CN110996953A - 用心脏肌小节激活剂治疗心力衰竭的方法 - Google Patents
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| PE20151786A1 (es) | 2013-03-14 | 2015-12-11 | Amgen Inc | Compuestos heterociclicos y sus usos |
| SG10202111790YA (en) | 2017-06-30 | 2021-12-30 | Amgen Inc | Synthesis of omecamtiv mecarbil |
| MA49508B1 (fr) * | 2017-06-30 | 2024-12-31 | Amgen Inc. | Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques |
| PL3594199T3 (pl) | 2018-07-09 | 2020-11-16 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Krystaliczny 2-fluoro-3-nitrotoluen i sposób jego wytwarzania |
| MX2021001792A (es) | 2018-08-17 | 2021-05-27 | Amgen Inc | Sales y formas cristalinas de omecamtiv mecarbil. |
| BR112021023074A2 (pt) * | 2019-05-19 | 2022-03-29 | Myokardia Inc | Tratamento de disfunção sistólica e insuficiência cardíaca com fração de ejeção reduzida com o composto (r)-4-(l-(1-((3-(difluorometil)-l--1-metil-1h-pirazol-4-il)sulfonil)-l-1-fluoroetil)-n-(isoxazol-3-il)piperidina-l-1-carboxamida |
| JP7696353B2 (ja) * | 2020-02-10 | 2025-06-20 | アムジェン インコーポレイテッド | オメカムチブメカルビル製剤 |
| WO2021257456A1 (en) * | 2020-06-15 | 2021-12-23 | MyoKardia, Inc. | Treatment of atrial dysfunction |
| EP4243825B1 (en) | 2020-11-12 | 2025-11-12 | Amgen Inc. | Omecamtiv mecarbil for the treatment of heart failure in selected patient groups |
| TW202300479A (zh) | 2021-03-10 | 2023-01-01 | 美商安進公司 | 奧美卡替莫卡必爾之合成 |
| US20250161298A1 (en) * | 2022-02-22 | 2025-05-22 | Yale University | Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth |
| WO2024081611A1 (en) * | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| KR20250174911A (ko) | 2023-03-27 | 2025-12-15 | 엣지와이즈 테라퓨틱스, 인크. | 퀴놀리논 아미드 화합물 및 이의 용도 |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
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| CN1296417A (zh) | 1998-02-10 | 2001-05-23 | 卫福有限公司 | 控释制剂 |
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| AU2003279842A1 (en) | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
| US7507735B2 (en) | 2004-06-17 | 2009-03-24 | Cytokinetics, Inc. | Compounds, compositions and methods |
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| CA2651283A1 (en) | 2006-05-15 | 2007-11-22 | Wisconsin Alumni Research Foundation | Pulmonary delivery of 1.alpha.,25-dihydroxyvitamin d3 and co-administration of parathyroid hormone or calcitonin |
| FR2902092B1 (fr) | 2006-06-07 | 2008-09-05 | Sapelem Soc Par Actions Simpli | Appareil de manutention de charge |
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| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| AU2018214629A1 (en) | 2017-02-06 | 2019-08-22 | Acceleron Pharma Inc. | Compositions and methods for treating heart failure |
| MA49508B1 (fr) | 2017-06-30 | 2024-12-31 | Amgen Inc. | Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques |
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| PL3594199T3 (pl) | 2018-07-09 | 2020-11-16 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Krystaliczny 2-fluoro-3-nitrotoluen i sposób jego wytwarzania |
| EP3820851A1 (en) | 2018-07-12 | 2021-05-19 | Assia Chemical Industries Ltd | Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl |
| PL3599243T3 (pl) | 2018-07-26 | 2023-08-21 | Cvie Therapeutics Limited | Związki podobne do 17beta-heterocyklilu naparstnicy do leczenia niewydolności serca |
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| US12442027B2 (en) | 2018-12-18 | 2025-10-14 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| BR112021017009A2 (pt) | 2019-03-05 | 2021-11-09 | Windtree Therapeutics Inc | Formulação intravenosa contendo istaroxima para o tratamento da insuficiência cardíaca aguda (ahf) |
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| EP4041198A4 (en) | 2019-10-09 | 2023-08-16 | Dr. Reddy's Laboratories Limited | SOLID FORMS OF OMECAMTIV MECARBIL DIHYDROCHLORIDE AND PROCESS THEREOF |
| US20220411374A1 (en) | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
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| EP4243825B1 (en) | 2020-11-12 | 2025-11-12 | Amgen Inc. | Omecamtiv mecarbil for the treatment of heart failure in selected patient groups |
| TW202300479A (zh) | 2021-03-10 | 2023-01-01 | 美商安進公司 | 奧美卡替莫卡必爾之合成 |
| WO2023205291A2 (en) | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
| WO2024081611A1 (en) | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| US11986474B1 (en) * | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116710139A (zh) * | 2020-11-12 | 2023-09-05 | 安进股份有限公司 | 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法 |
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