JP2023088944A5 - - Google Patents
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- JP2023088944A5 JP2023088944A5 JP2023040600A JP2023040600A JP2023088944A5 JP 2023088944 A5 JP2023088944 A5 JP 2023088944A5 JP 2023040600 A JP2023040600 A JP 2023040600A JP 2023040600 A JP2023040600 A JP 2023040600A JP 2023088944 A5 JP2023088944 A5 JP 2023088944A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- subject
- csa
- dose
- plasma concentration
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- 230000036470 plasma concentration Effects 0.000 claims 15
- 206010019280 Heart failures Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 3
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 2
- 210000004165 myocardium Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- 102400001263 NT-proBNP Human genes 0.000 claims 1
- QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025121073A JP2025165979A (ja) | 2017-06-30 | 2025-07-18 | 心筋節活性化剤で心不全を治療する方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527983P | 2017-06-30 | 2017-06-30 | |
| US62/527,983 | 2017-06-30 | ||
| PCT/US2018/040181 WO2019006235A1 (en) | 2017-06-30 | 2018-06-29 | METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS |
| JP2019570045A JP2020526483A (ja) | 2017-06-30 | 2018-06-29 | 心筋節活性化剤で心不全を治療する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570045A Division JP2020526483A (ja) | 2017-06-30 | 2018-06-29 | 心筋節活性化剤で心不全を治療する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025121073A Division JP2025165979A (ja) | 2017-06-30 | 2025-07-18 | 心筋節活性化剤で心不全を治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023088944A JP2023088944A (ja) | 2023-06-27 |
| JP2023088944A5 true JP2023088944A5 (enExample) | 2023-09-01 |
Family
ID=63013097
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570045A Pending JP2020526483A (ja) | 2017-06-30 | 2018-06-29 | 心筋節活性化剤で心不全を治療する方法 |
| JP2023040600A Pending JP2023088944A (ja) | 2017-06-30 | 2023-03-15 | 心筋節活性化剤で心不全を治療する方法 |
| JP2025121073A Pending JP2025165979A (ja) | 2017-06-30 | 2025-07-18 | 心筋節活性化剤で心不全を治療する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570045A Pending JP2020526483A (ja) | 2017-06-30 | 2018-06-29 | 心筋節活性化剤で心不全を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025121073A Pending JP2025165979A (ja) | 2017-06-30 | 2025-07-18 | 心筋節活性化剤で心不全を治療する方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US11576910B2 (enExample) |
| EP (2) | EP4512470A3 (enExample) |
| JP (3) | JP2020526483A (enExample) |
| CN (1) | CN110996953A (enExample) |
| AU (2) | AU2018290983B2 (enExample) |
| BR (1) | BR112019028046A2 (enExample) |
| CA (1) | CA3068588A1 (enExample) |
| DK (1) | DK3645002T3 (enExample) |
| ES (1) | ES3008457T3 (enExample) |
| FI (1) | FI3645002T3 (enExample) |
| HR (1) | HRP20241729T1 (enExample) |
| HU (1) | HUE069805T2 (enExample) |
| LT (1) | LT3645002T (enExample) |
| MA (1) | MA49508B1 (enExample) |
| MD (1) | MD3645002T2 (enExample) |
| MX (2) | MX2020000190A (enExample) |
| PL (1) | PL3645002T3 (enExample) |
| PT (1) | PT3645002T (enExample) |
| RS (1) | RS66581B1 (enExample) |
| SI (1) | SI3645002T1 (enExample) |
| SM (1) | SMT202500067T1 (enExample) |
| WO (1) | WO2019006235A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2015008789A0 (en) | 2013-03-14 | 2015-10-31 | Cytokinetics Inc | Heterocyclic compounds and their uses |
| CN110996953A (zh) | 2017-06-30 | 2020-04-10 | 安进公司 | 用心脏肌小节激活剂治疗心力衰竭的方法 |
| MD3645518T2 (ro) | 2017-06-30 | 2021-11-30 | Amgen Inc | Sinteză de mercabil omecamtiv |
