JP2015147762A5 - - Google Patents
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- Publication number
- JP2015147762A5 JP2015147762A5 JP2015002271A JP2015002271A JP2015147762A5 JP 2015147762 A5 JP2015147762 A5 JP 2015147762A5 JP 2015002271 A JP2015002271 A JP 2015002271A JP 2015002271 A JP2015002271 A JP 2015002271A JP 2015147762 A5 JP2015147762 A5 JP 2015147762A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- pyridin
- castor oil
- pharmaceutical composition
- ylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 39
- -1 (6-{[4- (pyrazol-1-yl) benzyl] (pyridin-3-ylsulfonyl) aminomethyl} pyridin-2-ylamino) isopropyl Chemical group 0.000 claims 33
- 239000004359 castor oil Substances 0.000 claims 30
- 235000019438 castor oil Nutrition 0.000 claims 30
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 30
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 28
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 8
- JIEXZSFMUWGAJW-UHFFFAOYSA-N propan-2-yl 2-[[6-[2-(4-pyrazol-1-ylphenyl)-1-(pyridin-3-ylsulfonylamino)ethyl]pyridin-2-yl]amino]acetate Chemical compound CC(C)OC(=O)CNC1=CC=CC(C(CC=2C=CC(=CC=2)N2N=CC=C2)NS(=O)(=O)C=2C=NC=CC=2)=N1 JIEXZSFMUWGAJW-UHFFFAOYSA-N 0.000 claims 8
- LMYFUAQCISSXDJ-UHFFFAOYSA-N 2-[[6-[2-(4-pyrazol-1-ylphenyl)-1-(pyridin-3-ylsulfonylamino)ethyl]pyridin-2-yl]amino]acetic acid Chemical compound OC(=O)CNC1=CC=CC(C(CC=2C=CC(=CC=2)N2N=CC=C2)NS(=O)(=O)C=2C=NC=CC=2)=N1 LMYFUAQCISSXDJ-UHFFFAOYSA-N 0.000 claims 6
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 5
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 5
- 239000004327 boric acid Substances 0.000 claims 5
- 229960001484 edetic acid Drugs 0.000 claims 5
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 5
- 239000004334 sorbic acid Substances 0.000 claims 5
- 229940075582 sorbic acid Drugs 0.000 claims 5
- 235000010199 sorbic acid Nutrition 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 235000011187 glycerol Nutrition 0.000 claims 4
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 4
- 229940011051 isopropyl acetate Drugs 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229920002675 Polyoxyl Polymers 0.000 claims 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920002696 Polyoxyl 40 castor oil Polymers 0.000 claims 1
- 235000004443 Ricinus communis Nutrition 0.000 claims 1
- QQLRUXZAEQYBSN-UHFFFAOYSA-N [[6-[2-(4-pyrazol-1-ylphenyl)-1-(pyridin-3-ylsulfonylamino)ethyl]pyridin-2-yl]amino] acetate Chemical compound CC(=O)ONC1=CC=CC(C(CC=2C=CC(=CC=2)N2N=CC=C2)NS(=O)(=O)C=2C=NC=CC=2)=N1 QQLRUXZAEQYBSN-UHFFFAOYSA-N 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015002271A JP6012775B2 (ja) | 2014-01-10 | 2015-01-08 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014002809 | 2014-01-10 | ||
| JP2014002809 | 2014-01-10 | ||
| JP2015002271A JP6012775B2 (ja) | 2014-01-10 | 2015-01-08 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016181739A Division JP6449205B2 (ja) | 2014-01-10 | 2016-09-16 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015147762A JP2015147762A (ja) | 2015-08-20 |
| JP2015147762A5 true JP2015147762A5 (https=) | 2016-09-23 |
| JP6012775B2 JP6012775B2 (ja) | 2016-10-25 |
Family
ID=53523959
