JP2013067635A5 - - Google Patents
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- Publication number
- JP2013067635A5 JP2013067635A5 JP2012255810A JP2012255810A JP2013067635A5 JP 2013067635 A5 JP2013067635 A5 JP 2013067635A5 JP 2012255810 A JP2012255810 A JP 2012255810A JP 2012255810 A JP2012255810 A JP 2012255810A JP 2013067635 A5 JP2013067635 A5 JP 2013067635A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- concentration
- enhancing polymer
- surfactants
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 229920000642 polymer Polymers 0.000 claims 14
- -1 sorbitan fatty acid ester Chemical class 0.000 claims 8
- 239000004094 surface-active agent Substances 0.000 claims 7
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 6
- 229920002678 cellulose Polymers 0.000 claims 5
- 239000001913 cellulose Substances 0.000 claims 5
- 239000002736 nonionic surfactant Substances 0.000 claims 5
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 4
- 239000004359 castor oil Substances 0.000 claims 4
- 235000019438 castor oil Nutrition 0.000 claims 4
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 4
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 4
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 4
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000003945 anionic surfactant Substances 0.000 claims 3
- 229920002301 cellulose acetate Polymers 0.000 claims 3
- 150000003950 cyclic amides Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229920002689 polyvinyl acetate Polymers 0.000 claims 3
- 239000011118 polyvinyl acetate Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 229920006163 vinyl copolymer Polymers 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 claims 2
- WZNRVWBKYDHTKI-UHFFFAOYSA-N cellulose, acetate 1,2,4-benzenetricarboxylate Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.OC(=O)C1=CC(C(=O)O)=CC=C1C(=O)OCC1C(OC2C(C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(COC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)O2)OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)O1 WZNRVWBKYDHTKI-UHFFFAOYSA-N 0.000 claims 2
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims 2
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 claims 2
- 229920001531 copovidone Polymers 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 125000005591 trimellitate group Chemical group 0.000 claims 2
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims 1
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 claims 1
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- ZNPLZHBZUSCANM-UHFFFAOYSA-N acetic acid;benzene-1,3-dicarboxylic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC(C(O)=O)=C1 ZNPLZHBZUSCANM-UHFFFAOYSA-N 0.000 claims 1
- FMTQGBMMIVVKSN-UHFFFAOYSA-N acetic acid;terephthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=C(C(O)=O)C=C1 FMTQGBMMIVVKSN-UHFFFAOYSA-N 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77178206P | 2006-02-09 | 2006-02-09 | |
| US60/771,782 | 2006-02-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554428A Division JP5773560B2 (ja) | 2006-02-09 | 2007-02-09 | Ｃｅｔｐ阻害剤のポリマー製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013067635A JP2013067635A (ja) | 2013-04-18 |
| JP2013067635A5 true JP2013067635A5 (https=) | 2013-09-05 |
| JP5648038B2 JP5648038B2 (ja) | 2015-01-07 |
Family
ID=38198472
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554428A Expired - Fee Related JP5773560B2 (ja) | 2006-02-09 | 2007-02-09 | Ｃｅｔｐ阻害剤のポリマー製剤 |
| JP2012255810A Expired - Fee Related JP5648038B2 (ja) | 2006-02-09 | 2012-11-22 | Ｃｅｔｐ阻害剤のポリマー製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554428A Expired - Fee Related JP5773560B2 (ja) | 2006-02-09 | 2007-02-09 | Ｃｅｔｐ阻害剤のポリマー製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8030359B2 (https=) |
| EP (1) | EP1983966B1 (https=) |
| JP (2) | JP5773560B2 (https=) |
| KR (1) | KR101418267B1 (https=) |
| CN (2) | CN103735515A (https=) |
| AU (1) | AU2007212197B2 (https=) |
| BR (1) | BRPI0707584A2 (https=) |
| CA (1) | CA2641451C (https=) |
| IL (1) | IL192977A (https=) |
| NO (1) | NO341326B1 (https=) |
| NZ (1) | NZ569700A (https=) |
| RU (1) | RU2457841C2 (https=) |
| WO (1) | WO2007092642A2 (https=) |
| ZA (1) | ZA200805854B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004085996A2 (en) | 2003-03-20 | 2004-10-07 | Albert Einstein College Of Medicine Of Yeshiva University | Biomarkers for longevity and disease and uses thereof |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| WO2006073973A2 (en) * | 2004-12-31 | 2006-07-13 | Reddy Us Therapeutics, Inc. | Novel benzylamine derivatives as cetp inhibitors |
| AU2008313620A1 (en) * | 2007-10-19 | 2009-04-23 | Abbott Gmbh & Co. Kg | Solid dispersion product containing N-aryl urea-based compound |
| JP2011513242A (ja) | 2008-02-25 | 2011-04-28 | アミラ ファーマシューティカルズ，インク． | プロスタグランジンｄ２受容体アンタゴニスト |
| AR071375A1 (es) * | 2008-04-22 | 2010-06-16 | Solvay Pharm Gmbh | Formulaciones para ingredientes farmaceuticos activos de permeabilidad deficiente, proceso de preparacion y producto |
