JP2013515742A5 - - Google Patents
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- Publication number
- JP2013515742A5 JP2013515742A5 JP2012546222A JP2012546222A JP2013515742A5 JP 2013515742 A5 JP2013515742 A5 JP 2013515742A5 JP 2012546222 A JP2012546222 A JP 2012546222A JP 2012546222 A JP2012546222 A JP 2012546222A JP 2013515742 A5 JP2013515742 A5 JP 2013515742A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- terbinafine
- preparation
- short
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 12
- 238000009472 formulation Methods 0.000 claims 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 150000001261 hydroxy acids Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229960002722 terbinafine Drugs 0.000 claims 3
- 239000002888 zwitterionic surfactant Substances 0.000 claims 3
- 208000010195 Onychomycosis Diseases 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- 201000005882 tinea unguium Diseases 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229940047648 cocoamphodiacetate Drugs 0.000 claims 1
- 229940047642 disodium cocoamphodiacetate Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 150000004666 short chain fatty acids Chemical class 0.000 claims 1
- 235000021391 short chain fatty acids Nutrition 0.000 claims 1
- 229960000699 terbinafine hydrochloride Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28996709P | 2009-12-23 | 2009-12-23 | |
| US28996209P | 2009-12-23 | 2009-12-23 | |
| US61/289,967 | 2009-12-23 | ||
| US61/289,962 | 2009-12-23 | ||
| PCT/US2010/061940 WO2011079234A2 (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515742A JP2013515742A (ja) | 2013-05-09 |
| JP2013515742A5 true JP2013515742A5 (https=) | 2014-02-13 |
| JP5829217B2 JP5829217B2 (ja) | 2015-12-09 |
Family
ID=43770418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546222A Expired - Fee Related JP5829217B2 (ja) | 2009-12-23 | 2010-12-22 | 高浸透性テルビナフィン製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9084754B2 (https=) |
| EP (1) | EP2544659A2 (https=) |
| JP (1) | JP5829217B2 (https=) |
| CN (1) | CN102770123A (https=) |
| AU (1) | AU2010336441B2 (https=) |
| CA (1) | CA2785643A1 (https=) |
| WO (1) | WO2011079234A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101647545B1 (ko) | 2011-02-11 | 2016-08-10 | 모베르그 파르마 아베 | 신규 항진균 조성물 |
| US10232047B2 (en) * | 2011-12-20 | 2019-03-19 | Vyome Biosciences Private Limited | Topical oil composition for the treatment of fungal infections |
| EP2664327A1 (en) * | 2012-05-14 | 2013-11-20 | Almirall S.A. | Topical pharmaceutical compositions comprising terbinafide and urea |
| NL2009669C2 (en) * | 2012-10-19 | 2014-04-23 | Dutch Renewable Energy B V | Enhanced nail penetrating composition. |
| EA030797B1 (ru) | 2012-12-21 | 2018-09-28 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Система трансдермальной доставки гормонов (варианты) и способы ее применения |
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| EP2952208A1 (en) * | 2014-06-04 | 2015-12-09 | Universidade de Santiago de Compostela | Hydroalcoholic system for nail treatment |
| DK3209319T3 (da) | 2014-10-21 | 2021-10-04 | Hexima Ltd | En fremgangsmåde til behandling af svampeinfektioner |
| KR101690765B1 (ko) * | 2015-04-17 | 2016-12-28 | 동아제약 주식회사 | 항진균성 활성물질을 포함하는 경피 제제 |
| GB201511799D0 (en) * | 2015-07-06 | 2015-08-19 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
| CN108472272A (zh) * | 2015-08-17 | 2018-08-31 | 俄亥俄州国家创新基金会 | 用于ar-12的增强的透甲递送的方法和组合物 |
| CN108135844A (zh) * | 2015-10-07 | 2018-06-08 | 埃克索多斯生命科学有限合伙公司 | 局部用抗真菌组合物 |
| GB201605127D0 (en) * | 2016-03-25 | 2016-05-11 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
| WO2017216722A2 (en) * | 2016-06-13 | 2017-12-21 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
| BR112018075998A2 (pt) * | 2016-06-13 | 2019-04-02 | Vyome Therapeutics Limited. | composições antifúngicas sinérgicas e métodos das mesmas |
| KR102567090B1 (ko) | 2016-11-28 | 2023-08-17 | 셀릭스 바이오 프라이빗 리미티드 | 곰팡이 감염의 치료를 위한 조성물 및 방법 |
| WO2019214838A1 (en) * | 2018-05-09 | 2019-11-14 | Eviderm Institute Ab | Use of an alcohol-containing composition for improving the skin barrier function |