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015002271A Active JP6012775B2 (ja) | 2014-01-10 | 2015-01-08 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2016181739A Active JP6449205B2 (ja) | 2014-01-10 | 2016-09-16 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2018227964A Active JP6793172B2 (ja) | 2014-01-10 | 2018-12-05 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2020186245A Active JP7170020B2 (ja) | 2014-01-10 | 2020-11-09 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2022174719A Active JP7546027B2 (ja) | 2014-01-10 | 2022-10-31 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016181739A Active JP6449205B2 (ja) | 2014-01-10 | 2016-09-16 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2018227964A Active JP6793172B2 (ja) | 2014-01-10 | 2018-12-05 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2020186245A Active JP7170020B2 (ja) | 2014-01-10 | 2020-11-09 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
| JP2022174719A Active JP7546027B2 (ja) | 2014-01-10 | 2022-10-31 | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20160317512A1 (https=) |
| EP (2) | EP3888654B1 (https=) |
| JP (5) | JP6012775B2 (https=) |
| KR (6) | KR101858373B1 (https=) |
| CN (2) | CN105828817B (https=) |
| AU (1) | AU2015205268B2 (https=) |
| BR (1) | BR112016015911B1 (https=) |
| CA (1) | CA2934612C (https=) |
| EA (1) | EA031723B1 (https=) |
| ES (2) | ES2874547T3 (https=) |
| GE (2) | GEP20186916B (https=) |
| IL (1) | IL246654B (https=) |
| MX (1) | MX2016009058A (https=) |
| MY (1) | MY166210A (https=) |
| PH (1) | PH12016501327B1 (https=) |
| SG (1) | SG11201605532YA (https=) |
| TW (1) | TWI612960B (https=) |
| UA (1) | UA121744C2 (https=) |
| WO (1) | WO2015105134A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101858373B1 (ko) * | 2014-01-10 | 2018-05-15 | 산텐 세이야꾸 가부시키가이샤 | 피리딜아미노아세트산 화합물과 폴리옥시에틸렌 피마자유를 함유하는 의약 조성물 |
| EP3093018B1 (en) | 2014-01-10 | 2018-11-28 | Santen Pharmaceutical Co., Ltd | Pharmaceutical preparation including pyridylamino acetic acid compound |
| CA2935055C (en) | 2014-01-10 | 2021-08-24 | Santen Pharmaceutical Co., Ltd. | Pharmaceutical composition containing pyridylaminoacetic acid compound |
| US20180200239A1 (en) | 2015-07-09 | 2018-07-19 | Santen Pharmaceutical Co., Ltd. | Prophylactic and/or therapeutic agent containing pyridylaminoacetic acid compound |
| US11433090B2 (en) | 2017-06-16 | 2022-09-06 | The Doshisha | mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof |
| WO2018230713A1 (ja) | 2017-06-16 | 2018-12-20 | 学校法人同志社 | カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用 |
| WO2019065838A1 (ja) | 2017-09-29 | 2019-04-04 | 参天製薬株式会社 | ピリジルアミノ酢酸化合物を含有する医薬 |
| CA3086445A1 (en) | 2017-12-21 | 2019-06-27 | Santen Pharmaceutical Co., Ltd. | Omidenepag combination |
| CN111526876A (zh) | 2017-12-28 | 2020-08-11 | 参天制药株式会社 | 含有吡啶基氨基乙酸化合物的药物制剂 |
| JP7217364B2 (ja) * | 2019-11-29 | 2023-02-02 | 千寿製薬株式会社 | 医薬組成物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960799A (en) * | 1988-09-13 | 1990-10-02 | Ciba-Geigy Corporation | Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use |
| US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| JP3297969B2 (ja) * | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| BR9906597A (pt) * | 1998-07-14 | 2000-07-18 | Alcon Lab Inc | Produto de prostaglandina |
| US6235781B1 (en) * | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| US20020009507A1 (en) * | 2000-01-19 | 2002-01-24 | Alcon Universal Ltd. | Use of polyethoxylated castor oil for the treatment of dry eye |
| JP2002356420A (ja) * | 2001-03-27 | 2002-12-13 | Santen Pharmaceut Co Ltd | 安定な水性液剤 |
| HRP20190509T1 (hr) * | 2008-03-12 | 2019-05-03 | Ube Industries, Ltd. | Spoj piridilaminooctene kiseline |
| PT2415763E (pt) | 2009-03-30 | 2016-03-30 | Ube Industries | Composição farmacêutica para tratamento ou prevenção do glaucoma |