| AU2011332031B2 (en) | 2010-11-24 | 2017-01-12 | Melinta Subsidiary Corp. | Pharmaceutical compositions |
| ES2683350T3 (es) * | 2011-07-08 | 2018-09-26 | Novartis Ag | Método para tratar la aterosclerosis en sujetos con alto nivel de triglicéridos |
| US9199967B2 (en) | 2011-08-18 | 2015-12-01 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors |
| MX352074B (es) | 2011-09-27 | 2017-11-08 | Dr Reddys Laboratories Ltd | Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis. |
| MX368859B (es) | 2012-05-31 | 2019-10-18 | Merck Sharp & Dohme | Formulaciones de dosis solida de un antagonista del receptor de orexina. |
| KR102160903B1 (ko) * | 2012-07-17 | 2020-10-05 | 다우 글로벌 테크놀로지스 엘엘씨 | 고도로 치환된 하이드록시알킬 메틸셀룰로즈를 포함하는 고체 분산물 |
| JP6301339B2 (ja) * | 2012-09-27 | 2018-03-28 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 少なくとも１種の水溶性ビタミンｅ誘導体および少なくとも１種の親水性ポリマーを含む、保存において安定な無塵の均質な粒子製剤 |
| US20170071930A1 (en) | 2012-11-19 | 2017-03-16 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| US20160287568A1 (en) * | 2013-11-22 | 2016-10-06 | Merck Sharp & Dohme Corp. | Composition of a non-nucleoside reverse transcriptase inhibitor |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| JP6491669B2 (ja) | 2014-02-05 | 2019-03-27 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｃｇｒｐ活性化合物の錠剤製剤 |
| WO2016084949A1 (ja) * | 2014-11-28 | 2016-06-02 | 興和株式会社 | 医薬 |
| JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| CN111803632B (zh) * | 2019-04-09 | 2022-04-29 | 北京五和博澳药业股份有限公司 | 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途 |
| BR112021020389A2 (pt) * | 2019-04-12 | 2021-12-07 | Oblita Therapeutics Bvba | Formulações de dosagem em comprimidos de oleil fosfocolina |
| TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
| CN116390712A (zh) | 2020-07-29 | 2023-07-04 | 阿勒根制药国际有限公司 | 治疗偏头痛 |
| CA3206184A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| WO2023049920A1 (en) | 2021-09-27 | 2023-03-30 | Allergan Pharmaceuticals International Limited | Combination comprising atogepant for treating migraine |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
| US6627767B2 (en) | 2000-08-29 | 2003-09-30 | Abbott Laboratories | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors |
| ES2284871T3 (es) | 2001-06-22 | 2007-11-16 | Pfizer Products Inc. | Composiciones farmaceuticas que contienen una dispersion solida de farmaco poco soluble y un polimero potenciador de la solubilidad. |
| EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| CN100410236C (zh) | 2002-01-29 | 2008-08-13 | 雪兰诺实验室有限公司 | 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物 |
| DE60322665D1 (de) * | 2002-02-01 | 2008-09-18 | Pfizer Prod Inc | Pharmazeutische darreichungsform mit gesteuerter freigabe eines cholesterylester-transferproteininhibitors |
| PL371593A1 (en) | 2002-02-01 | 2005-06-27 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles |
| BR0306208A (pt) | 2002-08-30 | 2004-10-13 | Japan Tobacco Inc | Compostos de dibenzilamina e seu uso farmacêutico |
| MXPA05009848A (es) | 2003-03-17 | 2005-12-06 | Japan Tobacco Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia del ester de colesterilo. |
| US20070043079A1 (en) | 2003-04-18 | 2007-02-22 | Hiromu Habashita | Heterocyclic compound containing nitrogen atom and use thereof |
| DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| FR2875409B1 (fr) * | 2004-09-17 | 2010-05-07 | Sanofi Aventis | Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose |
| CN102757397A (zh) * | 2005-07-01 | 2012-10-31 | 默沙东公司 | 合成cetp抑制剂的方法 |
| EP1965764B1 (en) * | 2005-12-05 | 2011-07-13 | Merck Sharp & Dohme Corp. | Self-emulsifying formulations of cetp inhibitors |
-
2007
- 2007-02-09 JP JP2008554428A patent/JP5773560B2/ja not_active Expired - Fee Related
- 2007-02-09 EP EP07763707.2A patent/EP1983966B1/en not_active Not-in-force
- 2007-02-09 AU AU2007212197A patent/AU2007212197B2/en not_active Ceased
- 2007-02-09 NZ NZ569700A patent/NZ569700A/en not_active IP Right Cessation
- 2007-02-09 RU RU2008136198/15A patent/RU2457841C2/ru not_active IP Right Cessation
- 2007-02-09 BR BRPI0707584-7A patent/BRPI0707584A2/pt not_active Application Discontinuation
- 2007-02-09 CN CN201410027847.9A patent/CN103735515A/zh active Pending
- 2007-02-09 CN CN200780004561.7A patent/CN101378731B/zh not_active Expired - Fee Related
- 2007-02-09 US US12/223,272 patent/US8030359B2/en not_active Expired - Fee Related
- 2007-02-09 KR KR1020087019569A patent/KR101418267B1/ko not_active Expired - Fee Related
- 2007-02-09 WO PCT/US2007/003799 patent/WO2007092642A2/en not_active Ceased
- 2007-02-09 CA CA2641451A patent/CA2641451C/en not_active Expired - Fee Related
-
2008
- 2008-07-04 ZA ZA200805854A patent/ZA200805854B/xx unknown
- 2008-07-22 IL IL192977A patent/IL192977A/en not_active IP Right Cessation
- 2008-09-08 NO NO20083821A patent/NO341326B1/no not_active IP Right Cessation
-
2012
- 2012-11-22 JP JP2012255810A patent/JP5648038B2/ja not_active Expired - Fee Related
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