JP2013067635A5 - - Google Patents

Info

Publication number

JP2013067635A5

JP2013067635A5 JP2012255810A JP2012255810A JP2013067635A5 JP 2013067635 A5 JP2013067635 A5 JP 2013067635A5 JP 2012255810 A JP2012255810 A JP 2012255810A JP 2012255810 A JP2012255810 A JP 2012255810A JP 2013067635 A5 JP2013067635 A5 JP 2013067635A5

Authority

JP

Japan

Prior art keywords

group

concentration

enhancing polymer

surfactants

cellulose

Prior art date

2012-11-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 20
• 229920000642 polymer Polymers 0.000 claims 14
• -1 sorbitan fatty acid ester Chemical class 0.000 claims 8
• 239000004094 surface-active agent Substances 0.000 claims 7
• 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 6
• 229920002678 cellulose Polymers 0.000 claims 5
• 239000001913 cellulose Substances 0.000 claims 5
• 239000002736 nonionic surfactant Substances 0.000 claims 5
• 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 4
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
• AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 4
• 239000004359 castor oil Substances 0.000 claims 4
• 235000019438 castor oil Nutrition 0.000 claims 4
• 229940081734 cellulose acetate phthalate Drugs 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 235000014113 dietary fatty acids Nutrition 0.000 claims 4
• 239000000194 fatty acid Substances 0.000 claims 4
• 229930195729 fatty acid Natural products 0.000 claims 4
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 4
• 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 4
• 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 4
• ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 3
• 125000004423 acyloxy group Chemical group 0.000 claims 3
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 239000003945 anionic surfactant Substances 0.000 claims 3
• 229920002301 cellulose acetate Polymers 0.000 claims 3
• 150000003950 cyclic amides Chemical group 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 229920002689 polyvinyl acetate Polymers 0.000 claims 3
• 239000011118 polyvinyl acetate Substances 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 229920006163 vinyl copolymer Polymers 0.000 claims 3
• 229920002554 vinyl polymer Polymers 0.000 claims 3
• 229920001214 Polysorbate 60 Polymers 0.000 claims 2
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
• GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 claims 2
• WZNRVWBKYDHTKI-UHFFFAOYSA-N cellulose, acetate 1,2,4-benzenetricarboxylate Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.OC(=O)C1=CC(C(=O)O)=CC=C1C(=O)OCC1C(OC2C(C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(COC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)O2)OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)O1 WZNRVWBKYDHTKI-UHFFFAOYSA-N 0.000 claims 2
• 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims 2
• 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 claims 2
• 229920001531 copovidone Polymers 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
• 125000005591 trimellitate group Chemical group 0.000 claims 2
• KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims 1
• 102100037637 Cholesteryl ester transfer protein Human genes 0.000 claims 1
• 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
• ZNPLZHBZUSCANM-UHFFFAOYSA-N acetic acid;benzene-1,3-dicarboxylic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC(C(O)=O)=C1 ZNPLZHBZUSCANM-UHFFFAOYSA-N 0.000 claims 1
• FMTQGBMMIVVKSN-UHFFFAOYSA-N acetic acid;terephthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=C(C(O)=O)C=C1 FMTQGBMMIVVKSN-UHFFFAOYSA-N 0.000 claims 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 229920000609 methyl cellulose Polymers 0.000 claims 1
• 239000001923 methylcellulose Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1