JP2023162343A5 - - Google Patents
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- JP2023162343A5 JP2023162343A5 JP2023139455A JP2023139455A JP2023162343A5 JP 2023162343 A5 JP2023162343 A5 JP 2023162343A5 JP 2023139455 A JP2023139455 A JP 2023139455A JP 2023139455 A JP2023139455 A JP 2023139455A JP 2023162343 A5 JP2023162343 A5 JP 2023162343A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antibody
- antigen
- binding fragment
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 54
- 239000000427 antigen Substances 0.000 claims 28
- 102000036639 antigens Human genes 0.000 claims 28
- 108091007433 antigens Proteins 0.000 claims 28
- 239000012634 fragment Substances 0.000 claims 28
- 238000012423 maintenance Methods 0.000 claims 28
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 12
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 12
- 229950003468 dupilumab Drugs 0.000 claims 10
- 229940125369 inhaled corticosteroids Drugs 0.000 claims 10
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000000048 adrenergic agonist Substances 0.000 claims 6
- 208000006673 asthma Diseases 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 6
- 230000002327 eosinophilic effect Effects 0.000 claims 6
- 229940124624 oral corticosteroid Drugs 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 229940090047 auto-injector Drugs 0.000 claims 4
- 238000011418 maintenance treatment Methods 0.000 claims 4
- 239000003246 corticosteroid Substances 0.000 claims 2
- 238000010254 subcutaneous injection Methods 0.000 claims 2
- 239000007929 subcutaneous injection Substances 0.000 claims 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025020415A JP2025072593A (ja) | 2014-02-21 | 2025-02-12 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943019P | 2014-02-21 | 2014-02-21 | |
| US61/943,019 | 2014-02-21 | ||
| EP14306413 | 2014-09-15 | ||
| EP14306413.7 | 2014-09-15 | ||
| US201462077669P | 2014-11-10 | 2014-11-10 | |
| US62/077,669 | 2014-11-10 | ||
| JP2020036331A JP6893265B2 (ja) | 2014-02-21 | 2020-03-04 | Ｉｌ−４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
| JP2021089717A JP7343547B2 (ja) | 2014-02-21 | 2021-05-28 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021089717A Division JP7343547B2 (ja) | 2014-02-21 | 2021-05-28 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025020415A Division JP2025072593A (ja) | 2014-02-21 | 2025-02-12 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023162343A JP2023162343A (ja) | 2023-11-08 |
| JP2023162343A5 true JP2023162343A5 (enExample) | 2024-07-25 |
| JP7636487B2 JP7636487B2 (ja) | 2025-02-26 |
Family
ID=51570453
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552595A Active JP6673840B2 (ja) | 2014-02-21 | 2015-02-20 | Ｉｌ−４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
| JP2023139455A Active JP7636487B2 (ja) | 2014-02-21 | 2023-08-30 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
| JP2025020415A Pending JP2025072593A (ja) | 2014-02-21 | 2025-02-12 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552595A Active JP6673840B2 (ja) | 2014-02-21 | 2015-02-20 | Ｉｌ−４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025020415A Pending JP2025072593A (ja) | 2014-02-21 | 2025-02-12 | Ｉｌ－４ｒ拮抗薬の投与により喘息を処置または予防するための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10137193B2 (enExample) |
| EP (3) | EP3973987B1 (enExample) |
| JP (3) | JP6673840B2 (enExample) |
| KR (4) | KR20230167770A (enExample) |
| CN (1) | CN106232140A (enExample) |
| AU (3) | AU2015218808B2 (enExample) |
| CA (1) | CA2940295A1 (enExample) |
| ES (2) | ES2977332T3 (enExample) |
| HU (1) | HUE065844T2 (enExample) |
| IL (1) | IL315136A (enExample) |
| MX (2) | MX384192B (enExample) |
| PL (2) | PL3107575T3 (enExample) |
| PT (2) | PT3107575T (enExample) |
| RU (1) | RU2713406C2 (enExample) |
| WO (1) | WO2015127229A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| WO2014031610A1 (en) | 2012-08-21 | 2014-02-27 | Sanofi | Methods for treating or preventing asthma by administering an il-4r antagonist |
| HRP20181227T1 (hr) | 2012-09-07 | 2018-10-05 | Regeneron Pharmaceuticals, Inc. | Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r |
| TWI755763B (zh) * | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| HRP20251187T1 (hr) | 2013-07-12 | 2025-11-21 | Areteia Therapeutics, Inc. | Liječenje povišenih razina eozinofila i/ili bazofila |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| RU2704999C2 (ru) | 2014-02-28 | 2019-11-01 | Ридженерон Фармасьютикалз, Инк. | Способ лечения кожной инфекции путем введения антагониста il-4r |
