|
US4737462A
(en)
|
1982-10-19 |
1988-04-12 |
Cetus Corporation |
Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
|
|
US4518584A
(en)
|
1983-04-15 |
1985-05-21 |
Cetus Corporation |
Human recombinant interleukin-2 muteins
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
EP0940468A1
(en)
|
1991-06-14 |
1999-09-08 |
Genentech, Inc. |
Humanized antibody variable domain
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
GB9325182D0
(en)
|
1993-12-08 |
1994-02-09 |
T Cell Sciences Inc |
Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
|
|
ES2285701T3
(es)
|
1994-11-07 |
2007-11-16 |
Human Genome Sciences, Inc. |
Factor-gamma de necrosis tumoral.
|
|
US20030198640A1
(en)
|
1994-11-07 |
2003-10-23 |
Human Genome Sciences, Inc. |
Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
|
|
US6824767B2
(en)
|
1994-11-07 |
2004-11-30 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US7597886B2
(en)
|
1994-11-07 |
2009-10-06 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US7820798B2
(en)
|
1994-11-07 |
2010-10-26 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6599719B2
(en)
|
1994-11-07 |
2003-07-29 |
Human Genome Sciences, Inc. |
Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
|
|
US20030129189A1
(en)
|
1994-11-07 |
2003-07-10 |
Guo-Liang Yu |
Tumor necrosis factor-gamma
|
|
ES2176484T3
(es)
|
1995-08-18 |
2002-12-01 |
Morphosys Ag |
Bancos de proteinas/(poli)peptidos.
|
|
US6706484B1
(en)
|
1995-08-18 |
2004-03-16 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
|
US7357927B2
(en)
|
1996-03-12 |
2008-04-15 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
BR9813365A
(pt)
|
1997-12-05 |
2004-06-15 |
Scripps Research Inst |
Método para produção e humanização de um anticorpo monoclonal de rato
|
|
US6297367B1
(en)
|
1997-12-30 |
2001-10-02 |
Chiron Corporation |
Polynucleotide encoding TNFL1
|
|
WO1999045959A1
(en)
|
1998-03-13 |
1999-09-16 |
Dana-Farber Cancer Institute, Inc. |
Humanized antibody and uses thereof
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
AU5124500A
(en)
|
1999-04-30 |
2000-11-17 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
ES2353268T3
(es)
|
1999-07-02 |
2011-02-28 |
Morphosys Ag |
Generacion de elementos de union especifica que se unen a (poli)peptidos codificados por fragmentos de adn genomico o est.
|
|
US6399857B1
(en)
*
|
1999-09-22 |
2002-06-04 |
Paradigm Genetics, Inc. |
Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
|
|
US20110131679A2
(en)
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US6571638B2
(en)
|
2000-06-30 |
2003-06-03 |
Sawtek, Inc. |
Surface-acoustic-wave pressure sensor and associated methods
|
|
WO2002004643A1
(en)
|
2000-07-07 |
2002-01-17 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6824989B1
(en)
|
2000-09-01 |
2004-11-30 |
Upstate Biotechnology, Inc. |
Recombinant monoclonal antibody to phosphotyrosine-containing proteins
|
|
CA2391711A1
(en)
|
2001-06-26 |
2002-12-26 |
University Of Guelph |
Non-radioactive assay of lipopolysaccharide kinases
|
|
EP2295468B1
(en)
*
|
2002-02-14 |
