CA3068588A1 - Methods of treating heart failure with cardiac sarcomere activators - Google Patents
Methods of treating heart failure with cardiac sarcomere activators Download PDFInfo
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| MA49508B1 (fr) * | 2017-06-30 | 2024-12-31 | Amgen Inc. | Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques |
| PL3594199T3 (pl) | 2018-07-09 | 2020-11-16 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Krystaliczny 2-fluoro-3-nitrotoluen i sposób jego wytwarzania |
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| BR112021023074A2 (pt) * | 2019-05-19 | 2022-03-29 | Myokardia Inc | Tratamento de disfunção sistólica e insuficiência cardíaca com fração de ejeção reduzida com o composto (r)-4-(l-(1-((3-(difluorometil)-l--1-metil-1h-pirazol-4-il)sulfonil)-l-1-fluoroetil)-n-(isoxazol-3-il)piperidina-l-1-carboxamida |
| JP7696353B2 (ja) * | 2020-02-10 | 2025-06-20 | アムジェン インコーポレイテッド | オメカムチブメカルビル製剤 |
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| AU2003279842A1 (en) | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
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| MA49508B1 (fr) | 2017-06-30 | 2024-12-31 | Amgen Inc. | Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques |
| SG10202111790YA (en) | 2017-06-30 | 2021-12-30 | Amgen Inc | Synthesis of omecamtiv mecarbil |
| PL3594199T3 (pl) | 2018-07-09 | 2020-11-16 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Krystaliczny 2-fluoro-3-nitrotoluen i sposób jego wytwarzania |
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| PL3599243T3 (pl) | 2018-07-26 | 2023-08-21 | Cvie Therapeutics Limited | Związki podobne do 17beta-heterocyklilu naparstnicy do leczenia niewydolności serca |
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| WO2021053175A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
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| WO2023205291A2 (en) | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
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