CN102770123A - 用于治疗甲癣的高渗透性特比萘芬制剂 - Google Patents

用于治疗甲癣的高渗透性特比萘芬制剂 Download PDF

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Publication number
CN102770123A
CN102770123A CN2010800643152A CN201080064315A CN102770123A CN 102770123 A CN102770123 A CN 102770123A CN 2010800643152 A CN2010800643152 A CN 2010800643152A CN 201080064315 A CN201080064315 A CN 201080064315A CN 102770123 A CN102770123 A CN 102770123A
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China
Prior art keywords
preparation
topical formulations
terbinafine
formulations
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN2010800643152A
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English (en)
Chinese (zh)
Inventor
S·比于克蒂姆金
N·比于克蒂姆金
J.辛格
J·M·纽萨姆
D·金-史密斯
E·基斯克
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Nuvo Research Inc
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Nuvo Research Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN2010800643152A 2009-12-23 2010-12-22 用于治疗甲癣的高渗透性特比萘芬制剂 Pending CN102770123A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28996209P 2009-12-23 2009-12-23
US28996709P 2009-12-23 2009-12-23
US61/289,962 2009-12-23
US61/289,967 2009-12-23
PCT/US2010/061940 WO2011079234A2 (en) 2009-12-23 2010-12-22 Highly permeating terbinafine formulation

Publications (1)

Publication Number Publication Date
CN102770123A true CN102770123A (zh) 2012-11-07

Family

ID=43770418

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800643152A Pending CN102770123A (zh) 2009-12-23 2010-12-22 用于治疗甲癣的高渗透性特比萘芬制剂

Country Status (7)

Country Link
US (1) US9084754B2 (https=)
EP (1) EP2544659A2 (https=)
JP (1) JP5829217B2 (https=)
CN (1) CN102770123A (https=)
AU (1) AU2010336441B2 (https=)
CA (1) CA2785643A1 (https=)
WO (1) WO2011079234A2 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109689034A (zh) * 2016-06-13 2019-04-26 维奥梅治疗有限公司 协同抗真菌组合物及其方法
US20210154215A1 (en) * 2018-06-04 2021-05-27 Zenvision Pharma Llp Antifungal Cuticle Oil Composition
CN113208937A (zh) * 2020-01-21 2021-08-06 中国医学科学院北京协和医院 一种角质软化组合物及其制备方法和应用及治疗灰指甲的外用复方及其制备方法和应用
CN113234028A (zh) * 2021-04-29 2021-08-10 上海大学 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途
CN113786382A (zh) * 2021-11-04 2021-12-14 浙江得恩德制药股份有限公司 一种盐酸特比萘酚凝胶及制备方法
US12528964B2 (en) 2019-03-19 2026-01-20 Dow Global Technologies Llc Aqueous dispersion comprising multistage polymeric particles

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SI2672962T1 (sl) 2011-02-11 2015-06-30 Moberg Pharma Ab Nov protiglivni sestavek
CN110075310A (zh) * 2011-12-20 2019-08-02 维奥姆治疗有限公司 用于治疗真菌感染的局部油组合物
EP2664327A1 (en) * 2012-05-14 2013-11-20 Almirall S.A. Topical pharmaceutical compositions comprising terbinafide and urea
NL2009669C2 (en) * 2012-10-19 2014-04-23 Dutch Renewable Energy B V Enhanced nail penetrating composition.
EA030797B1 (ru) 2012-12-21 2018-09-28 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Система трансдермальной доставки гормонов (варианты) и способы ее применения
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
EP2952208A1 (en) * 2014-06-04 2015-12-09 Universidade de Santiago de Compostela Hydroalcoholic system for nail treatment
PT3209319T (pt) 2014-10-21 2021-09-24 Hexima Ltd Um método de tratamento
KR101690765B1 (ko) * 2015-04-17 2016-12-28 동아제약 주식회사 항진균성 활성물질을 포함하는 경피 제제
GB201511799D0 (en) * 2015-07-06 2015-08-19 Blueberry Therapeutics Ltd Composition and methods of treatment
WO2017031075A1 (en) * 2015-08-17 2017-02-23 Arno Therapeutics, Inc. Methods and compositions for enhanced transungual delivery of ar-12
WO2017062761A1 (en) * 2015-10-07 2017-04-13 Exodos Life Sciences Lp Topical antifungal compositions
GB201605127D0 (en) * 2016-03-25 2016-05-11 Blueberry Therapeutics Ltd Composition and methods of treatment
WO2017216722A2 (en) * 2016-06-13 2017-12-21 Vyome Biosciences Pvt. Ltd. Synergistic antifungal compositions and methods thereof
IL287622B (en) 2016-11-28 2022-07-01 Cellix Bio Private Ltd Preparations and methods for treating fungal infections
WO2019214838A1 (en) * 2018-05-09 2019-11-14 Eviderm Institute Ab Use of an alcohol-containing composition for improving the skin barrier function
DK3829601T3 (da) 2018-08-01 2024-09-02 Edix O Sarl Injicerbare sammensætninger med depotvirkning til anvendelse til behandling af neglesygdomme
EP3603650A1 (fr) 2018-08-01 2020-02-05 Edix O Sarl Compositions injectables et a duree d'action prolongee pour leur utilisation dans le traitement de maladies de l'ongle et/ou pour accelerer la croissance de l'ongle
JP7664026B2 (ja) * 2020-08-06 2025-04-17 沢井製薬株式会社 エフィナコナゾール含有爪外用液
JP2022117408A (ja) * 2021-01-29 2022-08-10 花王株式会社 外用剤組成物

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WO2006042059A1 (en) * 2004-10-08 2006-04-20 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
WO2006131721A2 (en) * 2005-06-06 2006-12-14 Medpharm Limited Topical ungual formulations

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WO2006131721A2 (en) * 2005-06-06 2006-12-14 Medpharm Limited Topical ungual formulations

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109689034A (zh) * 2016-06-13 2019-04-26 维奥梅治疗有限公司 协同抗真菌组合物及其方法
US20210154215A1 (en) * 2018-06-04 2021-05-27 Zenvision Pharma Llp Antifungal Cuticle Oil Composition
US12528964B2 (en) 2019-03-19 2026-01-20 Dow Global Technologies Llc Aqueous dispersion comprising multistage polymeric particles
CN113208937A (zh) * 2020-01-21 2021-08-06 中国医学科学院北京协和医院 一种角质软化组合物及其制备方法和应用及治疗灰指甲的外用复方及其制备方法和应用
CN113234028A (zh) * 2021-04-29 2021-08-10 上海大学 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途
CN113234028B (zh) * 2021-04-29 2022-08-26 上海大学 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途
CN113786382A (zh) * 2021-11-04 2021-12-14 浙江得恩德制药股份有限公司 一种盐酸特比萘酚凝胶及制备方法
CN113786382B (zh) * 2021-11-04 2024-05-28 浙江得恩德制药股份有限公司 一种盐酸特比萘芬凝胶及制备方法

Also Published As

Publication number Publication date
US9084754B2 (en) 2015-07-21
US20120309843A1 (en) 2012-12-06
WO2011079234A2 (en) 2011-06-30
WO2011079234A3 (en) 2011-08-18
EP2544659A2 (en) 2013-01-16
AU2010336441B2 (en) 2015-02-05
CA2785643A1 (en) 2011-06-30
AU2010336441A1 (en) 2012-08-02
JP2013515742A (ja) 2013-05-09
JP5829217B2 (ja) 2015-12-09

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Application publication date: 20121107