2015-07-08 |
Immunomedics, Inc. |
Anti-CD20 antibodies and fusion proteins thereof and methods of use
|
|
US7314974B2
(en)
*
|
2002-02-21 |
2008-01-01 |
Monsanto Technology, Llc |
Expression of microbial proteins in plants for production of plants with improved properties
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20090042291A1
(en)
|
2002-03-01 |
2009-02-12 |
Xencor, Inc. |
Optimized Fc variants
|
|
DK1551876T3
(da)
|
2002-10-16 |
2011-06-14 |
Purdue Pharma Lp |
Antistoffer, der binder til celle-associerede ca 125/0722P og fremgangsmåder til anvendelse deraf
|
|
WO2004050836A2
(en)
|
2002-11-27 |
2004-06-17 |
Biogen Idec Ma Inc. |
Humanized antibodies against monocyte chemotactic proteins
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US20050101889A1
(en)
|
2003-11-06 |
2005-05-12 |
Freeman Gary A. |
Using chest velocity to process physiological signals to remove chest compression artifacts
|
|
CA2573293A1
(en)
*
|
2004-07-10 |
2006-02-16 |
Alexion Pharmaceuticals, Inc. |
Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby
|
|
KR100596277B1
(ko)
|
2004-08-20 |
2006-07-03 |
동부일렉트로닉스 주식회사 |
반도체 소자 및 그의 절연막 형성 방법
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
EP2301969B1
(en)
|
2005-05-06 |
2015-12-23 |
ZymoGenetics, Inc. |
IL-31 monoclonal antibodies and methods of use
|
|
CA2607697C
(en)
|
2005-05-10 |
2015-01-06 |
Biogen Idec Ma Inc. |
Treating and evaluating inflammatory disorders
|
|
US20090317388A1
(en)
|
2005-05-25 |
2009-12-24 |
Linda Burkly |
Tl1a in treatment of disease
|
|
CN103145840A
(zh)
*
|
2005-06-30 |
2013-06-12 |
Abbvie公司 |
Il-12/p40结合蛋白
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
EP1919954B1
(en)
|
2005-08-30 |
2016-10-19 |
University of Miami |
Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins
|
|
EP2418223A3
(en)
|
2006-06-12 |
2013-01-16 |
Emergent Product Development Seattle, LLC |
Single-chain multivalent binding proteins with effector function
|
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
US9068003B2
(en)
|
2007-01-10 |
2015-06-30 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
|
US20110217310A1
(en)
|
2007-01-10 |
2011-09-08 |
Siegel Richard M |
Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology
|
|
US9896511B2
(en)
*
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
|
WO2008106579A2
(en)
|
2007-02-28 |
2008-09-04 |
Cedars-Sinai Medical Center |
The role of il-12, il-23 and il-17 receptors in inflammatory bowel disease
|
|
US8263743B2
(en)
*
|
2007-11-13 |
2012-09-11 |
Teva Biopharmaceuticals Usa, Inc. |
Humanized antibodies against TL1A
|
|
CN101469270B
(zh)
|
2007-12-27 |
2012-08-22 |
牛斌 |
工业连续化塑料裂解器
|
|
US8093364B2
(en)
|
2008-01-18 |
2012-01-10 |
Bio-Rad Laboratories, Inc. |
Enhanced purification of antibodies and antibody fragments by apatite chromatography
|
|
UA103499C2
(ru)
|
2008-09-29 |
2013-10-25 |
Рош Глікарт Аг |
Антитело против интерлейкина-17 (ил-17) человека и его применение
|
|
CA2756186A1
(en)
|
2009-03-24 |
2010-09-30 |
Teva Biopharmaceuticals Usa, Inc. |
Humanized antibodies against light and uses thereof
