JP2023099107A5 - - Google Patents
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- Publication number
- JP2023099107A5 JP2023099107A5 JP2023073689A JP2023073689A JP2023099107A5 JP 2023099107 A5 JP2023099107 A5 JP 2023099107A5 JP 2023073689 A JP2023073689 A JP 2023073689A JP 2023073689 A JP2023073689 A JP 2023073689A JP 2023099107 A5 JP2023099107 A5 JP 2023099107A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous suspension
- cellulose
- trifluoromethylchroman
- tetrahydronaphthalen
- ylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001913 cellulose Substances 0.000 claims description 13
- 229920002678 cellulose Polymers 0.000 claims description 13
- 239000007900 aqueous suspension Substances 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 229920003174 cellulose-based polymer Polymers 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 2
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- MAWBBYZCTDJMDD-GXDHUFHOSA-N (2e)-n-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-2-[7-(trifluoromethyl)-2,3-dihydrochromen-4-ylidene]acetamide Chemical compound C\1COC2=CC(C(F)(F)F)=CC=C2C/1=C/C(=O)NC1=C(CC(O)CC2)C2=CC=C1 MAWBBYZCTDJMDD-GXDHUFHOSA-N 0.000 claims 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical group [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims 2
- 150000003751 zinc Chemical class 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims 1
- MAWBBYZCTDJMDD-HFQYIWAZSA-N FC(C1=CC=C2\C(\CCOC2=C1)=C\C(=O)NC1=CC=CC=2CC[C@H](CC1=2)O)(F)F Chemical group FC(C1=CC=C2\C(\CCOC2=C1)=C\C(=O)NC1=CC=CC=2CC[C@H](CC1=2)O)(F)F MAWBBYZCTDJMDD-HFQYIWAZSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- -1 polyoxyethylene Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910001961 silver nitrate Inorganic materials 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229920001664 tyloxapol Polymers 0.000 claims 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims 1
- 229960004224 tyloxapol Drugs 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
- 229960001763 zinc sulfate Drugs 0.000 claims 1
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
- 239000002245 particle Substances 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021057713 | 2021-03-30 | ||
| JP2021057713 | 2021-03-30 | ||
| JP2022178888A JP7273235B2 (ja) | 2021-03-30 | 2022-11-08 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022178888A Division JP7273235B2 (ja) | 2021-03-30 | 2022-11-08 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023099107A JP2023099107A (ja) | 2023-07-11 |
| JP2023099107A5 true JP2023099107A5 (https=) | 2025-04-07 |
Family
ID=83459508
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022546133A Active JP7175431B1 (ja) | 2021-03-30 | 2022-03-29 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
| JP2022178888A Active JP7273235B2 (ja) | 2021-03-30 | 2022-11-08 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
| JP2023073689A Pending JP2023099107A (ja) | 2021-03-30 | 2023-04-27 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022546133A Active JP7175431B1 (ja) | 2021-03-30 | 2022-03-29 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
| JP2022178888A Active JP7273235B2 (ja) | 2021-03-30 | 2022-11-08 | ヘテロシクリデンアセトアミド誘導体含有懸濁液 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12564553B2 (https=) |
| EP (1) | EP4316485A4 (https=) |
| JP (3) | JP7175431B1 (https=) |
| KR (1) | KR20230163502A (https=) |
| CN (1) | CN117120048A (https=) |
| AU (1) | AU2022250028A1 (https=) |
| BR (1) | BR112023019820A2 (https=) |
| CA (1) | CA3215750A1 (https=) |
| MX (1) | MX2023011649A (https=) |
| WO (1) | WO2022210784A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3262434A1 (en) | 2022-07-20 | 2025-06-12 | Asahi Kasei Kabushiki Kaisha | Hyaluronic acid derivative drug composition and drug composition |
| WO2025206172A1 (ja) * | 2024-03-28 | 2025-10-02 | 千寿製薬株式会社 | 電子線滅菌処理したヘテロシクリデンアセトアミド誘導体含有組成物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61164725A (ja) | 1985-01-11 | 1986-07-25 | Inoue Japax Res Inc | ワイヤ電極案内 |
| JPH07304663A (ja) * | 1994-03-18 | 1995-11-21 | Senju Pharmaceut Co Ltd | 眼圧降下用点眼剤 |
| EP0686393B1 (en) | 1994-03-18 | 1998-05-20 | Senju Pharmaceutical Co., Ltd. | Ophthalmic preparations containing sarpogrelate for reducing intraocular pressure |
| JP3402195B2 (ja) * | 1997-05-14 | 2003-04-28 | 千寿製薬株式会社 | 再分散性の良い水性懸濁液剤 |
| WO1998051281A1 (en) | 1997-05-14 | 1998-11-19 | Senju Pharmaceutical Co., Ltd. | Aqueous suspension preparations with excellent redispersibility |
| NZ565080A (en) | 2005-07-22 | 2011-03-31 | Mochida Pharm Co Ltd | Novel heterocyclidene acetamide derivative |
| WO2008123396A1 (ja) * | 2007-03-29 | 2008-10-16 | Santen Pharmaceutical Co., Ltd. | フルオロメトロンを含有する懸濁型点眼剤 |
| ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
| JP6230743B1 (ja) * | 2017-05-31 | 2017-11-15 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の結晶 |
| WO2021039023A1 (ja) | 2019-08-23 | 2021-03-04 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の製造方法 |
| CN112409191A (zh) | 2019-08-23 | 2021-02-26 | 持田制药株式会社 | 光学活性的氨基醇的制备方法 |
| JP6966667B2 (ja) * | 2019-08-27 | 2021-11-17 | 参天製薬株式会社 | ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 |
| JP7419728B2 (ja) | 2019-09-27 | 2024-01-23 | ブラザー工業株式会社 | 通信装置と通信装置のためのコンピュータプログラム |
| MY207759A (en) | 2019-10-04 | 2025-03-17 | Mochida Pharm Co Ltd | Pharmaceutical drug containing heterocyclidene acetamide derivative |
-
2022
- 2022-03-29 CA CA3215750A patent/CA3215750A1/en active Pending
- 2022-03-29 WO PCT/JP2022/015691 patent/WO2022210784A1/ja not_active Ceased
- 2022-03-29 JP JP2022546133A patent/JP7175431B1/ja active Active
- 2022-03-29 CN CN202280026310.3A patent/CN117120048A/zh active Pending
- 2022-03-29 EP EP22780995.1A patent/EP4316485A4/en active Pending
- 2022-03-29 AU AU2022250028A patent/AU2022250028A1/en active Pending
- 2022-03-29 US US18/553,141 patent/US12564553B2/en active Active
- 2022-03-29 MX MX2023011649A patent/MX2023011649A/es unknown
- 2022-03-29 BR BR112023019820A patent/BR112023019820A2/pt unknown
- 2022-03-29 KR KR1020237037161A patent/KR20230163502A/ko active Pending
- 2022-11-08 JP JP2022178888A patent/JP7273235B2/ja active Active
-
2023
- 2023-04-27 JP JP2023073689A patent/JP2023099107A/ja active Pending
-
2025
- 2025-01-03 US US19/009,331 patent/US12527740B2/en active Active
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