| EP3802502A4 (en) * | 2018-06-04 | 2022-03-30 | Zenvision Pharma LLP | ANTIFUNGAL CUTICLE OIL COMPOSITION |
| EP3603650A1 (fr) | 2018-08-01 | 2020-02-05 | Edix O Sarl | Compositions injectables et a duree d'action prolongee pour leur utilisation dans le traitement de maladies de l'ongle et/ou pour accelerer la croissance de l'ongle |
| EP3829601B1 (fr) | 2018-08-01 | 2024-05-29 | Edix-O Sarl | Compositions injectables à durée d'action prolongée pour leur utilisation dans le traitement de maladies de l'ongle |
| WO2020186447A1 (en) | 2019-03-19 | 2020-09-24 | Dow Global Technologies Llc | Aqueous dispersion comprising multistage polymeric particles |
| CN113208937A (zh) * | 2020-01-21 | 2021-08-06 | 中国医学科学院北京协和医院 | 一种角质软化组合物及其制备方法和应用及治疗灰指甲的外用复方及其制备方法和应用 |
| JP7664026B2 (ja) * | 2020-08-06 | 2025-04-17 | 沢井製薬株式会社 | エフィナコナゾール含有爪外用液 |
| JP2022117408A (ja) * | 2021-01-29 | 2022-08-10 | 花王株式会社 | 外用剤組成物 |
| CN113234028B (zh) * | 2021-04-29 | 2022-08-26 | 上海大学 | 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途 |
| CN113786382B (zh) * | 2021-11-04 | 2024-05-28 | 浙江得恩德制药股份有限公司 | 一种盐酸特比萘芬凝胶及制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7713618L (sv) | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | Lokalanestetisk blandning |
| IT1180295B (it) | 1984-10-08 | 1987-09-23 | Durst Phototechnik Srl | Ingranditore o riproduttore fotografico a colori |
| FR2673537B1 (fr) | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
| JP2001525820A (ja) | 1997-05-14 | 2001-12-11 | ガレン（ケミカルズ）リミティド | 局所組成物 |
| CA2325553A1 (en) * | 1998-04-17 | 1999-10-28 | Penederm Inc. | Topical formulations for the treatment of nail fungal diseases |
| US6368618B1 (en) | 1999-07-01 | 2002-04-09 | The University Of Georgia Research Foundation, Inc. | Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs |
| DE10035991A1 (de) * | 2000-07-24 | 2002-02-14 | Polichem Sa | Nagellackzusammensetzung |
| CZ301310B6 (cs) * | 2001-09-04 | 2010-01-13 | Trommsdorff Gmbh & Co. Kg Arzneimittel | Náplast |
| US20030091666A1 (en) * | 2001-11-14 | 2003-05-15 | Howard Murad | Methods and compositions for treating dermatological disorders with Morinda citrifolia |
| US7138394B2 (en) | 2002-09-27 | 2006-11-21 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
| EP1635770B1 (en) * | 2003-03-21 | 2009-05-27 | Nexmed Holdings, Inc. | Antifungal nail coat and method of use |
| EP2977043A3 (en) | 2003-08-25 | 2016-04-06 | Foamix Pharmaceuticals Ltd. | Penetrating pharmaceutical foam |
| US20060078580A1 (en) * | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US20060078599A1 (en) | 2004-10-12 | 2006-04-13 | Mathew Ebmeier | Pharmaceutical composition applicable to body tissue |
| CA2500907A1 (en) | 2005-03-15 | 2006-09-15 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
| EP1858556A1 (en) | 2005-03-16 | 2007-11-28 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
| GB0511499D0 (en) * | 2005-06-06 | 2005-07-13 | Medpharm Ltd | Topical ungual formulations |
| US20070224261A1 (en) | 2006-03-22 | 2007-09-27 | Peter Draper | Eutectic liquid drug formulation |
| EP2457560A1 (en) | 2006-06-14 | 2012-05-30 | Dr Reddy's Laboratories Limited | Topical compositions |
| US20080261986A1 (en) * | 2007-03-30 | 2008-10-23 | Friden Phillip M | Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug |
| CA2731455A1 (en) * | 2008-07-23 | 2010-01-28 | Gregor Cevc | Methods of administering topical antifungal formulations for the treatment of fungal infections |
| WO2011014850A2 (en) * | 2009-07-31 | 2011-02-03 | Nuvo Research Inc. | Topical eutectic-based formulations |
-
2010
- 2010-12-22 WO PCT/US2010/061940 patent/WO2011079234A2/en not_active Ceased
- 2010-12-22 CN CN2010800643152A patent/CN102770123A/zh active Pending
- 2010-12-22 JP JP2012546222A patent/JP5829217B2/ja not_active Expired - Fee Related
- 2010-12-22 EP EP10801340A patent/EP2544659A2/en not_active Withdrawn
- 2010-12-22 CA CA2785643A patent/CA2785643A1/en not_active Abandoned
- 2010-12-22 AU AU2010336441A patent/AU2010336441B2/en not_active Ceased
-
2012
- 2012-06-15 US US13/525,108 patent/US9084754B2/en not_active Expired - Fee Related
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