|
|
SG178125A1
(en)
|
2009-08-03 |
2012-03-29 |
Univ Miami |
Method for in vivo expansion of t regulatory cells
|
|
WO2011106707A2
(en)
|
2010-02-26 |
2011-09-01 |
Human Genome Sciences, Inc. |
Antibodies that specifically bind to dr3
|
|
CA2805054A1
(en)
|
2010-08-25 |
2012-03-01 |
F. Hoffmann-La Roche Ag |
Antibodies against il-18r1 and uses thereof
|
|
CA2810465C
(en)
|
2010-09-16 |
2018-10-02 |
Baliopharm Ag |
Anti-hutnfr1 antibody
|
|
US8766034B2
(en)
|
2010-09-22 |
2014-07-01 |
Cedars-Sinai Medical Center |
TL1A model of inflammation fibrosis and autoimmunity
|
|
JO3375B1
(ar)
|
2010-11-08 |
2019-03-13 |
Regeneron Pharma |
أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
|
|
US9902996B2
(en)
|
2011-02-11 |
2018-02-27 |
Cedars-Sinai Medical Center |
Methods of predicting the need for surgery in crohn's disease
|
|
MY171135A
(en)
|
2011-06-03 |
2019-09-27 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
|
EP4011913A1
(en)
|
2011-06-30 |
2022-06-15 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
JP2014531210A
(ja)
|
2011-09-30 |
2014-11-27 |
テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド |
ＴＬ１ａに対する抗体およびその使用
|
|
CN104080909A
(zh)
|
2011-11-30 |
2014-10-01 |
中外制药株式会社 |
包含进入细胞内以形成免疫复合体的搬运体(载体)的药物
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
CA2876099A1
(en)
|
2012-08-02 |
2014-02-06 |
F. Hoffmann-La Roche Ag |
Method for producing monomeric and multimeric molecules and uses thereof
|
|
CA2876096A1
(en)
|
2012-08-02 |
2014-02-06 |
Petra Rueger |
Method for producing soluble fcr as fc-fusion with inert immunoglobulin fc-region and uses thereof
|
|
WO2014051109A1
(ja)
*
|
2012-09-28 |
2014-04-03 |
協和発酵キリン株式会社 |
抗ヒトｂｍｐ９抗体および該抗体を有効成分とする異所性骨化疾患の治療剤
|
|
KR102249779B1
(ko)
|
2012-12-27 |
2021-05-07 |
추가이 세이야쿠 가부시키가이샤 |
헤테로이량화 폴리펩티드
|
|
JP2016503818A
(ja)
|
2013-01-02 |
2016-02-08 |
グレンマーク ファーマシューティカルズ， エセ．アー． |
Ｔｌ１ａと結合する抗体およびその使用
|
|
WO2014160463A1
(en)
|
2013-03-13 |
2014-10-02 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Prefusion rsv f proteins and their use
|
|
CA2907181C
(en)
|
2013-03-15 |
2023-10-17 |
Viktor Roschke |
Multivalent and monovalent multispecific complexes and their uses
|
|
US20140377253A1
(en)
|
2013-03-15 |
2014-12-25 |
Abbvie Biotherapeutics Inc. |
Fc variants
|
|
JP6824735B2
(ja)
*
|
2013-06-06 |
2021-02-03 |
ピエール、ファーブル、メディカマン |
抗Ｃ１０ｏｒｆ５４抗体およびその使用方法
|
|
EP4105236A1
(en)
|
2013-07-19 |
2022-12-21 |
Cedars-Sinai Medical Center |
Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
|
|
RS63571B9
(sr)
|
2013-09-13 |
2023-02-28 |
Beigene Switzerland Gmbh |
Anti-pd1 antitela i njihova primena kao terapeutska i dijagnostička sredstva
|
|
CA2929784C
(en)
|
2013-11-13 |
2019-11-26 |
Pfizer Inc. |
Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
|
|
ES2811274T3
(es)
*
|
2014-04-18 |
2021-03-11 |
Univ Leland Stanford Junior |
Anticuerpos monoclonales humanizados y quiméricos para CD99
|
|
MX2016014346A
(es)
|
2014-05-02 |
2017-04-27 |
Teva Pharma |
Tratamiento de enfermedad de crohn con 6-mercaptopurina de liberacion prolongada.