| JP2011057633A (ja) * | 2009-09-11 | 2011-03-24 | Ube Industries Ltd | ピリジルアミノ酢酸化合物を含有する医薬 |
| US20120058983A1 (en) * | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| US20140018350A1 (en) * | 2012-07-13 | 2014-01-16 | Asahi Glass Co., Ltd. | Combination of sulfonamide compound and tafluprost |
| JP2014019650A (ja) * | 2012-07-13 | 2014-02-03 | Santen Pharmaceut Co Ltd | スルホンアミド化合物とタフルプロストの組み合わせ |
| US9339496B2 (en) * | 2012-07-13 | 2016-05-17 | Santen Pharmaceutical Co., Ltd. | Composition for treating or preventing glaucoma comprising a sulfonamide compound, and a beta-receptor antagonist |
| CA3099517C (en) * | 2012-07-13 | 2022-04-26 | Santen Pharmaceutical Co., Ltd. | Combinations comprising a sulfonamide compound for the treatment of glaucoma or ocular hypertension |
| EP3093018B1 (en) * | 2014-01-10 | 2018-11-28 | Santen Pharmaceutical Co., Ltd | Pharmaceutical preparation including pyridylamino acetic acid compound |
| CA2935055C (en) * | 2014-01-10 | 2021-08-24 | Santen Pharmaceutical Co., Ltd. | Pharmaceutical composition containing pyridylaminoacetic acid compound |
| KR101858373B1 (ko) * | 2014-01-10 | 2018-05-15 | 산텐 세이야꾸 가부시키가이샤 | 피리딜아미노아세트산 화합물과 폴리옥시에틸렌 피마자유를 함유하는 의약 조성물 |
-
2015
- 2015-01-08 KR KR1020167016400A patent/KR101858373B1/ko active Active
- 2015-01-08 CN CN201580003056.5A patent/CN105828817B/zh active Active
- 2015-01-08 AU AU2015205268A patent/AU2015205268B2/en active Active
- 2015-01-08 TW TW104100527A patent/TWI612960B/zh active
- 2015-01-08 EP EP21174649.0A patent/EP3888654B1/en active Active
- 2015-01-08 KR KR1020217007751A patent/KR102458180B1/ko active Active
- 2015-01-08 MY MYPI2016001268A patent/MY166210A/en unknown
- 2015-01-08 WO PCT/JP2015/050333 patent/WO2015105134A1/ja not_active Ceased
- 2015-01-08 JP JP2015002271A patent/JP6012775B2/ja active Active
- 2015-01-08 KR KR1020207013304A patent/KR102230683B1/ko active Active
- 2015-01-08 EA EA201691139A patent/EA031723B1/ru unknown
- 2015-01-08 CN CN201910493497.8A patent/CN110251516B/zh active Active
- 2015-01-08 SG SG11201605532YA patent/SG11201605532YA/en unknown
- 2015-01-08 EP EP15735607.2A patent/EP3093021B1/en active Active
- 2015-01-08 KR KR1020187012966A patent/KR102111157B1/ko active Active
- 2015-01-08 KR KR1020247019428A patent/KR20240096869A/ko not_active Ceased
- 2015-01-08 MX MX2016009058A patent/MX2016009058A/es unknown
- 2015-01-08 GE GEAP201514216A patent/GEP20186916B/en unknown
- 2015-01-08 CA CA2934612A patent/CA2934612C/en active Active
- 2015-01-08 KR KR1020227036348A patent/KR102675685B1/ko active Active
- 2015-01-08 UA UAA201607761A patent/UA121744C2/uk unknown
- 2015-01-08 GE GEAP201814216A patent/GEAP201814216A/en unknown
- 2015-01-08 ES ES15735607T patent/ES2874547T3/es active Active
- 2015-01-08 BR BR112016015911-0A patent/BR112016015911B1/pt active IP Right Grant
- 2015-01-08 ES ES21174649T patent/ES2953346T3/es active Active
-
2016
- 2016-07-04 PH PH12016501327A patent/PH12016501327B1/en unknown
- 2016-07-07 IL IL246654A patent/IL246654B/en active IP Right Grant
- 2016-07-07 US US15/204,475 patent/US20160317512A1/en not_active Abandoned
- 2016-09-16 JP JP2016181739A patent/JP6449205B2/ja active Active
-
2018
- 2018-12-05 JP JP2018227964A patent/JP6793172B2/ja active Active
-
2019
- 2019-12-12 US US16/711,706 patent/US20200113880A1/en not_active Abandoned
-
2020
- 2020-11-09 JP JP2020186245A patent/JP7170020B2/ja active Active
-
2022
- 2022-10-31 JP JP2022174719A patent/JP7546027B2/ja active Active
-
2023
- 2023-08-02 US US18/363,961 patent/US20230372316A1/en active Pending
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