic ionizable cationic lipid |
| AU2017205101B2 (en) | 2016-01-08 | 2023-05-04 | Breast Cancer Now | Inhibitors of ataxia-telangiectasia mutated and Rad3-related protein kinase (ATR) for use in methods of treating cancer |
| US20190298657A1 (en) | 2016-05-18 | 2019-10-03 | Modernatx, Inc. | Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency |
| EP3458106A4 (en) | 2016-05-18 | 2020-03-18 | Modernatx, Inc. | POLYNUCLEOTIDS FOR CODING LIPOPROTEIN LIPASE FOR TREATING HYPERLIPIDEMIA |
| EP3458104A1 (en) | 2016-05-18 | 2019-03-27 | Modernatx, Inc. | Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria |
| WO2017201348A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1 |
| KR20230074598A (ko) | 2016-05-18 | 2023-05-30 | 모더나티엑스, 인크. | 릴랙신을 인코딩하는 폴리뉴클레오타이드 |
| MA45036A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2 |
| MA45052A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille |
| KR102469450B1 (ko) | 2016-05-18 | 2022-11-22 | 모더나티엑스, 인크. | 인터류킨-12 (il12)를 코딩하는 폴리뉴클레오티드 및 그의 용도 |
| EP3472193A4 (en) | 2016-06-20 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | CIRCULAR RNA AND THEIR USE IN IMMUNOMODULATION |
| US20180010175A1 (en) | 2016-09-22 | 2018-01-11 | Bio-Rad Laboratories, Inc. | Methods and compositions for cloning circular rna |
| SG11201903674YA (en) | 2016-10-26 | 2019-05-30 | Modernatx Inc | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
| US20190290694A1 (en) | 2016-12-21 | 2019-09-26 | Cellectis | Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy |
| EP3564375A4 (en) | 2016-12-27 | 2020-12-16 | The University Of Tokyo | ARNM FUNCTIONALIZATION PROCESS |
| JP2020514321A (ja) | 2017-02-01 | 2020-05-21 | モデルナティーエックス， インコーポレイテッド | 活性化がん遺伝子変異ペプチドをコードする免疫調節治療ｍＲＮＡ組成物 |
| CN106801050B (zh) | 2017-02-20 | 2020-01-14 | 广州永诺生物科技有限公司 | 一种环状rna高通量测序文库的构建方法及其试剂盒 |
| US20200368162A1 (en) | 2017-02-24 | 2020-11-26 | Modernatx, Inc. | Nucleic Acid-Based Therapy of Muscular Dystrophies |
| EP3595713A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | RESPIRATORY SYNCYTIAL VIRUS Vaccine |
| SMT202300097T1 (it) | 2017-03-15 | 2023-05-12 | Modernatx Inc | Composto e composizioni per il rilascio intracellulare di agenti terapeutici |
| US11753434B2 (en) | 2017-04-14 | 2023-09-12 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| EP3630966B1 (en) | 2017-05-31 | 2025-04-23 | Vilnius University | Production of cyclic adenylates and their use as allosteric regulators |
| US11756183B2 (en) | 2017-06-23 | 2023-09-12 | Cornell University | RNA molecules, methods of producing circular RNA, and treatment methods |
| IL316195A (en) | 2017-12-15 | 2024-12-01 | Flagship Pioneering Innovations Vi Llc | Preparations containing circular polyribonucleotides and uses thereof |
| JP2021512090A (ja) | 2018-01-30 | 2021-05-13 | モデルナティーエックス， インコーポレイテッド | 免疫細胞に薬剤を送達するための組成物及び方法 |
| CN111954542A (zh) | 2018-02-01 | 2020-11-17 | 塔夫茨大学信托人 | 脂质样纳米复合物及其用途 |
| US12083224B2 (en) | 2018-03-30 | 2024-09-10 | Arcturus Therapeutics, Inc. | Lipid particles for nucleic acid delivery |
| JP2021523110A (ja) | 2018-05-01 | 2021-09-02 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子発現のためのナノ粒子及びその使用 |
| WO2019222275A2 (en) | 2018-05-14 | 2019-11-21 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using inducible fusion proteins |
| CA3100276A1 (en) * | 2018-06-06 | 2019-12-12 | Massachusetts Institute Of Technology | Circular rna for translation in eukaryotic cells |
| WO2020010242A1 (en) | 2018-07-03 | 2020-01-09 | Washington State University | Pharmaceutical agents for use in smoking and tobacco cessation |
| CA3107456A1 (en) | 2018-07-24 | 2020-01-30 | Mayo Foundation For Medical Education And Research | Circularized engineered rna and methods |
| JP7283669B2 (ja) | 2018-08-17 | 2023-05-30 | チャンチョウ ピエン ツェ フアン ファーマシューティカル カンパニー リミテッド | ３－アリールオキシ－３－アリール－プロピルアミン化合物およびその用途 |
| US12263248B2 (en) | 2018-09-19 | 2025-04-01 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| CN113271926A (zh) * | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| CN113661242A (zh) | 2019-03-25 | 2021-11-16 | 旗舰创业创新第六有限责任公司 | 包含经修饰的环状多核糖核苷酸的组合物及其用途 |
| WO2020237227A1 (en) * | 2019-05-22 | 2020-11-26 | Massachusetts Institute Of Technology | Circular rna compositions and methods |
| CN114007655A (zh) | 2019-06-14 | 2022-02-01 | 旗舰创业创新第六有限责任公司 | 用于细胞疗法的环状rna |
| EP4022069A4 (en) | 2019-08-28 | 2023-12-20 | The Board of Trustees of the Leland Stanford Junior University | MODIFIED CIRCULAR RNAS AND METHOD OF USE THEREOF |
| WO2021055849A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Headgroup lipid compounds and compositions for intracellular delivery of therapeutic agents |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| EP3819377A1 (en) | 2019-11-08 | 2021-05-12 | Justus-Liebig-Universität Gießen | Circular rna and uses thereof for inhibiting rna-binding proteins |
| AU2020397956A1 (en) | 2019-12-04 | 2022-07-07 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
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