JP2019104727A5 - - Google Patents

Info

Publication number

JP2019104727A5

JP2019104727A5 JP2018229557A JP2018229557A JP2019104727A5 JP 2019104727 A5 JP2019104727 A5 JP 2019104727A5 JP 2018229557 A JP2018229557 A JP 2018229557A JP 2018229557 A JP2018229557 A JP 2018229557A JP 2019104727 A5 JP2019104727 A5 JP 2019104727A5

Authority

JP

Japan

Prior art keywords

salt

aqueous liquid

water

soluble polymer

content

Prior art date

2018-12-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000003839 salts Chemical class 0.000 claims 20
• 239000007788 liquid Substances 0.000 claims 14
• 229920003169 water-soluble polymer Polymers 0.000 claims 12
• XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 10
• 229960003679 brimonidine Drugs 0.000 claims 10
• 229960003333 chlorhexidine gluconate Drugs 0.000 claims 8
• YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims 8
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 5
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 5
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 5
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 5
• 239000003112 inhibitor Substances 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
• 239000007864 aqueous solution Substances 0.000 claims 3
• 229920002674 hyaluronan Polymers 0.000 claims 3
• 229960003160 hyaluronic acid Drugs 0.000 claims 3
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
• GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 229960003260 chlorhexidine Drugs 0.000 claims 2
• 208000010412 Glaucoma Diseases 0.000 claims 1
• 239000003889 eye drop Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1