| PT3613432T (pt) * | 2014-05-07 | 2025-10-29 | Regeneron Pharma | Métodos para tratar a polipose nasal através da administração de um antagonista de il-4r |
| US10066017B2 (en) | 2014-11-14 | 2018-09-04 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| US20180056018A1 (en) * | 2016-08-31 | 2018-03-01 | Cephalon, Inc. | Inhalation Systems, Devices and Methods |
| CN109789196B (zh) * | 2016-09-01 | 2024-03-19 | 瑞泽恩制药公司 | 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法 |
| CN118203659A (zh) | 2016-09-22 | 2024-06-18 | 瑞泽恩制药公司 | 用于通过施用il-4r抑制剂治疗严重特应性皮炎的方法 |
| TWI857389B (zh) * | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| MX2019012171A (es) | 2017-04-13 | 2019-11-25 | Regeneron Pharma | Tratamiento e inhibicion de enfermedades pulmonares inflamatorias en pacientes que tienen alelos de riesgo en los genes que codifican la il33 e il1rl1. |
| WO2019005898A1 (en) | 2017-06-27 | 2019-01-03 | Ohio State Innovation Foundation | LIPONUCLEOTID THERAPY FOR COPD |
| EP3645010A4 (en) * | 2017-06-27 | 2021-03-24 | Ohio State Innovation Foundation | NUCLEOTIDE-BASED THERAPY FOR ASTHMA |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| PL3703818T3 (pl) * | 2017-10-30 | 2024-03-25 | Sanofi Biotechnology | Antagonista IL-4R do zastosowania w sposobie leczenia lub zapobiegania astmie |
| EP3793597A1 (en) | 2018-05-13 | 2021-03-24 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r inhibitor |
| IL316308A (en) * | 2018-07-10 | 2024-12-01 | Regeneron Pharma | Modifying binding molecules to minimize pre-existing interactions |
| CN110872349A (zh) | 2018-09-04 | 2020-03-10 | 三生国健药业（上海）股份有限公司 | 结合人il-4r的抗体、其制备方法和用途 |
| CN111494625B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| CN111647082B (zh) * | 2018-12-27 | 2023-02-17 | 中山康方生物医药有限公司 | 抗人il-4ra的抗体及其用途 |
| MA55372A (fr) | 2019-03-21 | 2022-01-26 | Regeneron Pharma | Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie |
| BR112021021195A2 (pt) * | 2019-05-01 | 2022-03-03 | Regeneron Pharma | Métodos para tratamento ou prevenção da asma pela administração de um antagonista de il-33 |
| JP7592064B2 (ja) | 2019-07-16 | 2024-11-29 | サノフィ・バイオテクノロジー | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を治療するまたは予防するための方法 |
| AU2020326713A1 (en) | 2019-08-05 | 2022-02-17 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| CN114173819A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法 |
| EP4073810A1 (en) | 2019-12-09 | 2022-10-19 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| CN113797331A (zh) * | 2020-06-16 | 2021-12-17 | 三生国健药业（上海）股份有限公司 | 一种稳定的抗IL-4Rα单克隆抗体液体制剂 |
| MX2023001140A (es) * | 2020-08-05 | 2023-05-18 | Areteia Therapeutics Inc | Uso del dexpramipexol para el tratamiento de asma moderado a grave. |
| US20220169739A1 (en) * | 2020-10-05 | 2022-06-02 | Sanofi Biotechnology | Methods for treating asthma in pediatric subjects by administering an il-4r antagonist |
| IL310427A (en) * | 2021-08-26 | 2024-03-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Pharmaceutical composition of anti-il4r antibody and use thereof |
| CN117368487A (zh) * | 2023-09-28 | 2024-01-09 | 首都医科大学附属北京同仁医院 | 一种利用局部IgE预测或评估奥马珠单抗在治疗复发性鼻息肉中疗效的方法和应用 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8808015D0 (en) | 1988-04-06 | 1988-05-05 | Ritter M A | Chemical compounds |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US5714146A (en) | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
| EP0604693A1 (en) | 1992-12-29 | 1994-07-06 | Schering-Plough | Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| DE16192152T1 (de) | 2000-05-26 | 2020-08-06 | Immunex Corporation | Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US8178098B2 (en) | 2001-04-03 | 2012-05-15 | National Jewish Health | Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies |
| GEP20104991B (en) | 2003-11-07 | 2010-05-25 | Immunex Corp | Antibodies that bind interleukin-4 receptor |
| AU2004309373A1 (en) | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| CA2554596A1 (en) | 2004-02-27 | 2005-09-15 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 specific polypetides and therapeutic uses thereof |
| US20090098142A1 (en) | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| TW200902555A (en) | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
| JP2009523460A (ja) * | 2006-01-24 | 2009-06-25 | ドマンティス リミテッド | Ｉｌ−４および／またはｉｌ−１３に結合するリガンド |