|
|
WO2015173756A2
(en)
|
2014-05-16 |
2015-11-19 |
Pfizer Inc. |
Bispecific antibodies
|
|
US10160805B2
(en)
|
2014-07-11 |
2018-12-25 |
New York University |
Methods of treating inflammatory bowel disease by administering tumor necrosis factor-like ligand 1A or an agonistic death-domain receptor 3 antibody
|
|
LT3224275T
(lt)
|
2014-11-14 |
2020-05-25 |
F. Hoffmann-La Roche Ag |
Antigeną surišančios molekulės, apimančios tnf šeimos ligando trimerą
|
|
MA41460A
(fr)
|
2015-02-03 |
2017-12-12 |
Oncomed Pharm Inc |
Agents de liaison à la tnfrsf et leurs utilisations
|
|
JP6996979B2
(ja)
|
2015-03-31 |
2022-02-04 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
三量体ｔｎｆファミリーリガンドを含む抗原結合分子
|
|
WO2016162356A1
(en)
*
|
2015-04-07 |
2016-10-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-pd-l1 immunotoxin for use in therapy
|
|
US10647756B2
(en)
|
2015-05-18 |
2020-05-12 |
Pfizer Inc. |
Humanized antibodies
|
|
JP6932700B2
(ja)
|
2015-09-15 |
2021-09-08 |
アムジエン・インコーポレーテツド |
４価の二重特異性抗原結合タンパク質及び４価の四重特異性抗原結合タンパク質、ならびにそれらの使用
|
|
TWI703158B
(zh)
|
2015-09-18 |
2020-09-01 |
美商希佛隆公司 |
特異性結合tl1a之抗體
|
|
MA43017A
(fr)
|
2015-10-02 |
2018-08-08 |
Hoffmann La Roche |
Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf
|
|
US20180319889A1
(en)
|
2015-11-02 |
2018-11-08 |
La Jolla Institute For Allergy & Immunology |
Method and medicament for treating airway and/or lung diseases
|
|
ITUB20155097A1
(it)
*
|
2015-11-05 |
2017-05-05 |
Biouniversa Srl |
Anticorpi umanizzati anti-BAG3
|
|
CR20180365A
(es)
|
2015-12-16 |
2018-09-28 |
Amgen Inc |
PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS
|
|
IL262244B2
(en)
|
2016-04-29 |
2024-01-01 |
Pfizer |
Antibodies against beta interferon and their use
|
|
US10968279B2
(en)
|
2016-05-09 |
2021-04-06 |
Bristol-Myers Squibb Company |
TL1A antibodies and uses thereof
|
|
US10688412B2
(en)
|
2016-07-25 |
2020-06-23 |
Cehpalon, Inc. |
Affinity chromatography wash buffer
|
|
KR20190082815A
(ko)
|
2016-10-26 |
2019-07-10 |
세다르스-신나이 메디칼 센터 |
중화 항-tl1a 단일 클론 항체
|
|
WO2018112240A1
(en)
|
2016-12-14 |
2018-06-21 |
Progenity Inc. |
Treatment of a disease of the gastrointestinal tract with a tnf inhibitor
|
|
SG11202003212PA
(en)
|
2017-10-10 |
2020-05-28 |
Sanofi Sa |
Anti-cd38 antibodies and combinations with anti-cd3 and anti-cd28 antibodies
|
|
WO2019121906A1
(en)
|
2017-12-19 |
2019-06-27 |
F-Star Beta Limited |
Specific pd-l1 binding sequences inserted in a ch3 domain
|
|
CN112585165B8
(zh)
|
2018-04-25 |
2025-02-14 |
普罗米修斯生物科学公司 |
优化的抗tl1a抗体
|
|
GB201811404D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Anti-CD137 Antibodies
|
|
GB201811450D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Delta Ltd |
Mesothelin and CD137 binding molecules
|
|
AU2019301204B2
(en)
|
2018-07-12 |
2025-10-23 |
Invox Pharma Limited |
Antibody molecules that bind PD-L1 and CD137
|
|
GB201811415D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Anti-Mesothelin Anti bodies
|
|
GB201811410D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
OX40 Binding molecules
|
|
MX2021000399A
(es)
|
2018-07-12 |
2021-05-27 |
F Star Therapeutics Ltd |
Moleculas de anticuerpo que se unen a cd137 y ox40.
|
|
GB201811408D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
CD137 Binding Molecules
|
|
BR112021006558A2
(pt)
|
2018-10-09 |
2021-07-13 |
Sanofi |
proteínas de ligação triespecíficas anti-cd38, anti-cd28 e anti-cd3 e métodos de uso para o tratamento de infecção viral
|
|
PE20211279A1
(es)
|
2018-10-23 |
2021-07-19 |
Dragonfly Therapeutics Inc |
Proteinas heterodimericas fusionadas con fc
|
|
MX2022004942A
(es)
|
2019-10-24 |
2022-07-27 |
Prometheus Biosciences Inc |
Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos.
|
|
TWI871367B
(zh)
|
2019-10-24 |
2025-02-01 |
美商普羅米修斯生物科學股份有限公司 |
針對類-tnf配體1a(tl1a)之人類化抗體及其用途
|
|
BR112022025667A2
(pt)
|
2020-06-26 |
2023-03-07 |
Pfizer |
Métodos de tratamento da doença inflamatória intestinal com anticorpos tl1a
|