| LT3594199T (lt) | 2018-07-09 | 2020-11-10 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdas |
| CA3108800A1 (en) | 2018-08-17 | 2020-02-20 | Amgen Inc. | Salts and crystal forms of omecamtiv mecarbil |
| CN114173782A (zh) * | 2019-05-19 | 2022-03-11 | 迈奥卡迪亚公司 | 利用化合物(r)-4-(1-((3-(二氟甲基)-1-甲基-1h-吡唑-4-基)磺酰基)-1-氟乙基)-n-(异噁唑-3-基)哌啶-1-甲酰胺治疗心缩功能障碍和具有减小的射血分数的心脏衰竭 |
| CN115279349A (zh) * | 2020-02-10 | 2022-11-01 | 安进股份有限公司 | 奥美卡替莫卡必尔片剂 |
| AU2021293817A1 (en) * | 2020-06-15 | 2023-01-19 | MyoKardia, Inc. | Treatment of atrial dysfunction |
| EP4243825B1 (en) | 2020-11-12 | 2025-11-12 | Amgen Inc. | Omecamtiv mecarbil for the treatment of heart failure in selected patient groups |
| CN116710139A (zh) * | 2020-11-12 | 2023-09-05 | 安进股份有限公司 | 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法 |
| WO2022192414A2 (en) | 2021-03-10 | 2022-09-15 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| US20250161298A1 (en) * | 2022-02-22 | 2025-05-22 | Yale University | Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth |
| WO2024081611A1 (en) * | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| AU2024248193A1 (en) | 2023-03-27 | 2025-10-09 | Edgewise Therapeutics, Inc. | Quinolinone amide compounds and uses thereof |
| US11986474B1 (en) * | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| CN1296417A (zh) | 1998-02-10 | 2001-05-23 | 卫福有限公司 | 控释制剂 |
| GB2344287A (en) | 1998-12-03 | 2000-06-07 | Ferring Bv | Controlled release pharmaceutical formulation |
| DE60331455D1 (de) | 2002-10-04 | 2010-04-08 | Microchips Inc | Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation |
| WO2006009726A2 (en) | 2004-06-17 | 2006-01-26 | Cytokinetics, Inc. | Substituted urea derivatives for treating cardiac diseases |
| TW200808321A (en) | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
| MX2008014418A (es) | 2006-05-15 | 2008-11-27 | Wisconsin Alumni Res Found | Administracion pulmonar de la 1 alfa, 25-dihidroxivitamina d3 y co-administracion de la homona paratiroidea o calcitonina. |
| FR2902092B1 (fr) | 2006-06-07 | 2008-09-05 | Sapelem Soc Par Actions Simpli | Appareil de manutention de charge |
| NZ580700A (en) | 2007-04-19 | 2012-01-12 | Dong A Pharm Co Ltd | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
| AP2015008789A0 (en) | 2013-03-14 | 2015-10-31 | Cytokinetics Inc | Heterocyclic compounds and their uses |
| US9895308B2 (en) * | 2013-03-14 | 2018-02-20 | Amgen Inc. | Heterocyclic compounds and their uses |
| CA2975260C (en) | 2015-01-29 | 2024-05-21 | Signal Pharmaceuticals Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| US10543215B2 (en) | 2015-06-26 | 2020-01-28 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| CN110603049A (zh) | 2017-02-06 | 2019-12-20 | 阿塞勒隆制药公司 | 用于治疗心力衰竭的组合物和方法 |
| CN110996953A (zh) | 2017-06-30 | 2020-04-10 | 安进公司 | 用心脏肌小节激活剂治疗心力衰竭的方法 |
| MD3645518T2 (ro) | 2017-06-30 | 2021-11-30 | Amgen Inc | Sinteză de mercabil omecamtiv |
| LT3594199T (lt) | 2018-07-09 | 2020-11-10 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdas |
| WO2020014406A1 (en) | 2018-07-12 | 2020-01-16 | Assia Chemical Industries Ltd. | Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl |
| FI3599243T3 (fi) | 2018-07-26 | 2023-06-22 | Cvie Therapeutics Ltd | 17beeta-heterosyklyylidigitaliksen kaltaisia yhdisteitä sydämen vajaatoiminnan hoitoon |
| CA3108800A1 (en) | 2018-08-17 | 2020-02-20 | Amgen Inc. | Salts and crystal forms of omecamtiv mecarbil |