| RS52176B (sr) | 2006-06-02 | 2012-08-31 | Regeneron Pharmaceuticals Inc. | Antitela visokog afiniteta prema humanom il-6 receptoru |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| WO2008054606A2 (en) | 2006-10-02 | 2008-05-08 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| EP2022507A1 (en) | 2007-08-07 | 2009-02-11 | Universität Hamburg | Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| RU2490278C2 (ru) * | 2007-12-21 | 2013-08-20 | Медиммун Лимитед | ЭЛЕМЕНТ, СВЯЗЫВАЮЩИЙСЯ С α-РЕЦЕПТОРОМ ИНТЕРЛЕЙКИНА-4 (IL-4Rα)-173 |
| EP2376656A4 (en) | 2008-12-01 | 2012-05-16 | Cincinnati Children S Hospital Medical Ct | METHOD AND DETERMINATION OF THE EFFECTIVENESS OF A GLUCOCORTICOID TREATMENT OF EOSINOPHILIAN ESOPHAGITIS |
| EP2414520A2 (en) | 2009-03-31 | 2012-02-08 | Altair Therapeutics, Inc. | Methods of modulating an immune response to a viral infection |
| WO2011156000A2 (en) * | 2010-06-07 | 2011-12-15 | Aerovance, Inc. | Use of il-4/il-13 antagonists to treat eosinophilic disorders |
| PL2624865T3 (pl) | 2010-10-06 | 2018-11-30 | Regeneron Pharmaceuticals, Inc. | Stabilizowane preparaty zawierające przeciwciała przeciwko receptorowi interleukiny-4 (IL-4R) |
| CA2814431A1 (en) * | 2010-10-15 | 2012-04-19 | Medimmune Limited | Therapies for improving pulmonary function |
| US20130052190A1 (en) | 2011-02-22 | 2013-02-28 | Oxagen Limited | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions |
| KR20140097217A (ko) * | 2011-11-01 | 2014-08-06 | 메디뮨 엘엘씨 | 급성 천식 악화의 빈도 및 중증도를 감소시키는 방법 |
| WO2014031610A1 (en) | 2012-08-21 | 2014-02-27 | Sanofi | Methods for treating or preventing asthma by administering an il-4r antagonist |
| HRP20181227T1 (hr) | 2012-09-07 | 2018-10-05 | Regeneron Pharmaceuticals, Inc. | Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| PT3613432T (pt) | 2014-05-07 | 2025-10-29 | Regeneron Pharma | Métodos para tratar a polipose nasal através da administração de um antagonista de il-4r |
| US10066017B2 (en) | 2014-11-14 | 2018-09-04 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| PL3703818T3 (pl) * | 2017-10-30 | 2024-03-25 | Sanofi Biotechnology | Antagonista IL-4R do zastosowania w sposobie leczenia lub zapobiegania astmie |
| US20220169739A1 (en) | 2020-10-05 | 2022-06-02 | Sanofi Biotechnology | Methods for treating asthma in pediatric subjects by administering an il-4r antagonist |
-
2015
- 2015-02-19 IL IL315136A patent/IL315136A/en unknown
- 2015-02-20 PT PT157089913T patent/PT3107575T/pt unknown
- 2015-02-20 US US14/627,728 patent/US10137193B2/en active Active
- 2015-02-20 KR KR1020237041236A patent/KR20230167770A/ko not_active Ceased
- 2015-02-20 HU HUE21191120A patent/HUE065844T2/hu unknown
- 2015-02-20 MX MX2016010854A patent/MX384192B/es unknown
- 2015-02-20 AU AU2015218808A patent/AU2015218808B2/en active Active
- 2015-02-20 ES ES21191120T patent/ES2977332T3/es active Active
- 2015-02-20 EP EP21191120.1A patent/EP3973987B1/en active Active
- 2015-02-20 JP JP2016552595A patent/JP6673840B2/ja active Active
- 2015-02-20 CA CA2940295A patent/CA2940295A1/en active Pending
- 2015-02-20 PL PL15708991T patent/PL3107575T3/pl unknown
- 2015-02-20 KR KR1020257035292A patent/KR20250154567A/ko active Pending
- 2015-02-20 PL PL21191120.1T patent/PL3973987T3/pl unknown
- 2015-02-20 EP EP24150594.0A patent/EP4382164A3/en active Pending
- 2015-02-20 KR KR1020167025669A patent/KR102368450B1/ko active Active
- 2015-02-20 EP EP15708991.3A patent/EP3107575B1/en not_active Revoked
- 2015-02-20 ES ES15708991T patent/ES2897631T3/es active Active
- 2015-02-20 WO PCT/US2015/016852 patent/WO2015127229A1/en not_active Ceased
- 2015-02-20 CN CN201580020533.9A patent/CN106232140A/zh active Pending
- 2015-02-20 RU RU2016136364A patent/RU2713406C2/ru active
- 2015-02-20 KR KR1020227006120A patent/KR20220029765A/ko not_active Ceased
- 2015-02-20 PT PT211911201T patent/PT3973987T/pt unknown
-
2016
- 2016-08-19 MX MX2021008113A patent/MX2021008113A/es unknown
-
2018
- 2018-10-11 US US16/157,708 patent/US20190125865A1/en not_active Abandoned
-
2020
- 2020-11-26 AU AU2020277191A patent/AU2020277191B2/en active Active
-
2021
- 2021-03-29 US US17/215,604 patent/US20210322546A1/en active Pending
-
2023
- 2023-08-30 JP JP2023139455A patent/JP7636487B2/ja active Active
-
2024
- 2024-06-06 AU AU2024203849A patent/AU2024203849A1/en active Pending
-
2025
- 2025-02-12 JP JP2025020415A patent/JP2025072593A/ja active Pending
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