| US12442027B2 (en) | 2018-12-18 | 2025-10-14 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| CA3130261A1 (en) | 2019-03-05 | 2020-09-10 | Windtree Therapeutics, Inc. | Istaroxime-containing intravenous formulation for the treatment of acute heart failure (ahf) |
| EP4045492A1 (en) | 2019-09-19 | 2022-08-24 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| US20220340542A1 (en) | 2019-09-19 | 2022-10-27 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021070123A1 (en) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| US20220411374A1 (en) | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| US20230158027A1 (en) | 2019-11-10 | 2023-05-25 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| GB201918853D0 (en) | 2019-12-19 | 2020-02-05 | Lund Lars H | Methods of treatment |
| CN114929671B (zh) | 2020-01-03 | 2024-04-16 | 苏州科睿思制药有限公司 | 化合物i二盐酸盐的共晶及其制备方法和用途 |
| CN115279349A (zh) | 2020-02-10 | 2022-11-01 | 安进股份有限公司 | 奥美卡替莫卡必尔片剂 |
| EP4243825B1 (en) | 2020-11-12 | 2025-11-12 | Amgen Inc. | Omecamtiv mecarbil for the treatment of heart failure in selected patient groups |
| WO2022192414A2 (en) | 2021-03-10 | 2022-09-15 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| WO2023205291A2 (en) | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
| WO2024081611A1 (en) | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| US11986474B1 (en) * | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
-
2018
- 2018-06-29 CN CN201880053343.0A patent/CN110996953A/zh active Pending
- 2018-06-29 HU HUE18745732A patent/HUE069805T2/hu unknown
- 2018-06-29 LT LTEPPCT/US2018/040181T patent/LT3645002T/lt unknown
- 2018-06-29 PL PL18745732.0T patent/PL3645002T3/pl unknown
- 2018-06-29 JP JP2019570045A patent/JP2020526483A/ja active Pending
- 2018-06-29 RS RS20250023A patent/RS66581B1/sr unknown
- 2018-06-29 HR HRP20241729TT patent/HRP20241729T1/hr unknown
- 2018-06-29 US US16/625,958 patent/US11576910B2/en active Active
- 2018-06-29 MX MX2020000190A patent/MX2020000190A/es unknown
- 2018-06-29 SI SI201831198T patent/SI3645002T1/sl unknown
- 2018-06-29 PT PT187457320T patent/PT3645002T/pt unknown
- 2018-06-29 MD MDE20200488T patent/MD3645002T2/ro unknown
- 2018-06-29 AU AU2018290983A patent/AU2018290983B2/en active Active
- 2018-06-29 CA CA3068588A patent/CA3068588A1/en active Pending
- 2018-06-29 BR BR112019028046-4A patent/BR112019028046A2/pt not_active Application Discontinuation
- 2018-06-29 EP EP24209435.7A patent/EP4512470A3/en active Pending
- 2018-06-29 FI FIEP18745732.0T patent/FI3645002T3/fi active
- 2018-06-29 WO PCT/US2018/040181 patent/WO2019006235A1/en not_active Ceased
- 2018-06-29 EP EP18745732.0A patent/EP3645002B1/en active Active
- 2018-06-29 SM SM20250067T patent/SMT202500067T1/it unknown
- 2018-06-29 DK DK18745732.0T patent/DK3645002T3/da active
- 2018-06-29 ES ES18745732T patent/ES3008457T3/es active Active
- 2018-06-29 MA MA49508A patent/MA49508B1/fr unknown
-
2020
- 2020-01-08 MX MX2022015115A patent/MX2022015115A/es unknown
-
2023
- 2023-01-17 US US18/155,483 patent/US12295952B2/en active Active
- 2023-03-15 JP JP2023040600A patent/JP2023088944A/ja active Pending
- 2023-05-05 US US18/313,267 patent/US11931358B2/en active Active
-
2024
- 2024-02-15 AU AU2024200991A patent/AU2024200991B2/en active Active
-
2025
- 2025-04-18 US US19/183,619 patent/US20250255862A1/en active Pending
- 2025-07-18 JP JP2025121073A patent/JP2025165979A/ja active Pending
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